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The Gunners delivered the statement Champions League victory their manager had demanded to bounce back from a narrow defeat at Inter Milan last time out. Goals from Gabriel Martinelli, Kai Havertz, Gabriel Magalhaes, Bukayo Saka and Leandro Trossard got their continental campaign back on track, lifting them to seventh place with 10 points in the new-look 36-team table. It was Arsenal’s biggest away win in the Champions League since beating Inter by the same scoreline in 2003. “For sure, especially against opposition we played at their home who have not lost a game in 18 months – they have been in top form here – so to play with the level, the determination, the purpose and the fluidity we showed today, I am very pleased,” said Arteta. “The team played with so much courage, because they are so good. When I’m watching them live they are so good! They were all exceptional today. It was a big performance, a big win and we are really happy. “The performance was there a few times when we have played big teams. That’s the level that we have to be able to cope and you have to make it happen, and that creates belief.” A memorable victory also ended Sporting’s unbeaten start to the season, a streak of 17 wins and one draw, the vast majority of which prompted Manchester United to prise away head coach Ruben Amorim. The Gunners took the lead after only seven minutes when Martinelli tucked in Jurrien Timber’s cross, and Saka teed up Havertz for a tap-in to double the advantage. Arsenal added a third on the stroke of half-time, Gabriel charging in to head Declan Rice’s corner into the back of the net. To rub salt in the wound, the Brazilian defender mimicked Viktor Gyokeres’ hands-over-his-face goal celebration. That may have wound Sporting up as they came out after the interval meaning business, and they pulled one back after David Raya tipped Hidemasa Morita’s shot behind, with Goncalo Inacio netting at the near post from the corner. But when Martin Odegaard’s darting run into the area was halted by Ousmane Diomande’s foul, Saka tucked away the penalty. Substitute Trossard added the fifth with eight minutes remaining, heading in the rebound after Mikel Merino’s shot was saved. A miserable night for prolific Sporting striker Gyokeres was summed up when his late shot crashed back off the post.
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Prime Minister Paetongtarn Shinawatra will hold her first mobile cabinet meeting in Chiang Mai under the theme "From Flood To Flourish", to rehabilitate Chiang Mai following major floods. A budget of 256 million baht has been earmarked for the restoration project, with the Chiang Mai business community putting forth rehab proposals. Government spokesman Jirayu Houngsub said on Tuesday that Ms Paetongtarn is preparing to visit Chiang Mai and Chiang Rai, two provinces ravaged by recent floods. There, she will lead official inspection trips and chair her first mobile cabinet meeting since assuming the premiership, from Nov 28-Dec 1. Ms Paetongtarn's visit to the upper North will focus on pressing issues, including monitoring the problems of haze and forest fire smoke, as well as PM2.5 fine dust pollution, which is commonplace during the cool season in the North. The meeting agenda will also touch on drug trafficking along the border. Also high on the agenda will be tourism promotion in the aftermath of the floods. The sector suffered a setback during the floods, and visitor confidence must be restored, which will help stimulate the local economy. The mobile cabinet meeting is set to take place in Chiang Mai on Nov 29. One of the rehab proposals is to repair and improve basic infrastructure through 18 projects, including road repairs and the re-landscaping of areas hard-hit by the floods. Also to be fixed are sluice gates that regulate the flow of water and embankment structure protection developments. Also afoot are five tourism restoration projects, such as turning Chiang Mai into a world heritage city and other tourism promotion activities. Lastly, relief measures have been proposed to assist flood victims, including extending deadlines for payments of corporate tax and r educing tax rates imposed on billboard signs, land and building taxes; suspending debt and interest repayments, waiving fees for licences and import duties on machinery parts and components; waiving electricity and tap water fees for affected businesses; and social security measures. Deputy Prime Minister Phumtham Wechayachai, in his capacity as director of the disaster operations centre, said a working group has already planned a long-term solution to solve flooding and landslides in the North.Lions vs. Bears, Buccaneers vs. Cowboys predictions: NFL Week 16 odds, picks
Ian Jackson scores career-high 26, UNC beats Campbell 97-81KYIV, (Ukraine): Ukraine on Thursday accused Russia of having deployed a ballistic missile designed to carry nuclear warheads for the first time in history which, if confirmed, would be a major escalation of the war. Ukrainian allies have yet to confirm initial assessments from Kyiv’s military that Russia had launched an intercontinental ballistic missile (ICBM). The Kremlin has not denied it used the weapon, which can strike targets from a distance of thousands of kilometres, spokesman Dmitri Peskov refusing to comment when questioned. The Ukrainian air force said Moscow had launched the nuclear-capable missile as part of a barrage towards the central city of Dnipro, where local authorities said an infrastructure facility was hit and two civilians were wounded. Ukrainian President Volodymyr Zelensky said experts were examining evidence before confirming an intercontinental ballistic missile had been fired by “our crazy neighbour”. He said that the attack bore “all the characteristics” of an ICBM attack and accused the Kremlin of “using Ukraine as a testing ground”. Ukraine’s foreign ministry spokesman said analysts were preparing their “expert conclusions” while adding that the attack bore “all flight characteristics of an ICBM”. “The strike itself proves: Russia does not seek peace. To the contrary, it makes every effort to expand the war,” spokesman Georgiy Tykhy said in a statement on social media. The attack on Dnipro comes just days after several foreign embassies shuttered temporarily in the Ukrainian capital, citing the threat of a large-scale strike. Tension has been building between Moscow and Kyiv’s allies in the West since Ukrainian forces struck Russian territory with Western-supplied long-range weapons on Tuesday after getting the green light from Washington. Asked whether Moscow had fired an ICBM, Kremlin spokesman Peskov said he had “nothing to say on this topic”. He did however say the Kremlin was doing everything to avoid a nuclear conflict, having updated its nuclear doctrine this week. “We have stressed in the context of our doctrine that Russia is taking a responsible position to make maximum effort not to allow such a conflict,” Peskov said. Russia’s foreign ministry spokeswoman received a phone call during a live press briefing, in which she was ordered not to comment on reports of the ballistic strike, video showed. Yuzhmash is the Russian name of an aerospace manufacturer — now called Pivdenmash — in Dnipro that produced missiles during the Soviet era and is reported now to make satellites. Russia claimed to have struck the facility in September this year. Western countries reacted with alarm. “While we’re assessing the full facts it’s obvious that such (an) attack would mark yet another clear escalation from the side of (Vladimir) Putin,” European Union foreign affairs spokesman Peter Stano told reporters. The United Kingdom said the strike would be “reckless and escalatory” if confirmed. France said it would represent an “extremely serious” incident. Ukraine’s air force said it had downed missiles launched on the industrial city, without elaborating on whether the alleged intercontinental ballistic missile (ICBM) was among those downed. The head of the Dnipropetrovsk region where the city of Dnipro is located said the Russian aerial bombardment damaged a rehabilitation centre and several homes, as well as an industrial enterprise. “Two people were wounded — a 57-year-old man was treated on the scene and a 42-year-old woman was hospitalised,” said the official, Sergiy Lysak. Fabian Hoffmann, a research fellow at the University of Oslo, who specialises in missile technology, said Russia had nothing to gain militarily by using an ICBM in such an attack. “This is all about the political effect. This is not about the military value,” Hoffmann told AFP. Russia and Ukraine have escalated their use of long-range missiles in recent days since the Washington gave Kyiv permission to use its Army Tactical Missile System (ATACMS) against military targets inside Russia — a long-standing Ukrainian request. British media meanwhile reported on Wednesday that Kyiv had launched UK-supplied Storm Shadow missiles at targets in Russia after being given the green light from London. The defence ministry in Moscow said Thursday its air-defence systems had downed two Storm Shadows, without saying whether they had come down on Russian territory or in occupied Ukraine. The missile escalation is coming at a critical moment on the ground for Ukraine, as its defensive lines buckle under Russian pressure across the sprawling front line. Russia claimed deeper advances in the war-battered Donetsk region, announcing on Thursday that its forces had captured another village close to Kurakhove, closing in on the town after months of steady advances. Moscow’s defence ministry said Russian forces had taken the small village of Dalne, five kilometres (three miles) south of Kurakhove. Lysak, the governor of the Dnipropetrovsk region, said that 26 people had been wounded in another strike on the town of Kryvyi Rig, where Zelensky was born.(BPT) - This article was sponsored and developed by Neurocrine Biosciences, Inc. Cerebral palsy (CP) is a neurodevelopmental disorder affecting movement and posture that begins in early childhood development. It is the most common cause of motor disability in children, affecting about one in 345 children in the United States. 1-2 It may happen as a result of lack of oxygen during or around birth, stroke, infection, a problem with metabolism or other problems that cause injury or affect the development of parts of the brain involved in movement control in the first few years of life. 3 CP is a permanent condition, affecting a person for their entire life. People living with CP typically have motor problems, which may include spasticity (abnormal muscle tightness), dyskinesia (uncontrolled movements) or ataxia (poor muscle control), and many people have a mix of these motor disorders. 4 Dyskinesia due to CP (DCP) is one of the most disabling forms of CP and impacts approximately 10% to 20% of people living with CP. 5-6 According to the Cerebral Palsy Foundation (CPF), the combination of irregular and unpredictable movements (chorea) and twisting and repeating movements (dystonia) often disrupt activities and cause significant functional impairment, including the ability to maintain balance, walk or fine motor control. 7 Heather Riordan, M.D., Neurologist and Movement Disorders Specialist, Director of the Phelps Center for Cerebral Palsy at the Kennedy Krieger Institute, discusses the symptoms of chorea and impact on patients in a video shared on the CPF website here . About 30% of people with DCP are affected mostly by these involuntary and irregular movements (chorea), while dystonia is the predominant motor finding in the remaining 70%. 8 However, it is common for both chorea and dystonia movements to be present together. 6 For people living with DCP, these movements can occur in any region of the body, including the arms and legs, torso and face and may vary in severity. They are often triggered or made worse by stimulation or stress. Because dyskinesia can occur at rest and/or when actively using the body, the problems with movement are very burdensome in day-to-day living, with discomfort and pain affecting the quality of life for people and their caregivers. 9 Jen Lyman, mom to a son with DCP, highlights how dyskinesia makes communicating more difficult. "The most difficult thing about dyskinesia is watching my son struggle to do things that he wants to do, but the extra movements get in the way...special things, such as using a touch screen to video chat with his grandmother, are nearly impossible despite his best efforts to use his hands and fingers. Something so simple, yet so special for him should be effortless." DCP has a wide-ranging impact on the individual, including lifelong challenges with movement, a higher risk of other medical issues, a higher rate of mental health challenges and difficulties with communication. 10-12 "Those of us who have the privilege to serve patients with dyskinetic, hyperkinetic or mixed cerebral palsy see the functional impact of this very challenging type of tone every day," said Susan Biffl, M.D., Rehabilitation Medicine Specialist at Rady Children's Hospital-San Diego and Assistant Professor at UC San Diego School of Medicine. "Patients face challenges with self-care, independence, mobility, communication, fine motor skills that affect occupational and recreational activities, swallowing, social interactions and even sleep. As this tone is variable, it is much more challenging to treat than more consistent tone issues, such as spasticity." Treatment Options There are currently no Food and Drug Administration-approved treatments for DCP. Dystonia and chorea are often managed separately as they respond differently to various treatments, which can make treatment challenging. 3 Most drugs being investigated for DCP have focused on dystonia, and more research is needed to determine potential treatments for chorea. New treatment options are needed to help manage these movement disorders and improve daily function and quality of life for those affected. "After 20 years of caring for individuals with cerebral palsy, I continue to find those with dyskinetic cerebral palsy among the most challenging to treat, largely due to the limited effectiveness of available pharmacologic options," said Joyce Oleszek, M.D., Professor, Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine. "There is an urgent need for more robust evidence to support pharmacologic treatments for this condition, given its profound impact on function, comfort and quality of life." Ongoing Research Clinical studies are important in the development of treatment options, allowing researchers to evaluate the safety and effectiveness of new medicines. The data from clinical studies are used to determine if an investigational treatment can be approved for use to treat certain disorders. There are ongoing clinical studies evaluating potential treatments for DCP, including one for chorea. Neurocrine Biosciences is conducting the KINECT ® -DCP clinical study, a Phase 3, randomized, double-blind placebo-controlled study investigating the study drug, valbenazine, for the treatment of DCP. The clinical study is currently enrolling children, adolescents and adults six to 70 years of age who have been diagnosed with DCP. "The Cerebral Palsy Foundation is excited to partner with Neurocrine Biosciences on this study," said Rachel Byrne, Executive Director of the Cerebral Palsy Foundation. "We are proud to support strong research that can potentially bring meaningful change to the lives of those living with cerebral palsy." If you or someone you know may be eligible for this research study, please visit the study website for additional information here: FindADCPStudy.com . REFERENCES © 2024 Neurocrine Biosciences, Inc. All Rights Reserved. CAP-NBI-US-0115 12/2024 NBI-98854-DCP3018_11DecMatRelease_v1.0_25November2024
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