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is jili games legit The Best ‘Value Bottles’ In Bourbon, RankedTOPEKA — School districts across Kansas will receive a 20-page report containing guidance on cell phones that recommends daytime cell phone bans, mental health awareness and bolstered parental oversight. The Kansas State Board of Education hasn’t mandated digital device policies, instead deferring to local districts and schools to create their own. The board voted unanimously Tuesday to accept the report’s recommendations and directed Kansas Department of Education staff to send it to local districts. “Prior to the vote, Board Chair Melanie Haas of Overland Park emphasized the State Board accepting the report was an acknowledgement of the task force’s work, not an endorsement of the recommendations,” said Denise Kahler, a spokeswoman for the Kansas Department of Education, in a Tuesday news release. The 36-member task force consisted of state board members, district officials, school employees, students, parents and legislators who crafted 22 recommendations for locales. They met weekly between late August and early November and divided their recommendations into three categories: personal devices in school, screen time and mental health and parental oversight of district-owned devices. State education officials proposed the task force in July, envisioning it as a way to examine how students use cell phones and other digital devices and the toll social media takes on their mental health. It was a way to help districts distill research into clear guidelines that they can use if they choose to create local policies, said Randy Watson, state education commissioner, at Tuesday’s meeting. “This is not the state board telling any local district what you shall do,” he said. Initial recommendations suggest districts should mandate K-12 students’ personal cell phones be powered off from the beginning of the school day to the end, including during lunch and passing periods, and stored in an off-limits location. Such restrictions are called bell-to-bell policies. “A 2024 study reveals 72% of high school teachers, 33% of middle school teachers, and 6% of elementary school teachers say students distracted by cell phones in class is a major problem,” the report said. Some studies also link screen time and school performance, the report said. The task force also recommended districts create personal device policies for school staff, develop safety and emergency procedures that don’t rely on students’ personal devices and identify a district’s technology gaps so students aren’t forced to use their own devices. Parental oversight had the lengthiest list of recommendations, with 13 items. The task force suggested policies should allow families to have stronger oversight over their students’ district-owned devices Some included broader parental controls, full access to student devices, the ability to block certain websites and the use of systems that let families see a mirrored view of a student’s screen. About 47% of voting task force members opposed the screen mirroring recommendation, and 45% opposed the recommendation suggesting districts allow families to manage and request additional blocked websites on district-owned devices, according to the report. The task force also endorsed stronger educational efforts to help parents understand how they can manage and monitor student devices. Under mental health and screentime, the task force recommended districts implement independent, research-based guidance on online use and its effects on mental health, regular breaks from screens throughout the school day and means of communication with students and families outside of social media platforms. About 40% of voting members opposed the recommendation for communication outside of social media.

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RNA Therapeutics Market Future Trends, New Opportunities, Business Growth, Share, Global Size, Demand, Key Segments And Forecast 12-13-2024 08:42 PM CET | Health & Medicine Press release from: ABNewswire The prominent players in the global RNA therapeutics market include Moderna, Inc. (US), Alnylam Pharmaceuticals, Inc. (US), Pfizer Inc. (US), Novartis AG (Switzerland), Ionis Pharmaceuticals, Inc. (US) Browse 135 market data Tables and 36 Figures spread through 171 Pages and in-depth TOC on "RNA Therapeutics Market by Product (Vaccines, Drugs), Type (mRNA Therapeutics, RNA Interference, Antisense Oligonucleotides), Indication (Infectious Diseases, Rare Genetic Diseases), End User (Hospitals & Clinics) - Global Forecast to 2028 RNA Therapeutics Market [ https://www.marketsandmarkets.com/Market-Reports/rna-therapeutics-market-235963408.html?utm_source=abnewswire.com&utm_medium=referral&utm_campaign=paidpr ] in terms of revenue was estimated to be worth $13.7 billion in 2023 and is poised to reach $18.0 billion by 2028, growing at a CAGR of 5.6% from 2023 to 2028 according to a new report by MarketsandMarkets Trademark . Growth in this market is largely driven by factors such as the increasing number of partnerships and collaborations among market players and RNA technology manufacturers, expanding modalities for RNA therapeutics, and the rising number of emergency use authorizations and approvals for COVID-19 booster vaccines. The emergence of small activating RNAs (saRNAs) and circular RNAs (circRNAs) has expanded the scope of RNA therapeutics. saRNAs are 21-nucleotide long double-stranded RNAs (dsRNAs) complementary to the promoter region of a targeted gene. They can upregulate gene expression, potentially correcting deficiencies associated with genetic disorders and re-activating tumor suppressor genes in multiple types of cancers. On the other hand, the discontinuation/recalls of RNA therapeutic products is expected to hinder market growth. Download an Illustrative overview: https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=235963408 [ https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=235963408&utm_source=abnewswire.com&utm_medium=referral&utm_campaign=paidpr ] The vaccines segment accounted for the largest share of the RNA therapeutics market in 2022. Based on product, the RNA therapeutics market is segmented into drugs and vaccines. In 2022, vaccines represented majority of the market share and is anticipated to maintain this dominance throughout the forecast period. Two key vaccine products that have showcased majority revenue contribution in this segment, include Spikevax (Moderna, Inc.) and Comirnaty (Pfizer, Inc.) vaccines. Additionally, these COVID-19 vaccines showcased a considerable revenue growth between from 2021 and 2022. On the other hand, the recent recall/discontinuation of Spikevax (Moderna, Inc.) is anticipated to hinder the revenue growth post 2022. Increase in the development of innovative RNA medicine companies in the RNA therapeutics market has rendered it the fastest growing segment during the forecast period. The RNA interference (RNAi) therapeutics segment is expected to grow at the highest CAGR from 2023 to 2028. Based on the type, the RNA therapeutics market is segmented into RNA interference (RNAi) therapeutics, mRNA therapeutics, antisense oligonucleotide (ASO) therapeutics, and other therapeutics. Factors associated with RNA interference (RNAi) therapeutics such as precision and versatility have increased the potential of RNAi applications in personalized medicine and other clinical applications. On the other hand, the mRNA therapeutics segment accounted for the highest share in the global market in 2022 and is expected to maintain this trend through 2021-2028. The advantages of mRNA over DNA or proteins/peptides coupled with advent of novel vaccine and molecular entities are the key attributive reason to this dominance. The infectious diseases segment accounted for the largest share in the RNA therapeutics market in 2022. Based on the indication, the RNA therapeutics market is segmented into infectious diseases, rare genetic diseases/hereditary diseases, and other indications. The large share of the infectious diseases segment is a result of the rapid developments in RNA vaccine manufacturing capabilities for the treatment of infectious diseases along with the outbreak of COVID-19. Demand for mRNA vaccines grew significantly through 2021-2022, for immunization against SARS-COV-2 infection. Increase in the use of RNA-based therapeutics for the treatment of rare/genetic disorders contributes to the high share of hospitals & clinics. The RNA therapeutics market is segmented into hospitals and clinics and research settings. The growing use of RNA therapeutics across hospitals and clinics is driven by factors such as the increasing understanding and advancements of RNA-based therapeutics, the growing number of trends in personalized medicine, the increasing prevalence of chronic diseases, and the rising research investments by governments, private foundations, and industry stakeholders. Europe dominates the global RNA therapeutics market throughout the forecast period. The global RNA therapeutics market is segmented into four major regions, namely, North America, Europe, the Asia Pacific, and the Rest of the World. Europe leads the market for RNA vaccines, with highest share of revenue in this segment in 2022. North America has emerged as the fastest growing region from 2023 to 2028. The collective revenue share of Europe, across both RNA vaccines and RNA drugs is highest in 2022, and this is set to continue through the forecast period. Request Sample Pages: https://www.marketsandmarkets.com/requestsampleNew.asp?id=235963408 [ https://www.marketsandmarkets.com/requestsampleNew.asp?id=235963408&utm_source=abnewswire.com&utm_medium=referral&utm_campaign=paidpr ] RNA Therapeutics Market Dynamics: Drivers: 1. Increasing partnerships and collaborations among market players and RNA technology manufacturers Restraints: 1. Discontinuation or recalls of RNA therapeutic products Opportunities: 1. Higher progress in the development of RNA aptamer-based therapeutics Challenge: 1. Rapid degradation by ubiquitous RNases in environment and tissues with strong immunogenicity of exogenous RNA Key Market Players: The prominent players in the global RNA therapeutics market include Moderna, Inc. (US), Alnylam Pharmaceuticals, Inc. (US), Pfizer Inc. (US), Novartis AG (Switzerland), Ionis Pharmaceuticals, Inc. (US), Sarepta Therapeutics, Inc. (US), Sanofi (France), Arrowhead Pharmaceuticals, Inc. (US), BioNtech SE (Germany), Orna Therapeutics (US), CRISPR Therapeutics (Switzerland), Silence Therapeutics (UK), Astellas Pharma Inc. (Japan), CureVac SE (Germany), Sirnaomics (US), Arcturus Therapeutics Inc. (US) and Arbutus Biopharma (US). Get 10% Free Customization on this Report: https://www.marketsandmarkets.com/requestCustomizationNew.asp?id=235963408 [ https://www.marketsandmarkets.com/requestCustomizationNew.asp?id=235963408&utm_source=abnewswire.com&utm_medium=referral&utm_campaign=paidpr ] RNA Therapeutics Market Advantages: * Precision Medicine: RNA-based therapies can be tailored to target specific genetic mutations or disease pathways, allowing for personalized treatments that are more effective and have fewer side effects. * Speed of Development: The rapid development of RNA-based vaccines during the COVID-19 pandemic demonstrated the agility of this technology, which can potentially accelerate the response to emerging diseases and medical challenges. * Versatility: RNA can be engineered to address a wide range of diseases, including genetic disorders, cancer, infectious diseases, and rare diseases, making it a versatile platform for therapeutic development. * Reduced Off-Target Effects: Compared to traditional small molecule drugs, RNA therapies can have a higher degree of specificity, minimizing off-target effects on healthy cells and tissues. * Lower Manufacturing Costs: Advances in RNA synthesis and production techniques are driving down manufacturing costs, potentially making RNA therapies more accessible and affordable. * Targeting Undruggable Proteins: RNA therapeutics can target proteins that were previously considered "undruggable" with small molecules, expanding the range of potential drug targets. * Potential for Gene Editing: RNA-based therapies, such as CRISPR-Cas9, hold promise for precise gene editing and the treatment of genetic diseases at their root cause. * Immunomodulation: RNA molecules can be designed to stimulate or inhibit immune responses, making them valuable tools in the treatment of autoimmune diseases and for enhancing cancer immunotherapies. * Reduced Development Risk: The ability to rapidly iterate and optimize RNA therapies in preclinical and clinical stages can reduce the risks associated with drug development. * Therapeutic Innovation: RNA therapeutics represent a novel class of drugs that can complement existing treatment modalities, offering innovative solutions to unmet medical needs. Media Contact Company Name: MarketsandMarkets Trademark Research Private Ltd. Contact Person: Mr. Rohan Salgarkar Email:Send Email [ https://www.abnewswire.com/email_contact_us.php?pr=rna-therapeutics-market-future-trends-new-opportunities-business-growth-share-global-size-demand-key-segments-and-forecast ] Phone: 18886006441 Address:1615 South Congress Ave. Suite 103, Delray Beach, FL 33445 City: Florida State: Florida Country: United States Website: https://www.marketsandmarkets.com/Market-Reports/rna-therapeutics-market-235963408.html This release was published on openPR.

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MIAMI GARDENS, Fla. (AP) — Dolphins coach Mike McDaniel said he was caught off guard by reports early Tuesday that linebacker Shaq Barrett wants to unretire. The two-time Super Bowl winner signed a one-year deal with the Dolphins in March, then abruptly announced his retirement on social media in July, just days before the start of Miami’s training camp. “Just to be candid, obviously there’s a reason why you target and sign somebody,” McDaniel said Tuesday afternoon. “I was fully caught off guard, or caught by surprise this morning as I found out.” McDaniel indicated the Dolphins have not had any conversations with Barrett recently. Miami holds the 32-year-old’s contractual rights. ESPN first reported the news. “It was kind of news as you guys got it,” McDaniel said. He also said he hasn’t had a chance to think about Barrett potentially rejoining the team, and that his immediate focus is on Miami’s Thursday night game at Green Bay. “The team is counting on me to think about the Packers,” he said. “I’ll get with (GM) Chris (Grier), and we’ll work through that. There’s a ton of implications that go along with it in terms of team and roster stuff, so we’ll work through that as we just got the news today.” Barrett has 400 tackles, 59 sacks, 22 forced fumbles and three interceptions in nine seasons — four with Denver and five with Tampa Bay. He was a second-team All-Pro with the Buccaneers in 2019, with a league-high 19 1/2 sacks. The AP Top 25 college football poll is back every week throughout the season! Get the poll delivered straight to your inbox with AP Top 25 Poll Alerts. Sign up here . Dolphins waive veteran safety The Dolphins waived veteran safety Marcus Maye on Tuesday and activated rookie safety Patrick McMorris from injured reserve. Maye, who signed with the Dolphins in June, played in 11 games with three starts for Miami this season. He had 30 tackles and a tackle for loss. He could re-sign to the team’s practice squad if he clears waivers. Maye previously played for New Orleans, but was cut in a money-saving move in March after two seasons with the Saints. Maye’s release made room on the roster for McMorris, who was drafted in the sixth round by Miami in April. He began the season on injured reserve because of a calf injury. ___ AP NFL: https://apnews.com/hub/nfl

Biden's broken promise on pardoning his son Hunter is raising new questions about his legacy WASHINGTON (AP) — President Joe Biden’s decision to go back on his word and pardon his son Hunter wasn't all that surprising to those who are familiar with the president's devotion to his family. But by choosing to put his family first, the 82-year-old president has raised new questions about his legacy. Biden has held himself up as placing his respect for the American judicial system and rule of law over his own personal concerns. It was part of an effort to draw a deliberate contrast with Republican Donald Trump. Now, both his broken promise and his act of clemency are a political lightning rod.

Tim McGraw and Faith Hill were the stars of Taylor Sheridan's Yellowstone spinoff 1883 , and now it's the turn of their daughter Audrey. Eagle-eyed fans have spotted the actress in episode five of the new series Landman , alongside Demi Moore, Ali Larter, and Billy Bob Thornton. The Paramount+ series is based on the 2019 Texas Monthly podcast Boomtown, which "takes you to the heart of the historic oil boom that is playing out in West Texas," and specifically across the Permian Basin — located in western Texas and southeastern New Mexico – which is now one of the world's most productive oil fields. Audrey makes an appearance midway through the episode, as Shelby, a neighbor of Ainsley Norris, "the wild and strong-willed seventeen year old daughter of Tommy Norris". In the scene, Ainsley is listening to Zach Bryan when Shelby calls out their shared fence to say she had "heard of the family". "Is your dad one of the oil dads?" Shelby asks to which Ainsley reveals that she was in town because her parents had canceled her spring break plans because "a bunch of tourists got killed" in Tulum. Ainsley is then invited to a patch party by Shelby, who shares that they "go out to the oil wells and bring kegs and circle up the cars on the patch and dance and blow off some steam". Audrey graduated from high school in 2020, and was reportedly attending the American Academy of Dramatic Arts, which has campuses in both New York City and Los Angeles. She has a passion for singing and photography, and shares pictures and videos on social media with fans. She is currently dating actor Manuel García-Rulfo, most well known to viewers of Netflix's The Lincoln Lawyer, and they have recently gone more public with their romance, with Audrey even joining Manuel at the Los Cabos International Film Festival where his new comedy film Una Historia de Amor y Guerra (A Story of Love and War), was screening. In photos shared by Edge Film on Instagram, Manuel and Audrey are seen posing next to each other; Manuel, wearing a monochromatic beige look, has his arm around her, and she's wearing a cinched black dress with chunky white heels. Audrey also shared the picture and added a red heart emoji.

NoneArguments over whether Luigi Mangione is a 'hero' offer glimpse into unusual American momentBy MICHAEL R. SISAK and JENNIFER PELTZ NEW YORK (AP) — President-elect Donald Trump’s lawyers urged a judge again Friday to throw out his hush money conviction, balking at the prosecution’s suggestion of preserving the verdict by treating the case the way some courts do when a defendant dies. They called the idea “absurd.” Related Articles National Politics | Trump wants to turn the clock on daylight saving time National Politics | Ruling by a conservative Supreme Court could help blue states resist Trump policies National Politics | A nonprofit leader, a social worker: Here are the stories of the people on Biden’s clemency list National Politics | Nancy Pelosi hospitalized after she ‘sustained an injury’ on official trip to Luxembourg National Politics | Veteran Daniel Penny, acquitted in NYC subway chokehold, will join Trump’s suite at football game The Manhattan district attorney’s office is asking Judge Juan M. Merchan to “pretend as if one of the assassination attempts against President Trump had been successful,” Trump’s lawyers wrote in a blistering 23-page response. In court papers made public Tuesday, District Attorney Alvin Bragg’s office proposed an array of options for keeping the historic conviction on the books after Trump’s lawyers filed paperwork earlier this month asking for the case to be dismissed. They include freezing the case until Trump leaves office in 2029, agreeing that any future sentence won’t include jail time, or closing the case by noting he was convicted but that he wasn’t sentenced and his appeal wasn’t resolved because of presidential immunity. Trump lawyers Todd Blanche and Emil Bove reiterated Friday their position that the only acceptable option is overturning his conviction and dismissing his indictment, writing that anything less will interfere with the transition process and his ability to lead the country. The Manhattan district attorney’s office declined comment. It’s unclear how soon Merchan will decide. He could grant Trump’s request for dismissal, go with one of the prosecution’s suggestions, wait until a federal appeals court rules on Trump’s parallel effort to get the case moved out of state court, or choose some other option. In their response Friday, Blanche and Bove ripped each of the prosecution’s suggestions. Halting the case until Trump leaves office would force the incoming president to govern while facing the “ongoing threat” that he’ll be sentenced to imprisonment, fines or other punishment as soon as his term ends, Blanche and Bove wrote. Trump, a Republican, takes office Jan. 20. “To be clear, President Trump will never deviate from the public interest in response to these thuggish tactics,” the defense lawyers wrote. “However, the threat itself is unconstitutional.” The prosecution’s suggestion that Merchan could mitigate those concerns by promising not to sentence Trump to jail time on presidential immunity grounds is also a non-starter, Blanche and Bove wrote. The immunity statute requires dropping the case, not merely limiting sentencing options, they argued. Blanche and Bove, both of whom Trump has tabbed for high-ranking Justice Department positions, expressed outrage at the prosecution’s novel suggestion that Merchan borrow from Alabama and other states and treat the case as if Trump had died. Blanche and Bove accused prosecutors of ignoring New York precedent and attempting to “fabricate” a solution “based on an extremely troubling and irresponsible analogy between President Trump” who survived assassination attempts in Pennsylvania in July and Florida in September “and a hypothetical dead defendant.” Such an option normally comes into play when a defendant dies after being convicted but before appeals are exhausted. It is unclear whether it is viable under New York law, but prosecutors suggested that Merchan could innovate in what’s already a unique case. “This remedy would prevent defendant from being burdened during his presidency by an ongoing criminal proceeding,” prosecutors wrote in their filing this week. But at the same time, it wouldn’t “precipitously discard” the “meaningful fact that defendant was indicted and found guilty by a jury of his peers.” Prosecutors acknowledged that “presidential immunity requires accommodation” during Trump’s impending return to the White House but argued that his election to a second term should not upend the jury’s verdict, which came when he was out of office. Longstanding Justice Department policy says sitting presidents cannot face criminal prosecution . Other world leaders don’t enjoy the same protection. For example, Israeli Prime Minister Benjamin Netanyahu is on trial on corruption charges even as he leads that nation’s wars in Lebanon and Gaza . Trump has been fighting for months to reverse his May 30 conviction on 34 counts of falsifying business records . Prosecutors said he fudged the documents to conceal a $130,000 payment to porn actor Stormy Daniels to suppress her claim that they had sex a decade earlier, which Trump denies. In their filing Friday, Trump’s lawyers citing a social media post in which Sen. John Fetterman used profane language to criticize Trump’s hush money prosecution. The Pennsylvania Democrat suggested that Trump deserved a pardon, comparing his case to that of President Joe Biden’s pardoned son Hunter Biden, who had been convicted of tax and gun charges . “Weaponizing the judiciary for blatant, partisan gain diminishes the collective faith in our institutions and sows further division,” Fetterman wrote Wednesday on Truth Social. Trump’s hush money conviction was in state court, meaning a presidential pardon — issued by Biden or himself when he takes office — would not apply to the case. Presidential pardons only apply to federal crimes. Since the election, special counsel Jack Smith has ended his two federal cases , which pertained to Trump’s efforts to overturn his 2020 election loss and allegations that he hoarded classified documents at his Mar-a-Lago estate. A separate state election interference case in Fulton County, Georgia, is largely on hold. Trump denies wrongdoing in all. Trump had been scheduled for sentencing in the hush money case in late November. But following Trump’s Nov. 5 election victory, Merchan halted proceedings and indefinitely postponed the former and future president’s sentencing so the defense and prosecution could weigh in on the future of the case. Merchan also delayed a decision on Trump’s prior bid to dismiss the case on immunity grounds. A dismissal would erase Trump’s conviction, sparing him the cloud of a criminal record and possible prison sentence. Trump is the first former president to be convicted of a crime and the first convicted criminal to be elected to the office.

Staten Island lawmakers, baffled by the lack of information regarding large drones spotted in the tri-state area skies, are demanding action from the New York Police Department and Federal Bureau of Investigation. Staten Island President Vito Fossella claimed a drone flew over his house last night — but said he’s just as concerned about drones being spotted over critical city infrastructure like the Verrazano Bridge. Officials want to know why federal officials have been unable to answer questions about the drones. If the troubling situation is not some major international conspiracy , they said, it’s certainly at least a safety risk . “We believe there was a drone flying over the [Verrazano] bridge ... and we’re supposed to let it go? They [the feds] have an obligation to let us know what is going on,” Fossella told reporters on Friday morning. Fossella went as far as to say “there should be an executive order to let people shoot them down .” Staten Island officials reached out to the FBI and FAA last week after the first reported sighting of the drones, which have mostly been spotted over neighboring New Jersey in recent weeks, according to Fossella Congresswoman Nicole Malliotakis (R-NY) told The Post she was briefed on the situation yesterday. Federal authorities believe some of the reports are airplanes, but many of the lower-flying objects remained a mystery. She proposed flight restrictions in some of the sensitive areas but “quite frankly got a cookie cutter response.” Malliotakis is convinced that it’s either the US government testing some military or law enforcement technology — or the drones are a foreign entity. “I don’t believe that the United States of America, with its capabilities, does not know what is going on,” she said. “The best way to address this is just be honest. It’s our government or there is a foreign nexus. Either our government is doing some surveillance or surveying or some foreign government.” the congresswoman said. White House National Security Council spokesman John Kirby dismissed concerns Wednesday , telling reporters that federal investigators have been unable to verify any of the 3,000-plus reports of car-size drones hovering in the night skies over the past several weeks. Staten Islanders first reported the strange objects in the sky last week, officials said. The aircraft have now been spotted above half the island. Multiple drones were spotted in the Bronx before dawn Thursday, leading frightened Big Apple residents to flood 911 with calls, police sources told The Post . New York Gov. Kathy Hochul confirmed her office was aware of drones flying over the city Friday. She echoed New Jersey Gov. Phil Murphy’s comments saying there is no safety threat at this time. “We know New Yorkers have spotted drones in the air this week & we are investigating,” Hochul tweeted . “At this time, there’s no evidence that these drones pose a public safety or national security threat.”

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