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shotgun roulette As science continues its evolution, discoveries and technologies can act like a master key that open doors leading to novel advancements. Artificial intelligence is one such key, making innovations possible by solving complex problems, automating tasks and enabling research that would have been impossible, or very time-consuming, without it. Mohammad Hosseini But do we want to do research on all topics, and shall we try the AI master key on every door? To explore this question, let’s consider the use of AI by genomics experts as an example. In recent years, genomics experts have added unbelievable depth to what we know about the world and ourselves. For example, genetics researchers have revealed facts about when certain animals and plants were domesticated. In another example, researchers used DNA from 30,000-year-old permafrost to create fertile samples of a plant called narrow-leafed campion. Importantly, genetic engineering has facilitated extraordinary advances in the treatment of complicated conditions, such as sickle-cell anemia. Thanks to AI, we are witnessing a dramatic increase in the pace and scalability of genomic exploration. But given the risks and possible consequences of AI use in science, should we rush headlong into using AI in all kinds of projects? One relevant example is research on Neanderthals, our closest relatives, who lived about 40,000 years ago. Neanderthals have been studied for several years now through genetic investigation of their fossils and their DNA. Genetic engineering can potentially use ancient DNA and genome editing methods to re-create a Neanderthal or aspects of a Neanderthal’s genetics and physiology. To do this, scientists could start by figuring out the DNA sequence of a Neanderthal by comparing it with the DNA of modern humans, because they are closely related. Then, scientists could use the gene-editing tool known as CRISPR to swap out parts of human DNA with Neanderthal DNA. This process would require a lot of trial and error and might not succeed soon. But based on what we know about genetics, if something is possible, AI can help make it happen faster, cheaper and with less effort. Scientists are excited about these developments because they could facilitate new discoveries and open up many research opportunities in genetic research. With or without AI, research on Neanderthals will proceed. But the extraordinary power of AI could give the final push to these discoveries and facilitate this kind of resurrection. At that point, the scientific community must develop norms and guidelines about how to treat these resurrected beings with dispositions very similar to humans. We would need to carefully consider their rights and well-being almost in the same way as when humans are involved and not as research subjects or artifacts of scientific curiosity. These ethical issues are discussed in more detail in a new paper published in the journal Nature Machine Intelligence. A more holistic question to consider is: Should we prioritize the use of resource-intensive AI, researchers’ time and public funds to resurrect extinct beings? Or should we invest these resources into conserving species that are critically endangered today to prevent biodiversity from more degradation? Hosseini is an assistant professor in the Department of Preventive Medicine at Northwestern University’s Feinberg School of Medicine. He wrote this for . Get opinion pieces, letters and editorials sent directly to your inbox weekly!BARCELONA, Spain (AP) — Celta Vigo gave 10-man Barcelona a shock by scoring two late goals and snatching a 2-2 draw at home in the Spanish league on Saturday. Barcelona was minutes away from a win to pad its league lead after Raphinha and Lewandowski had put Barcelona in control. But the game dramatically swung after Barcelona defensive midfielder Marc Casadó was sent off with a second booking in the 81st. Moments later Jules Koundé’s poor control of a ball in his area allowed Alfon González to pick his pocket and give the hosts hope in the 84th minute. Celta poured forward at Balaidos Stadium and Hugo Álvarez rifled in the 86th-minute equalizer with Barcelona unable to mark the extra man. AP soccer: https://apnews.com/hub/soccer

Houston's Al-Shaair apologizes for hit on Jacksonville's Lawrence that led to concussion HOUSTON (AP) — Houston’s Azeez Al-Shaair took to X to apologize to Jacksonville’s Trevor Lawrence after his violent blow to the quarterback’s facemask led to him being carted off the field with a concussion. Back in the starting lineup after missing two games with a sprained left shoulder, Lawrence scrambled left on a second-and-7 play in the second quarter of Houston’s 23-20 win on Sunday. He initiated a slide before Al-Shaair raised his forearm and unleashed on the defenseless quarterback. In the long post, Al-Shaair says "To Trevor I genuinely apologize to you for what ended up happening.” Jets are sticking with struggling Aaron Rodgers as their starting quarterback Aaron Rodgers will remain the New York Jets’ starting quarterback despite speculation the team could bench him in what has been a disappointing season. Interim coach Jeff Ulbrich said during a video call that he still believes Rodgers, who turned 41 on Monday, gives the Jets their best chance to win. Rodgers was 21 of 39 for 185 yards and touchdown passes to Davante Adams and Isaiah Davis but also had an interception returned 92 yards for a touchdown by Leonard Williams in the Jets’ 26-21 loss to Seattle on Sunday. Hall of Famer Randy Moss reveals he's 'battling something' internal and asks for prayers Hall of Fame wide receiver Randy Moss revealed he’s dealing with a health issue and asked fans to pray for him and his family. The 47-year-old ESPN football analyst made the announcement on Instagram from the set of the network’s “Sunday NFL Countdown” show. He directed his message to men and urged them to get checkups and bloodwork done, without specifying for any particular illness. Moss explained why he’s been wearing tinted sunglasses, saying, “I’m battling something, man, and it’s something internal, your boy is going to get through it.” College playoff bracket offers last dress rehearsal and one more chance to see where the SEC stands The next set of College Football Playoff rankings will be released Tuesday night under heavy scrutiny before the final bracket is set on Sunday. It will be one last chance to see just how much the selection committee loves the Southeastern Conference. The best gauge will be whether Miami, which suffered its second loss over the weekend, is placed behind any or all three SEC teams with three losses — Alabama, Mississippi and South Carolina, all of which are coming off wins. Whatever happens, the SEC is likely to have at least five teams in the 12-team field when the final bracket comes out. Mollie Marcoux Samaan stepping down as LPGA commissioner after 3 1/2 years of record prize money Mollie Marcoux Samaan is leaving after more than three years as LPGA commissioner. In a surprise announcement Monday, Marcoux Samaan says she will step down in January, just three weeks before the LPGA starts its 75th season. Liz Moore is the chief legal and technology officer. She'll be serving as interim commissioner until a search committee can find a permanent replacement. Marcoux Samaan was the athletic director at Princeton when she took over the LPGA in May 2021. Prize money has soared during her tenure. She also has faced criticism for the LPGA not gaining in popularity during a rise in women's sports. Kansas holds off Auburn for No. 1 in AP Top 25 as SEC grabs 3 of top 4 spots; UConn slides to No. 25 Kansas continues to hold the No. 1 ranking in The Associated Press Top 25 men’s college basketball poll. Auburn is pushing the Jayhawks in the latest poll after winning the Maui Invitational and checked in at No. 2. Two-time reigning national champion UConn nearly fell out entirely after an 0-3 week at Maui, falling from No. 2 to 25th. The Southeastern Conference had three of the top four teams with No. 3 Tennessee and No. 4 Kentucky behind the Tigers. The poll featured six new teams, headlined by No. 13 Oregon, No. 16 Memphis and No. 18 Pittsburgh. TCU, Duke climb into top 10, Notre Dame drops in women's AP Top 25; UCLA and UConn remain 1-2 TCU has its best ranking ever in The Associated Press Top 25 women’s basketball poll after a convincing win over Notre Dame. The Horned Frogs jumped eight spots to No. 9, the first time the school has ever been in the top 10. The Fighting Irish, who were third last week, fell seven spots to 10th after losses to TCU and Utah. UCLA remained No. 1, followed by UConn, South Carolina, Texas and LSU. USC, Maryland and Duke are next. USC QB Miller Moss enters transfer portal after losing starting job to Jayden Maiava LOS ANGELES (AP) — Southern California quarterback Miller Moss is entering the transfer portal after losing the Trojans’ starting job last month. Moss started the Trojans’ bowl victory last season and their first nine games this season before coach Lincoln Riley replaced him with Jayden Maiava in early November. Moss signed with USC before Riley arrived at the school. Moss also stayed after Caleb Williams transferred from Oklahoma to rejoin Riley, and he served as Williams’ backup for two seasons before getting his chance to play with six touchdown passes in last year’s Holiday Bowl. Michael Andretti's Formula 1 dream comes to bittersweet fruition without his involvement Michael Andretti has been sidelined from his namesake motorsports organization and won’t have any role with the Formula 1 program he spent the last four years desperately trying to launch. His effort to get a program partnered with General Motors into F1 was approved last week, a month after he stepped aside from his teams. F1’s decision to expand its grid for Cadillac F1 came amidst a federal antitrust investigation into why Liberty Media refused to admit Andretti Global and after Andretti partners Dan Towriss and Mark Walter claimed controlling interest of the fledgling effort. Ryan Poles to remain Bears general manager and lead search for new head coach LAKE FOREST, Ill. (AP) — Chicago Bears president Kevin Warren said Ryan Poles will remain the general manager and serve as the point person in the search for a head coach to replace the fired Matt Eberflus. He says Poles will have the “final say” if the two have differing opinions on who should get the job. Chicago had never fired a coach during a season. But a six-game losing streak marked by questionable coaching decisions spurred the founding NFL franchise to change course. The Bears let Eberflus go Friday and replaced him on an interim basis with offensive coordinator Thomas Brown.

Murray – who retired after the summer Olympics at the age of 37 after finally admitting defeat in his battle against his body – will join the Serbian’s team in the off-season and coach him through the opening grand slam of 2025. It will see the Scot surprisingly join forces with the man who was his biggest nemesis during his long career, especially in Australia where he lost to Djokovic in four finals. Murray, who beat Djokovic to win the US Open in 2012 and Wimbledon in 2013, says he wants to help the 24-time grand slam champion achieve his goals. He never liked retirement anyway. 🙌 pic.twitter.com/Ga4UlV2kQW — Novak Djokovic (@DjokerNole) November 23, 2024 “I’m going to be joining Novak’s team in the off-season, helping him to prepare for the Australian Open, he said. “I’m really excited for it and looking forward to spending time on the same side of the net as Novak for a change, helping him to achieve his goals.” Djokovic, a week younger than his new coach, added: “I am excited to have one of my greatest rivals on the same side of the net, as my coach. “Looking forward to start of the season and competing in Australia alongside Andy with whom I have shared many exceptional moments on the Australian soil.” In posting a teaser about the appointment on social media, Djokovic said: “He never liked retirement anyway.” He then added: “We played each other since we were boys, 25 years of pushing each other to our limits. We had some of the most epic battles in in our sport. They called us gamechangers, risk takers, history makers. “I thought our story may be over. Turns out it has one final chapter. It’s time for one of my toughest opponents to step into my corner. Welcome aboard coach, Andy Murray.” Djokovic beat Murray in the 2011, 2013, 2015 and 2016 Australian Open finals while also losing in the French Open final in 2016. It was his pursuit of toppling Djokovic at the top of the rankings in 2016 which was a precursor to his 2017 hip injury which derailed Murray’s career. Djokovic, who split with coach Goran Ivanisevic earlier this year, hopes that adding Murray to his team will help him get back to the top of the game as he went through a calendar year without winning a grand slam for the first time since 2017. Jannik Sinner and Carlos Alcaraz have developed a stranglehold at the top of the men’s game and Djokovic, who has seen Murray, Roger Federer and Rafael Nadal all retire in recent years, is still hoping to move clear of the record 24 grand slams he shares with Margaret Court.

Taylor Swift congratulated boyfriend Travis Kelce's brother Jason and Kylie Kelce on their good news. The NFL great and his wife Kylie, who exchanged vows in 2018, revealed they are expecting their fourth child together. On Friday, Kylie revealed the news on Instagram with a cute picture of their three girls, Wyatt, Elliotte, and Bennett, all sporting sweaters with the words “Big Sister” printed on them. As the happy news surfaced on social media, Swift joined the several well-wishers responding to the thrilling announcement. Swift has been dating Travis Kelce of the Kansas City Chiefs for more than a year. The pop star showed her support for the pair by liking the post. Travis' mother, Brittany Mahomes react to the news Travis' mother, Donna Kelce, also responded to the good news as she is ready to welcome her fourth grandchild. She enthusiastically commented, “Love it!!!”, adding three heart-eye and four fire emojis. Chiefs quarterback Patrick Mahomes' wife, Brittany Mahomes , who is Swift's WAG bestie, also congratulated the couple on announcement, “Ahhhhhhhh Congrats, you guys!” Brittany, who is also expecting her third child with the three-time Super Bowl champion, commented. The Kelces announced that they're prepared to welcome another girl into their family after months of denying that they were expecting a fourth child. “I feel like we captured a very accurate representation of how each of the girls feel about getting another sister. At least Ellie, mom and dad are on the same page!” Kylie captioned a funny picture of her three daughters. Also Read: How Taylor Swift rescued Cara Delevingne from a 'horrible breakup' despite being 'very different people' A post shared by Kylie (McDevitt) Kelce (@kykelce) In the picture, Bennett, the youngest kid, can be seen crying, while Wyatt, the oldest, appears to be stunned by the news. Moreover, Elliotte, the middle child, can be seen grinning over the news. Kylie gave birth to Wyatt in October 2019, Elliotte in March 2021, and Bennett in February 2023.

OpenAI’s new o1 model sometimes fights back when it thinks it’ll be shut down and then lies about it