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cash carnival play slots game Final Fantasy 7 Rebirth director says the JRPG's success in year-end awards proves "why it's a good thing to have it as a trilogy"The Indian arm of UK-headquartered pharmaceutical giant AstraZeneca has laid off more than 125 employees from its biopharmaceutical business unit, according to people aware of the development. ET Year-end Special Reads What kept India's stock market investors on toes in 2024? India's car race: How far EVs went in 2024 Investing in 2025: Six wealth management trends to watch out for Among them are some 20 senior managers and 110 executives at various levels in the sales department, the people cited earlier told ET. The downsizing has affected employees across the board and includes those having put in 15 years in the company, they said. AstraZeneca India confirmed that the headcount has changed but did not say how many jobs have been cut. "In the biopharmaceutical business unit, we are furthering efforts to deliver the next generation of therapeutics in our pipeline, focusing on specialists, science and innovation, while improving access of our existing portfolio in specialist disease areas," a company spokesperson said in an email response to ET's query. The company statement said, "This has led to strategic restructuring of our biopharmaceutical team impacting certain roles. We are fully cognizant of the impact this has caused, and our first responsibility remains towards our employees and meeting the needs of patients." 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The unit sold some of the old, legacy brands such as anti-cholesterol brand Crestor, clot buster Brilinta and Forxiga, one of the best prescribed brands for the treatment of diabetes. Along with a few other brands, the annual sales from the biopharma unit were around ₹400 crore, according to an industry source. However, the loss of patent exclusivity of these brands in India resulted in a deluge of generic drugs in the market. "When dapagliflozin (Forxiga) lost its patent rights four years ago, at least 250 generic substitutes came in. It gets tough for MNCs to compete on pricing," the source said. However, AstraZeneca's ambitions for India remain. A significant traction is seen in its new wave of patented drugs like Tagrisso for lung cancer, Koselugo for a rare genetic disorder, Breztri (drug to treat COPD) and Enhertu used in the treatment of breast and gastric cancer. In that direction, AstraZeneca said in the statement, "Our aspiration to be pioneers in science has increased our focus on specialist disease areas where we can make the most meaningful difference in helping people with cancer, other chronic and rare diseases." Over the last few years, AstraZeneca has seen a series of job cuts in its core India operations, while it has continued to invest and ramped up capacity at its global capability centres at Bengaluru and Chennai to support research and innovation efforts. Nominations for ET MSME Awards are now open. The last day to apply is December 31, 2024. Click here to submit your entry for any one or more of the 22 categories and stand a chance to win a prestigious award. (You can now subscribe to our Economic Times WhatsApp channel )

Saudi Gazette report RIYADH — The Saudi Space Agency announced on Sunday the launch of the "Centre for Space Futures ," the first center of its kind within the World Economic Forum’s Fourth Industrial Revolution Network. This launch comes within the framework of the Kingdom’s efforts to enhance its leadership in the space sector and support economic, research and innovation growth in this vital field. The center also announced the members of its board of directors, which includes a group of international experts; most notably Dr. Mohammed Altamimi, CEO of the Saudi Space Agency and chairman of the Board of Directors of the Center; Deputy Minister of Economy and Planning Eng. Ammar Nagadi; Managing Director of the World Economic Forum Jeremy Jurgens; Martijn Blanken, CEO of Neo Space Group; co-founder and CEO of the Board of Directors of “Axiom Space” Kam Ghaffarian; and founder of Spaceport SARABHAI Susmita Mohanty. The board embodies the expertise and strategic vision necessary to achieve its ambitious goals. In a statement on this occasion, Dr. Mohammed Altamimi stressed that the "Centre for Space Futures ," represents a qualitative addition to the global arena in the space sector. "The Kingdom seeks through it to enhance a vital and sustainable space economy, develop knowledge and exchange experiences, in addition to improving models of cooperation and partnerships. Its launch will enhance the Kingdom's role at the regional and global levels and enable humanity to seize the opportunities that the vast space holds with awareness and responsibility," he said. For her part, Director General of the Center Eng. Mishaal Al-Shamimri stressed the importance of this launch, saying that the "Centre for Space Futures "will work to enhance the growth of research and innovation fields in space, in addition to developing best practices and regulatory and legislative policies. She highlighted the importance of international cooperation in facing common challenges to achieve a sustainable space future. "The center will enhance the Kingdom's role in the global space industry, and give it an additional pioneering role in finding solutions to technical and regulatory challenges," she said. It is noteworthy that the "Centre for Space Futures" aims to establish a global platform to maximize the economic and environmental value of the space sector, develop the best regulatory policies, and stimulate technical innovation. It also enables the Kingdom to access the Fourth Industrial Revolution community and cooperate closely with global partners to achieve its ambitious goals in the space sector, and thus enhancing its future vision. It is noteworthy that the World Economic Forum had signed an agreement with the Saudi Space Agency to establish the Centre for Space Futures in April 2024. The center aims to facilitate public-private discussions on space collaboration, incorporating best practices from the forum and its communities into the global space sector, and generating forward-looking contributions to accelerate space technologies. The Centre for Space Futures is the first in the network of the Fourth Industrial Revolution Centers to focus exclusively on space. It will work alongside the existing center in the Kingdom (C4IR Saudi Arabia) to advance Saudi Vision 2030, the country’s roadmap for economic diversification, global engagement, and improved quality of life. < Previous Page Next Page >

Nebraska offensive coordinator Dana Holgorsen has no shortage of memories of the Iowa football program. An Iowa native born in Davenport, Holgorsen’s days as a Hawkeye fan are long in the past — but he remembers what it’s like to coach against them. An experience that Holgorsen first underwent as a young Texas Tech assistant in 2001 will be reprised again this weekend. “Twenty-some years later, it’s the same scheme, the same coach, the same everything; this is crazy,” Holgorsen said of Iowa. “It’s going to take another good effort and more improvement to be able to go to Iowa and play in that atmosphere against a good football team.” Nebraska’s recent surge on offense will have the Huskers feeling confident about their upcoming matchup. While Nebraska may not have equaled its recent 44-point outburst against Wisconsin during a loss to USC two weeks prior, foundational improvements were there from the start in Holgorsen’s eyes. Despite scoring 13 points on offense against the Trojans, the Husker offense “just felt better” in that game, Holgorsen said, leading to a “very motivated team” during the week’s practice efforts. And when NU hit the field on Saturday, improvements were there. After struggling to finish drives against USC, Nebraska scored five touchdowns in its seven red zone attempts against Wisconsin. Nebraska threw the ball well, protected its quarterback and found a "difference-maker" in running back Emmett Johnson. “We ran the ball better; that’s the second week in a row I thought the O-line has played well,” Holgorsen said. “Dylan (Raiola) hasn’t been hit a whole lot, he feels good, he’s getting better and processing things well. We’re throwing it and catching it better and our receivers are in the right spots.” It’s been no easy task to drive those improvements in a short amount of time. Holgorsen has only been in Lincoln for a little over three weeks, having first been summoned by head coach Matt Rhule to evaluate the team’s offense before taking over control of it. Midseason coordinator changes may not be rare, but hiring a new face from outside the program is, and Holgorsen admits it made for a “rough” first week on the job. After all, none of the Husker coaches Holgorsen was joining and players he was beginning to coach knew exactly how the situation would play out. Instead, they had to go through it together. “I started getting into the offensive room and those coaches were looking at me crazy like, ‘What are you doing here?’ It’s just true, so we had to sit down and talk and start feeling things out and start working together,” Holgorsen said. “Give those assistant coaches a lot of credit because they didn’t bat an eye. I thought we were smart with how we handled it — I could’ve came in here and changed specific things and that wouldn’t have been the right thing to do for the coaches and the players. I was the one that had to learn.” A desire to challenge himself was one reason Holgorsen said he took the Nebraska job, something which showed up in the new offensive language he needed to familiarize himself with. Having come up as a young coach in the Air Raid offense, Holgorsen exclusively learned, mastered and taught those principles in the years since. It had been 35 years since he last had to learn a new offensive language, Holgorsen estimated. Flash cards with terminology from the Nebraska offense and help from other assistants have helped smooth over that process. Holgorsen may not have been able to stamp his identity all over the offense yet, but he has been able to tweak things, including the very playbook Nebraska operates from. Rhule’s original concepts of a pro-style offense have been added to, transformed and adjusted over the years, with current coaches Marcus Satterfield, Glenn Thomas and Donovan Raiola all bringing different principles and focuses to the playbook. “There’s just all kinds of ideas, so that playbook got pretty big,” Holgorsen said. “I was just like, ‘Look, there’s only one sheet and whatever’s on the sheet is what’s going to get called.’” Trimming down the number of plays Nebraska practices is one such adjustment Holgorsen has made, a process that is collaborative among the Husker coaching staff. Holgorsen also said Nebraska was “probably playing people in too many different spots,” something he’s looked to change so players can focus on their individual roles with more accuracy. “We’ve done a good job of coming together and coming up with a plan of what makes sense to our players,” Holgorsen said. “If it don’t make sense to me, it ain’t gonna make sense to them.” Those changes, and the potential Nebraska showed on offense last week, have excited Husker fans about what the future of a Holgorsen-led offense will look like. However, nothing is guaranteed yet. Holgorsen said that when taking the job he told Rhule he’d get the team ready for USC, Wisconsin and Iowa before figuring out what the future holds. “I don’t want to talk about it, and I don’t want to know what’s next,” Holgorsen. What Holgorsen does know is that he’s enjoying the opportunity in front of him. In part because of the responsibilities he had as a head coach compared to being an offensive coordinator, Holgorsen said he had “more fun on Saturday than I’ve had in a long time” overseeing the Husker offense. As Holgorsen continues furthering improvements within the Nebraska offense, the only guarantee Husker fans have is that he’ll be on the sidelines Friday. It’s currently “the plan” that he will continue as Nebraska’s playcaller during its bowl game, Holgorsen said. “My plan’s to focus on Iowa, try to beat Iowa and see what happens after that.” Get local news delivered to your inbox!Trump threatens to impose sweeping new tariffs on Mexico, Canada and China on first day in office NEW YORK (AP) — President-elect Donald Trump is threatening to impose sweeping new tariffs on Mexico, Canada and China as soon as he takes office as part of his efforts to crack down on illegal immigration and drugs. He said he would impose a 25% tax on all products entering the country from Canada and Mexico, and an additional 10% tariff on goods from China as one of his first executive orders. The tariffs, if implemented, could dramatically raise prices for American consumers on everything from gas to automobiles to agricultural products. The U.S. is the largest importer of goods in the world, with Mexico, China and Canada its top three suppliers. Trump’s latest tariff plan aims at multiple countries. What does it mean for the US? WASHINGTON (AP) — President-elect Donald Trump has identified what he sees as an all-purpose fix for what ails America: Slap huge new tariffs on foreign goods entering the United States. On Monday, Trump sent shockwaves across the nation’s northern and southern borders, vowing sweeping new tariffs on Mexico, Canada, as well as China, as part of his effort to crack down on illegal immigration and drugs. Trump said he will impose a 25% tax on all products entering the country from Canada and Mexico, and an additional 10% tariff on goods from China, as one of his first executive orders. Canadian officials blast Trump's tariff threat and one calls Mexico comparison an insult TORONTO (AP) — Some Canadian officials have blasted President-elect Donald’s Trump’s threat to impose sweeping tariffs. The leader of Canada's most populous province on Tuesday called Trump’s comparison of Canada to Mexico “the most insulting thing I’ve ever heard.” Trump has threatened to impose tariffs on products from Canada, Mexico and China as soon as he takes office in January as part of efforts to crack down on illegal immigration and drugs. He said he would impose a 25% tax on all products entering the U.S. from Canada and Mexico. Canadians say their economy and the U.S. one are deeply intertwined and Americans would feel tariffs, too. Biden proposes Medicare and Medicaid cover costly weight-loss drugs for millions of obese Americans WASHINGTON (AP) — Millions of obese Americans would be eligible to have popular weight-loss drugs like Wegovy or Zepbound covered by Medicare or Medicaid under a new rule the Biden administration proposed Tuesday morning. The proposal, which would not be finalized until after President-elect Donald Trump takes office, could cost taxpayers as much as $35 billion over the next decade. It would give millions of people access to weekly injectables that have helped people shed pounds so quickly that some people have labeled them miracle drugs. Stock market today: Wall Street hangs near its records despite tariff talk NEW YORK (AP) — U.S. stocks are hanging near their records on Tuesday as Wall Street takes Donald Trump’s latest talk about tariffs in stride. The S&P 500 rose 0.4% in Tuesday afternoon trading and was on track to top its all-time high set a couple weeks ago. The Dow Jones Industrial Average lost 49 points from its own record set the day before, while the Nasdaq composite rose 0.6%. Stock markets abroad were down, but mostly only modestly, after President-elect Trump said he plans to impose sweeping new tariffs on Mexico, Canada and China as soon as he takes office. Treasury yields rose modestly in the bond market. What Black Friday's history tells us about holiday shopping in 2024 NEW YORK (AP) — The holiday shopping season is about to reach full speed with Black Friday, which kicks off the post-Thanksgiving retail rush later this week. The annual sales event no longer creates the midnight mall crowds or doorbuster mayhem of recent decades, in large part due to the ease of online shopping and habits forged during the COVID-19 pandemic. Hoping to entice equivocating consumers, retailers already have spent weeks bombarding customers with ads and early offers. Still, whether visiting stores or clicking on countless emails promising huge savings, tens of millions of U.S. shoppers are expected to spend money on Black Friday itself this year. Biden administration to loan $6.6B to EV maker Rivian to build Georgia factory that automaker paused ATLANTA (AP) — President Joe Biden’s administration will loan $6.6 billion to electric vehicle maker Rivian Automotive to build a Georgia factory. The announcement Tuesday comes less than two months before Donald Trump becomes president again. It’s unclear whether the Biden administration can complete the loan in that time, or whether the Trump administration might try to claw the money back. Rivian announced a $5 billion Georgia factory in 2021. But the startup automaker couldn't meet production targets and rapidly burned through cash. The company paused construction of the Georgia plant in March. The company now says its plans for producing electric vehicles in Georgia are back on. US consumer confidence ticks higher on better outlook for hiring WASHINGTON (AP) — Americans’ outlook on the economy improved modestly in November, lifted by expectations for lower inflation and more hiring. The Conference Board, a business research group, said Tuesday that its consumer confidence index ticked up to 111.7 from 109.6 in October. The small uptick followed a large gain in October. Small business owners breathe easier over labor costs after decision to strike down overtime rule Small business owners have had a mostly positive reaction to a judge’s decision to strike down an overtime rule that would have qualified more workers for overtime pay. On Nov. 15, a federal judge in Texas blocked a new rule from the Biden administration that would have expanded access to overtime pay to millions more salaried workers across the U.S. Nearly all hourly workers in the U.S. are entitled to overtime pay after 40 hours a week. But many salaried workers are exempt from that requirement — unless they earn below a certain level. Will Trump's return lead to a new wave of bestselling books? NEW YORK (AP) — Donald Trump is coming back to the White House, but don't expect another “Fire and Fury,” or much fire and fury in book publishing in general. Authors and publishers doubt that the reading public will snap up Trump-related works in the same way it did the first time around. Among the skeptics is Mary Trump. As Donald Trump's niece and author of the bestselling takedown “Too Much and Never Enough” told The Associated Press in a recent interview, “What else is there to learn?” Bob Woodward has written several Trump-related books and now wonders what he's to write about next.

No. 22 Xavier unbeaten but looking for more effort vs. South Carolina

Nobel recipient Geoffrey Hinton wishes he thoughts of AI safety soonerDSWD 7 ready food packs, funds for disasters

The Yucatán Peninsula in Mexico is renowned for its stunning beaches, Mayan ruins, and vibrant cultural heritage. In recent years, however, it has also become a growing hub for the casino industry. While not as prominent as other gambling destinations in Mexico like Baja California or Quintana Roo, Yucatán’s casino sector is steadily expanding, offering both residents and tourists a unique blend of entertainment that complements the region’s cultural appeal. From boutique gaming establishments to larger entertainment centres, the casino industry in Yucatán is carving out its place in the broader Mexican gambling market. Gambling in Mexico “ .” — Modern casinos, however, only began to emerge in the 20th century, heavily influenced by the legalisation of gambling under regulated conditions. In Yucatán, the growth of casinos has been more recent, spurred by the region’s rise as a tourism hotspot and the increasing demand for entertainment options among locals. The city of Mérida, Yucatán’s capital, has become the focal point for the casino industry in the state. Known for its colonial charm and thriving tourism scene, Mérida now hosts several casinos offering a range of games, from slot machines to electronic poker and roulette. Casinos such as Casino Life Mérida and Golden Island have become popular spots for those seeking entertainment beyond the region’s cultural and natural attractions. These establishments cater not only to tourists but also to a growing local clientele, reflecting a shift in how gambling is perceived in the region. The casino industry in Yucatán has brought significant economic benefits to the state. First and foremost, casinos provide jobs for locals, ranging from dealers and floor managers to hospitality and security staff. With the state’s focus on diversifying its economy beyond traditional sectors like agriculture and tourism, the gambling industry has emerged as a promising contributor to employment and local business development. Additionally, casinos in Yucatán attract a mix of domestic and international tourists, many of whom stay in nearby hotels, dine at local restaurants, and visit other attractions in the region. This influx of visitors contributes to the broader tourism economy, creating a ripple effect that benefits multiple sectors. Some casinos have even partnered with local tour operators to offer packages that combine gaming with visits to iconic sites like Chichén Itzá or the cenotes that dot the peninsula. Tax revenues generated by casinos also play a crucial role in supporting state and municipal budgets. These funds are often allocated to public services, infrastructure development, and social programs. As the industry grows, so does its potential to contribute to Yucatán’s overall economic stability and development. What sets apart from those in more saturated markets like Las Vegas or Macau is their integration with the region’s unique cultural identity. Casinos in Yucatán often adopt a more boutique approach, focusing on creating intimate, high-quality experiences rather than sprawling mega-resorts. Many establishments blend traditional Mexican decor with modern gaming technology, creating a distinct ambiance that appeals to a diverse audience. For example, some casinos incorporate local cuisine and live music into their offerings, providing a well-rounded entertainment experience. Visitors might enjoy a gourmet dinner featuring Yucatecan dishes like cochinita pibil or sopa de lima before heading to the gaming floor. Others host special events, such as mariachi performances or themed nights, which add a cultural flavour to the gambling experience. This tailored approach not only attracts tourists but also resonates with local patrons who appreciate the nod to their heritage. Despite its growth, the casino industry in Yucatán faces several challenges, particularly in terms of regulation. Gambling in Mexico is governed by a complex legal framework, with licenses issued at the federal level by the Ministry of the Interior (SEGOB). While this centralised system helps ensure consistency, it also creates bureaucratic hurdles that can slow down the development of new casinos or the expansion of existing ones. Additionally, the perception of gambling in Mexican society remains a point of contention. While casinos are increasingly seen as legitimate entertainment venues, concerns about problem gambling, money laundering, and organised crime persist. Operators in Yucatán must navigate these issues carefully, implementing robust security measures and responsible gambling programs to maintain public trust and compliance with federal regulations. Competition is another factor shaping the industry. Yucatán’s casinos must contend not only with other gambling establishments within the state but also with the larger and more established casino markets in neighbouring regions like Quintana Roo, home to Cancun and Playa del Carmen. These destinations attract a high volume of international tourists, many of whom are drawn to the luxurious casino resorts available there. To compete, Yucatán’s casinos have focused on offering more personalised and culturally immersive experiences. The future of the casino industry in Yucatán looks promising, driven by both local demand and increasing tourist arrivals. The state’s strategic location, safe reputation, and rich cultural offerings make it an attractive destination for travellers seeking a mix of relaxation and entertainment. With ongoing investments in infrastructure, including improved roadways and airport expansions, Yucatán is well-positioned to support the growth of its gambling sector. Moreover, the rise of digital and mobile gaming presents new opportunities for the industry. Many Yucatán-based casinos are exploring the integration of online platforms, allowing players to enjoy games remotely while still engaging with local brands. This hybrid approach could help casinos reach a wider audience while maintaining their connection to the region’s identity. To sustain growth, stakeholders in the industry must continue prioritising responsible gambling practices and community engagement. Public education campaigns, partnerships with local businesses, and transparent regulatory compliance will be essential for building trust and ensuring long-term success. The casino industry in Yucatán, Mexico, is evolving into a key player in the state’s economy and tourism sector. From the bustling gaming floors of Mérida to the cultural integration of Yucatán’s rich heritage into casino experiences, the industry offers a unique blend of modern entertainment and traditional charm. While challenges remain, the region’s strategic approach to growth, combined with its focus on quality and cultural authenticity, sets it apart from larger gambling markets. As Yucatán continues to invest in its infrastructure and diversify its tourism offerings, its casino industry is poised to become a cornerstone of its economic future.

The Chicago Cubs are entering quite an important offseason. Last winter, they stole the Milwaukee Brewers manager, Craig Counsell, from the National League division rivals, but in Counsell's first season, the Cubs fell short of the postseason. Now, they have the winter to build the team of Counsell's dreams, though it may not be with the big name players that many imagined. USA Today's Bob Nightengale has reported the Cubs won't be landing any of the big free agents that the fans have been raving about. "Yet, instead of negotiating with any of the marquee free agents, they instead are focusing on the mid-market players. They're probably out on Soto, Burnes, Fried and Snell," Nightengale wrote. "The only thing that could change their plan is if they're able to unload first baseman/outfielder Cody Bellinger. The worst-kept secret at the GM meetings was the Cubs offering Bellinger to anyone and everyone. So far, no team has expressed strong interest." But, it doesn't seem likely at all that Chicago is able to move Bellinger unless they're willing to eat some of his contract. "Come on," one GM told Nightengale, "who's going to touch that contract? The risk is just too great for the production." With Bellinger likely to remain in the Windy City, the Cubs will need to pivot to cheaper options. They could look to boost their bullpen quite a bit this winter while also using the trade market to acquire cheaper players. Either way, I'd imagine Bellinger will remain a Cub and the top free agents will sign elsewhere. More MLB: What Will Yankees Emergency Plan B Look Like If Mets Steal $600 Million Juan Soto?Another week, another touchdown for Nick Westbrook-Ikhine. I know, it's not the sexiest call in fantasy football, to suggest adding a Titans wide receiver not named Calvin Ridley (or, in the past, DeAndre Hopkins, or A.J. Brown, etc.). But the numbers speak for themselves. Westbrook-Ikhine has now scored six times in seven games. He's a clear big-play weapon who's shown himself to be a threat to score whenever the ball is in his hands. And hey, Titans' wideouts have a beauty of a remaining schedule. There are no byes in Week 13, but there is another bye-pocalypse in Week 14 — add NWI now in advance. And speaking of bye weeks ... A lot of players were dropped this week in order to fill roster holes left gaping by bye weeks. One of those players is MVS, who was off in Week 12. But let's not forget, MVS was looking like a monster in a Saints uniform, scoring 40.1 fantasy points in two games with his new team. And sure, Valdes-Scantling will likely never be a huge target earner on the Saints, but he's already proven to be a big-play threat in his new offense. He'll return from bye to a few plus matchups (vs. LAR, @NYG, vs. WAS), so he's worth a flier off the waiver wire. Another receiver cut from many fantasy lineups to fill roster gaps was rookie Keon Coleman, whose Bills were also on bye in Week 12. Coleman looked like he was starting to get that second-half rookie boost we often see in young wideouts before being ruled out of Week 11 with a wrist injury, and then the subsequent bye. That week off came at the perfect time, hopefully allowing the rookie time to heal his wrist. He'll hopefully return to the field in Week 13 for a showdown against the San Francisco 49ers, followed by some plus matchups with the Rams and Lions. Add him where available.