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ATLANTA (AP) — The Atlanta Falcons are back in first place in the NFC South and again in control of their playoff hopes. Rookie quarterback Michael Penix Jr. showed the poise in his first NFL start the Falcons will need to take advantage of their opportunity to end a six-year playoff drought. Powered by a big-play defense that produced two pick-6s, a solid starting debut by Penix and two rushing touchdowns by Bijan Robinson, the Falcons cruised past the hapless New York Giants 34-7 on Sunday. On Sunday night, the Falcons (8-7) received the assist they needed when Tampa Bay lost at Dallas . Because the Falcons swept the Buccaneers, they hold the tiebreaker advantage if they remain tied atop the division. The Falcons have games remaining at Washington on Sunday night and at home against Carolina to close the regular season. If Atlanta wins both games, it would win the division and have a home playoff game. The Falcons are assured of their best record since a 10-6 finish under coach Dan Quinn in 2017, their most recent playoff season. Quinn is in his first season as Washington's coach and has led the Commanders (10-5) to three straight wins, including Sunday's 36-33 victory over Philadelphia. Penix, the No. 8 overall pick in this year's NFL draft, was promoted after coach Raheem Morris benched Kirk Cousins. Penix completed 18 of 27 passes for 202 yards with one interception on a pass that should have been caught by tight end Kyle Pitts. Penix is not a dual-threat quarterback, but he showed the ability to escape pressure in the pocket that Cousins lacks following his 2023 Achilles tendon injury. The left-hander's superior arm strength also was immediately obvious. Robinson's production provided a safety net for the offense which helped make for a smooth transition to Penix. Robinson had scoring runs of 2 and 4 yards. Robinson has rushed for 10 touchdowns this season. He's the first Atlanta player with 10 more more rushing touchdowns since Devonta Freeman during the 2016 Super Bowl season. Robinson ran for 94 yards on 22 carries and had 103 yards from scrimmage. His 11th game this season with at least 100 yards from scrimmage are the most for the Falcons since Warrick Dunn's 11 in 2005. Morris said Robinson deserves to be considered with Philadelphia's Saquon Barkley in discussions regarding the league's top running backs. “Bijan has been outstanding all year in the things that he’s able to do," Morris said. “He’s special. If it wasn’t for this other guy out in Philly, he’d get a lot more recognition across the league. But that guy is having a special year, and Bijan’s not far behind him.” With kicker Younghoe Koo on injured reserve and watching from the sideline, Riley Patterson was wide left on his first field-goal attempt from 43 yards. Patterson rebounded to make attempts from 52 and 37 yards. Jessie Bates III and Matthew Judon each had a pick-6 to highlight a day of big plays for the defense. Arnold Ebiketie had his fifth sack of the season and added a fumble recovery. Kaden Ellis added a strip-sack. He also has five sacks this season, including sacks in four consecutive games. It is the longest streak for Atlanta since Patrick Kerney had sacks in five straight games in 2001. There was some thought that a change at quarterback could be good news for Pitts, who often seemed to be missing in action with Cousins running the offense. After all, a tight end often is a natural target for quick passes from a rookie making his first start. Instead, Pitts had a poor start to the Penix era when he bobbled his first pass from the left-hander, creating an interception by cornerback Cor’Dale Flott. Pitts caught a 7-yard pass on his only other target. For the season, Pitts has 41 catches for 543 yards and three touchdowns. There will be much interest in this week's injury report after WR Drake London (hamstring) was hurt in the second half. Morris provided an optimistic postgame outlook on London. CB Antonio Hamilton (quad) did not return after leaving the game in the first half. 8: Bates has four interceptions and four forced fumbles. His combined eight forced turnovers lead the NFL. The game against Jayden Daniels and the Commanders is a reminder Penix was only the fourth of six quarterbacks selected in the first round of the NFL draft. Daniels, from LSU, was the No. 2 overall pick behind Caleb Williams by Chicago. AP NFL: https://apnews.com/hub/nfl

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Tulsi Gabbard, Trump's pick for intel chief, faces questions on Capitol Hill amid Syria falloutThe railway community in Sri Lanka and all national-minded islanders commemorate 27 December as the day on which the inaugural Ceylon Government Railway (CGR) train ran between Colombo Fort and Ambepussa (34 miles on the main line) in 1864. One day prior to it, the same folks remember with pain and anguish the devastating effect of the 2004 tsunami which destroyed a 1,500 passenger train at Peraliya on 26 December, taking over 1,000 lives in an island-wide cataclysm that resulted in 30,000 deaths. But Sri Lanka Railways endeavoured to restore the stricken locomotive – a Class M2a EMD-G12 (‘Manitoba’), imported under the Colombo Plan in 1956 – and a few years later, it makes a regular run on ‘D-Day’ every year, heading the now-iconic Train No. 8051 (‘51). And in a trifecta of rail happenings, this December’s media has been rife with reports of how the Government of Sri Lanka is in talks with its counterparts in Japan to get back on track the much vaunted Light Rail Transit (LRT) project that was arbitrarily derailed by the Gotabaya Rajapaksa administration in 2021. Then Sri Lanka’s so-called “LRT fiasco” and the international fallout from a former regime’s ad-hoc policy decision is much in the news these days... for the right reasons, for a change. So much so that the case study of an arbitrary cancellation of the Japan-funded Light Rail Transit project in the context of international relations in an emerging geopolitical milieu may make interesting reading for all of SLR’s swains and stakeholders in good governance being restored. Ergo, this two-part piece on Sri Lanka’s ill-fated LRT project, on which fortune and the Government of Japan seem to be smiling again. [CONTINUED FROM A PREVIOUS ISSUE] Two further items in the same news report also signal salutary indications for Sri Lanka in general and the LRT project in particular. First, as regards the partnership of Japan, which was the original donor nation associated with the LRT project, and its ongoing support: “The President also conveyed appreciation for continued support provided by the Government of Japan and JICA.” (Colombo Gazette) Second, as regards the all-important factor of funding on the same or similar concessionary basis as below for the resumption and completion of at least the first planned phase of the pilot project of the LRT involving Line 1 and Line 4 in the road map: “Dr Tanaka Akihiko, the President of Japan International Cooperation Agency, called on President Wickremesinghe in Colombo. ... Dr. Akihiko elaborated on JICA’s efforts, highlighting the priority of concluding debt restructuring while also aiming for the resumption of stalled projects” (emphasis added). The sustainable role played by JICA is much in evidence in the Japanese agency’s rationalisation of the LRT project in its analyses and assessments of the scope of the work. JICA has long since affirmed on its website that “the project falls into the railways sector under the JICA guidelines for environmental and social considerations” per its mandate as of long ago as April 2010 (Japan International Cooperation Agency, ‘Project for Establishment of New Light Rail Transit System in Colombo’). JICA in its project outline affirms and undergirds the value of the LRT’s contribution to Sri Lanka’s national developmental agenda: “The objectives of the project are to alleviate traffic congestion, provide better connectivity and mitigate air pollution in the Western Region by constructing [a] mass rapid transit system, thereby contributing to the economic and social development of the Western Region and improvement of [the] urban environment” (JICA). And the same portal, by dint of its publication of ‘past’ and ‘latest’ monitoring reports spanning May, September and December 2019, not only indicates its commitment to the project but the ongoing interest shown and acted upon by JICA until the abrupt unilateral termination of the project by the Government of Sri Lanka under the then President Gotabaya Rajapaksa in September 2021. The ramifications of such an arbitrary action, although ostensibly taken at the behest of a single individual at the uppermost echelon of executive power, had consequences that affected not only personal relationships but also impacted on Sri Lanka at the sovereign state level. As an Echelon Media Company report commented editorially: “Sri Lanka is in the process to mend severed ties with Japan after the island nation unilaterally cancelled a 1.5 billion US Dollar Light Rail Transit (LRT) and East Container Terminal (ECT) projects as the crisis-hit South Asian nation is seeking international help to come out of its economic down turn amid a political crisis. Higher government officials and ruling Sri Lanka Podujana Peramuna (SLPP) members have told Economy Next that most foreign countries were unwilling to help Sri Lanka unlike in the past because of some harsh ‘undiplomatic’ experiences. A former SLPP cabinet minister has said some countries have indirectly told the government that they would not help until [what was meant is ‘as long as’] President Mahinda Rajapaksa and his family members are in power” (EconomyNext, ‘Crisis-hit Sri Lanka in process to mend Japanese ties after cancelling LRT, ECT projects’, 16 June 2022). The cancellation of the LRT project in particular hamstrung Sri Lanka’s longstanding relationship with Japan, according to the then Deputy Foreign Minister Prof. G.L. Pieris, who affirmed that “the relationship with Japan is vital for Sri Lanka” (Economy Next), who also noted that the Japanese contribution to the island nation spanned decades – ever since the South Asian nation stood up for the defeated World War II country at the San Francisco Conference in 1945, after the conclusion of hostilities – and included substantial aid, loans, technological assistance and support for numerous projects spanning the gamut from the Sri Lanka Rupavahini Corporation (SLRC) and the Sri Jayewardenepura Hospital (SJH) to sundry helps in terms of skills development, computer technology, construction industry initiatives, and medical and pharmaceutical items, in a milieu where Japan was allied to the US’ post-Cold War interests. In addition, the souring of relations between the two sovereign nations, which were celebrating their 70th anniversary of diplomatic relations at the time (2022), would come with attendant opportunity costs as “Sri Lanka wished to expand cooperation with Japan in the areas of digitalisation, carbon credit, and ocean-related activities including coast conservation, fisheries and global warming”, according to the Deputy Foreign Minister, who added: “Reference was also made to exploring cooperation in areas coming under the purview of the World Trade Organization.” Unsaid was the steps away from Chinese debt-trap diplomacy these would take, where previously the People’s Republic had wrested control of Hambantota Port from Sri Lanka. These costs and opportunity costs could be construed as not only a severe setback for international relations between the two previously harmoniously allied nation states but also an impediment to aid for Sri Lanka as “Japan has been the top lender for Sri Lanka under its concessionary funding and has poured billions of yens (sic) into Sri Lanka’s main Colombo port and many other infrastructure projects”, in addition to the fact that “Japan played a key role when Sri Lanka faced an economic collapse in 2001.” Further underlining the severity of the impact that the LRT project cancellation had was the recollection in 2022 that in 2003, Japan “helped to host a donor forum for Sri Lanka and raise 4.5 billion US Dollars ... to rebuild war ravaged infrastructure during a ceasefire agreement in the island nation’s civil war.” In December 2022, after the abovementioned developments took place between Japan and Sri Lanka on the sidelines of the UN Human Rights Council (UNHRC) meeting, the island’s new head of state President Ranil Wickremesinghe announced that his government was intent on mending fences with the East Asian giant that had been supportive of Sri Lanka over the decades, with a special emphasis on trying to get the abandoned LRT project back on the track (Wikipedia, ‘Western Region Megapolis Light Rail Transit’). “However ... and even a few months later, the Japanese Ambassador to Sri Lanka at the time (March 2023) told a forum in Colombo that “a decision has not been made as yet about the revival of the Japan International Cooperation Agency (JICA)-funded Light Rail Transit (LRT) project stretching from Colombo Fort to Malabe”, as quoted in a media report (NewsWire, ‘Japan yet to consider revival of Light Rail project’, 30 March 2023). The Japanese official intimated that “the decision about the project depends on the reforms of the Sri Lankan government, and if Sri Lanka can regain the trust of the Japanese government and business community”...”the revival of the project will be considered when those conditions are met.” In a post-Cold War milieu where until recently at least Russia was marginalised in an increasingly multi-polar world, the emergence of China as a contender against US economic hegemony was to some extent counterbalanced by the role played by American ally Japan in Asian region development. As a news report on the cancelled LRT project observed: “Sri Lanka, which lies along key shipping routes in the Indian Ocean, has become a hotspot for influence between India and Japan on the one side and China on the other” (Reuters, ‘Sri Lanka suspends Japanese-funded rail project over costs’, 24 September 2020). With Japan out of the equation for the LRT project, there was growing concern that China might step in once again. The poor governance ethos of arbitrary policy making and summary decision taking was thereafter to be compounded by other issues of governance such as covering up mistakes made. The project that was due to commence with land acquisition in 2020 and be concluded in 2024 with an LRT that would have trains running along an elevated track at four-minute intervals during rush hour and 10-minute intervals at off-peak times ended in ignominy for the Sri Lankan Government when the project was arbitrarily terminated by the Gotabaya Rajapaksa administration citing the ongoing economic crisis at the time (Janaka Ratnasiri, ‘Cancellation of Light Rail Project: Some alternatives to reduce congestion’, 7 October 2020) – but that was not to be all. The Government of Sri Lanka later claimed that the LRT project was not terminated per se but only temporarily halted (Wikipedia, ‘Western Region Megapolis Light Rail Transit’). Three months after President Gotabaya Rajapaksa terminated the project unilaterally in a letter issued through the Secretary to the President as written proof of cancellation, a government minister claimed that “the Light Rail Transit (LRT) system funded by Japan has not been cancelled, but is under review” (NewsWire, ‘LRT project not cancelled, but under review – Minister’, 17 February 2021); with that government official, the State Minister of Urban Development among other ministries asserting: “The construction of a 15.8 km LRT track between the Colombo Fort area and Malabe is under review.” The minister in question had attempted in his statement to the media to explain the perceived cancellation in terms of the suspension of one of the four lanes (at US$ 2 billion compared to 400 million US dollars) of the two-line project, citing a cost discrepancy on which grounds it was allegedly temporarily suspended. Also claiming that the project was still up and running, the Secretary to the Ministry of Transport had previously, as much as a year after the cancellation (that is in September 2022), stated that since Cabinet had approved the project, it required termination by the Cabinet, and that a letter issued by the Secretary to the President was insufficient grounds to terminate the project (The Morning, ‘Colombo Light Rail Transit project still alive’, 27 September 2020). This attempt at political spin cast further shadows over poor governance and deepened the dark cloud over the goodwill between Sri Lanka and one of its longest-standing allies and international developmental partners in a multi-polar world – one where post-Cold War realities had brought China as a rival to Russia in the conflict with the superpower US. The proposed LRT project, formerly known as the Colombo Light Railway (Wikipedia, ‘Western Region Megapolis Light Rail Transit’), was an integral part of the Western Region Megapolis plan, and was “developed encompassing all aspects of transportation to provide a framework for urban transport development in the Western Region up to 2035” (Ministry of Megapolis and Western Development, ‘Western Region Megapolis Transport Master Plan: Final Report’, November 2016) and was therefore a visionary, timely and strategically outlined project. Its “development plan priorities” [were] “prepared based on the urgency of the [need] to resolve the critical urban transport problems” (Ministry of Megapolis and Western Development, ‘Western Region Megapolis Transport Master Plan: Final Report’, November 2016); and as a project of not only local, capital or regional but also national importance, because of the international cooperation dimension involving sovereign states and bilateral donor relations in a geopolitical milieu, it was “based on a logical sequence of implementation in order to maximize the outcomes in achieving the urban mobility objectives”. But in what was widely perceived as an arbitrary move and even a blasé exercise of authoritarian power, the then incumbent President Gotabaya Rajapaksa ordered the Ministry of Transport to “terminate this project and close the project office with immediate effect” (AFP, ‘Sri Lanka scraps $1.5bn Japan funded light rail system’, 24 September 2020), bringing to an abrupt halt the project that “commenced during the presidency of Maithripala Sirisena, in 2017, and was regarded as the largest single foreign-funded infrastructure project in Sri Lanka”. It was a terminal move that received Cabinet approval for cancellation on 29 September 2020, on the grounds that it would cause “huge environmental damage” (Janaka Ratnasiri, ‘Cancellation of Light Rail Project: Some alternatives to reduce congestion’, 7 October 2020, The Island Online) and come at “a very high cost”, although “Cabinet approval had been granted previously, both on environmental and financial grounds”. And yet, it was the decision to unilaterally terminate the project – and not the implementation of the project itself – that came at a very high set of costs. Firstly, financial: as “a Japan-based firm involved in a scrapped light rail transit project had claimed 5,896 billion rupees from Sri Lanka” (EconomyNext, ‘Japan firm claims damages of Rs.5.8bn from Sri Lanka after LRT deal scrapped’, 18 June 2021) as a result of termination of the US$130 million dollar contract with that consultancy, according to a revelation by the country’s Auditor-General. Secondly, fiscal: the suspension of a Japanese Government 30 billion yen concessionary loan signed with Sri Lanka in March 2020. Thirdly, reputational: the souring of relations between Sri Lanka and its long-time supporter, the nation, government and people of Japan. Fourthly, political: the fallout from this policy imbroglio as well as other political fiascoes such as a short-sighted chemical fertiliser ban and myopic monetary policies saw the regime of Gotabaya Rajapaksa coming to an ignominious end in July 2022 through the exercise of popular sovereignty vested in the people instrumentalising a citizens’ movement. Fifthly, social: the ongoing predicament of millions of commuters who continue to literally take their lives in their hands on inadequate and outdated railway infrastructure that is subject to delays, derailments and railroad union strikes. Finally (last not least), geopolitical: naïve governmental approaches to honouring international agreements and blasé cancellation of the deal between sovereign states that had partnered in development, which could precariously affect the balance of a post-Cold War regional order. In an emerging, complex and potentially threatening geopolitical milieu, the greatest fallout from the LRT fiasco was – over and above sovereign state-level displeasure – a realignment of allies, whereby Sri Lanka, ostensibly abandoned and at Japan’s displeasure, could slide towards China. A vision to develop Sri Lanka’s railway infrastructure is the need of the hour even now, over four years after the island nation arbitrarily terminated a project that would meet its creaking infrastructural needs at concessionary terms from a friendly nation’s government. It must be a vision that is ably backed up by the precise planning and meticulous attention to detail that the aborted LRT system that was funded by JICA and the Government of Japan displayed. But it would serve the national interest better if the type of bureaucratic bungling that was brought on by a regime change could be pre-empted, perhaps by the simple expedient of a parliamentary act to prevent successive governments from undoing the good work attempted by their administrative predecessors. This is by no means an easy task in a parliament where remnants of regimes can hold the executive arm of government to ransom or take the people’s will hostage because of bitter political rivalries that trump the national interest. It will take not only a regime change but a paradigm shift in the Standard Operating Procedure of ensuing Sri Lankan governments to enable the emergence of such a set of principles whereby the sovereign commitments of the state do not get derailed by the whims and fancies of authoritarian chief executives or any arbitrary bureaucratic decisions. There needs to be a radical redrafting of the social contract for this to eventuate whereby there is a better check and balance between the executive and the legislature, as well as between the government and state bureaucracy, and the people’s will versus wilful presidents. Such a reality will not eventuate without the awareness of the general populace about the international-level costs to the national interest. So especially in a global milieu where the old world order of bipolarity has changed so drastically that in an increasingly multi-polar world, even the (albeit arbitrary) cancellation of a developmental project can cause a regional geopolitical shift by driving a strategically important small country such as Sri Lanka away from US allies to China. It is in the context of all of the above that the mutual interest of and initiative shown by the governments of Japan and Sri Lanka to get the long-abandoned LRT project back on the track is to be welcomed and wholeheartedly endorsed by the public – especially commuters but also all stakeholders in growth, development, progress under a renascent good governance.

Published 5:40 pm Thursday, December 26, 2024 By Data Skrive The New Orleans Pelicans’ (5-26) injury report has four players listed as they ready for their Friday, December 27 matchup with the Memphis Grizzlies (21-10, also four injured players) at Smoothie King Center, with a start time of 8:00 PM ET. Watch the NBA, other live sports and more on Fubo. What is Fubo? Fubo is a streaming service that gives you access to your favorite live sports and shows on demand. Use our link to sign up. Their last time out, the Grizzlies won on Thursday 155-126 over the Raptors. In the victory, Zach Edey paced the Grizzlies with 21 points. The Pelicans are coming off of a 128-111 loss to the Rockets in their last outing on Thursday. Trey Murphy III scored 21 points in the Pelicans’ loss, leading the team. Sign up for NBA League Pass to get live and on-demand access to NBA games. Get tickets for any NBA game this season at StubHub. Catch NBA action all season long on Fubo. Bet on this or any NBA matchup at BetMGM. Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER .WW3 countdown begins in 2025 with Putin landgrab forcing war, claims expertJarrod Bowen held Antonio’s number nine shirt aloft after scoring the winner in support of the Hammers striker, who is recovering after a horror car crash on Saturday. Boss Julen Lopetegui said: “He is not in his best moment but he kept his humour. It was a special moment for us. “I think we have a lot of reason to win matches but this was one reason more. He’s alive so we are happy.” MA9 ❤️ pic.twitter.com/fXwtdSQWYE — West Ham United (@WestHam) December 9, 2024 West Ham players wore ‘Antonio 9′ shirts while warming up and walking out before kick-off. The shirts will be signed by the players, including Antonio, and auctioned off with the proceeds going to the NHS and Air Ambulances UK. Tomas Soucek headed West Ham into the lead and held up nine fingers to a TV camera. The Czech midfielder told Sky Sports: “He’s been here since I came here. He is really my favourite. I said it would be tough for me to play without him. "He was here since I came and he's really my favourite" Tomáš Souček on dedicating his goal to Michail Antonio ❤️ pic.twitter.com/smNy26wmuX — Sky Sports Premier League (@SkySportsPL) December 9, 2024 “I was so scared what was going to happen. It was a really tough week for him, his family and us.” Matt Doherty equalised for Wolves, and boss Gary O’Neil felt they should have had two penalties for fouls on Goncalo Guedes and Jean-Ricner Bellegarde, both of which were checked by VAR. But Bowen’s winner – O’Neil believed there was a foul in the build-up – condemned Wolves to a 10th defeat of the season and a third in a row. While under-pressure Lopetegui may have earned a stay of execution, O’Neil’s future as Wolves manager is now in serious doubt. “A lot of things went against us but ultimately we have not found a way to turn the game in our favour,” he said. “But the players showed they are still fighting for me, for the fans and the group. “Where does this leave me? In the same place I was. I’m aware of the noise. But if anyone expected this to be easy – I’m happy to be judged on results but it should be done in context. “Whenever this journey ends with Wolves I’ll be proud of it.” There was an acrimonious end to the match as captains Bowen and Mario Lemina scuffled after the final whistle, with the Wolves midfielder angrily shoving people including one of his own coaches, Shaun Derry. “I just went to shake his hand after the game,” Bowen said. “He didn’t want to shake my hand, two captains together just to say ‘well done’ after the game. “I know it’s difficult when you lose. I’ve been on the end of that situation.” O’Neil added: “Mario is calm now. He’s a passionate guy and something was said that upset him. “The instinct of the staff was to make sure he didn’t get into trouble, but he took some calming down.”

California to consider requiring mental health warnings on social media sitesNoneRett syndrome is a rare and complex neurodevelopmental disorder that affects approximately 6,000 to 9,000 patients in the U.S.1,2 It typically presents in children ages 6 to 18 months, with symptoms such as stereotypic hand movements, like wringing and clapping, and loss of acquired speech and motor skills.3,4 Diagnosis can take two to four years after symptoms first appear, with many cases confirmed around age 3.5 Most individuals with Rett syndrome live into adulthood, requiring continuous care, often provided by family members.2,6,7 This responsibility can be emotionally, physically and financially challenging for parents.7 “Rett syndrome presents an array of debilitating and often unpredictable features over the course of a patient’s life,” said Alan Percy, M.D., professor of pediatrics, neurology, neurobiology, genetics and psychology at the University of Alabama at Birmingham. “Patients with Rett syndrome and their families may face many challenges as this disorder becomes part of their daily routine. While no cure is available, a combination of supportive therapies and treatment with DAYBUETM (trofinetide), the first and only FDA-approved drug for Rett syndrome in adults and pediatric patients 2 years of age and older, can lead to meaningful improvements for patients, offering hope to families.” The following stories, shared by parents reflecting on their children’s experience with DAYBUE and other supportive therapies, highlight these families’ resilience and optimism. The families featured are paid Acadia consultants and were compensated for sharing their stories. Ellie’s Story Ellie is a 15-year-old girl from a family of four. Her mother, Heidi; father, Rob; and younger brother, Rhys, all adore her, and those who know her can’t help but feel the same. “Ellie’s kind of shy when you first meet her, and it can take some time to warm up, but when she does connect with you, you’re hooked,” Heidi said. The family spends lots of time together, taking ski trips up the Colorado mountains. Although Ellie’s parents started her on speech and yoga therapy at age 2 to address her developmental symptoms, she wasn’t diagnosed with Rett syndrome until she was 7 years old. Ellie displayed some of the common symptoms seen in children with Rett. She couldn’t communicate. Repetitive hand movements prevented her from grasping objects. She would have off days, acting out in emotional outbursts. Since her diagnosis, Ellie’s treatment has expanded to physical, speech, occupational and swim therapy. Ellie also started taking the medication DAYBUE. With therapy and medication, Heidi has seen an impactful difference in Ellie’s symptoms as she watches her daughter’s personality and unique interests shine through. According to Heidi, some of the changes “come in these small, beautiful moments we wouldn’t always pay attention to.” On one family trip, Ellie exclaimed, “Fun!” after a day of adaptive skiing. “It was a big deal!” Heidi said of that moment. This may seem like a small victory, but to Ellie’s family, it’s a big and hopeful leap forward. “Ellie is just like any other teen,” said Heidi. “She loves music, especially boy bands, and gives a great teenage eye roll.” Olivia’s Story Olivia is a bubbly 5-year-old who loves to smile. From an active family of four, Olivia is partial to the outdoors, particularly the backyard swimming pool, her happy place. Besides the pool, Olivia loves going to school. “Some days when she gets off the bus, she cries because she knows her day is over,” said her father, Jeff. Olivia also loves playing with other children. Her favorite playmate is her older brother. “Nick plays with her and shows her things,” Jeff said. “He likes having her as an audience.” Olivia was a talkative child. Then, at around 15 to 18 months old, she stopped speaking. “She was saying lots of words — simple words that kids start off with. Then those words suddenly went away,” Jeff said. She had low muscle tone and stopped climbing on furniture. She had difficulty grasping objects. Olivia’s mother, Peggy, studied early childhood development and saw these as red flags. Peggy and Jeff expressed their concerns to a pediatrician, who ordered an MRI. The results were normal. Still, the pediatrician thought it best to enroll Olivia in early-development classes, including physical, speech and occupational therapy. The results were promising. Olivia started walking. She was vocal and used sounds to convey her needs. In December 2021, about a year and a half later, Olivia was sent to the emergency room for heavy breathing. After assessing Olivia’s developmental history, the doctor ordered a genetic test. At 21⁄2 years old, Olivia was diagnosed with Rett syndrome. Jeff and his wife began educating themselves about the condition, consulting advocacy groups and continuing with Olivia’s speech, occupational and physical therapy. In July 2023, a neurologist prescribed DAYBUE, which she takes in combination with her supportive therapies. The family has seen noticeable differences in Olivia. “Since we started Olivia on this combined treatment plan, we’ve seen it’s really helped to manage her symptoms,” Jeff said. “Olivia loves being social and engaged in the world around her. It means everything to us that we continue to find ways for her to participate in our family activities and also support her to pursue her interests, despite her Rett syndrome symptoms.” These victories, no matter how small, bring great hope to Olivia’s family. Ellie and Olivia did experience some side effects when taking DAYBUE. See below for Important Safety Information related to diarrhea, vomiting, weight loss and other possible side effects of DAYBUE. Ellie’s and Olivia’s stories bring hope to families caring for children with Rett syndrome. The experiences of Ellie, Olivia and their families may not be the same as yours. Because everyone with Rett syndrome is unique — with a unique set of symptoms — the response to DAYBUE may be different for each individual. To learn more, visit DAYBUE.com/caregiver-stories . All photos provided by Acadia. About DAYBUE What is DAYBUE? DAYBUE is a prescription medicine used to treat Rett syndrome in adults and children 2 years of age and older. It is not known if DAYBUE is safe and effective in children under 2 years of age. DAYBUE Important Safety Information What are the possible side effects of DAYBUE? Diarrhea : Diarrhea is a common side effect of DAYBUE that can sometimes be severe. Diarrhea may cause you to lose too much water from your body (dehydration). Before starting treatment with DAYBUE, stop taking laxatives. Tell your healthcare provider if you have diarrhea while taking DAYBUE. Your healthcare provider may ask you to increase the amount you drink or take antidiarrheal medicine as needed. Vomiting: Vomiting is a common side effect of DAYBUE. Sometimes vomit can get into your lungs (aspiration), which could cause an infection (aspiration pneumonia). Tell your healthcare provider if you have severe vomiting or if vomiting happens often. Weight loss : DAYBUE can cause weight loss. Tell your healthcare provider if you notice you are losing weight at any time during treatment with DAYBUE. The most common side effects of DAYBUE were diarrhea and vomiting. Other side effects include fever, seizure, anxiety, decreased appetite, tiredness, and the common cold. These are not all the possible side effects of DAYBUE. Tell your healthcare provider if you have any side effects that bother you or do not go away. What should I tell my healthcare provider before taking DAYBUE? Before taking DAYBUE, tell your healthcare provider about all of your medical conditions, including if you: have kidney problems. are pregnant or plan to become pregnant. It is not known if DAYBUE will harm your unborn baby. are breastfeeding or plan to breastfeed. It is not known if DAYBUE passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while taking DAYBUE. Tell your healthcare provider about all of the medicines you take , including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking DAYBUE with certain medicines may affect how the other medicines work and can cause serious side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088 . You can also call Acadia Pharmaceuticals Inc. at 1-844-4ACADIA (1-844-422-2342). DAYBUE is available as an oral solution (200mg/mL). The risk information provided here is not comprehensive. To learn more, talk with your healthcare provider and read the full Prescribing Information , including Patient Information, also available at DAYBUE.com . *** 1. Acadia Pharmaceuticals Inc. Data on file. RTT US Prevalence. March 2022. 2. Fu C, Armstrong D, Marsh E, et al. Consensus guidelines on managing Rett syndrome across the lifespan. BMJ Paediatrics Open. 2020; 4: 1-14. 3. Kyle SM, Vashi N, Justice MJ. Rett syndrome: a neurological disorder with metabolic components. Open Biol. 2018; 8:170216. 4. Neul JL, Kaufmann WE, Glaze DG, et al. Rett syndrome: revised diagnostic criteria and nomenclature. Ann Neurol . 2010;68(6):944-950. 5. Tarquinio DC, Hou W, Neul JL, et al. Age of diagnosis in Rett syndrome: patterns of recognition among diagnosticians and risk factors for late diagnosis. Pediatric Neurology . 2015; 52: 585-591. 6. Daniel C, Tarquinio DO, Hou W, et al. The changing face of survival in Rett syndrome and MECP2-related disorders. Pediatr Neurol . 2015; 53(5): 402-411. 7. Palacios-Cena D, Famoso-Perez P, Salom-Moreno J, et al. “Living an obstacle course”: a qualitative study examining the experiences of caregivers of children with Rett syndrome. In. J. Environ. Res. Public Health . 2018; 16 (41): 1-10. DAY-US-0331 11/24 Related