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NEW YORK (AP) — U.S. stock indexes rose to more records Wednesday after tech companies talked up how much of a boost they’re getting from the artificial-intelligence boom. The S&P 500 climbed 0.6% to add to what’s set to be one of its best years of the millennium. It’s the 56th time the index has hit an all-time high this year after climbing in 11 of the last 12 days . The Dow Jones Industrial Average rose 308 points, or 0.7%, while the Nasdaq composite added 1.3% to its own record. Salesforce helped pull the market higher after delivering stronger revenue for the latest quarter than analysts expected, though its profit fell just short. CEO Mark Benioff highlighted the company’s artificial-intelligence offering for customers, saying “the rise of autonomous AI agents is revolutionizing global labor, reshaping how industries operate and scale.” The stock price of the company, which helps businesses manage their customers, jumped 11%. Marvell Technology leaped even more after delivering better results than expected, up 23.2%. CEO Matt Murphy said the semiconductor supplier is seeing strong demand from AI and gave a forecast for profit in the upcoming quarter that topped analysts’ expectations. All the optimistic talk helped Nvidia , the company whose chips are powering much of the move into AI, rally 3.5%. It was the strongest force pushing upward on the S&P 500 by far. They helped offset an 8.9% drop for Foot Locker, which reported profit and revenue that fell short of analysts’ expectations. CEO Mary Dillon said the company is taking a more cautious view, and it cut its forecasts for sales and profit this year. Dillon pointed to how keen customers are for discounts and how soft demand has been outside of Thanksgiving week and other key selling periods. Retailers overall have offered mixed signals about how resilient U.S. shoppers can remain. Their spending has been one of the main reasons the U.S. economy has avoided a recession that earlier seemed inevitable after the Federal Reserve hiked interest rates to crush inflation. But shoppers are now contending with still-high prices and a slowing job market . This week’s highlight for Wall Street will be Friday’s jobs report from the U.S. government, which will show how many people employers hired and fired last month. A narrower report released Wednesday morning suggested employers in the private sector increased their payrolls by less last month than economists expected. Hiring in manufacturing was the weakest since the spring, according to Nela Richardson, chief economist at ADP. The report strengthened traders’ expectations that the Fed will cut its main interest rate again when it meets in two weeks. The Fed began easing its main interest rate from a two-decade high in September, hoping to offer more support for the job market. The central bank had appeared set to continue cutting rates into next year, but the election of Donald Trump has scrambled Wall Street’s expectations somewhat. Trump’s preference for higher tariffs and other policies could lead to higher inflation , which could alter the Fed’s plans . Fed Chair Jerome Powell said Wednesday that the central bank can afford to cut rates cautiously because inflation has slowed from its peak two years ago and the economy remains sturdy. A separate report on Wednesday said health care, finance and other businesses in the U.S. services sector are continuing to grow, but not by as much as before and not by as much as economists expected. One respondent from the construction industry told the survey from the Institute for Supply Management that the Fed’s rate cuts haven't pulled down mortgage rates as much as hoped. Plus, “the unknown effect of tariffs clouds the future.” In the bond market, the yield on the 10-year Treasury fell to 4.18% from 4.23% late Tuesday. On Wall Street, Campbell’s sank 6.2% for one of the S&P 500’s sharper losses despite increasing its dividend and reporting a stronger profit than analysts expected. Its revenue fell short of Wall Street’s expectations, and the National Football League’s Washington Commanders hired Campbell’s CEO Mark Clouse as its team president. Gains for airline stocks helped offset that drop after JetBlue Airways said it saw stronger bookings for travel in November and December following the presidential election. It also said it’s benefiting from lower fuel prices, as well as lower costs due to improved on-time performance. JetBlue jumped 8.3%, while Southwest Airlines climbed 3.5%. All told, the S&P 500 rose 36.61 points to 6,086.49. The Dow climbed 308.51 to 45,014.04, and the Nasdaq composite rallied 254.21 to 19,735.12. In stock markets abroad, South Korea’s Kospi sank 1.4% following a night full of drama in Seoul. President Yoon Suk Yeol was facing possible impeachment after he suddenly declared martial law on Tuesday night, prompting troops to surround the parliament. He revoked the martial law declaration six hours later. In the crypto market , bitcoin climbed near $99,000 after Trump said he would nominate Paul Atkins , a cryptocurrency advocate, to chair the Securities and Exchange Commission. AP Writers Matt Ott and Zimo Zhong contributed.Melbourne teen’s workplace pays heartbreaking tribute after tragic passing
American car manufacturer Cadillac will become the eleventh team on the Formula One grid in 2026, after the sport's owners announced Monday they had given their backing to the plan. Formula 1 said it had reached "an agreement in principle" with General Motors (GM), which owns Cadillac, to support bringing a team into the paddock. "Formula 1 has maintained a dialogue with General Motors, and its partners at TWG Global, regarding the viability of an entry following the commercial assessment and decision made by Formula 1 in January 2024," Formula One said in its statement. "Over the course of this year, they have achieved operational milestones and made clear their commitment to brand the eleventh team GM/Cadillac, and that GM will enter as an engine supplier at a later time," Formula One said in a statement. The cars are expected to be powered by Ferrari before it develops its own engines. The move comes after Formula 1 rejected the bid which was headed up by Andretti – owned by Michael Andretti, son of 1978 world champion Mario Andretti – earlier this year. Nearly a fortnight ago, GM announced it had registered with the FIA to become a Formula One engine manufacturer from 2028, offering support to Andretti's bid to join the F1 grid. The Andretti name has since been dropped from the proposal with Michael no longer involved, although Mario is understood to be taking on an ambassadorial role. "It's an honour for General Motors and Cadillac to join the world's premier racing series, and we're committed to competing with passion and integrity to elevate the sport for race fans around the world," said GM president Mark Reuss. The US has become an increasingly important stop on the F1 tour. This announcement comes less than 48 hours after the Las Vegas Grand Prix which, after Miami and Austin, is the third US race on the calendar. The Netflix series 'Drive to Survive' has also boosted the sport's profile in the US. FIA president Mohammed Ben Sulayem, who had been in favour of the original Andretti bid, said he was "fully supportive" of the arrival of the GM/Cadillac team. "All parties, including the FIA, will continue to work together to ensure the process progresses smoothly," he said. Stefano Domenicali, the president and CEO of Formula 1, described the news as "an important and positive demonstration of the evolution of our sport". "We look forward to seeing the progress and growth of this entry, certain of the full collaboration and support of all the parties involved," he said. (AFP)
Gates Group Files for 2.5M Share IPO at $5.50-$6.50/sh2022 Wimbledon finalist Nick Kyrgios has been outspoken about World No. 1 Jannik Sinner ‘s doping scandal. Recently, he made more controversial remarks about the Italian star. In a story published by The Tennis Letter, Sinner shared his thoughts on the doping allegations and how they might affect his career. Kyrgios responded to the post on social media, making his views clear once again. Yes. You tested for steroids. Very hard to talk to other people who aren’t. Yes. You tested for steroids. Very hard to talk to other people who aren’t. Kyrgios’ criticism focuses on what he sees as “double standards” in tennis. He argued that Sinner should not be allowed to play after failing doping tests, citing examples like Simona Halep and Maria Sharapova , who faced lengthy suspensions for similar issues. For now, Sinner is cleared to compete at the Australian Open, where he will defend his title in January at Rod Laver Arena. However, the World Anti-Doping Agency (WADA) is expected to deliver its final verdict on Sinner’s case after the tournament. It is uncertain whether he will be allowed to play in Rotterdam, where he is also the defending champion. Jannik Sinner headlines the entry list at the Australian Open World No. 1 Jannik Sinner will lead the field at the Australian Open in Melbourne. The Italian star is the defending champion, having won the 2024 title. Other top players like Alexander Zverev , Carlos Alcaraz , and Taylor Fritz will also compete. Former champions Novak Djokovic and Daniil Medvedev join Sinner on the main-draw list. Djokovic is aiming for a record 11th Australian Open title. With Andy Murray as his new coach, the 24-time Grand Slam champion also hopes to win his 100th tour-level title. He may reach that milestone earlier, as he is set to play at the Brisbane International at the start of the season. Top 10 players like Zverev, Fritz, Casper Ruud , Andrey Rublev , and Grigor Dimitrov are chasing their first Grand Slam title in Melbourne. Australian No. 9 Alex de Minaur , who has reached the fourth round three years in a row, will lead the local hopes. Nick Kyrgios is set to return to the Australian Open for the first time in two years. The 29-year-old will play his first competitive match since June 2023 in Brisbane before heading to Melbourne. Alexei Popyrin and Jordan Thompson, both in the Top 30, will also represent Australia. This article first appeared on FirstSportz and was syndicated with permission.Enzo Maresca ‘thankful’ for connection at Leicester ahead of return with Chelsea
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Grupo Aeroportuario del Pacifico Reports in November 2024 a Passenger Traffic Increase of 1.8% Compared to 2023
NoneIn response to an ultimatum from the Pinellas County (Fla.) Commission last week, Tampa Bay Rays ownership said in a letter Monday that its deal to build a new $1.3 billion ballpark is still "in effect." The letter was the latest salvo in a verbal back-and-forth between the MLB franchise and the county. Rays presidents Brian Auld and Matt Silverman wrote to the County Commission on Nov. 19 and suggested the team would not agree to a deal for a new stadium. The Rays claimed they had spent more than $50 million toward building that new stadium, but the county had allegedly "suspended work on the entire project," making its targeted 2028 opening unfeasible. Last Monday, Pinellas County Court Commission Chairperson Kathleen Peters replied in a letter to Auld and Silverman requesting they declare by Dec. 1 whether they are in or out. "In response to your question regarding the status of the various agreements, they are in effect until a party terminates or outside dates are reached," Silverman responded Monday, with Dec. 1 now past. "The Rays have fulfilled its obligations to date and continue to wait for decisions and actions by the City of St. Petersburg and Pinellas County." "We would not have gone forward with the project if a future Pinellas County Commission had the ability to revoke the approval we all celebrated in July or to unilaterally delay the project's completion into 2029." Silverman also fired back at Peters for bringing up a conversation Auld had with Pinellas County Commissioner Brian Scott last month, prompting the county to allege that Auld was not committed to following through on the project. "The conversation primarily concerned the near-term challenges to our business given the damage to Tropicana Field as well as the dynamics related to the location of our home games in 2025," Silverman wrote Monday. "Brian Auld did not waver from our commitment to the new ballpark project." It is unclear how the county will proceed. The Pinellas County Commission already voted 6-1 last month to put off its final decision on whether to approve bonds until Dec. 17. Regardless of what happens in the Rays' long-term planning, the club will not play its 2025 home games in St. Petersburg after Tropicana Field was heavily damaged by Hurricane Milton in early October. The team will instead welcome opponents to Tampa's George M. Steinbrenner Field, the spring training home of the New York Yankees. --Field Level MediaNone
THOUSAND OAKS, Calif. , Dec. 2, 2024 /PRNewswire/ -- Amgen (NASDAQ:AMGN) will present at Citi's 2024 Global Healthcare Conference at 9:30 a.m. ET on Thursday , Dec. 5, 2024. Peter Griffith , executive vice president and chief financial officer at Amgen, Jay Bradner , executive vice president of Research and Development and chief scientific officer at Amgen, and Susan Sweeney , executive vice president of Obesity and Related Conditions at Amgen, will participate in a fireside chat at the conference. The webcast will be broadcast over the internet simultaneously and will be available to members of the news media, investors and the general public. The webcast, as with other selected presentations regarding developments in Amgen's business given by management at certain investor and medical conferences, can be found on Amgen's website, www.amgen.com , under Investors. Information regarding presentation times, webcast availability and webcast links are noted on Amgen's Investor Relations Events Calendar. The webcast will be archived and available for replay for at least 90 days after the event. About Amgen Amgen discovers, develops, manufactures and delivers innovative medicines to help millions of patients in their fight against some of the world's toughest diseases. More than 40 years ago, Amgen helped to establish the biotechnology industry and remains on the cutting-edge of innovation, using technology and human genetic data to push beyond what's known today. Amgen is advancing a broad and deep pipeline that builds on its existing portfolio of medicines to treat cancer, heart disease, osteoporosis, inflammatory diseases and rare diseases. In 2024, Amgen was named one of the "World's Most Innovative Companies" by Fast Company and one of "America's Best Large Employers" by Forbes, among other external recognitions . Amgen is one of the 30 companies that comprise the Dow Jones Industrial Average ® , and it is also part of the Nasdaq-100 Index ® , which includes the largest and most innovative non-financial companies listed on the Nasdaq Stock Market based on market capitalization. Amgen is one of the 30 companies that comprise the Dow Jones Industrial Average and is also part of the Nasdaq-100 index. In 2023, Amgen was named one of "America's Greatest Workplaces" by Newsweek, one of "America's Climate Leaders" by USA Today and one of the "World's Best Companies" by TIME. For more information, visit Amgen.com and follow us on X (formerly known as Twitter), LinkedIn , Instagram , TikTok , YouTube and Threads . Amgen Forward-Looking Statements This news release contains forward-looking statements that are based on the current expectations and beliefs of Amgen. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including any statements on the outcome, benefits and synergies of collaborations, or potential collaborations, with any other company (including BeiGene, Ltd. or Kyowa Kirin Co., Ltd.), the performance of Otezla ® (apremilast) (including anticipated Otezla sales growth and the timing of non-GAAP EPS accretion), our acquisitions of Teneobio, Inc., ChemoCentryx, Inc., or Horizon Therapeutics plc (including the prospective performance and outlook of Horizon's business, performance and opportunities, any potential strategic benefits, synergies or opportunities expected as a result of such acquisition, and any projected impacts from the Horizon acquisition on our acquisition-related expenses going forward), as well as estimates of revenues, operating margins, capital expenditures, cash, other financial metrics, expected legal, arbitration, political, regulatory or clinical results or practices, customer and prescriber patterns or practices, reimbursement activities and outcomes, effects of pandemics or other widespread health problems on our business, outcomes, progress, and other such estimates and results. Forward-looking statements involve significant risks and uncertainties, including those discussed below and more fully described in the Securities and Exchange Commission reports filed by Amgen, including our most recent annual report on Form 10-K and any subsequent periodic reports on Form 10-Q and current reports on Form 8-K. Unless otherwise noted, Amgen is providing this information as of the date of this news release and does not undertake any obligation to update any forward-looking statements contained in this document as a result of new information, future events or otherwise. No forward-looking statement can be guaranteed and actual results may differ materially from those we project. Our results may be affected by our ability to successfully market both new and existing products domestically and internationally, clinical and regulatory developments involving current and future products, sales growth of recently launched products, competition from other products including biosimilars, difficulties or delays in manufacturing our products and global economic conditions. In addition, sales of our products are affected by pricing pressure, political and public scrutiny and reimbursement policies imposed by third-party payers, including governments, private insurance plans and managed care providers and may be affected by regulatory, clinical and guideline developments and domestic and international trends toward managed care and healthcare cost containment. Furthermore, our research, testing, pricing, marketing and other operations are subject to extensive regulation by domestic and foreign government regulatory authorities. We or others could identify safety, side effects or manufacturing problems with our products, including our devices, after they are on the market. Our business may be impacted by government investigations, litigation and product liability claims. In addition, our business may be impacted by the adoption of new tax legislation or exposure to additional tax liabilities. If we fail to meet the compliance obligations in the corporate integrity agreement between us and the U.S. government, we could become subject to significant sanctions. Further, while we routinely obtain patents for our products and technology, the protection offered by our patents and patent applications may be challenged, invalidated or circumvented by our competitors, or we may fail to prevail in present and future intellectual property litigation. We perform a substantial amount of our commercial manufacturing activities at a few key facilities, including in Puerto Rico , and also depend on third parties for a portion of our manufacturing activities, and limits on supply may constrain sales of certain of our current products and product candidate development. An outbreak of disease or similar public health threat, such as COVID-19, and the public and governmental effort to mitigate against the spread of such disease, could have a significant adverse effect on the supply of materials for our manufacturing activities, the distribution of our products, the commercialization of our product candidates, and our clinical trial operations, and any such events may have a material adverse effect on our product development, product sales, business and results of operations. We rely on collaborations with third parties for the development of some of our product candidates and for the commercialization and sales of some of our commercial products. In addition, we compete with other companies with respect to many of our marketed products as well as for the discovery and development of new products. Discovery or identification of new product candidates or development of new indications for existing products cannot be guaranteed and movement from concept to product is uncertain; consequently, there can be no guarantee that any particular product candidate or development of a new indication for an existing product will be successful and become a commercial product. Further, some raw materials, medical devices and component parts for our products are supplied by sole third-party suppliers. Certain of our distributors, customers and payers have substantial purchasing leverage in their dealings with us. The discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. Our efforts to collaborate with or acquire other companies, products or technology, and to integrate the operations of companies or to support the products or technology we have acquired, may not be successful. There can be no guarantee that we will be able to realize any of the strategic benefits, synergies or opportunities arising from the Horizon acquisition, and such benefits, synergies or opportunities may take longer to realize than expected. We may not be able to successfully integrate Horizon, and such integration may take longer, be more difficult or cost more than expected. A breakdown, cyberattack or information security breach of our information technology systems could compromise the confidentiality, integrity and availability of our systems and our data. Our stock price is volatile and may be affected by a number of events. Our business and operations may be negatively affected by the failure, or perceived failure, of achieving our environmental, social and governance objectives. The effects of global climate change and related natural disasters could negatively affect our business and operations. Global economic conditions may magnify certain risks that affect our business. Our business performance could affect or limit the ability of our Board of Directors to declare a dividend or our ability to pay a dividend or repurchase our common stock. We may not be able to access the capital and credit markets on terms that are favorable to us, or at all. CONTACT: Amgen, Thousand Oaks Elissa Snook , 609-251-1407 (media) Justin Claeys , 805-313-9775 (investors) View original content to download multimedia: https://www.prnewswire.com/news-releases/amgen-to-present-at-citis-2024-global-healthcare-conference-302319891.html SOURCE Amgen
Israel launches new strikes on Lebanon as leaders draw closer to ceasefire with HezbollahIt was the fourth time this season they had conceded four or more and the performance showed why they have the Premier League’s worst defence. When O’Neil and the players went over to acknowledge the visiting supporters there were boos for a run of two wins in 14 league matches. “Whatever the fans think of me, there is definitely no-none working harder than me and I will continue to do so until someone tells me not to,” said O’Neil, who is under increasing pressure with his side second bottom of the table. “I go over there to see them because I appreciate every one of the Wolves fans. They have given me unbelievable support since I arrived at the football club,” he said. “We managed to produce some unbelievable stuff last season with a team that was heavily tipped by most of the nation for relegation. We managed to enjoy it together. “Now it is tough. I was happy to go over there and look them right in the face and take any criticism they want to throw at me. “I accept responsibility for my part in that. Whatever criticism they want to throw at me will not change how I feel about them. “Everyone at this football club needs to do more. We will get back to be ready to fight again on Monday (another crucial game against West Ham, whose manager Julen Lopetegui’s tenure is hanging by a thread). “I will work with everything I have. I will back myself to get the most out of the group. I understand the drive for change (but) you never know how much of a percentage of supporters it is.” Veteran Ashley Young ended Everton’s 370-minute wait for a goal with a 10th-minute free-kick, his first league goal for more than two years, and on-loan Lyon midfielder Orel Mangala blasted home his first for the club to establish a 2-0 half-time lead. Two Craig Dawson own goals secured Everton’s biggest home league win since April 2019, but manager Sean Dyche insisted their issues up front were far from sorted. He said: “It’s our fifth clean sheet in the last eight so the consistency has been there in one degree, we just haven’t been scoring goals. That’s been the hardest thing to find consistently and we haven’t solved it yet. “Goals change everything, they change opinions. That’s what football is like.” The victory was hugely important in a month in which, having been hammered 4-0 at Manchester United, they face top-six sides Liverpool, Arsenal, Chelsea, Manchester City and Nottingham Forest and undoubtedly eased some of the pressure on Dyche and his players. “I’ve told them how proud I am of them,” he added. “The challenges come thick and fast on and off the pitch and they just keep going. “It’s only a step and there are many more to go but it’s a good step and a positive step. “It’s a temporary moment in time because the next one is a big one (Saturday’s Merseyside derby).”
CLEVELAND (AP) — Shortly after doing a face-down snow angel, firing a few celebratory snowballs and singing “Jingle Bells” on his way to the media room, Jameis Winston ended his postgame news conference with a simple question. “Am I a Brown yet?” he asked. He is now. And who knows? Maybe for a lot longer than expected. Winston entered Cleveland football folklore on Thursday night by leading the Browns to a 24-19 win over the division rival Pittsburgh Steelers, who had their five-game winning streak stopped. Winston's performance at Huntington Bank Field, which transformed into the world's largest snow globe, not only made him an instantaneous hero in the eyes of Browns fans but added another wrinkle to the team's ever-changing, never-ending quarterback conundrum. In his fourth start since Deshaun Watson's season-ending Achilles tendon injury, Winston made enough big plays to help the Browns (3-8) get a victory that should quiet conjecture about coach Kevin Stefanski's job. Some wins mean more than others. In Cleveland, beating the Steelers is as big as it gets. But beyond any instant gratification, Winston has given the Browns more to consider as they move forward. Watson's future with Cleveland is highly uncertain since it will still be months before the team has a grip on whether he's even an option in 2025, his fourth year since signing a $230 million, fully guaranteed contract that has proven calamitous. It's also possible the Browns will cut ties with Watson. They signed Winston to a one-year contract to be Watson's backup. But the unexpected events of 2024 have changed plans and led to the possibility that the 30-year-old Winston could become Cleveland's full-time QB or a bridge to their next young one. So much is unclear. What's not is that Winston, who leaped into the end zone on fourth-and-2 for a TD to put the Browns ahead 18-6 in the fourth quarter, is a difference maker. With his larger-than-life personality and the joy he shows whether practicing or throwing three touchdown passes, he has lifted the Browns. A man of faith, he's made his teammates believe. Winston has done what Watson couldn't: made the Browns better. “A very, very authentic person,” Stefanski said Friday on a Zoom call. “He’s the same guy every single day. He's the same guy at 5 a.m. as he at 5 p.m. He brings great energy to everything he does, and I think his teammates appreciate that about him.” Winston, who is 2-2 as a starter with wins over the Steelers and Baltimore Ravens, has a knack for inspiring through fiery, preacher-like pregame speeches. But what has impressed the Browns is his ability to stay calm in the storm. “He doesn’t get rattled,” said Myles Garrett, who had three sacks against the Steelers . “He’s just tuned in and focused as anyone I’ve seen at that position. Turn the page. There was a turnover, came back to the sideline, ‘Love you. I’m sorry. We’re going to get it back.’ He was already on to the next one, ‘How can we complete the mission?’ “I have a lot of respect for him. First was from afar and now seeing it on the field in front of me, it’s a blessing to have someone who plays a game with such a passion and want-to. You can’t ask for a better teammate when they take those things to heart and they want to play for you like we’re actually brothers and that’s what we have to attain. That brotherhood.” Winston has done something else Watson couldn't: move the offense. The Browns scored more than 20 points for just the second time this season, and like Joe Flacco a year ago, Winston has shown that Stefanski's system works with a quarterback patient enough to let plays develop and unafraid to take shots downfield. The conditions certainly were a factor, but the Browns were a miserable 1 of 10 on third down, a season-long trend. However, Cleveland converted all four fourth-down tries, including a fourth-and-3 pass from Winston to Jerry Jeudy with 2:36 left that helped set up Nick Chubb's go-ahead TD run. RT Jack Conklin. Garrett outplayed Steelers star T.J. Watt in their rivalry within the rivalry partly because Conklin did a nice job containing Pittsburgh's edge rusher, who was held without a sack and had one tackle for loss. Conklin has made a remarkable comeback since undergoing reconstructive knee surgery last year. Owners Dee and Jimmy Haslam. Their desire to build a dome is well intended, but an indoor game could never come close to matching the surreal setting of Thursday night, when snow swirled throughout the stadium and covered nearly all the yard lines and hash marks. “It was beautiful,” Winston said. WR Cedric Tillman is in the concussion protocol. He had two catches before taking a big hit on the final play of the third quarter. 9 — Consecutive home wins for the Browns in Thursday night games. Three of those have come against Pittsburgh. An extended break before visiting the Denver Broncos on Dec. 2. AP NFL: https://apnews.com/hub/NFLNAFDAC withdraws approval for multiple Pharmaceutical products in NigeriaIsrael launches new strikes on Lebanon as leaders draw closer to ceasefire with Hezbollah
