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December 11, 2024 This article has been reviewed according to Science X's editorial process and policies . Editors have highlightedthe following attributes while ensuring the content's credibility: fact-checked peer-reviewed publication trusted source proofread by Carnegie Institution for Science A team of researchers led by Carnegie Science's Will Ludington, Karina Gutiérrez-García, and Kevin Aumiller identified genes that enable a beneficial bacterial species to colonize specific regions of the gastrointestinal tract. Their work, published in Science , could revolutionize our understanding of how the composition of the gut microbiome is determined and open the door to microbiome engineering. The gut microbiome is an ecosystem of hundreds to thousands of microbial species living within the human body and influencing our health, fertility, and even longevity. These populations can aid digestion, inform immune responses, and help fight off pathogens among other functions. However, the microbiome isn't uniform throughout the gut. Just as various organs within the gastrointestinal system have different specialties when it comes to digesting food and absorbing nutrients, different microbial communities are localized within each zone and play unique roles there. Successful colonization of each region of the G.I. tract by different microbial populations is dependent on a variety of factors such as nutrient requirements of the bacteria; the local pH and dissolved oxygen content ; competition with other bacterial strains; and survivability in harsh conditions —including stomach acid, bile salts, and immune-response cells. "We're talking about an incredibly complex system of interconnected microbial communities, and each species needs to get to the right place where it can thrive and contribute to host health," explained Ludington, who has been probing microbiome acquisition and composition for several years at Carnegie. "Researchers have been trying to figure out how each bacterial species is directed to the right location and how colonization by harmful or less-than-ideal species is minimized." Think about checked luggage moving through the system of conveyor belts behind the scenes at a busy, urban airport. The baggage handling system may look disorganized and chaotic, but the majority of bags get to the plane where they need to be. And processes are in place to correct any erroneous sorting that occurs over time. "Likewise, in the gut, beneficial bacteria need to get to the region where they can successfully create a colony," co-lead author Gutiérrez-García indicated. "We worked to reveal the mechanisms that enable this to happen." Successful colonization hinges on proteins in bacterial cell walls called adhesins. As you might guess from their name, they can stick to a variety of different surfaces within the body. But they typically bind non-specifically, meaning they could just as soon attach to one tissue as another. So how do symbiotic microbiome species get to the place they need to go? To tackle this mystery, Ludington, Gutiérrez-García, Aumiller and their colleagues developed technology that enabled them to watch a single cell of the bacterial species Lactiplantibacillus plantarum colonize its niche within the fruit fly gut in real time. The team also included Carnegie's Ren Dodge, Benjamin Obadia, Haolong Zhu, and Ru-Ching Hsia, as well as Ann Deng, Sneha Agrawal, and Xincheng Yuan from Johns Hopkins University and, Richard Wolff and Nandita Garud from UCLA. Discover the latest in science, tech, and space with over 100,000 subscribers who rely on Phys.org for daily insights. Sign up for our free newsletter and get updates on breakthroughs, innovations, and research that matter— daily or weekly . The fruit fly may be a pest in the kitchen, but it's a workhorse in the laboratory and the perfect organism for this type of research, because the species that comprise its microbiome are well defined and small in number. Watching the events unfold in such high-resolution detail enabled the scientists to see the difference between short-lived colonization and long-term success. "Developing this imaging technique was an exciting challenge," said Dodge, a key contributor to the study. "It allowed us to see the interactions of individual bacteria cells with the host gut in unprecedented detail." They found that L. plantarum isolated from the guts of wild fruit flies was able to stably attach to host tissue whereas L. plantarum from humans and other sources formed only transient attachments. With this information in hand, the researchers set out to determine the genetic basis for this super-affinity. Through diligent and painstaking work, they were able to identify a set of genes for symbiotic gut colonization within a niche. "By identifying the genes that enable L. plantarum to colonize specific niches, we now have the insights into how to engineer greater precision into other bacteria," said Aumiller, a co-lead author on the project. "This opens the door to creating probiotics that are optimized for specific niches in the human gut." "Looking ahead, we will attempt to elucidate the mechanism underlying this binding specificity," Ludington concluded. More information: Karina Gutiérrez-García et al, A conserved bacterial genetic basis for commensal-host specificity, Science (2024). DOI: 10.1126/science.adp7748 Journal information: Science Provided by Carnegie Institution for Science
An explosion destroys an apartment block in a Dutch city, killing at least 3 and injuring others THE HAGUE, Netherlands (AP) — An explosion and fire rocked a neighborhood in the Dutch city of The Hague on Saturday, killing three people and injuring other people and destroying several apartments, according to authorities. Molly Quell, The Associated Press Dec 7, 2024 8:47 AM Share by Email Share on Facebook Share on X Share on LinkedIn Print Share via Text Message Firefighters stand by a building destruction at the site of an explosion which destroyed several apartments and injured multiple people, at The Hague, Saturday, Dec. 7, 2024. (AP Photo/Phil Nijhuis) THE HAGUE, Netherlands (AP) — An explosion and fire rocked a neighborhood in the Dutch city of The Hague on Saturday, killing three people and injuring other people and destroying several apartments, according to authorities. The cause of the disaster was unclear. Mayor Jan van Zanen said investigators were looking into “all possibilities.” Police said they are looking for a car seen leaving the scene in case that helps with the investigation. Van Zanen said three bodies were pulled from the rubble. Emergency authorities said four people were rescued and taken to the hospital. The mayor said rescuers were no longer looking for survivors but for eventual bodies, given that the ‘’slim chance of survival'' under what's left of the apartments. He could not specify how many people might still be unaccounted for. Residents of the northeastern neighborhood of Mariahoeve in The Hague heard a huge bang and screams before dawn. One woman told local media that she thought an earthquake had happened. Dutch authorities deployed a specialized urban search and rescue team to the scene, with four dogs trained to find victims. The team was previously used during the devastating earthquake in Turkey in 2023. Soon after the explosion, a line of ambulances could be seen waiting nearby in anticipation of more victims. The spokesperson for the local hospital said that they were on standby to deal with injuries. The mayor called it “an extremely heavy day." “I had expected a different Saturday,'' van Zanen told a news conference. Prime Minister Dick Schoof said in a statement he was shocked by the images of the disaster. “My thoughts go out to the victims, all other people involved and the emergency services who are now working on the scene,” he said. The Dutch royal family expressed similar sentiments. “Our thoughts are with those affected in The Hague after the explosion and fire this morning,'' including those "who are afraid of the fate of their loved ones,” King Willem-Alexander and Queen Máxima said in a statement. ___ Associated Press journalists Aleksandar Furtula and Ahmad Seir contributed to this report. Molly Quell, The Associated Press See a typo/mistake? Have a story/tip? This has been shared 0 times 0 Shares Share by Email Share on Facebook Share on X Share on LinkedIn Print Share via Text Message More World News Trump is welcomed by Macron to Paris with presidential pomp and joined by Zelenskyy for their talks Dec 7, 2024 9:29 AM Syrian insurgents reach the capital's suburbs. Worried residents flee and stock up on supplies Dec 7, 2024 9:22 AM South Korea's president avoids an impeachment attempt over short-lived martial law Dec 7, 2024 7:02 AM Featured Flyer
Sony’s cloud streaming makes the PlayStation Portal far more usefulSaquon Barkley is the NFL’s version of Shohei Ohtani: AnalysisThe cable car system of San Francisco is the last manually operated cable car system in the world, with three of the original twenty-three lines still operating today. With these systems being installed between 1873 and 1890, they were due major maintenance and upgrades by the time the 1980s and with it their 100th year of operation rolled around. This rebuilding and upgrading process was by a local SF television station, which makes for some fascinating viewing. While the cars themselves were fairly straight-forward to restore, and the original grips that’d latch onto the cable didn’t need any changes. But there were upgrades to the lubrication used (originally pine tar), and the powerhouse (the ‘barn’) was completely gutted and rebuilt. As opposed to a funicular system where the cars are permanently attached to the cable, a cable car system features a constantly moving cable that the cars can grip onto at will, with most of the wear and tear on the grip dies. Despite researchers at San Francisco State University (SFSU) investigating alternatives, the original metal grip dies were left in place, despite their 4-day replacement schedule. Ultimately, the rails and related guides were all ripped out and replaced with new ones, with the rails thermite-welded in place, and the cars largely rebuilt from scratch. Although new technologies were used where available, the goal was to keep the look as close as possible to what it looked at the dawn of the 20th century. While more expensive than demolishing and scrapping the original buildings and rolling stock, this helped to keep the look that has made it a historical symbol when the upgraded system rolled back into action on June 21, 1984. Decades later, this rebuilt cable car system is still running as smoothly as ever, thanks to these efforts. Although SF’s cable car system is reportedly mostly used by tourists, the technology has seen somewhat of a resurgence. Amidst a number of funicular systems, a true new cable car system can be found in the form of e.g. the system which fills the automated people mover niche. Thanks to [JRD] for the tip.
Social Democrats deputy leader ‘very angry’ about Eoin Hayes' misleading statements
Wavegate Corporation Announces $26 Million Series A Funding Round Led by UCEA Capital Partners Ltd.The Philadelphia Eagles have received NFL approval for the sale of an 8% minority stake, a deal that values the franchise at a whopping $8.3 billion, according to league reports. The approval was granted during Wednesday's NFL owners' meeting in Dallas, marking another milestone in the escalating valuation of NFL teams. The transaction introduces new minority stakeholders to the Eagles organization while maintaining majority owner Jeffrey Lurie's full control of the team. Notably, the sale excludes assets such as Lincoln Financial Field. Among the new investors are Susan Kim, chairman of the board at Amkor Technology, as well as Zack Peskowitz and Olivia Peskowitz Suter, children of Ed Peskowitz—co-founder of United Communications Group and a former co-owner of the Atlanta Hawks. Javascript is required for you to be able to read premium content. Thanks for the feedback.
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Wicked star Ariana Grande has said she and Cynthia Erivo were “insufferable” and “horrible” in the build-up to the film’s release. Grande, 31, also said her co-star was a “brilliant gift of a human being” while being interviewed by Gladiator star Paul Mescal for US news outlet Variety. Mescal told the singer and actor: “I’m watching you guys in the press tour. You’re obviously in love with each other.” To which she replied: “Insufferable. Yes. We’re horrible. It’s bad.” The 7 Rings singer plays Glinda, while her 37-year-old co-star plays Elphaba, in the film which is an adaption of the musical stage show of the same name and is set in The Land Of Oz before the events of The Wizard Of Oz. Their interviews for the film, which have seen the two being emotional towards one another and holding hands, have gone viral on social media. Speaking about Erivo, Grande said: “Cynthia is just an absolute brilliant gift of a human being. I think we tried to keep the pressure out of the room, obviously, as much as possible.” She also said she had not had any read throughs with her co-star before joining the cast. Grande said: “We never chemistry read together, it was three rounds for me, and I read with two different actresses. “I stayed for three and a half hours the final day, and I had cried so much. “We did Popular, Defying Gravity, (and) For Good (songs from the film), and I left my lashes on the mirror, because I left everything else in the room.” The film follows Elphaba, who is misunderstood because of her green skin, as she forges an unlikely friendship with Glinda, a student with a desire for popularity. Bullying of the green-skinned witch saw the movie, which also stars Peter Dinklage, Jeff Goldblum and Jonathan Bailey, given a PG rating by the British Board Of Film Classification (BBFC) for “discrimination”.Three Things to Watch as FDIC Tightens Up on FinTech
