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The United States has sanctioned Gazprombank, Russia’s third-largest lender, and dozens of other financial institutions as President Joe Biden seeks to further curtail the Kremlin’s ability to finance its war in Ukraine before he leaves office in two months. Gazprombank, which plays an important role in facilitating Russian energy exports, was the only remaining large Russian lender not under U.S. sanctions. Washington and Brussels had avoided sanctioning Gazprombank amid concern over possible energy export interruptions. Along with Gazprombank, the United States also announced sanctions on more than 50 other Russian banks conducting international operations, more than 40 Russian securities registrars and 15 Russian finance officials. The United States also warned financial institutions against joining Russia’s version of the international messaging system for banks known as SWIFT. Russia is seeking to attract international banks to its messaging platform to get around U.S. financial sanctions. “Today’s action reaffirms the U.S. commitment to curtail Russia’s ability to use the international financial system to conduct its war against Ukraine and disrupts Russia’s attempts to make cross-border payments for dual-use goods and military materiel,” State Department spokesman Matthew Miller said in a November 21 statement. Ukraine backers had been calling on the Biden administration for months to tighten sanctions on Russia’s banking sector, saying the Kremlin was finding ways around existing sanctions to pay for technology imports and other dual-use items. In addition to facilitating energy payments, Gazprombank had been acting as a conduit for the purchase of military goods. The Kremlin also uses Gazprombank to pay Russian soldiers and compensate families for war deaths. “I am grateful to @POTUS and his administration for today’s strong package of financial and banking sanctions targeting Russia’s economy and war chest,” Ukrainian President Volodymyr Zelenskiy said in a tweet . Eddie Fishman, a former State Department official and sanctions expert, called the latest announcement a “strong step” toward closing loopholes around Russia’s energy sector, which generates about half of federal budget revenues. Biden will leave office on January 20 to make way for President-elect Donald Trump, who has promised to end the war in Ukraine by getting Zelenskiy and Russian President Vladimir Putin to sit down at the negotiating table, something that experts say will be harder done than said. The financial sanctions come at a critical time for Russia’s economy as Putin’s record spending on the war effort drives up inflation and interest rates. The Russian Central Bank last month raised interest rates to 21 percent, the highest in decades, and could continue to ratchet them up with no end in sight to the war. A senior North Korean general has been wounded in Russia’s Kursk region, The Wall Street Journal reported, citing Western officials. More than 10,000 North Korean troops are supporting Russian forces in Kursk. Russian President Vladimir Putin is hoping to recover the swath of the Kursk region that Ukraine seized in August before President Donald Trump takes office early next year. The United States this week gave Ukraine the green light to use its long-range ATACMS missiles to strike Russian assets in Kursk and said North Korean troops would be fair game. It is unclear how the North Korean general was wounded, the WSJ reported . Russian President Vladimir Putin said his military fired a new intermediate-range missile into Ukraine following accusations by Kyiv that it was an intercontinental ballistic missile (ICBM). In a November 21 video statement to the nation, Putin said the use of the new weapon was a response to the United States and United Kingdom giving permission to Kyiv to fire their long-range missiles into Russia. "In combat conditions, one of the newest Russian medium-range missile systems was tested," Putin said, adding that it was a hypersonic missile capable of carrying a nuclear warhead. Earlier in the day, Kyiv said Russia had fired what appeared to be an ICBM into Ukraine as part of a massive missile attack on Dnipropetrovsk, home to important military-industrial plants. ICBMs, which are designed to deliver long-distance nuclear strikes, have never been used in war before. "On the morning of November 21, 2024...Russian troops attacked the city of Dnipro (facilities and critical infrastructure) with missiles of various types. In particular, an intercontinental ballistic missile was launched from the Astrakhan region of the Russian Federation," the Ukrainian Air Force said in its statement on Telegram. Ukrainian President Volodymyr Zelenskiy said on Telegram that the new Russian weapon had "all characteristics -- speed, altitude -- [of an] intercontinental ballistic missile." A U.S. official speaking on the condition of anonymity told Reuters that Russia used a new intermediate weapon. The U.S. official said Washington had informed Kyiv in recent days that Russia might use it to strike Ukraine. The U.S. official said Putin was seeking to intimidate Ukraine but added that Moscow only had a few of the "experimental" missiles. The Russian attack comes just days after reports that Ukraine used British-supplied Storm Shadow missiles and U.S.-made ATACMS systems to strike military targets deeper inside Russia following the long-sought approval by President Joe Biden. Military analysts said ICBM missiles can be classified as intermediate-range weapons when their payloads are increased and ranges decreased. French Foreign Ministry spokesman Christophe Lemoine said the use of an ICBM would be "extremely serious." The main target of the Russian attack was the southeastern region of Dnipropetrovsk, Ukraine's most important industrial region, and its capital, the city of Dnipro. Ukraine's air force said that besides the ICBM, Russian aircraft also launched a hypersonic Kh-47M2 Kinzhal missile and seven subsonic Kh-101 cruise missiles. Ukrainian air defenses shot down six Kh-101 missiles, the air force reported. Dnipropetrovsk Governor Serhiy Lysak said his region bore the brunt of the Russian attack. "Since early in the morning, the aggressor massively attacked our region," Lysak reported on Telegram, adding that preliminary information showed that an industrial facility was damaged in the regional capital, Dnipro, where two fires were started by the attack. Explosions were also reported in Kremenchuk, in the central Poltava region. Moscow's use of a large number of sophisticated missiles as opposed to the usual drone attacks appears to be in response to Ukraine's gaining approval to use some Western-donated long-range missile systems to strike deeper into Russia. On November 20, Russian military bloggers and a source cited by Reuters reported that Ukraine had fired up to 12 Franco-British Storm Shadow missiles into Russia's Kursk region, part of which has been under Ukrainian control following a surprise incursion by Ukrainian troops in August. A spokesman for British Prime Minister Keir Starmer declined to confirm whether the missiles had been used. Previously, London had given permission to use the Storm Shadows, which have a 250-kilometer range, within Ukraine's territory. Earlier this week, Ukraine reportedly used ATACMS to strike a military facility in Russia's Bryansk region after Biden was reported as giving his OK. The White House has not officially confirmed the approval and Ukraine hasn't directly acknowledged the use of ATACMS on Russian targets. Russia has long warned that Ukraine's use Western-supplied long-range weapons to strike inside its territory would mark a serious escalation of the conflict. On November 21, Moscow said a new U.S. missile defence base in the Polish town of Redzikowo near the Baltic coast, which was opened on November 13 as part of a broader NATO missile shield, will lead to an increase in the overall level of nuclear danger. "This is another frankly provocative step in a series of deeply destabilising actions by the Americans and their allies in the North Atlantic alliance in the strategic sphere," Russian Foreign Ministry spokeswoman Maria Zakharova said. "This leads to undermining strategic stability, increasing strategic risks and, as a result, to an increase in the overall level of nuclear danger," Zakharova said. Poland rejected the claim, saying there were no nuclear missiles at the base. "It is a base that serves the purpose of defense, not attack," Foreign Ministry spokesman Pawel Wronski said on November 21. At least 38 people were killed and more than 40 wounded after gunmen opened fire on a convoy of cars carrying Shi'ite Muslims in northwest Pakistan as religious tension in the region rises. Three women and a child were among those killed in the November 21 attack, police told RFE/RL's Radio Mashaal. The convoy of 200 cars was heading from Peshawar to Parachinar in Khyber Pakhtunkhwa Province near the border with Afghanistan when the unknown gunmen attacked. No one has taken responsibility for the attack, the latest in a series of deadly confrontations in the Kurram region. Police, who were escorting the cars, said the death toll could climb. There were about 700 people in the convoy, according to law enforcement. Tension in Kurram began to heat up after 17 people were killed in an attack on a convoy on October 12. There have been about a handful of deadly attacks since then. Sunnis and Shi'a live together in Kurram and have clashed violently over land, forests, and other property as well as religion over the years, despite government and law enforcement efforts to build peace. Influential Ukrainian tycoon Dmytro Firtash is among eight people targeted by fresh British sanctions that accuse the group, which includes his wife, Lada, of large-scale, international corruption. Angolan-Russian billionaire Isabel dos Santos and Latvian politician and businessman Aivars Lembergs are also among those hit by the new sanctions announced on November 21. The British government accuses Firtash of bribing officials to secure mining licenses for his companies and profiting illegally from Ukraine's gas-transportation system. Firtash is also linked to financier Denys Horbunenko, a resident of the United Kingdom who was added to the sanctions list on November 21 for his association with Firtash. Firtash has faced legal scrutiny in Ukraine over embezzlement and money-laundering accusations involving fraudulent gas-trading schemes. The United States has been seeking his extradition from Austria on charges of bribing Indian officials. Firtash, who gained prominence in the 2000s through his joint venture RosUkrEnergo with Russian energy giant Gazprom, has denied allegations of working in Russia's interests. Dos Santos, daughter of former Angolan President Jose Eduardo dos Santos, is Africa's first female billionaire. She is accused of corruption in Angola, where she allegedly exploited her political connections for personal gain. Dos Santos claims she has held Russian citizenship since birth, as she was born in Baku, Azerbaijan, in 1973 under the former Soviet Union. Lembergs, a former populist mayor of the Latvian city of Ventspils, has been convicted in Latvia of corruption and sentenced to five years in prison. He claims the charges against him are politically motivated. The sanctions are part of a British efforts to combat international corruption and disrupt the financial networks of individuals accused of abusing their power for personal enrichment. The measures include asset freezes, travel bans, and restricting these individuals from accessing the U.K.'s financial system or entering the country. The International Criminal Court (ICC) has issued arrest warrants for Israel's Prime Minister Benjamin Netanyahu and former Defense Minister Yoav Gallant, and Muhammad Deif, a military commander in the Iran-backed group Hamas, alleging they committed crimes against humanity in the ongoing Gaza war. All three are accused of committing war crimes connected to the October 7, 2023, attack on Israel by Hamas, an EU- and U.S-designated terrorist organization that is part of Tehran's network of proxies in the Middle East, and Israel's subsequent military intervention in the Gaza Strip. Iran's backing of Hamas and Hezbollah, another Iran-supported militant group and political party that controls much of the southern part of Israel's neighbor, Lebanon, has sparked fears that the war in the Gaza Strip will engulf the Middle East. Hezbollah is designated as a terrorist organization by the United States, while the European Union blacklists its armed wing but not its political party. Hezbollah’s political party has seats in the Lebanese parliament. The court said the warrants had been classified as "secret" to protect witnesses and to safeguard the conduct of the investigations. Israel, which claims it killed Deif in July, blasted the move as "a dark moment for the ICC." Hamas, which has never officially acknowledged Deif's death, called the warrants against Netanyahu and Gallant an "important step toward justice." The ICC said it had issued the arrest warrant for Deif as the prosecutor had not been able to determine whether he was dead. His warrant shows charges of mass killings during the October 7 attack on Israel that left some 1,200 dead, as well as charges of rape and the taking of around 240 hostages in the attack. "The Chamber considered that there are reasonable grounds to believe that both [Israeli] individuals intentionally and knowingly deprived the civilian population in Gaza of objects indispensable to their survival, including food, water, and medicine and medical supplies, as well as fuel and electricity, from at least 8 October 2023 to 20 May 2024," the ICC said in a statement . "This finding is based on the role of Mr. Netanyahu and Mr. Gallant in impeding humanitarian aid in violation of international humanitarian law and their failure to facilitate relief by all means at its disposal," it said. Israeli Foreign Minister Gideon Sa'ar called the move against Netanyahu and Gallant "absurd" in a post on X, saying it was an attack of Israel's right to self-defense. "A dark moment for the ICC in The Hague, in which it lost all legitimacy for its existence and activity," Sa'ar said. Tehran has yet to comment publicly on the warrants. Neither the United States nor Israel have recognized the ICC's jurisdiction. A U.S. National Security Council spokesperson said Washington "fundamentally rejects" the issuance of the arrest warrants and "the troubling process errors that led to this decision. Meanwhile, the EU's top diplomat, Josep Borrell, said in a post on X that ICC decisions "are binding on all states party to the Rome Statute, which includes all EU Member States." The court said Israel's acceptance of the court's jurisdiction was not required. However, the court itself has no law enforcement levers to enforce warrants and relies on cooperation from its member states. Russian police have conducted searches at the PERMM Museum of Contemporary Art in the city of Perm, as well as at the home of its current director, in connection with a case against former director Marat Gelman , REN-TV reported, citing anonymous sources. The PERMM Museum announced on social media that it would remain closed until 3 p.m. local time due to "technical reasons." Gelman, a well-known art dealer who currently lives in Montenegro, where he owns an art gallery, was placed on Russia’s federal wanted list in December 2022 under a criminal charge, though details of the accusation remain unclear. In an interview with Current Time, Gelman suggested that the charges might be in connection with him "discrediting" the Russian military, a common pretext used against critics of Russia's ongoing invasion of Ukraine. Gelman has been a vocal member of the Anti-War Committee and a member of the Permanent Committee of the Free Russia Forum. He has repeatedly expressed his support for Ukraine and his opposition to Russia's war efforts. The raid in Perm is part of a broader pattern of increasing pressure on Gelman. In the past week, he was added to Russia's list of "terrorists and extremists," with a designation indicating an ongoing criminal case against him. Critics argue this move is part of a crackdown on anti-war activists and dissenting voices within and beyond Russia. The Higher Public Prosecutor's Office in Novi Sad announced on November 21 that 11 people were arrested after being found responsible for the deadly collapse of a concrete canopy at the railway station in Serbia's second-largest city. The huge canopy collapsed on November 1, killing 15 people and seriously injuring another two. The accident occurred after the railway station, built in 1964, had been renovated twice in recent years by a consortium of four companies -- China Railway International and China Communications Construction, France's Egis, and Hungary's Utiber. Among those arrested are former Construction, Transport, and Infrastructure Minister Goran Vesic, and the ex-director of Railway Infrastructure, Jelena Tanaskovic. They face charges of committing criminal acts against public security, endangering the public, and irregular construction work, the prosecutor said in a statement, adding that they faced up to 12 years in prison. The arrests came after public protests that turned violent demanded the punishment of those responsible amid accusations of corruption that resulted in substandard renovation work on the railway station. In a message on X, Vesic wrote that he had not been arrested, but had "voluntarily responded to the call of the police officers" and "made himself available to police authorities." Vesic, an official from the ruling Serbian Progressive Party, resigned after the accident on November 4 but said he did not accept blame for the accident. Tomislav Momirovic, who headed the Construction, Transport, and Infrastructure Ministry from 2020 to 2022, submitted his resignation as trade minister on November 20. The same day, Tanaskovic resigned as head of Serbian Railway Infrastructure. Opposition politicians have voiced scepticism about the arrests and demanded that the case be handed over to organized-crime prosecutors. The office of Belarusian opposition leader Svyatlana Tsikhanouskaya has issued a statement condemning the recent extradition from Vietnam to Belarus of Vasil Verameychyk, who fought on the Ukrainian side against invading Russian troops. Verameychyk, who moved to Vietnam after he was denied permission to settle in Lithuania because of he had previously served in the Belarusian Army, was detained in Vietnam earlier this year. Despite international appeals, Vietnamese authorities proceeded with his extradition in late October 2024. Tsikhanouskaya's office described the extradition as a direct consequence of the repressive policies of the authoritarian ruler of Belarus, Alyaksandr Lukashenka, highlighting the regime's efforts to target opponents beyond its borders. The statement emphasizes the urgent need for stronger international mechanisms to protect human rights, not only for Belarusians fleeing repression but also for those supporting Ukraine in its efforts to repel Russia's ongoing invasion. It calls on the international community to adopt individualized approaches when reviewing cases for international protection, end cooperation with the Belarusian security forces, and suspend bilateral agreements on extradition and legal assistance with Belarus. Additionally, the statement advises Belarusians abroad to remain vigilant against potential actions by Lukashenka's security services. It recommends consulting resources like Pashpart.org to identify countries deemed unsafe for Belarusians at risk of persecution. Russian mathematician and political prisoner Azat Miftakhov has been placed in solitary confinement for seven days. According to a support group for Miftakhov, the decision came after he reported feeling endangered by his current cellmate. In a letter shared by the group, Miftakhov explained that instead of being transferred to another cell, he was put in solitary confinement. It remains unclear whether Miftakhov will be returned to the same cell after completing his time in solitary. His support group says that his cellmate appears to be mentally ill. Miftakhov said that the man had undergone treatment while in pretrial detention but was nonetheless sentenced to more than 10 years in prison and is now being held in a general cell without access to medical care. Miftakhov is currently serving his sentence in a prison in Dimitrovgrad in the Ulyanovsk region. In March 2023, he was sentenced to four years in prison for "justifying terrorism." The charges stemmed from comments Miftakhov allegedly made while serving a previous sentence expressing support for Mikhail Zhlobitsky, who carried out a suicide bombing in 2018 at a Federal Security Service building in Arkhangelsk. Only Zhlobitsky was killed in the bombing. Before this, Miftakhov served five years and nine months on charges of hooliganism for allegedly participating in an attack on a Moscow office of the ruling United Russia party in 2018. He and his supporters have maintained his innocence, stating that he was tortured during the investigation and coerced into signing a confession, which he retracted. In 2019, the Russian human rights organization Memorial recognized Miftakhov as a political prisoner. Vietnam has extradited a Belarusian national who fought as a volunteer in Ukraine on Kyiv's side to Minsk, Belarusian media reported on November 20. The opposition-led Coordination Council said Vasyl Verameychyk, who is a member of the council, was turned over to Belarus on November 14. Verameychyk served in the Belarusian Army for seven years but participated in the 2020 anti-government protests. After the threat of arrest, he fled to Ukraine, where he joined the fighting against Russian forcesand was wounded in April 2022. Nasha Niva news reported Verameychyk moved to Vietnam after he was denied permission to settle in Lithuania because of his former Belarusian Army service. To read the original story by RFE/RL’s Belarus Service, click here . European Commissioner for Home Affairs Ylva Johansson told RFE/RL in an interview that she is “optimistic” that Romania and Bulgaria will be fully integrated into the visa-free Schengen travel zone by the end of the year. “Romania and Bulgaria are ready, the Schengen area is ready, so I can’t see any obstacles,” she said. “It’s time to lift internal border controls now.” The interview, conducted on November 19, will be published in full on November 21. In March, both countries joined the Schengen area on a partial basis , allowing visa-free travel for those arriving and departing on flights and by boat to both countries, but not by road. To read the original story by RFE/RL’s Romanian Service, click here . Serbian Trade Minister Tomislav Momirovic on November 20 became the second government minister to resign following the collapse of a railway station overhang in Novi Sad that killed 15 people on November 1. He didn't mention the tragedy in his resignation statement. Goran Vesic, minister of construction, transport, and infrastructure, resigned on November 5, saying he was quitting for "moral" reasons, without admitting any guilt. Protests have been held in Novi Sad and Belgrade demanding those responsible for the collapse be held to account. The railway station was built in 1964 but recently underwent a renovation. Serbian Railways insisted that work didn’t include the concrete overhang, but some experts disputed that. To read the original story by RFE/RL’s Balkan Service, click here . A Ukrainian court has sentenced prominent Russian actor Vladimir Mashkov in absentia to 10 years in prison, according to the Security Service of Ukraine (SBU). Mashkov was found guilty of undermining Ukraine’s territorial integrity and promoting war propaganda. Additionally, the court ordered the confiscation of Mashkov’s apartment in Odesa, reportedly gifted to him by fans for his role in the TV series Liquidation, which is set in post-war Odesa. The SBU highlighted Mashkov’s participation in pro-Kremlin events, including “concert rallies” advocating aggression against Ukraine, some of which took place in Russian-occupied territories. Mashkov was a trusted ally of Russian President Vladimir Putin and served as a senior member of Putin’s election campaign team this year. To read the original story by RFE/RL's Russian Service, click here . The United States, Germany, and the Netherland -- three key Ukrainian allies -- on November 20 provided details of additional aid to Kyiv as it battles against Russia’s full-scale invasion, which passed the 1,000-day mark this week. The Dutch Defense Ministry said the Netherlands had turned over the final two of 18 promised U.S.-made F-16 fighter warplanes to a Romania training base, where Ukrainian pilots and staff are being taught to fly and maintain the jets. The Netherlands has been one of the main players in a coalition of Western partners to supply Ukraine with the sophisticated F-16s to strengthen its defenses against destructive Russian attacks on military and civilian sites. Ukrainian President Volodymyr Zelenskiy in the past hailed the delivery of the warplanes as he pressed allies to step up aid to his country’s stretched military. Separately, the U.S. Defense Department announced an additional security assistance package worth $275 million under the Presidential Drawdown Authority (PDA) program. It said the package will provide Ukraine with “additional capabilities to meet its most urgent needs, including munitions for rocket systems and artillery and anti-tank weapons.” “The United States will continue to work together with some 50 Allies and partners through the Ukraine Defense Contact Group and its associated Capability Coalitions to meet Ukraine's urgently needed battlefield requirements and defend against Russian aggression ,” it said. President Joe Biden is scrambling to provide Ukraine with assistance in the face of increased Russian military activity ahead of the return to the White House on January 20 of Donald Trump, who has expressed opposition to the massive aid packages of the current administration. The U.S. statement said the Biden administration has provided Ukraine with $61.3 billion in security assistance, including $60.7 billion since Russia launched its full-scale invasion in February 2022. The Germany government said it had sent a package of military aid to Ukraine, including armored vehicles, artillery, and drones. Four Panzerhaubitze 2000 howitzers and seven M109 howitzers were included, along with 41,000 rounds of 155-mm artillery shells. The German government noted that its military assistance is delivered in two different manners -- through federal government funds that are used to finance deliveries of military hardware from industry and, separately, from deliveries taken out of current armed forces stocks. Berlin is the second-largest foreign supplier of military aid to Ukraine since February 2022, behind only the United States. Germany in total has provided 28 billion euros ($29.5 billion) to Kyiv. Meanwhile, multiple media reports have stated the United States has given Ukraine permission to launch long-range ATACMS cruise missiles deeper inside Russia, while unconfirmed reports on November 20 said Kyiv had fired British-made Storm Shadow missiles into Russian territory for the first time. Kyiv, Washington, and London have not denied the reports but also have not officially confirmed them. Permission for such strikes had been denied in the past by Western allies amid fears of provoking a wider war. Following the ATACMS and Storm Shadow reports, Ukraine has criticized Germany for refusing to provide its down long-range weapons, the Taurus cruise missile. An Almaty court has found RFE/RL's Kazakh Service, known locally as Radio Azattyq , guilty of disseminating false information, and the court imposed a fine of 184,000 tenges ($371), it said on November 20. The case originated from a complaint filed on November 13 by Shymkent resident Alisher Turabaev. Turabaev alleged that a Kazakh-language video published on Radio Azattyq’s portal on September 13 falsely stated that a prosecutor had requested an eight-year prison sentence for journalist Daniyar Adilbekov on September 12. Turabaev pointed out that court proceedings did not reach this stage until October 16, making the prosecutor’s request impossible at the time. Radio Azattyq acknowledged the error was due to a translation mistake when adapting content from a Russian-language publication. The original Russian report stated that Adilbekov faced "up to eight years in prison" for charges of defamation based on a Telegram post. However, during translation into Kazakh, the phrase was inaccurately rendered as stating that the prosecutor had already "requested eight years." Radio Azattyq expressed readiness to correct the mistake. This marks the second time Radio Azattyq has been fined under Article 456-2 of Kazakhstan’s Administrative Offenses Code. In October 2023, Turabaev successfully filed another complaint against Radio Azattyq, alleging the phrase "Russian-led CSTO (Collective Security Treaty Organization)” on its Russian-language site was false information. The court fined Radio Azattyq 103,500 tenge ($220) in that case. Details of Turabaev's motives in filing the accusations are unknown. Some people have speculated that he has taken the action on the orders of the authorities. The Dissemination of False Information article was added to Kazakhstan’s Administrative Offenses Code in September 2023 and has been widely criticized by human rights organizations as a tool to restrict freedom of speech. The law does not require proof of intent to spread falsehoods, nor does it provide opportunities for corrections or warnings. It also does not require the existence of a victim. Critics have likened the law to Russia’s legislation against "fake news," warning it is being used to silence journalists, activists, and bloggers. Radio Azattyq’s challenges extend beyond legal battles. On January 3, the Kazakh Foreign Ministry denied or refused to renew accreditation for 36 of its employees, citing violations of the Dissemination of False Information law. This dispute was later resolved through mediation. The growing use of Article 456-2 to penalize media and activists has raised concerns about press freedom and the shrinking space for dissent in Kazakhstan. Alyaksandr Lukashenka, the authoritarian ruler of Belarus, has pardoned an additional 32 political prisoners, according to reports from the pro-government Pul Pervogo Telegram channel, although an estimated 1,300 opposition activists remain behind bars in the country. The identities of those pardoned were not disclosed, but the report said they had all been convicted of extremism, a charge widely used against political activists. The report further identified the pardoned individuals as 24 men and eight women, with nine of them above the age of 50. The pardons released the individuals from serving their full sentences but did not remove their criminal records. Their behavior will continue to be monitored by the Interior Ministry after their release, the report said. This marks the sixth instance of political prisoner pardons in Belarus this year, bringing the total number of individuals set free to 178. Earlier this month , 31 political prisoners were pardoned. In July, the government pardoned 18 people, including Ryhor Kastusyou , the former leader of the opposition Belarusian Popular Front party who had been serving a 10-year sentence and is reportedly in poor health. Additional pardons followed in August (30 individuals), early September (30), and mid-September (37). In mid-November, prominent opposition figure Maryya Kalesnikava , who is serving an 11-year sentence on charges of conspiring to seize power, met with her father for the first time in 21 months. A month earlier, Lukashenka had suggested he might consider pardoning Kalesnikava if she submitted a formal request. However, it remains unclear whether she has accepted the offer. Kalesnikava has previously refused to request a pardon, maintaining her innocence and rejecting the legitimacy of the charges against her. The latest pardons come in the context of a harsh crackdown on dissent following the mass protests in Belarus in 2020, sparked by contested presidential election results. Lukashenka responded to the demonstrations with widespread repression, forcing at least 13,000 people into exile. According to human rights organizations, approximately 1,300 political prisoners remain in Belarusian jails, including politicians, journalists, human rights advocates, and civic activists. Belarus has scheduled its next presidential election for January 2025, with Lukashenka widely expected to be declared the winner. PRISTINA -- European soccer's governing body ordered Kosovo to forfeit its November 15 Nations League match in Bucharest that was abandoned after Kosovar players left the field complaining of "racist" abuse. UEFA on November 20 ruled Kosovo was responsible for the match not being completed. It fined the Kosovo soccer federation 6,000 euros ($6,300). The Romanian federation was also punished for the behavior of Romanian fans. It was ordered to play its first World Cup qualifying home game next year in an empty stadium and was fined 128,000 euros ($136,000) for a variety of offenses, including what UEFA called "the racist and/or discriminatory behavior” of its supporters and "provocative political messages not fit for a sports event." The federation was also fined for its supporters' throwing objects, lighting fireworks, and causing disturbances during national anthems, among other issues, UEFA said . Kosovo’s soccer federation said the fines against the Romanian federation was confirmation of the "validity" of the Kosovo national team's decision to abandon the match. "This decision fully justifies our actions, and we are proud that our national team correctly assessed the situation when it decided to leave the field in protest against these racist chants, provocative political messages, and other discriminatory behaviors," it said of the ruling, which officially meant a 3-0 victory for Romania. It added, however, that it disagreed with the decision that Kosovo should lose points in the league table, indicating it will appeal the case to the Court of Arbitration for Sport (CAS) in Switzerland. DigiSport in Romania reported that the Romanian Soccer Federation will await further details from UEFA before deciding on its next actions. The GSP sports site, meanwhile, quoted Romanian coach Mircea Lucescu as welcoming the ruling granting his team the victory, but he said he was stunned by the fines. "Us? Fined? Such a large amount? It's absurd," he was quoted as saying. Kosovo national team manager Bajram Shala had said the decision to abandon the match was made by the Kosovar federation, coach Franco Foda, and the players after "racist calls" against their country. The captain of the Kosovo team, Amir Rrahmani, said Romanian fans chanted, "Serbia, Serbia," and "Kosovo is Serbia," and that he had informed Danish referee Morten Krogh "at least three times" that his team would leave the field. Kosovo declared independence from Serbia in 2008 and has been recognized by more than 100 countries, but not Romania and other four EU states -- Spain, Cyprus, Greece, and Slovakia. After Kosovar players departed, the Romanian team remained on the pitch for about an hour before the referee decided to abandon the game after the Kosovo's team refused to return. DigiSport quoted Romanian team captain Nicolae Stanciu as expressing puzzlement that his team continues to play Kosovo, even though the Romanian state does not recognize its independence. "If we as a state do not recognize [Kosovo] and considering what happened in past matches, why do we continue to play against them?" The Danish Defense Command said it is "present" in the area near the Chinese cargo ship Yi Peng 3, which is anchored off the coast of Denmark and suspected of being involved in recent damage to fiber-optic communications cables in the Baltic Sea. Suspicions have been growing in Western capitals that damage to two key Baltic Sea cables was likely the result of deliberate actions. The Chinese ship, reportedly captained by a Russian naval officer, was sailing from the Russian port of Ust-Luga. It is suspected of having traveled over the area in the Baltic Sea where the cables connecting Sweden and Lithuania are located. European governments and Washington have not tied Moscow directly to the damage, but they have accused Russia of orchestrating "hybrid attacks" on Western infrastructure to punish European countries for their assistance and support for Ukraine's military as it tries to repel invading Russian forces. Some analysts say the ship may have damaged the cables when dragging its anchor. "The Danish Defense can confirm that we are present in the area near the Chinese ship Yi Peng 3. The Danish Defense currently has no further comments," the Danish Defense Command said in a post on X on November 20. Ukraine's allies pointed to past incidents of alleged sabotage by Moscow, especially following its full-scale invasion of Ukraine, which has hit the 1,000-day mark this week amid devastating losses on both sides. Authorities in states bordering the Baltic Sea are investigating the cutting of the cables -- the second connects Finland to Germany -- following similar suspicious occurrences in the sea in recent years. A year ago, Finland said it couldn't exclude that a "state actor" was responsible for damage to the Balticconnector gas pipeline and a telecommunications cable in the Baltic Sea. The pipeline was damaged by an anchor dropped from the deck of the Chinese container ship Newnew Polar Bear. The ship was not detained and sailed away. Moscow has said such allegations are being fabricated by the West to discredit Russia. Chinese officials have not commented on the situation surrounding the Yi Peng 3. Russia's Federal Security Service (FSB) said on November 20 that its officers had detained a German citizen on suspicion of involvement in a March explosion that damaged a gas pipeline at a distribution center in Kaliningrad, the capital of Russia's western exclave of the same name. According to the FSB, Nikolaj Gajduk was detained after investigators found 0.5 liters of an unspecified "explosive substance" in his car while he was entering Kaliningrad from Poland. The statement also said that Gajduk had planned to conduct "sabotage acts" at energy facilities in the region, adding that the plan had been "masterminded" by a Ukrainian citizen residing in Germany. Gajduk was charged with terrorism and smuggling explosive substances. The Agentstvo Telegram channel said that Gajduk is a 57-year-old native of Ukraine. German authorities are yet to comment on the situation. T o read the original report by RFE/RL's Russian Service, click here . Iranian authorities are using executions as "a tool of fear," particularly directed at ethnic minorities, dissidents, and foreign nationals, Human Rights Watch (HRW) said on November 20. The rights watchdog highlighted a recent surge in capital punishment sentences against these groups, noting that the verdicts are handed down amid rampant violations of due process. According to Iran Human Rights group, in the first 10 months of this year, at least 651 people were executed in Iran -- 166 people in October alone. HRW noted the case of Kurdish political prisoner Varisheh Moradi, sentenced to death by Iran’s revolutionary court in Tehran on November 10 on the charge of “armed rebellion against the state." Moradi, a member of the Free Women’s Society of Eastern Kurdistan, was arrested in the city of Sanandaj in Kurdistan Province in August last year and kept for five months in solitary confinement in the infamous Evin prison where she was tortured. Her family has not been allowed to visit her since May, the group said. Moradi was not allowed to defend herself, and the judge did not permit her lawyers to present a defense, the Kurdistan Human Rights Network reported. “Iranian authorities use the death penalty as a tool of fear, particularly targeting ethnic minorities and political dissidents after unfair trials,” said HRW's Nahid Naghshbandi. “This brutal tactic aims to suppress any opposition to an autocratic government through intimidation,” she said. Five other Kurdish men were sentenced to death in recent weeks on charges of “espionage for Israel," HRW said. Four Arab prisoners from Ahvaz, Khuzestan Province, are at risk of imminent execution, after being sentenced to death by a revolutionary court with two other individuals for their alleged involvement in the killings of two Basij members, a law enforcement officer, and a soldier. The four -- Ali Majdam, Moein Khonafri, Mohammadreza Moghadam, and Adnan Gheibshavi (Musavi) -- were arrested in 2017 and 2018, according to human rights groups. Afghan citizens in Iran have been targeted, in particular, by death sentences, HRW noted, adding that according to human rights groups, at least 49 Afghan nationals have been executed in Iran this year, 13 in the past month alone. “Iran’s revolutionary courts are a tool of systematic repression that violate citizens’ fundamental rights and hand out death sentences indiscriminately, leaving legal protections meaningless,” Naghshbandi said. “The international community should categorically condemn this alarming trend and pressure Iranian authorities to halt these executions,” she added. Mai Sato, the United Nations special rapporteur on the human rights situation in Iran, has also voiced concern about the "alarming" increase in the number of executions. "In August 2024 alone, at least 93 people were executed, with nearly half in relation to drug offences," Sato said on November 1. At least 11 members of Pakistan's security forces were killed and at least four others were wounded in a car-bombing and shooting attack, the country's military said in a statement. The attack occurred late on November 19 in Bannu, a district in the restive northwestern Khyber Pakhtunkhwa Province, the statement said. Residents told RFE/RL that the sound of gunfire could be heard until late at night. A splinter faction of the Pakistani Taliban, the Hafiz Gul Bahadur group, claimed responsibility for the attack in a statement, saying that 23 members of the Pakistani security forces had been killed, a toll that could not be independently verified. The attack occurred as Pakistan's political and military leadership was meeting in Islamabad to discuss ways to tackle the current surge in militant violence. To read the original story by RFE/RL's Radio Mashaal, click here . TBILISI -- Hundreds of Georgian police have forced demonstrators for a second night in a row out of the area near Tbilisi State University where they were protesting the results of last month's parliamentary elections and calling for a repeat of the vote. Unlike the previous day , there were no clashes early on November 20 as protesters retreated from the advancing police forces and left the university area, moving to the nearby Melikishvili Avenue in downtown Tbilisi. The protest leaders then announced that they were temporarily suspending their action in order to come up with a new plan. "We have to somehow replan and think about something different, not the same as what we have been doing here," Zurab Japaridze, one of the leaders of the Coalition for Change movement, told the demonstrators. On November 19, Georgian police violently dispersed the days-long protest at the university, detaining at least 16 people and taking down the tents where demonstrators had taken shelter from the cold during the night. The Interior Ministry told RFE/RL that the 16 people detained were held for alleged disobedience to the lawful demands of the police and petty hooliganism. Three of them were released on their own recognizance. Tbilisi has been rocked by protests since the elections, with opposition leaders demanding a repeat of parliamentary elections amid claims of widespread fraud and Russian influence during the October 26 polls that were won by the Georgian Dream party, which has been in power since 2012. The latest protests broke out after Georgia's Central Election Commission (CEC) on November 16 validated the results of last month's disputed elections, despite accusations of widespread fraud and Russian interference. According to the official results, Georgian Dream won 53.93 percent of the vote against 37.79 percent garnered by an opposition alliance. The office of pro-European President Salome Zurabishvili -- who backs the protesters and has refused to recognize the October 26 vote -- said she filed a lawsuit in the Constitutional Court on November 19, "requesting annulment of the election results as unconstitutional,” although she acknowledged little hope of success. "This is not because I believe in the Constitutional Court -- we all know that no institution in this country is independent any longer and we have received evidence of this repeatedly. Georgia's pro-European opposition has boycotted the new parliament, renouncing its mandates from the October 26 vote, alleging widespread fraud and Russian interference. EU and other Western officials have expressed serious doubts about the elections and perceived irregularities. Georgia has been a candidate for EU membership since last year, but a "foreign influence" law and anti-LGBT measures have stalled that effort. On November 20, the EU Delegation to Georgia issued a statement voicing support for young people who are fighting to protect the country's European values . "Here in Georgia, youth is safeguarding their rights, freedoms and the country's EU future. We stand firmly by them and stress the need to respect their fundamental right to freedom of expression and assembly," the EU Delegation said in a message on X on the occasion of "World Children's Day." The United States in July announced that it would pause more than $95 million in assistance to the Georgian government, warning it that it was backsliding on democracy. Dilmurod Ergashev, a Tajik opposition activist who was deported from Germany despite significant concerns about the risk of his detention and torture upon returning to Tajikistan, has been jailed for two months, Human Rights Watch (HRW) said on November 20, calling on Berlin to press for his release. An administrative court in Germany ordered Ergashev's deportation on October 28. The 40-year-old is a prominent member of Group 24, an opposition movement that is banned in Tajikistan, and part of the Reforms and Development of Tajikistan movement established by exiled dissidents. His activism has included participating in demonstrations in Berlin, notably during a protest against Tajik President Emomali Rahmon's visit to Germany in September 2023. "Germany should urgently press Tajikistani authorities to release Ergashev or make clear the legal grounds and evidence justifying his detention and ensure that his due process rights are fully respected," HRW said in a statement . "This includes access to appropriate and quality medical care and ensuring that he is not mistreated. Ergashev was deported after a German court dismissed concerns, that he and human rights groups had raised, that he would be detained on arrival in Tajikistan," it said. Ergashev has been in Germany since February 2011 and first applied for asylum on political grounds that same year. Despite several applications, his asylum requests have been consistently rejected. According to his lawyer, German immigration authorities have expressed doubts about the sincerity of Ergashev's commitment to opposition causes. On November 6, The Insider investigative group reported that Ergashev had attempted to commit suicide before being deported from Germany to Tajikistan, citing self-exiled Tajik opposition activist Sharofiddin Gadoev. Germany has faced criticism for similar actions in the past. In 2023, two Tajik dissidents, Abdullohi Shamsiddin and Bilol Qurbonaliev, were deported to Tajikistan, where they were immediately detained and later sentenced to lengthy prison terms on dubious charges related to attempts to overthrow the constitutional order. Reports indicate that Shamsiddin has faced mistreatment while incarcerated. The Tajik government is known for its systematic persecution of opposition members, especially those affiliated with banned groups like Group 24. A recent report by HRW highlighted Tajikistan as a country of major concern regarding transnational repression, noting that the government actively targets critics abroad on charges of extremism and terrorism, leading to severe penalties and mistreatment upon forced return. Given Ergashev's documented activism and participation in protests, he is seen as a clear target for persecution by the Tajik authorities. KYIV -- The White House said it will provide Ukraine with antipersonnel mines to help it fend off Russia’s battlefield advances , despite widespread opposition to such weapons by international rights groups and following heavy usage of similar devices by Russia. U.S. Defense Secretary Lloyd Austin was quoted on November 20 by news agencies as saying during a visit to Laos that the decision to provide the controversial mines was made because of a change in Russian tactics. "They don't lead with their mechanized forces anymore," he said "They lead with dismounted forces who are able to close and do things to kind of pave the way for mechanized forces." Ukraine has a need "for things that can help slow down that effort on the part of the Russians," he added. Human Rights Watch (HRW) said Russia had used at least 13 types of antipersonnel mines in Ukraine since February 2022. "Russia has used anti-personnel land mines widely in Ukraine...causing hundreds of casualties and contaminating vast tracts of agricultural land," it said. Rights and humanitarian groups have long criticized the use of antipersonnel mines, saying they pose a danger to civilians. In a statement following the U.S. announcement, HRW said the "decision to transfer antipersonnel land mines risks civilian lives and sets back international efforts to eradicate these indiscriminate weapons.” More than 160 countries have agreed to ban the use of antipersonnel mines, although the United States and Russia are not signatories to the convention . Ukraine ratified the convention in December 2005. When asked in the past about possible use of such mines, Ukraine said it could not comment on the types of weapons utilized during the current armed conflict "before the end of the war and the restoration of our sovereignty and territorial integrity." Antipersonnel mines are hidden in the ground and are designed to detonate when enemy troops walk on or near them. Some reports have said the mines being provided by Washington are "nonpersisent," meaning that after a set period of time they no longer are operational and are rendered harmless. President Volodymyr Zelenskiy hailed the decision on the mines, calling them "very important" weapons in the effort to blunt Russian assaults and saying the move would "totally strengthen" Ukraine's frontline troops. Meanwhile, U.S. officials said Washington's embassy in Kyiv will likely resume normal operations on November 21 after having closed earlier on November 20 when it received "specific information" about "a potential significant air strike." Late in the day, State Department spokesman Matthew Miller told a briefing that "I can't go into the details of the threat, but we're always keeping a close eye on it. “The embassy is expected to return to normal operations tomorrow," he added. In closing, the embassy urged employees and U.S. citizens in the Ukrainian capital to take immediate shelter if an air-raid alert was announced. "Out of an abundance of caution, the Embassy will be closed, and Embassy employees are being instructed to shelter in place," it said in a statement, without giving any details about the possible strike. The embassies of Italy, Greece, and Spain said they had also shut their operations following the unusual U.S. warning. Spain later said it reopened its facility after a temporarily closing. The Ukrainian military suggested the information the U.S. Embassy was referring to was "fake." "Messengers and social networks...are spreading a message about the threat of a 'particularly massive' missile and bomb attack on Ukrainian cities today." "This message is a fake. It contains grammatical errors typical of Russian information and psychological operations,” it added. It urged residents not to ignore air-raid sirens but also "not to succumb to panic." An air-raid alert was issued for several Ukrainian regions, including Kyiv, early on November 20 due to the imminence of Russian drone strikes. The U.S. warning came one day after Moscow said Ukraine had used U.S.-made long-range missile systems to strike a weapons depot in Russia's Bryansk region following U.S. President Joe Biden's reported authorization of their use. The White House has not officially confirmed the decision. In another move by the current U.S. administration aimed at aiding Ukraine, Biden has informed Congress that he intends to cancel $4.65 billion in loans to Ukraine, a State Department spokesman said. Zelenskiy did not confirm or deny the use of ATACMS in the attack on Bryansk, saying during a news conference that "Ukraine has long-range capabilities.... We now have a long 'Neptune' (Ukrainian-made cruise missiles) and not just one. And now we have ATACMS. And we will use all of this." On November 20, Ukraine's military intelligence agency said a Russian military command post had been "successfully struck" in the town of Gubkin in Russia's Belgorod region, some 168 kilometers from the Ukrainian border. It did not say what kind of missiles had been used in the attack. Meanwhile, Bloomberg News reported the Ukrainian military had also fired a British-supplied Storm Shadow into Russia for the first time, citing an unnamed Western official. Separately, the Ukrainian Air Force said Russian troops attacked Ukraine early on November 20 with 122 drones, 56 of which were shot down over 14 regions -- Kyiv, Cherkasy, Chernihiv, Poltava, Kirovohrad, Zhytomyr, Khmelnytskiy, Sumy, Mykolayiv, Kherson, Zaporizhzhya, Dnipropetrovsk, Donetsk, and Kharkiv. The mayor of Ukraine's Black Sea port of Odesa, Hennadiy Trukhanov, said the death toll after a Russian strike on the city on November 18 had risen to 11.
No. 7 Tennessee outscored UT Martin by 28 points in the second half in routing the visiting Skyhawks 78-35 on Friday afternoon in Knoxville. Chaz Lanier scored a game-high 18 points for the Volunteers (7-0), who expanded on a 35-20 halftime lead with a 43-15 second half. Felix Okpara had 10 points, 11 rebounds and four blocks, helping Tennessee command the paint along with Igor Milicic, who added nine points and 13 rebounds. Zakai Zeigler nearly had a double-double with 11 points and nine assists. The Volunteers used their size to their advantage, outscoring UT Martin 36-10 in the paint and out rebounding the Skyhawks 49-24. That included 20 offensive rebounds for Tennessee, which led to 19 second-chance points. UT Martin (2-5) was cold coming out of the locker room after halftime, missing its first eight shots. Conversely, the Vols started the second half with a nine-point run to extend their lead to 24 points. The Vols never let the Skyhawks score consecutive baskets in the first half, holding UT Martin to 25 percent shooting (4 of 16) from beyond the arc and allowing a total of only three points from the starting five. For the game, guard Josue Grullon led UT Martin with 15 points. The leading scorer in the Ohio Valley Conference entering Friday at 18.2 points per game, Grullon has not started any game for head coach Jeremy Shulman. Most of the Skyhawks' points -- 28 of 35 -- came from their reserves. The starting five combined to score seven points -- six points from Matija Zuzic and a free throw for Lamine Niag. The starters went a combined 2 of 18 from the floor, while UT Martin as a team shot 22.6 percent (12 of 53) from the field. The Skyhawks made 5 of 7 free-throw attempts and made 18 turnovers. The Volunteers, who got 23 points off the bench, were 8-for-10 and had 11 turnovers. Tennessee improved to 6-0 all-time against UT Martin since 1993. --Field Level MediaTrent Williams' wife, Sondra, says their son was stillborn
Multiple reports on Thursday and Friday indicated that Abe Akie, wife of late former Japanese Prime Minister Abe Shinzo, is planning on visiting President-elect Donald Trump’s estate at Mar-a-Lago on Sunday. Abe, who served as prime minister during Trump’s first term in office, was the first world leader to meet with Trump after his election victory in 2016. The two developed a close friendship, and Abe was often cited as the world head of government with the most access to Trump. Abe Akie and First Lady Melania Trump also reportedly developed a close relationship, sharing the responsibilities of being First Lady of their countries, and regularly engaged each other when their husbands met. Reuters reported , citing an anonymous source, on Friday that the Trumps invited Akie to dine at Mar-a-Lago and that she would attend on Sunday, apparently with Melania Trump. It noted the detail, originally reported by CNN, that the Trumps continued investing in their relationship with Abe Akie after her husband’s death and that the president-elect has, in the two years since Abe Shinzo’s murder, called his widow regularly to check on her. The Japanese newspaper Yomiuri Shimbun also reported , citing its own sources, that Abe Akie was “making arrangements to visit the United States.” The newspaper reported that the former first lady was planning on meeting with Melania Trump and could potentially meet the president-elect as part of that engagement. U.S. first lady Melania Trump, left, and Japanese Prime Minister Shinzo Abe’s wife Akie Abe look at koi carps in a pond at the Japanese style annex inside the State Guest House in Tokyo Monday, May 27, 2019. (Tomohiro Ohsumi/Pool Photo via AP) A conservative and one of the most dominant political figures in modern Japanese history, Abe ultimately stepped down from his position due to health issues. The politician struggled with ulcerative colitis and, at the time of his resignation, said that he had not brought the condition under enough control to make it possible for him to fulfill his duties at prime minister. He appeared to be preparing a political comeback, supporting his conservative Liberal Democratic Party (LDP) on the campaign trail, when he was shockingly assassinated in broad daylight in July 2022. The killer, identified as 41-year-old Yamagami Tetsuya, said he was looking for revenge against the controversial Unification Church, which he claimed had stolen money from his mother, and Abe was the closest figure with any notable ties to the church that he could find with minimal enough security around him to make him a viable target. Abe Akie was a highly visible part of Abe’s tenure as prime minister. The first lady was supportive of her husband and a presence on the campaign trail while also advocating for her own political views, which often differed to those advanced by the LDP. Abe, for example, participated in a gay rights march in 2014, in support of an end to social stigmas against gay and lesbian people. Abe Akie has also publicly participated in events apparently expressing contrition for the position of Imperial Japan against the United States. In 2016, for example, when the Abes visited the United States, Abe Akie made an individual trip to Pearl Harbor, Hawaii, to honor the American soldiers killed by the surprise Japanese attack that marked the beginning of American involvement in World War II. “I understand that there are various debates and stances on Pearl Harbor, but I think that we have to pass on the memory to the next generation, transcending the feelings of hate and anger,” she said at the time. The visit was notable as Shinzo Abe was an enthusiastic supporter of amending the Japanese constitution to allow the country to possess a military, which pacifists in the country have long opposed. While Akie Abe was even often jokingly referred to as the true “opposition party” of Japan – especially given the years of ineffective organizing by Japanese leftist groups, the two maintained a united front and supported each other. The reports of an invitation and potential in-person meeting with President-elect Trump has caused some stirrings in Japan as the current prime minister, Ishiba Shigeru, has attempted repeatedly to meet with Trump to no avail. Ishiba is a member of Abe’s LDP but has struggled with favorability and was handed a party in shambles, hurt by corruption scandals and the growing animosity towards the Unification Church, which has been tied to the LDP in the public eye since Abe’s assassination. Ishiba spoke to Trump shortly after the presidential election in November, but has not succeeded in meeting with him. Ishiba claimed that he was told that Trump could not legally meet with foreign leaders until after inauguration, but Trump has held multiple such meetings, including with Argentine President Javier Milei, Canadian Prime Minister Justin Trudeau, and several world leaders at the reopening of the Notre Dame cathedral in Paris. Follow Frances Martel on Facebook and Twitter.
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Jones scores 20 in Cent. Conn. St.'s 69-56 win against Holy Cross
Miami enters the week still stunned after losing its fourth straight game. Next up, the Hurricanes will play host to Arkansas on Tuesday night in Coral Gables, Fla., as part of the ACC/SEC Challenge. Miami (3-4) lost on Saturday afternoon to Charleston Southern, a team that entered with a 1-7 record. Arkansas (5-2) is coming off a Thanksgiving loss to Illinois on a neutral floor in Kansas City, Mo. "We've got a lot to learn," said John Calipari, in his first season coaching Arkansas. "We really haven't scrimmaged because we haven't had 10 guys (due to injuries). "But this team is going to be fine." The same thing cannot confidently be said about the Hurricanes. Their first three defeats of the current skid were tough for Miami to take, losing to Drake, Oklahoma State and VCU on a neutral court as part of the Charleston Classic. But the loss to Charleston Southern -- which was a 25-point underdog -- has to be considered among the worst in Miami history. Hurricanes coach Jim Larranaga was without point guard Nijel Pack, who missed the contest due to a lower-body injury. Pack leads Miami in scoring (15.2) and assists (4.7). There are no reports on how long he will be out. With Pack unavailable, five-star freshman Jalil Bethea made his first college start. However, the 6-foot-5 shooting guard has not yet played up to his ranking. Bethea is averaging 6.3 points, 1.1 rebounds and 0.7 assists. He is also shooting 30.0 percent on 3-pointers. Miami ranks 284th in the nation in rebounds and 259th in blocked shots. "We haven't been able to put together a solid defensive effort," Larranaga said following the loss to Charleston Southern. "Some of it has to do with fundamentals. Some of it has to do with athletic ability. Some of it has to do with size." Tuesday's game will match two veteran coaches: Larranaga, 75, and Calipari, 65. Calipari brought in seven transfers and five freshmen for his first season in Fayetteville. Two of those transfers -- 6-foot-8 wing Adou Thiero and 7-foot-2 center Zvonimir Ivisic -- were signed after leaving Kentucky, Calipari's previous stop. Thiero leads Arkansas in scoring (19.1), rebounds (5.9) and steals (2.9). Ivisic leads Arkansas in blocks (2.7) while ranking third in points (12.1). Freshman Boogie Fland, a McDonald's All-American, has made a quick transition to college ball. The 6-foot-2 point guard is second on the team in scoring (15.9) and steals (1.9) and first in assists (4.9). Among Arkansas' bench pieces are 6-foot-11 Tennessee transfer Jonas Aidoo and 6-foot-10 Arkansas holdover Trevon Brazile. Their combined 92 college starts illustrate Arkansas' depth. "The ceiling is there," Calipari said. "But we need to be the aggressors." --Field Level MediaBy JILL COLVIN and STEPHEN GROVES WASHINGTON (AP) — After several weeks working mostly behind closed doors, Vice President-elect JD Vance returned to Capitol Hill this week in a new, more visible role: Helping Donald Trump try to get his most contentious Cabinet picks to confirmation in the Senate, where Vance has served for the last two years. Vance arrived at the Capitol on Wednesday with former Rep. Matt Gaetz and spent the morning sitting in on meetings between Trump’s choice for attorney general and key Republicans, including members of the Senate Judiciary Committee. The effort was for naught: Gaetz announced a day later that he was withdrawing his name amid scrutiny over sex trafficking allegations and the reality that he was unlikely to be confirmed. Thursday morning Vance was back, this time accompanying Pete Hegseth, the “Fox & Friends Weekend” host whom Trump has tapped to be the next secretary of defense. Hegseth also has faced allegations of sexual assault that he denies. Vance is expected to accompany other nominees for meetings in coming weeks as he tries to leverage the two years he has spent in the Senate to help push through Trump’s picks. Vice President-elect JD Vance, still a Republican senator from Ohio, walks from a private meeting with President-elect Donald Trump’s nominee to be attorney general, former Rep. Matt Gaetz, R-Fla., at the Capitol in Washington, Wednesday, Nov. 20, 2024. (AP Photo/J. Scott Applewhite) President-elect Donald Trump’s nominee to be attorney general, former Rep. Matt Gaetz, R-Fla., center, and Vice President-elect JD Vance, left, walk out of a meeting with Republican Senate Judiciary Committee members, at the Capitol in Washington, Wednesday, Nov. 20, 2024. (AP Photo/Ben Curtis) FILE – Sen. JD Vance, R-Ohio, departs the chamber at the Capitol in Washington, March 15, 2023. (AP Photo/J. Scott Applewhite, File) FILE – Sen. JD Vance, R-Ohio, center speaks during a Senate Banking Committee hearing on Capitol Hill in Washington, March 7, 2023. (AP Photo/Andrew Harnik, File) FILE – Sen. JD Vance, R-Ohio, right, speaks with Sen. Sherrod Brown, D-Ohio, before testifying at a hearing, March 9, 2023, in Washington. (AP Photo/Kevin Wolf, File) FILE – Sen. JD Vance, R-Ohio, arrives for a classified briefing on China, at the Capitol in Washington, Feb. 15, 2023. (AP Photo/J. Scott Applewhite, File) FILE – Sen. JD Vance, R-Ohio, arrives for a vote on Capitol Hill, Sept. 12, 2023 in Washington. (AP Photo/Mark Schiefelbein, File) FILE – Sen. JD Vance R-Ohio speaks during a news conference on Capitol Hill in Washington, Feb. 6, 2024. (AP Photo/Jose Luis Magana, File) Vice President-elect JD Vance, still a Republican senator from Ohio, walks from a private meeting with President-elect Donald Trump’s nominee to be attorney general, former Rep. Matt Gaetz, R-Fla., at the Capitol in Washington, Wednesday, Nov. 20, 2024. (AP Photo/J. Scott Applewhite) The role of introducing nominees around Capitol Hill is an unusual one for a vice president-elect. Usually the job goes to a former senator who has close relationships on the Hill, or a more junior aide. But this time the role fits Vance, said Marc Short, who served as Trump’s first director of legislative affairs as well as chief of staff to Trump’s first vice president, Mike Pence, who spent more than a decade in Congress and led the former president’s transition ahead of his first term. ”JD probably has a lot of current allies in the Senate and so it makes sense to have him utilized in that capacity,” Short said. Unlike the first Trump transition, which played out before cameras at Trump Tower in New York and at the president-elect’s golf club in Bedminster, New Jersey, this one has largely happened behind closed doors in Palm Beach, Florida. There, a small group of officials and aides meet daily at Trump’s Mar-a-Lago resort to run through possible contenders and interview job candidates. The group includes Elon Musk, the billionaire who has spent so much time at the club that Trump has joked he can’t get rid of him. Vance has been a constant presence, even as he’s kept a lower profile. The Ohio senator has spent much of the last two weeks in Palm Beach, according to people familiar with his plans, playing an active role in the transition, on which he serves as honorary chair. Vance has been staying at a cottage on the property of the gilded club, where rooms are adorned with cherubs, oriental rugs and intricate golden inlays. It’s a world away from the famously hardscrabble upbringing that Vance documented in the memoir that made him famous, “Hillbilly Elegy.” His young children have also joined him at Mar-a-Lago, at times. Vance was photographed in shorts and a polo shirt playing with his kids on the seawall of the property with a large palm frond, a U.S. Secret Service robotic security dog in the distance. On the rare days when he is not in Palm Beach, Vance has been joining the sessions remotely via Zoom. Though he has taken a break from TV interviews after months of constant appearances, Vance has been active in the meetings, which began immediately after the election and include interviews and as well as presentations on candidates’ pluses and minuses. Among those interviewed: Contenders to replace FBI Director Christopher Wray , as Vance wrote in a since-deleted social media post. Defending himself from criticism that he’d missed a Senate vote in which one of President Joe Biden’s judicial nominees was confirmed, Vance wrote that he was meeting at the time “with President Trump to interview multiple positions for our government, including for FBI Director.” “I tend to think it’s more important to get an FBI director who will dismantle the deep state than it is for Republicans to lose a vote 49-46 rather than 49-45,” Vance added on X. “But that’s just me.” While Vance did not come in to the transition with a list of people he wanted to see in specific roles, he and his friend, Trump’s eldest son, Donald Trump Jr., who is also a member of the transition team, were eager to see former Democratic Rep. Tulsi Gabbard and Robert F. Kennedy Jr. find roles in the administration. Trump ended up selecting Gabbard as the next director of national intelligence , a powerful position that sits atop the nation’s spy agencies and acts as the president’s top intelligence adviser. And he chose Kennedy to lead the Department of Health and Human Services , a massive agency that oversees everything from drug and food safety to Medicare and Medicaid. Vance was also a big booster of Tom Homan, the former acting director of Immigration and Customs Enforcement, who will serve as Trump’s “border czar.” In another sign of Vance’s influence, James Braid, a top aide to the senator, is expected to serve as Trump’s legislative affairs director. Allies say it’s too early to discuss what portfolio Vance might take on in the White House. While he gravitates to issues like trade, immigration and tech policy, Vance sees his role as doing whatever Trump needs. Vance was spotted days after the election giving his son’s Boy Scout troop a tour of the Capitol and was there the day of leadership elections. He returned in earnest this week, first with Gaetz — arguably Trump’s most divisive pick — and then Hegseth, who has was been accused of sexually assaulting a woman in 2017, according to an investigative report made public this week. Hegseth told police at the time that the encounter had been consensual and denied any wrongdoing. Vance hosted Hegseth in his Senate office as GOP senators, including those who sit on the Senate Armed Services Committee, filtered in to meet with the nominee for defense secretary. While a president’s nominees usually visit individual senators’ offices, meeting them on their own turf, the freshman senator — who is accompanied everywhere by a large Secret Service detail that makes moving around more unwieldy — instead brought Gaetz to a room in the Capitol on Wednesday and Hegseth to his office on Thursday. Senators came to them. Vance made it to votes Wednesday and Thursday, but missed others on Thursday afternoon. Vance is expected to continue to leverage his relationships in the Senate after Trump takes office. But many Republicans there have longer relationships with Trump himself. Sen. Kevin Cramer, a North Dakota Republican, said that Trump was often the first person to call him back when he was trying to reach high-level White House officials during Trump’s first term. “He has the most active Rolodex of just about anybody I’ve ever known,” Cramer said, adding that Vance would make a good addition. “They’ll divide names up by who has the most persuasion here,” Cramer said, but added, “Whoever his liaison is will not work as hard at it as he will.” Cramer was complimentary of the Ohio senator, saying he was “pleasant” and ” interesting” to be around. ′′He doesn’t have the long relationships,” he said. “But we all like people that have done what we’ve done. I mean, that’s sort of a natural kinship, just probably not as personally tied.” Under the Constitution, Vance will also have a role presiding over the Senate and breaking tie votes. But he’s not likely to be needed for that as often as was Kamala Harris, who broke a record number of ties for Democrats as vice president, since Republicans will have a bigger cushion in the chamber next year. Colvin reported from New York. Associated Press writer Mary Clare Jalonick contributed to this report.
BOZEMAN, Mont. (AP) — Tommy Mellott threw for 300 yards and four touchdowns and top-seeded Montana State tied a school record with its 13th straight win, dominating Tennessee-Martin 49-17 on Saturday in the second round of the FCS playoffs. Scottre Humphrey ran for 102 yards and a touchdown, one of three rushing touchdowns for the Bobcats (13-0), who are home next weekend against the winner of Saturday's late game between Lehigh and eighth-seeded Idaho. MSU, which has scored at least 30 points in every game this season, won 13 games in 1975-76. Mellott threw for 178 yards and three touchdowns in the first half and the Bobcats rolled to a 28-10 lead. Mellott had touchdown passes of 24 yards to Hunter Provience and 12 yards to Taco Dowler in the first quarter and 39 yards to Ty McCullouch in the second. McCullouch also had a 6-yard touchdown run. The pass to McCullouch ended a six-play, 73-yard drive that took just 53 seconds, and came immediately after Trevonte Rucker took a pass from Kinkead Dent 78 yards to the end zone that made it 21-10. The Bobcats only allowed only 10 total points in the first half of home games in the regular season. Story continues below video Humphrey had a 36-yard TD run and Mellott hit Dowler for a 29-yard score in the third quarter Adam Jones contributed a 30-yard scoring run in the fourth. Mellott finished 22-of-25 passing and the Bobcats had 501 total yards. Dent threw for 167 yards and two touchdowns, both to Rucker, who had six receptions for 107 yards. The Skyhawks (9-6) finished with 264 yards. AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-football . Sign up for the AP’s college football newsletter: https://apnews.com/cfbtop25Trump's plan for retribution against DOJ prosecutors gets GOP senator's backing: analyst
Kansas holds off Auburn for No. 1 in AP Top 25 as SEC grabs 3 of top 4 spots; UConn slides to No. 25 Kansas continues to hold the No. 1 ranking in The Associated Press Top 25 men’s college basketball poll. Auburn is pushing the Jayhawks in the latest poll after winning the Maui Invitational and checked in at No. 2. Two-time reigning national champion UConn nearly fell out entirely after an 0-3 week at Maui, falling from No. 2 to 25th. The Southeastern Conference had three of the top four teams with No. 3 Tennessee and No. 4 Kentucky behind the Tigers. The poll featured six new teams, headlined by No. 13 Oregon, No. 16 Memphis and No. 18 Pittsburgh. TCU, Duke climb into top 10, Notre Dame drops in women's AP Top 25; UCLA and UConn remain 1-2 TCU has its best ranking ever in The Associated Press Top 25 women’s basketball poll after a convincing win over Notre Dame. The Horned Frogs jumped eight spots to No. 9, the first time the school has ever been in the top 10. The Fighting Irish, who were third last week, fell seven spots to 10th after losses to TCU and Utah. UCLA remained No. 1, followed by UConn, South Carolina, Texas and LSU. USC, Maryland and Duke are next. Houston's Al-Shaair apologizes for hit on Jacksonville's Lawrence that led to concussion HOUSTON (AP) — Houston’s Azeez Al-Shaair took to X to apologize to Jacksonville’s Trevor Lawrence after his violent blow to the quarterback’s facemask led to him being carted off the field with a concussion. Back in the starting lineup after missing two games with a sprained left shoulder, Lawrence scrambled left on a second-and-7 play in the second quarter of Houston’s 23-20 win on Sunday. He initiated a slide before Al-Shaair raised his forearm and unleashed on the defenseless quarterback. In the long post, Al-Shaair says "To Trevor I genuinely apologize to you for what ended up happening.” Philadelphia ready to go the distance with RockyFest week dedicated to 'Rocky' movies PHILADELPHIA (AP) — Rocky Balboa fans are ready to go the distance to honor Philly’s favorite fictional fighter almost 50 years after the first movie launched the enduring series of an underdog boxer persevering despite the odds. The city Rocky called home at last has a week dedicated to the box office heavyweight champion of the world a year after the inaugural Rocky Day was held at the Philadelphia Museum of Art steps. RockyFest officially kicks off Tuesday and a series of events dedicated to the movies series are set to be held around the city. How to sum up 2024? The Oxford University Press word of the year is 'brain rot' LONDON (AP) — Oxford University Press has named “brain rot” its word of the year. It's defined as “the supposed deterioration of a person’s mental or intellectual state,” especially from consuming too much low-grade online content. Oxford University Press said Monday that the phrase “gained new prominence in 2024,” with its frequency of use increasing 230% from the year before. It was chosen by a combination of public vote and language analysis by Oxford lexicographers. The five other word-of-the-year finalists were demure, slop, dynamic pricing, romantasy and lore. Oxford Languages President Casper Grathwohl said the choice of phrase “feels like a rightful next chapter in the cultural conversation about humanity and technology.” Scientists gather to decode puzzle of the world's rarest whale in 'extraordinary' New Zealand study WELLINGTON, New Zealand (AP) — Scientists and culture experts in New Zealand have begun the first-ever dissection of a spade-toothed whale, the world's rarest whale species. The creature, which washed up dead on a beach on New Zealand's South Island in July, is only the seventh specimen ever found. None has ever been seen alive at sea. Almost nothing is known about it but scientists, working with Māori cultural experts, hope to answer some of the many lingering questions this week, including where they live, what they eat, how they produce sound and how this specimen died. Hong Kong launches panda sculpture tour as the city hopes the bear craze boosts tourism HONG KONG (AP) — Thousands of giant panda sculptures will greet residents and tourists starting on Saturday in Hong Kong, where enthusiasm for the bears has grown since two cubs were born in a local theme park. The 2,500 exhibits will be publicly displayed at the Avenue of Stars in Tsim Sha Tsui, one of Hong Kong’s popular shopping districts, this weekend before setting their footprint at three other locations this month. The displays reflect Hong Kong’s use of pandas to boost its economy as the Chinese financial hub works to regain its position as one of Asia’s top tourism destinations. Violent hit on Jaguars QB Trevor Lawrence 'has no business being in our league,' coach says JACKSONVILLE, Fla. (AP) — Jacksonville Jaguars quarterback Trevor Lawrence was carted off the field after taking a violent elbow to the facemask from Houston linebacker Azeez Al-Shaair. It prompted two sideline-clearing scuffles. Lawrence clenched both fists after the hit, movements consistent with what’s referred to as the “fencing response,” which can be common after a traumatic brain injury. Lawrence was on the ground for several minutes as teammates came to his defense and mobbed Al-Shaair. Lawrence eventually was helped to his feet and loaded into the front seat of a cart to be taken off the field. He was not transported to a hospital. He was quickly ruled out with a concussion, though. Al-Shaair and Jaguars rookie cornerback Jarrian Jones were ejected after the first altercation. Big Ten fines Michigan and Ohio State $100,000 each for postgame melee ROSEMONT, Ill. (AP) — The Big Ten Conference has announced it fined Michigan and Ohio State $100,000 each for violating the conference’s sportsmanship policy for the on-field melee at the end of the Wolverines’ win in Columbus .A fight broke out at midfield Saturday after the Wolverines’ 13-10 victory when Michigan players attempted to plant their flag on the OSU logo and were confronted by the Buckeyes. Police used pepper spray to break up the players, who threw punches and shoves. One officer suffered a head injury when he was “knocked down and trampled while trying to separate players fighting." The officer was taken to a hospital and has since been released. Marshall Brickman, who co-wrote 'Annie Hall' with Woody Allen, dies at 85 NEW YORK (AP) — The Oscar-winning screenwriter Marshall Brickman, whose wide-ranging career spanned some of Woody Allen’s best films, the Broadway musical “Jersey Boys” and a number of Johnny Carson’s most beloved sketches, has died. He was 85. Brickman died Friday in Manhattan, his daughter Sophie Brickman told The New York Times. No cause of death was cited. Brickman was best known for his extensive collaboration with Allen, beginning with the 1973 film “Sleeper.” Together, they co-wrote “Annie Hall," “Manhattan” and “Manhattan Murder Mystery." The loosely structured script for “Annie Hall,” in particular, has been hailed as one of the wittiest comedies. It won Brickman and Allen an Oscar for best original screenplay.Gourmet Market, the supermarket brand of The Mall Group, plans to open 1-2 new stores next year amid challenging economic conditions. Supawut Chaiprasitkul, chief business officer for supermarkets and food at The Mall Group, said spending among the middle class for Thai fast-moving consumer goods dipped by single digits in October month-on-month, according to data from Nielsen Thailand, a market research firm. "This could mean the sluggish economy has affected the middle-income segment in the country," he said. The purchasing power of the high-income segment might not be affected by the gloomy economy, though Mr Supawut said they could be more cautious with their spending. However, the company has not experienced a significant impact from this segment as customer spending remains stable, he said. Average spending per bill for M card customers, the loyalty programme of The Mall Group, is around 3,000 baht. Mr Supawut said the Thai retail market is expected to be tough next year as the country still faces a high level of household debt amid global political uncertainty. Thailand's household debt-to-GDP ratio was 89.6% in the second quarter, a slight drop from 90.7% in the previous quarter, according to the National Economic and Social Development Council. To navigate through these headwinds, the company aims to focus more on creating a personalised shopping experience for customers. For in-store shopping, Gourmet Market plans to launch the Gourmet Market Smart Cart on Dec 12 at Siam Paragon, Emporium and EmQuartier, expanding to The Mall Lifestyle Stores in 2025, said Ploychompu Umphuj, vice-president of merchandising at Gourmet Market. The carts are equipped with digital touchscreens and barcode scanners that help customers find products and access promotions and pricing. Customers can make their payment directly through the Smart Cart Self-Check Out dedicated lane, without having to put products through the barcode scanner again. Furthermore, the company plans to renovate some of its existing stores to feature more restaurant space as it believes customers will have a high demand for eateries next year, said Mr Supawut. The eateries inside Gourmet Market will vary to suit the store's location, such as food courts, takeaways, or restaurants. Moreover, the company also plans to add more products with fresh ingredients, with the aim of increasing the proportion of fresh ingredients to 50%, from 20%. Gourmet Market has 17 stores located in Bangkok, Nonthaburi, Prachuap Khiri Khan and Nakhon Ratchasima. The company aims to add 1-2 branches each year, Mr Supawut said.SACRAMENTO, Calif. (AP) — Marquel Sutton scored 23 points as Omaha beat Sacramento State 70-60 on Saturday night. Sutton added eight rebounds for the Mavericks (4-7). Tony Osburn scored 15 points and added five rebounds and three steals. JJ White had nine points and went 4 of 5 from the field. Jacob Holt led the way for the Hornets (2-7) with 15 points, six rebounds and two blocks. Mike Wilson added nine points and six rebounds for Sacramento State. Chudi Dioramma had seven points, 10 rebounds and two blocks. Omaha's next game is Friday against Northern Iowa on the road, and Sacramento State hosts UC Davis on Saturday. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .
SAN DIEGO , Dec. 13, 2024 /PRNewswire/ -- Neurocrine Biosciences, Inc. (Nasdaq: NBIX) today announced the U.S. Food and Drug Administration has approved CRENESSITYTM (crinecerfont) capsules and oral solution as an adjunctive treatment to glucocorticoid replacement to control androgens in adult and pediatric patients four years of age and older with classic congenital adrenal hyperplasia (CAH), a rare, serious and lifelong genetic condition involving the adrenal glands. CRENESSITY, a potent and selective oral corticotropin-releasing factor type 1 receptor (CRF 1 ) antagonist, is the first and only classic CAH treatment that directly reduces excess adrenocorticotropic hormone (ACTH) and downstream adrenal androgen production, allowing for glucocorticoid dose reduction. It is a breakthrough in the treatment landscape for classic CAH. "For the last three decades, Neurocrine Biosciences, together with our late founder, Wylie W. Vale , has conducted groundbreaking research uncovering the critical role of corticotropin-releasing factor and its receptor, CRF 1 , in the pathophysiology of congenital adrenal hyperplasia," said Kyle W. Gano , Ph.D., Chief Executive Officer, Neurocrine Biosciences. "The approval of CRENESSITY is a significant milestone for the CAH community, and we are grateful to the individuals who participated in our clinical trials, including their families and caregivers, and to the clinical investigators who helped advance a new therapy and class of medicines." "Patients and families struggle to achieve balance between managing the symptoms of CAH and the side effects or complications of treatment with high-dose steroids, which may impact quality of life," said Dina Matos , Executive Director, CARES Foundation. "We are grateful to Neurocrine Biosciences for engaging with our community throughout the drug development process to understand our needs and ultimately providing this new medication that can help reduce excess adrenal androgens and the need for high-dose steroid treatment for individuals living with CAH." CRENESSITY is expected to be commercially available in approximately one week. The medication will be provided through PANTHERx Rare, a specialty pharmacy, to centralize and simplify CRENESSITY prescription fulfillment. Neurocrine Biosciences is committed to supporting patients in obtaining treatment with CRENESSITY by offering Neurocrine Access Support, a free, comprehensive assistance program created for patients, caregivers and healthcare providers. It offers a range of options to make sure patients have everything they need to begin and continue taking CRENESSITY. A dedicated Care Coordinator, backed by a team, is available to help patients and caregivers navigate the insurance process and identify appropriate financial assistance options. Most patients will pay $10 or less per month for CRENESSITY*. For more information, visit www.NBIaccess.com/crenessity or call 1-855-CRNSITY (276-7489) Monday-Friday 8 am-8 pm ET . *Additional terms and conditions apply. CAHtalyst TM Clinical Program Overview: The FDA approval is supported by the largest-ever clinical trial program of classic CAH, the CAHtalyst Pediatric and Adult Phase 3 global registrational studies. CAHtalyst Phase 3 data results in pediatric and adult patients with classic CAH were published in The New England Journal of Medicine . "The clinical results across both CAHtalyst studies support the efficacy and safety profile of CRENESSITY and its ability to reduce the overproduction of adrenal androgens, allowing for a meaningful reduction in glucocorticoid dosage, while maintaining or enhancing control of these androgens," said Richard Auchus , M.D., Ph.D., Professor, University of Michigan Health, Principal Investigator. "Chronic treatment with supraphysiologic glucocorticoids can cause a number of short- and long-term health consequences, such as obesity, hypertension and osteoporosis, so the ability for patients with CAH to lower their glucocorticoid dose to a more physiologic level can have profound benefits." In both CAHtalyst studies, CRENESSITY enabled lower steroid doses and decreased androgen levels. Phase 3 CAHtalyst Pediatric Study: Phase 3 CAHtalyst Adult Study: CRENESSITY was well tolerated with few treatment-related adverse events in both CAHtalyst studies. Pediatric and adult patients taking CRENESSITY had no treatment-related serious adverse events. Adrenal insufficiency and crisis are risks of living with CAH that CRENESSITY does not address and can occur when a patient's GC dose is too low. In the CAHtalyst Pediatric study, there were no cases of adrenal crisis among patients taking CRENESSITY or placebo. In the CAHtalyst Adult study, two patients (1.6%) taking CRENESSITY experienced adrenal crisis. No patients on placebo experienced adrenal crisis. However, one patient (1.7%) on placebo experienced adrenal insufficiency. Patients should work with their healthcare provider to manage GC dosing while taking CRENESSITY. For more information about CRENESSITY, visit Crenessity.com . About Congenital Adrenal Hyperplasia Congenital adrenal hyperplasia (CAH) is a rare genetic condition that results in an enzyme deficiency that alters the production of adrenal steroid hormones, such as cortisol, aldosterone and adrenal androgens, which are essential for life. Approximately 95% of CAH cases are caused by variants of the CYP21A2 gene that leads to deficiency of the enzyme 21-hydroxylase (21-OH). Severe deficiency of this enzyme leads to an inability of the adrenal glands to produce enough cortisol and, in approximately 75% of cases, aldosterone. Because individuals with CAH are still able to produce androgens, the unused precursors that would normally be used to make cortisol instead result in the production of excess amounts of androgens. If left untreated, CAH can result in salt wasting, dehydration and even death. Historically, exogenous glucocorticoids (GCs) have been used not only to correct the endogenous cortisol deficiency, but doses used are higher than cortisol replacement needed (supraphysiologic) to lower the levels of adrenocorticotropic hormone (ACTH) and adrenal androgens. However, GC treatment at high doses has been associated with serious and significant complications of steroid excess, including metabolic issues such as weight gain and diabetes, cardiovascular disease and osteoporosis. Additionally, long-term treatment with high-dose GCs may have psychological and cognitive impact, such as changes in mood and memory. Adrenal androgen excess has been associated with abnormal bone growth and development in pediatric patients, female health problems such as excess facial hair growth and menstrual irregularities, testicular rest tumors in males and fertility issues in both sexes. About The CAHtalystTM Studies The Phase 3 CAHtalystTM global registrational studies were designed to evaluate the safety, efficacy and tolerability of CRENESSITY in children and adults with classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. The CAHtalyst studies were the largest-ever clinical trial program in classic CAH, including 285 pediatric and adult patients. The CAHtalyst Pediatric study included 103 pediatric patients aged four to 17 years. The study tested two questions. The first question evaluated whether four weeks of CRENESSITY treatment could improve androgen control. The second question evaluated whether an additional 24 weeks of CRENESSITY treatment enabled customized glucocorticoid (GC) down-titration while androstenedione levels were maintained or improved. The CAHtalyst Adult study included 182 adult patients aged 18 to 58 years. Similarly, the first question of the study evaluated whether four weeks of CRENESSITY treatment could improve androgen control, and the second question evaluated whether an additional 20 weeks of CRENESSITY treatment enabled GC reduction to physiologic range while androstenedione levels were maintained or improved. Data from the CAHtalyst Phase 3 studies supported approval of CRENESSITY by the U.S. Food and Drug Administration in December 2024. The open-label extension treatment portions of both studies are ongoing. About CRENESSITYTM (crinecerfont) CRENESSITYTM is a potent and selective, oral corticotropin-releasing factor type 1 receptor (CRF 1 ) antagonist developed to reduce and control excess adrenocorticotropic hormone (ACTH) and adrenal androgens through a non-glucocorticoid (GC) mechanism for the treatment of classic congenital adrenal hyperplasia (CAH). Antagonism of CRF 1 receptors in the pituitary has been shown to decrease ACTH levels, which in turn decreases the production of adrenal androgens and potentially the symptoms associated with CAH. The robust clinical study data demonstrate that lowering adrenal androgen levels with CRENESSITY enables lower, more physiologic dosing of GCs to replace missing cortisol. CRENESSITY comes in capsules and an oral solution. The capsule formulation is available in 50 mg and 100 mg doses. The oral solution is available as a 50 mg/mL strength formulation. For adults 18 years and older, the recommended dosage is 100 mg twice daily taken orally with a meal. For pediatric patients four to 17 years of age weighing less than 55 kg (121 lbs), the recommended dosage is based on body weight and is administered twice daily, taken orally with a meal. For pediatric patients weighing more than 55 kg (121 lbs), the recommended dosage is 100 mg twice daily taken orally with a meal. Healthcare providers can work with patients to determine the appropriate formulation for use depending on patient needs. Patients receiving CRENESSITY should continue GC therapy for cortisol replacement. Important Information Approved Uses CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH). IMPORTANT SAFETY INFORMATION Do not take CRENESSITY if you: Are allergic to crinecerfont, or any of the ingredients in CRENESSITY. CRENESSITY may cause serious side effects, including : Allergic Reactions. Symptoms of an allergic reaction include tightness of the throat, trouble breathing or swallowing, swelling of the lips, tongue, or face, and rash. If you have an allergic reaction to CRENESSITY, get emergency medical help right away and stop taking CRENESSITY. Risk of Sudden Adrenal Insufficiency or Adrenal Crisis With Too Little Glucocorticoid (Steroid) Medicine. Sudden adrenal insufficiency or adrenal crisis can happen in people with congenital adrenal hyperplasia who are not taking enough glucocorticoid (steroid) medicine. You should continue taking your glucocorticoid (steroid) medicine during treatment with CRENESSITY. Certain conditions such as infection, severe injury, or shock may increase your risk for sudden adrenal insufficiency or adrenal crisis. Tell your healthcare provider if you get a severe injury, infection, illness, or have planned surgery during treatment. Your healthcare provider may need to change your dose of glucocorticoid (steroid) medicine. Before taking CRENESSITY, tell your healthcare provider about all of your medical conditions, including if you are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Tell your healthcare provider about all the medicines you take , including prescription and over-the counter medicines, vitamins, and herbal supplements. The most common side effects of CRENESSITY in adults include tiredness, headache, dizziness, joint pain, back pain, decreased appetite, and muscle pain. The most common side effects of CRENESSITY in children include headache, stomach pain, tiredness, nasal congestion, and nose bleeds. These are not all the possible side effects of CRENESSITY. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088. Dosage Forms and Strengths: CRENESSITY is available in 50 mg and 100 mg capsules and as an oral solution of 50 mg/mL. Please see full Prescribing Information About Neurocrine Biosciences, Inc. Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com , and follow the company on LinkedIn , X (formerly Twitter) and Facebook . (*in collaboration with AbbVie) The NEUROCRINE BIOSCIENCES Logo Lockup and YOU DESERVE BRAVE SCIENCE are registered trademarks of Neurocrine Biosciences, Inc. CRENESSITY and CAHtalyst are trademarks of Neurocrine Biosciences, Inc. Forward-Looking Statements In addition to historical facts, this press release contains forward-looking statements that involve a number of risks and uncertainties. These statements include, but are not limited to, statements regarding the potential benefits to be derived from CRENESSITY for the treatment of classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency; the value and benefits CRENESSITY brings to patients with CAH; the ability of Neurocrine Biosciences to ensure patients have access to CRENESSITY; and whether the results from our clinical trials of CRENESSITY are indicative of real-world results. Factors that could cause actual results to differ materially from those stated or implied in the forward-looking statements include, but are not limited to, the following: risks and uncertainties associated with Neurocrine Biosciences' business and finances in general, as well as risks and uncertainties associated with the commercialization of CRENESSITY; whether CRENESSITY receives adequate reimbursement from third-party payors; the degree and pace of market uptake of CRENESSITY; risks and uncertainties relating to competitive products and technological changes that may limit demand for CRENESSITY; risks associated with the Company's dependence on third parties for development and manufacturing activities related to CRENESSITY, and the ability of the Company to manage these third parties; risks that additional regulatory submissions for CRENESSITY or other product candidates may not occur or be submitted in a timely manner; risks that the FDA or other regulatory authorities may make adverse decisions regarding CRENESSITY; risks that post-approval CRENESSITY commitments or requirements may be delayed; risks that CRENESSITY may be precluded from commercialization by the proprietary or regulatory rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; risks and uncertainties relating to competitive products and technological changes that may limit demand for CRENESSITY; and other risks described in the Company's periodic reports filed with the Securities and Exchange Commission, including without limitation the Company's quarterly report on Form 10-Q for the quarter ended September 30, 2024 . Neurocrine Biosciences disclaims any obligation to update the statements contained in this press release after the date hereof other than required by law. © 2024 Neurocrine Biosciences, Inc. All Rights Reserved. CP-CFT-US-0070 12/2024 View original content to download multimedia: https://www.prnewswire.com/news-releases/neurocrine-biosciences-announces-fda-approval-of-crenessity-crinecerfont-a-first-in-class-treatment-for-children-and-adults-with-classic-congenital-adrenal-hyperplasia-302331772.html SOURCE Neurocrine Biosciences, Inc.None
President-elect Donald Trump joined the chorus of people raising concerns about mysterious drone sightings over New Jersey and other states on the East Coast, calling on government officials to shoot down the aircraft if they are truly unidentifiable. In a Friday post on his social media platform Truth Social , Trump indicated that he believes authorities know more about the drones than they are letting on. “Mystery Drone sightings all over the Country. Can this really be happening without our government’s knowledge. I don [sic] think so! Let the public know, and now. Otherwise, shot [sic] them down!!! DJT,” the president-elect wrote. Residents of Morris County, New Jersey, first started reporting nighttime sightings of the drones last month. Since then, the FBI and the Department of Homeland Security have investigated the objects and are looking into whether people are seeing actual drones, manned aircraft or something else. “We have no evidence at this time that the reported drone sightings pose a national security or public safety threat or have a foreign nexus,” the FBI and DHS said in a joint statement Thursday. “Upon review of available imagery, it appears that many of the reported sightings are actually manned aircraft, operating lawfully. There are no reported or confirmed drone sightings in any restricted air space.” Nevertheless, reports of drone sightings continued to proliferate on Friday, with even former Maryland Gov. Larry Hogan posting video of what he said were “dozens of large drones” flying over his home on Thursday night. Individuals in New York and Connecticut have also reported seeing the aircraft. Trump’s missive came after White House national security spokesperson John Kirby appeared on Fox News ’ “The Story” on Friday afternoon, where host Martha MacCallum pressed him about whether officials really do not have an explanation for the drone sightings. “I’m not going to lie to you or to the American people, and I’m not going to say we know something when we don’t,” Kirby said. “And we would never, ever stoop to think that an American citizen was crazy or nuts because of what they’re seeing and what they’re documenting. We’re taking that imagery seriously and we’re doing the best we can to analyze it, and we encourage people to come forward if they have additional sightings.” “Why not just take one down and figure out what’s going on?” MacCallum asked. “We don’t have enough conclusions to take that kind of a policy action,” Kirby replied. “But let’s just assume for a minute, Martha, that we did. You’re not going to want to shoot something down where it could hit somebody’s house, or hurt somebody.” Don't let this be the end of the free press. The free press is under attack — and America's future hangs in the balance. As other newsrooms bow to political pressure, HuffPost is not backing down. Would you help us keep our news free for all? We can't do it without you. Can't afford to contribute? Support HuffPost by creating a free account and log in while you read. You've supported HuffPost before, and we'll be honest — we could use your help again . We view our mission to provide free, fair news as critically important in this crucial moment, and we can't do it without you. Whether you give once or many more times, we appreciate your contribution to keeping our journalism free for all. You've supported HuffPost before, and we'll be honest — we could use your help again . We view our mission to provide free, fair news as critically important in this crucial moment, and we can't do it without you. Whether you give just one more time or sign up again to contribute regularly, we appreciate you playing a part in keeping our journalism free for all. Already contributed? Log in to hide these messages. She also asked what President Joe Biden has to say on the issue, and whether Elon Musk or other “outside experts” had been called in to give their opinions. Biden “has tasked the team to look into this and to be energetic in doing it, to try to get answers,” Kirby said. Related From Our PartnerLorain prosecutor seeks to exonerate four men convicted of 1991 murder of Marsha BlakelyA fire broke out Wednesday in the Tokyo apartment building where Liberal Democratic Party lawmaker Kuniko Inoguchi lives with her family, and two unidentified bodies have been found at the scene, police said, noting that her husband and one of their daughters remain unaccounted for. Four people were living in the 72-year-old House of Councillors member's residence and contact was made with Inoguchi and her other daughter, the metropolitan police said. Inoguchi's husband, Takashi, 80, is a professor emeritus of politics and international relations at the University of Tokyo. A report was made after 7 p.m. that a fire had started at the six-story apartment building in Bunkyo Ward of the Japanese capital. More than 30 firetrucks and other emergency vehicles were dispatched to the scene, located in an area lined with apartment buildings and houses, about 500 meters north of Tokyo Dome. The fire was subdued before 1 a.m. Thursday. Inoguchi was first elected to the House of Representatives in 2005 after being a professor at Sophia University. She served as minister in charge of addressing the declining birthrate and promoting gender equality. She has been a member of the House of Councillors since 2010 and is currently in her third term.
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INDIANAPOLIS (AP) — Trey Robinson's 19 points helped Northern Kentucky defeat IU Indianapolis 66-64 on Saturday. Robinson added six rebounds for the Norse (3-6, 1-0 Horizon League). Josh Dilling went 6 of 11 from the field (5 for 9 from 3-point range) to add 17 points. Sam Vinson had nine points and finished 4 of 13 from the field. The Jaguars (4-6, 1-1) were led by Paul Zilinskas, who recorded 24 points. Jarvis Walker added 23 points for IU Indianapolis. DeSean Goode finished with six points. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .Neurocrine Biosciences Announces FDA Approval of CRENESSITYTM (crinecerfont), a First-in-Class Treatment for Children and Adults With Classic Congenital Adrenal HyperplasiaSutton scores 23, Omaha knocks off Sacramento State 70-60
By DAVID BAUDER Time magazine gave Donald Trump something it has never done for a Person of the Year designee: a lengthy fact-check of claims he made in an accompanying interview. Related Articles National Politics | Trump’s lawyers rebuff DA’s idea for upholding his hush money conviction, calling it ‘absurd’ National Politics | Trump wants to turn the clock on daylight saving time National Politics | Ruling by a conservative Supreme Court could help blue states resist Trump policies National Politics | A nonprofit leader, a social worker: Here are the stories of the people on Biden’s clemency list National Politics | Nancy Pelosi hospitalized after she ‘sustained an injury’ on official trip to Luxembourg The fact-check accompanies a transcript of what the president-elect told the newsmagazine’s journalists. Described as a “12 minute read,” it calls into question 15 separate statements that Trump made. It was the second time Trump earned the Time accolade; he also won in 2016, the first year he was elected president. Time editors said it wasn’t a particularly hard choice over other finalists Kamala Harris, Elon Musk, Benjamin Netanyahu and Kate Middleton. Time said Friday that no other Person of the Year has been fact-checked in the near-century that the magazine has annually written about the figure that has had the greatest impact on the news. But it has done the same for past interviews with the likes of Joe Biden, Netanyahu and Trump. Such corrections have been a sticking point for Trump and his team in the past, most notably when ABC News did it during his only debate with Democrat Kamala Harris this fall. There was no immediate response to a request for comment on Friday. In the piece, Time called into question statements Trump made about border security, autism and the size of a crowd at one of his rallies. When the president-elect talked about the “massive” mandate he had received from voters, Time pointed out that former President Barack Obama won more electoral votes the two times he had run for president. The magazine also questioned Trump’s claim that he would do interviews with anyone who asked during the campaign, if he had the time. The candidate rejected a request to speak to CBS’ “60 Minutes,” the magazine said. “In the final months of his campaign, Trump prioritized interviews with podcasts over mainstream media,” reporters Simmone Shah and Leslie Dickstein wrote. David Bauder writes about media for the AP. Follow him at http://x.com/dbauder and https://bsky.app/profile/dbauder.bsky.social.
