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WASHINGTON (AP) — President-elect Donald Trump’s incoming administration is set to be less diverse than President Joe Biden’s administration, but several people of color and women appear likely to serve in top roles. While Trump vigorously campaigned against diversity and inclusion efforts in business and government, his Cabinet selections and other high-profile staffing choices include some barrier-breaking nominations. The Cabinet, if confirmed, is set to be one-third women and include some historic firsts. Florida Sen. Marco Rubio, Trump’s pick to lead the State Department, would be the first Latino secretary of state. Scott Bessent, an American hedge fund manager and Trump’s pick to lead the Treasury Department, would be the first openly gay man in that post. const iframes=document.querySelectorAll('iframe.ap-embed');const iframeMap=new Map();iframes.forEach(iframe=>iframeMap.set(iframe.contentWindow,iframe));window.addEventListener('message',msg=>{const iframe=iframeMap.get(msg.source);if(!iframe)return;if(msg.data.type==='embed-size'){iframe.setAttribute('height',msg.data.height);iframe.style.height=`${msg.data.height}px`;return;}});iframes.forEach(iframe=>{const data={type:'embed-size-query'};iframe.contentWindow.postMessage(data,'*');}); Susie Wiles, Trump’s choice for White House chief of staff, will also be the first woman to serve in the position. Scott Turner, a former NFL player who led the White House Opportunity and Revitalization Council in the first Trump term, will serve as secretary of housing and urban development. Turner, who is Black, will be the fourth confirmed HUD secretary of color since 2014. Neurosurgeon Ben Carson, who is also Black, served in that post under Trump. RELATED COVERAGE So you’re gathering with relatives whose politics are different. Here are some tips for the holidays Democrats plan to elect new party leader just days after Trump’s inauguration Special counsel moves to abandon election interference and classified documents cases against Trump Trump’s first administration also included some historic firsts, including Veteran spy Gina Haspel serving as the first female director of the CIA, but, overall, it still lagged behind his predecessors on diversity. The incoming administration is set to include some people of color in other high-profile roles. Vivek Ramaswamy, a former biotechnology executive and 2024 GOP presidential candidate, will co-lead an outside advisory committee on government efficiency with billionaire Elon Musk. Tulsi Gabbard, a former Democratic congresswoman, is Trump’s pick to serve as director of national intelligence, the chief coordinator of the nation’s intelligence departments. Gabbard is of Samoan descent and Ramaswamy is Indian American. Mehmet Oz, a former TV doctor who unsuccessfully ran for Senate in Pennsylvania, has been tapped by Trump to lead the Centers for Medicare and Medicaid Services. And Janette Nesheiwat, a physician and Fox News personality, is Trump’s pick to serve as surgeon general. Nesheiwat is the daughter of Christian Jordanian immigrants; Oz is Turkish American and would be the first Muslim to serve in the role. Trump’s Cabinet also includes a wide breadth of ideological diversity with some nominees holding views broadly considered eccentric in Washington. Others have clashing opinions on priorities for the incoming administration like trade and foreign policy. ____ The Associated Press receives support from several private foundations to enhance its explanatory coverage of elections and democracy. See more about AP’s democracy initiative here . The AP is solely responsible for all content.

Trump's tariffs in his first term did little to alter the economy, but this time could be different WASHINGTON (AP) — Donald Trump loved to use tariffs during his first presidency. But their impact was barely noticeable in the overall economy, even if their aftershocks were clear in specific industries. The data show they never fully delivered on his promised factory jobs. Nor did they provoke the avalanche of inflation that critics feared. This time, though, his tariff threats might be different. The president-elect is talking about going much bigger — on a potential scale that creates more uncertainty about whether he’ll do what he says and what the consequences could be. His proposed tariffs against Canada and Mexico could blow up an existing trade deal. US consumer price increases accelerated last month with inflation pressures resilient WASHINGTON (AP) — Consumer price increases accelerated last month, the latest sign that inflation’s steady decline over the past two years has stalled. According to the Federal Reserve’s preferred inflation gauge, consumer prices rose 2.3% in October from a year earlier, the Commerce Department said Wednesday. That is up from just 2.1% in September, though it is still only modestly above the Fed’s 2% target. Trump fills out his economic team with two veterans of his first administration WEST PALM BEACH, Fla. (AP) — President-elect Donald Trump is turning to two officials with experience navigating not only Washington but the key issues of income taxes and tariffs as he fills out his economic team. Trump on Tuesday announced he has chosen international trade attorney Jamieson Greer to be his U.S. trade representative and Kevin Hassett as director of the White House National Economic Council. While Trump has in several cases nominated outsiders to key posts, these picks reflect a recognition that his reputation will likely hinge on restoring the public’s confidence in the economy. US economy grows at 2.8% pace in third quarter on consumer spending, unchanged from first estimate WASHINGTON (AP) — The American economy expanded at a healthy 2.8% annual pace from July through September on strong consumer spending and a surge in exports, the government said Wednesday, leaving unchanged its initial estimate of third-quarter growth. The Commerce Department reported that growth in U.S. gross domestic product — the economy’s output of goods and services — slowed from the April-July rate of 3%. But the GDP report still showed that the American economy — the world’s largest — is proving surprisingly durable. Growth has topped 2% for eight of the last nine quarters. Trump’s latest tariff plan aims at multiple countries. What does it mean for the US? WASHINGTON (AP) — President-elect Donald Trump has identified what he sees as an all-purpose fix for what ails America: Slap huge new tariffs on foreign goods entering the United States. On Monday, Trump sent shockwaves across the nation’s northern and southern borders, vowing sweeping new tariffs on Mexico, Canada, as well as China, as part of his effort to crack down on illegal immigration and drugs. Trump said he will impose a 25% tax on all products entering the country from Canada and Mexico, and an additional 10% tariff on goods from China, as one of his first executive orders. The UK will consult on sales targets for automakers during the transition to electric vehicles LONDON (AP) — Britain’s new Labour government will launch a consultation on sales targets set for auto manufacturers during the transition to electric vehicles. That's in the wake of the decision by Stellantis, the owner of Vauxhall, to close its van factory in southern England at the potential cost of 1,100 jobs. Business Secretary Jonathan Reynolds told lawmakers Wednesday that the problems encountered by Stellantis in the transition to electric vehicles are not unique, adding that the government will do all it can to prevent the closure of the plant. Stellantis blamed its decision on the U.K.’s “stringent” zero-emission vehicle mandate that sets strict targets for manufacturers. After fast start, electric cars need a recharge as range limits, cost leave some drivers skeptical DETROIT (AP) — While sales of electric vehicles surge in China, the spread of more environmentally friendly vehicles is stumbling in the United States and Europe as carmakers and governments struggle to meet years-old promises about affordability and charging stations. And consumers worried more about price and practicality are holding back where first-adopter climate warriors once piled in. Range, charging infrastructure and higher prices are sore points among both electric car enthusiasts and skeptics in Europe and the U.S. China is the exception. Driven by government subsidies and mandates, vehicles with electric motors, including plug-in hybrids that combine electric and fossil fuel motors, topped 50% of sales in July. Stock market today: Wall Street wavers as Big Tech stocks fall Stocks wavered on Wall Street as losses for Big Tech companies offset gains elsewhere in the market. The S&P 500 was down 0.4% in afternoon trading on Wednesday, even though more stocks were rising than falling within the index. Losses for Nvidia and Microsoft helped pull the index lower. Dell sank after reporting revenue that fell shy of forecasts, and HP fell after giving a weaker-than-expected outlook. The Dow Jones Industrial Average slipped 0.3% from its record high a day earlier. The Nasdaq composite fell 0.7%. U.S. markets will be closed Thursday for Thanksgiving, and will reopen for a half day on Friday. Average rate on a 30-year mortgage in the US slips to 6.81% The average rate on a 30-year mortgage in the U.S. eased this week, though it remains near 7% after mostly rising in recent weeks. The rate slipped to 6.81% from 6.84% last week, mortgage buyer Freddie Mac said Wednesday. That’s still down from a year ago, when the rate averaged 7.22%. The average rate on a 30-year mortgage has been mostly rising since sliding to a two-year low of 6.08% in late September. Elevated mortgage rates and rising home prices have kept homeownership out of reach of many would-be homebuyers. U.S. home sales are on track for their worst year since 1995. Landmark fish and meat markets in London to close, ending 1,000 years of tradition LONDON (AP) — Two of London’s most famous markets — one selling fish, the other meat — are set to close in the coming years, bringing an end to traditions stretching back to medieval times. On Wednesday, The City of London Corporation, the governing body in the capital city’s historic hub, is set to present a bill to Parliament to bring an end to its responsibilities to operate the Billingsgate fish market and the Smithfield meat market, both of which have existed in some shape or form since the 11th century. That comes a day after the corporation decided not to relocate the markets to a new development just east of London in Dagenham.Brock Purdy skips Thursday media session: What it means for 49ers-Packers showdownJuan Soto spends Christmas with his family in a way that everyone can affordCan we teach kids about the most wonderful — and most sorrowful — time of the year? It's a season of magic, yes — but also one of grief, gratitude and appreciation for the things we no longer have. Amberly McAteer, The Globe and Mail Dec 24, 2024 3:00 PM Share by Email Share on Facebook Share on X Share on LinkedIn Print Share via Text Message Parents need to be honest about why Christmas brings us all down sometimes, says a Canadian developmental psychologist. Lew Robertson/Moment/Getty Images Listen to this article 00:06:06 “We don’t have enough time,” I had said to my daughter as she ducked into the gift store on Toronto’s Bloor Street – just to look, of course. I had a million things to do after her ballet class, and Christmas shopping with a four-year-old was not on the list. But then I saw it, and time stopped. The ceramic tree behind the counter was a near replica of the one my grandma owned – hers, one she had made with her bridge ladies decades before I was born. I could hear her calm voice and feel her soft hands guiding me away from the tree’s bright bulbs, each nestled in a pocket of painted snow, and always too hot to touch. I could feel the comfort of sitting on her lap in the wingback chair, admiring her ceramic tree in the front window of the fancy sitting room, off limits to her grandkids any other time of year. The Victorian furniture. The plush floral carpet. If I closed my eyes long enough, I could see her eyes twinkle as we spoke; I could hear her shoulder-shaking laugh. “Mama, why are you crying?” It’s nothing, I told my daughter as she bolted down another aisle. My mind has gone back to that tree, those moments with my grandma, every Christmas. The sadness I feel that she – and so many others – aren’t with us is a rite of passage into December. The missing and the magic mixed into one bittersweet, forlorn feeling that is somehow festive to me. The hurt is not just about personal loss – it’s about injustice, too. The guilt of living in abundance here, and not clinging on to life there, feels more palpable. What right do I have to be overwhelmed about a Christmas holiday, when so many children have been torn from their homes this year, never to return – or worse? How can I sigh at my husband for playing the worst Christmas music – yes, of course the people in Africa know it’s Christmas – when so many loved ones aren’t with us any more, and so many are fighting for basic survival? The melancholy and guilt and nostalgia are all wrapped up together like Christmas lights I’ll never untangle. And though I don’t want my kids to feel unhappy – in fact, I go to great lengths to ensure this is their most wonderful time of year – I do want them to feel some of these less-bright parts of Christmas: gratitude, reflection and, okay, maybe feel a bit sad for others who don’t have as much, instead of simply seeing Christmas as an opportunity to ask for more, more, more. I wish my kid would put down the toy catalogue and understand a deeper meaning of the season; is that too much to ask? “Gratitude is actually the opposite of entitlement, and you can absolutely teach your kids to know there is nuance and sadness at Christmas,” says Dona Matthews, a developmental psychologist in Toronto, and author of Imperfect Parenting – a handbook on creating kids who are, among other things, grateful and understanding of the world around them. She says parents need to be honest about why Christmas brings us all down sometimes, and name our complicated feelings out loud. If, for example, your child sees a person asking for money on the street, Matthews says, “it’s okay to tell them that person doesn’t have what he needs by way of food and shelter. We are so lucky [to] have a warm house and food to eat.” She says we can teach kids about the cruelty and injustice of the world by speaking about our good fortune in contrast with the less fortunate, and then encouraging kids – even at 4 – to try to do something about it: donate to a food bank, give money or gift cards to a person on the street, or take their too-small clothes to a shelter. “They can learn firsthand that they can make the world a better place – that’s the next step in the gratitude project,” Matthews says. Gratitude and reflection – the things I’m needing most for my kids – are also achieved, she says, by saying no and not giving them the most things at Christmas – even when we all want to make merry. “If you want Veruca Salt for a child,” she says, “just give them everything they ask for.” I won’t tell her about my daughter, hands full of knick-knacks in the toy store, begging for a bejewelled reindeer and gingerbread chapstick. I told her to put it all back, though she’s grown up in a world where materialistic overconsumption is the norm, and she understands anything she wants can theoretically arrive at her doorstep the next day. It’s no wonder, then, that she views Christmas as an endless fire hose of stuff, when all of her parents’ holiday packages keep multiplying in our entranceway. And yet, if TikTok is to be believed, “underconsumption core” is actually having a moment: that is, the Gen Z aesthetic trending on the social-media app shows carefully curated young people showing off how they live with less, buy very little and reject messaging from big corporations that you need more stuff. It’s a message millennial parents – and their kids – seemingly haven’t heard. In the U.S., holiday spending has steadily increased every year – with 2024 expected to top US$989 billion , and millennials – specifically, those with young kids – leading the spending charge. According to a Harris poll, Gen Z may be watching those “less is more” videos but their holiday spending is extraordinary: A Gen Z shopper spends an average of US$1,638 – more than double their boomer counterpart. How can anyone expect to sit with the sadness of the season when we are all consuming too much – myself (and my daughter) included? “Mama, can we go home?” A Gen Z trend that is truly making a comeback is colourful, vintage décor – or so the store clerk told me as she wrapped up my purchase, with my impatient daughter pulling at my coat. “I got us something,” I said to my daughter when we got in the door. “I thought you said no more stuff,” she wisely observed, as she climbed into my lap to unwrap our new, old, sad, wonderful tree. Tags: See a typo/mistake? Have a story/tip? This has been shared 0 times 0 Shares Share by Email Share on Facebook Share on X Share on LinkedIn Print Share via Text Message More Highlights How to cook a turkey and other holiday cooking tips and recipes Dec 24, 2024 4:00 PM Dismiss Trump taunts, expert says after 'churlish' social media posts about Canada Dec 24, 2024 2:49 PM NORAD's Santa tracker was a Cold War morale boost. Now it attracts millions of kids Dec 24, 2024 2:26 PM Featured Flyer

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NoneFor the first time, Northwestern Medicine scientists have identified a population of long-lived proteins in the ovaries which likely support the stability and longevity of the female reproductive system and may contribute to reproductive aging, according to a recent study published in eLife . "We've generated a resource for the field because now we have a catalog of long-lived proteins that we and others can now go after to understand mechanistically how they are contributing to reproductive aging," said Francesca Duncan, Ph.D., the Thomas J. Watkins Memorial Professor of Reproductive Science, and co-senior author of the study. As the body ages, all organ systems slowly decline in function. The female reproductive system, however, is one of the first organ systems to age, with fertility beginning to decrease in women in their mid-thirties and reproductive function stopping completely at menopause. Reproductive aging is also associated with a loss in egg quantity and quality, which can cause infertility, miscarriages and birth defects. "The mammalian ovary is comprised of a fixed and nonrenewable pool of long-lived cells , or oocytes . They have to remain functional for up to decades in humans, so you can imagine that these cells are extremely vulnerable to any sort of damage that happens over that period of time," said Duncan, who is also a member of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. To better understand the mechanisms that contribute to reproductive aging, Duncan teamed up with Jeffrey Savas, Ph.D., associate professor in the Ken and Ruth Davee Department of Neurology in the Division of Behavioral Neurology, to study the impact of the loss of protein function and quality in the ovaries and in oocytes, or egg cells that have not yet matured. "You can imagine that if you have proteins in a cell that are sticking around for long periods of time without turning over, that could lead to damage in a long-lived cell," Duncan said. Using a comprehensive protein identification technique developed by Savas, which involved multi-generational whole animal metabolic stable isotope labeling and mass spectrometry-based quantitative proteomic approaches, the investigators were able to visualize and identify ovarian and oocyte long-lived molecules and proteins from mice at specific time points relevant to female reproductive aging. "In the overall structure of the ovary, which contains oocytes and follicles, there's a lot of diversity in terms of cell types and very specialized proteins are expressed there, so it seemed like a rich organ to study this aspect of biology," said Savas, who is also a professor of Pharmacology and of Medicine in the Division of Nephrology and Hypertension. In the mice oocytes and ovaries, the investigators found that long-lived proteins persisted after six months. At 10 months, however, most of these proteins had turned over and degraded. They also found increased subtypes of proteins in the oocytes, including histone proteins and several cytoskeletal proteins, as well as organ-specific proteins, including the ZP3 protein, which helps mediate sperm binding to the egg during fertilization. Unexpectedly, the scientists also discovered a large percentage of these long-lived proteins were mitochondrial proteins; it is known that the mitochondria, the energy producing organelles of the cell, are essential for supporting egg quality. This may suggest that long-lived proteins are essential for ensuring the structural and functional integrity of oocytes, Duncan said. "We know that with age, there's deterioration of mitochondrial function, but long-lived proteins have never been implicated in the oocyte before, especially in terms of their mitochondria," Duncan said. "This would suggest that the 'scaffolding' of the egg is actually made very early on and ultimately probably built upon with new proteins as the egg develops. This changes our fundamental understanding of egg biology and how we think about how these cells manage being long-lived." The findings underscore the role long-lived proteins have in maintenance and age-dependent deterioration of the female reproductive system. The next steps in the investigation, according to Duncan, will be determining if these long-lived mitochondrial proteins are beneficial or damaging to oocytes over time and how this impacts overall egg quality and survival. "I think this study is an excellent example of how at Northwestern interdisciplinary research can come together in highly impactful ways. It's been incredibly exciting and rewarding to establish a common language and apply state-of-the-art technologies across disciplines to drive biology forward," Duncan said. More information: Ewa K Bomba-Warczak et al, Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan, eLife (2024). DOI: 10.7554/eLife.93172.3

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