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casino game no deposit In a statement released by the Tianjin Municipal Education Commission, they clarified that there is no such program as the "Free Education Assistance Program" currently being implemented in the city. The Commission emphasized that it is committed to providing quality education and support to students in need, but the information circulating online is completely false and misleading.

ESSA Bancorp, Inc. (NASDAQ:ESSA) Shares Bought by Empowered Funds LLCThe elaborate scheme came to light when several shop owners reported receiving counterfeit bills. The police launched an investigation and eventually traced the fake currency back to the man. It was discovered that he had set up a makeshift printing operation in his own home, complete with specialized equipment for producing realistic-looking bills.

Coronation of King Charles cost at least £72 millionThe issue came to light when several high school graduates raised concerns about the intrusive nature of the question on the political review form. The form, which is part of the graduation procedures for high school students in certain regions, requires students to provide detailed information about their family background, including their great-grandparents' origins. Many students expressed confusion and discomfort about the requirement, questioning the relevance of such personal information to their academic records.

The images of Gong Li on the badminton court captured more than just physical prowess – they portrayed a woman who exudes confidence, grace, and a zest for life. Her radiant smile, focused gaze, and fluid movements serve as a reminder that true beauty transcends age and lies in one's spirit and attitude towards life.GAINESVILLE, Fla. (AP) — Coach Billy Napier and his team did something no one at Florida had done in nearly two decades. It could be the turning point for a once-proud program that clearly slipped in recent years. DJ Lagway threw two touchdown passes , Montrell Johnson ran for 127 yards and a score , and the Gators upset No. 9 Mississippi 24-17 on Saturday to knock the Rebels out of College Football Playoff contention . Florida (6-5, 4-4 Southeastern Conference), which topped LSU last Saturday in the Swamp, beat ranked teams in consecutive weeks for the first time since 2008. “We're just getting started,” said Napier, who is expected back for a fourth season in 2025. “This is part of the big-picture journey. Belief is the most powerful thing in the world." Ole Miss (8-3, 4-3), which was a 10-point favorite, lost for the first time in four games and will drop out of the 12-team playoff picture. The Rebels ranked ninth in the latest CFP and needed only to avoid a letdown against Florida and lowly Mississippi State to clinch a spot in the playoff field. “Obviously a lot was at stake, and we didn’t come through," coach Lane Kiffin said. "A lot of missed opportunities.” The Rebels failed to score in three trips inside the red zone and dropped countless passes in perfect weather, miscues Kiffin called “very unusual.” Still, Ole Miss had chances late. But Jaxson Dart threw interceptions to end the team's last two drives . Bryce Thornton, beaten for a touchdown in the first half, picked off both. The second one came with 17 seconds remaining and set up a raucous celebration by defenders in the end zone. Dart completed 24 of 41 passes for 323 yards, with two TDs and the two picks. He was sacked four times and also scrambled 14 times for a team-high 71 yards. “You look at the way we played, we had a chip on our shoulder for sure," defensive tackle Cam Jackson said. The Rebels probably would have had a comfortable lead had it not been for repeated failures inside the 20-yard line. Defensive tackle J.J. Pegues, a 325-pound wrecking ball out of the backfield, was stopped on two fourth-down runs inside the 20-yard line, and Caden Davis missed a 34-yard field goal in the second quarter. Ole Miss' drops were egregious, including at least three that probably would have been touchdowns. Jordan Watkins (twice), Wells (twice), Dae’Quan Wright and star receiver Tre Harris were among the droppers. Florida was much more efficient. Lagway completed 10 of 17 passes for 180 yards , with an interception. He made three throws with defenders draped all over him. “Those were the plays of the game,” Napier said. Johnson had a few of those, too. His 9-yard scoring run from the wildcat formation was huge and came after missed most of the last four games. “I focused on grinding and trying to work my way back," Johnson said. "Last week I got a couple carries and this week I shot to the moon.” Days after Kiffin raved about the health of his team, the Rebels had three starters go down with injuries. Harris, returning after missing the last three games with a strained groin, re-injured it the second quarter and did not return. Safety Yam Banks also was carted off the field after injuring his left knee, and center Reece McIntyre left the game. Right tackle Micah Pettus also was injured on a play but was able to return. Injured quarterback Graham Mertz got the loudest ovation during Florida’s senior day. Mertz’s college career ended when he tore the anterior cruciate ligament in his left knee during a 23-17 overtime loss at then-No. 8 Tennessee last month. The graduating class also includes Johnson, defensive tackle Desmond Watson and cornerback Jason Marshall, who also is out for the season. Mississippi: The Rebels needed better offensive balance. Playing without running back Henry Parrish Jr. (knee) for the second consecutive game, Ole Miss threw the ball 41 times. Dart also scrambled 14 more. It worked at times against Florida’s depleted secondary but wasn't a recipe for success. Florida: The Gators now have a chance to close the regular season with three consecutive wins, more proof that Napier has the team on the right track. Mississippi: The Rebels host Mississippi State in a rivalry known as the Egg Bowl on Friday. Florida: The Gators play at rival Florida State next Saturday. Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-footballTitle: Yuan Rises Sharply, Breaking Through the 7.25 Exchange Rate BarrierFurthermore, China's proactive measures to stabilize the yuan exchange rate have also played a role in its recent surge. The People's Bank of China has consistently intervened in the foreign exchange market to prevent excessive depreciation of the yuan and maintain stability. The central bank's efforts, combined with strong economic fundamentals, have instilled confidence in the yuan and supported its upward trajectory.

Meet Liang, a 90s young man with a passion for entrepreneurship and a heart full of love. Having worked in a corporate setting for several years, Liang found himself feeling unfulfilled and yearning for something more meaningful in life. His world changed when he met a girl named Xiaojie during a business trip to Wuhan. It was love at first sight, and ever since that moment, Liang knew that he had found his soulmate.North Carolina GOP lawmakers enact a law eroding the incoming Democratic governor's powersJason Kelce's wife announces she is pregnant with the couple's fourth child Former Philadelphia Eagles center Jason Kelce's wife is announcing she's pregnant with the couple's fourth child. Kylie Kelce posted a photo on Instagram on Friday of the couple's three young daughters reacting to the news. The oldest daughter, Wyatt, appears to be cupping her head in shock. The middle daughter, Ellioette, is smiling. The youngest, Bennett, is in tears. A caption attached to the photo reads: “I feel like we captured a very accurate representation of how each of the girls feel about getting another sister. At least Ellie, mom and dad are on the same page!” Israeli-Moldovan rabbi living in UAE is missing. Israeli officials fear he may have been kidnapped DUBAI, United Arab Emirates (AP) — An Israeli-Moldovan rabbi living in the United Arab Emirates has gone missing, with Israeli authorities raising the suspicion he may have been kidnapped as tensions remain high with Iran. The Israeli prime minister’s office said that Zvi Kogan has been missing since noon Thursday. It said that against the backdrop of information that this was a terrorist incident, an extensive investigation has been opened in the country. Emirati officials did not immediately respond to a request for comment Saturday. State-run media in the UAE, an autocratic federation of seven sheikhdoms on the Arabian Peninsula and home to Abu Dhabi and Dubai, did not immediately report the incident. Alyssa Nakken, first full-time female coach in MLB history, leaving Giants to join Guardians CLEVELAND (AP) — Alyssa Nakken, the first woman to coach in an MLB game, is leaving the San Francisco Giants to join the Cleveland Guardians. Nakken made history in 2022 when she took over as first-base coach following an ejection. A former college softball star at Sacramento State, Nakken joined the Giants in 2014 and was promoted to a spot on manager Gabe Kapler’s staff in 2020, becoming the majors’ first full-time female coach. Nakken has been hired as an assistant director within player development for the Guardians, who won the AL Central last season under first-year manager Stephen Vogt. Nakken, 34, will work with former Giants coaches Craig Albernaz and Kai Correa. Officer kills pet dog mistaken for a coyote in Massachusetts town. The owner says it was unnecessary An animal control officer shot and killed a pet dog in a Massachusetts town after mistaking it for a coyote in an incident local police are describing as a sad mix-up. Police in Northbridge, Massachusetts, say the shooting happened on Tuesday after police received a call of a report of a coyote in a residential backyard. Police say the animal control officer went into the woods to look for the coyote and found what they thought was the animal in a threatening position and shot it. The incident happened as communities around Massachusetts and the country have dealt with an uptick in interactions between coyotes and people. Kendrick Lamar surprises with new album 'GNX' LOS ANGELES (AP) — Kendrick Lamar gave music listeners an early holiday present with a new album. The Grammy winner released his sixth studio album “GNX” on Friday. The 12-track project is the rapper’s first release since 2022’s “Mr. Morale & The Big Steppers.” Lamar’s new album comes just months after his rap battle with Drake. The rap megastar will headline February's Apple Music Super Bowl Halftime Show in New Orleans. The 37-year-old has experienced massive success since his debut album “good kid, m.A.A.d city” in 2012. Since then, he’s accumulated 17 Grammy wins and became the first non-classical, non-jazz musician to win a Pulitzer Prize. NBA memo to players urges increased vigilance regarding home security following break-ins MIAMI (AP) — The NBA is urging its players to take additional precautions to secure their homes following reports of recent high-profile burglaries of dwellings owned by Milwaukee Bucks forward Bobby Portis and Kansas City Chiefs teammates Patrick Mahomes and Travis Kelce. In a memo sent to team officials, a copy of which was obtained by The Associated Press, the NBA revealed that the FBI has connected some burglaries to “transnational South American Theft Groups” that are “reportedly well-organized, sophisticated rings that incorporate advanced techniques and technologies, including pre-surveillance, drones, and signal jamming devices.” Ancient meets modern as a new subway in Greece showcases archaeological treasures THESSALONIKI, Greece (AP) — Thessaloniki, Greece’s second-largest city, is opening a new subway system, blending ancient archaeological treasures with modern transit technology like driverless trains and platform screen doors. The project, which began in 2003, uncovered over 300,000 artifacts, including a Roman-era thoroughfare and Byzantine relics, many of which are now displayed in its 13 stations. Despite delays caused by preserving these findings, the inaugural line has been completed, with a second line set to open next year. Conor McGregor must pay $250K to woman who says he raped her, civil jury rules LONDON (AP) — A civil jury in Ireland has awarded more than $250,000 to a woman who says she was raped by mixed martial arts fighter Conor McGregor in a Dublin hotel penthouse after a night of heavy partying. The jury on Friday awarded Nikita Hand in her lawsuit that claimed McGregor “brutally raped and battered” her in 2018. The lawsuit says the assault left her heavily bruised and suffering from post-traumatic stress disorder. McGregor testified that he never forced her to do anything and that Hand fabricated her allegations after the two had consensual sex. McGregor says he will appeal the verdict. At least 19 people are sick in Minnesota from ground beef tied to E. coli recall U.S. health officials say at least 19 people in Minnesota have been sickened by E. coli poisoning tied to a national recall of more than 167,000 pounds of potentially tainted ground beef. Detroit-based Wolverine Packing Co. recalled the meat sent to restaurants nationwide. Minnesota state agriculture officials reported multiple illnesses and found that a sample of the product tested positive for E. coli, which can cause life-threatening infections. No illnesses have been reported outside of Minnesota. Symptoms of E. coli poisoning include fever, vomiting, diarrhea and signs of dehydration. Actor Jonathan Majors’ ex-girlfriend drops assault and defamation lawsuit against once-rising star NEW YORK (AP) — Jonathan Majors’ ex-girlfriend has dropped her assault and defamation lawsuit against the once-rising Hollywood star after reaching a settlement. Lawyers for Majors and Grace Jabbari agreed to dismiss the case with prejudice Thursday. Jabbari is a British dancer who had accused Majors of subjecting her to escalating incidents of physical and verbal abuse during their relationship. Representatives for Majors didn’t respond to emails seeking comment Friday. Jabbari’s lawyer said the suit was “favorably settled” and her client is moving on with “her head held high.” Majors was convicted of misdemeanor assault and harassment last December and sentenced to a yearlong counseling program.

Incredible PS5 Pro Black Friday sale cuts £300 from the price2. Extreme exercise routines: While regular exercise is vital for overall health and well-being, pushing yourself to the limit with extreme workout programs can have negative consequences. Over-exercising can lead to chronic injuries, muscle fatigue, and a weakened immune system. It is essential to listen to your body's cues and practice moderation in your exercise routine. Aim for a mix of cardiovascular, strength training, and flexibility exercises to achieve a balanced and sustainable fitness regimen.RALEIGH, N.C. (AP) — North Carolina Democratic Gov.-elect Josh Stein announced his choices for a majority of his Cabinet positions Monday before he takes office next month, with two of the seven revealed department secretaries being holdovers from outgoing Gov. Roy Cooper's administration. The two current secretaries — Reid Wilson and Pamela Cashwell — have been appointed by Stein to lead departments new to them. Other Cabinet appointees include a top lieutenant for Stein while in his current job as attorney general. Stein’s transition office also said the Cabinet will include its first Latino and first Indian American secretaries in Gabe Esparza and Dr. Devdutta Sangvai, respectively. Wilson, at present the Natural and Cultural Resources Department secretary, is set to become the next head of the Department of Environmental Quality. And Cashwell, the current Department of Administration secretary, is Stein's choice to succeed Wilson. Stein, who defeated Republican Lt. Gov. Mark Robinson last month, and his transition leadership team have been working to fill out positions in the next administration. A public inauguration ceremony for the governor and others elected to statewide executive branch positions is set for Jan. 11 in Raleigh. It’s anticipated that Stein will get officially sworn as governor earlier as the new year begins. His Cabinet appointees — likely 11 in all — will be subject to confirmation by the state Senate. Since a 2016 law that laid out the confirmation process, the Senate has rejected only one Cabinet appointee — Dionne Delli-Gatti as environment secretary in 2021. Wilson's long work history includes stints at the U.S. Environmental Protection Agency and the Conservation Trust for North Carolina, and as national political director for the Sierra Club. Stein picked Sangvai as the Department of Health and Human Services secretary, which in part oversees Medicaid, mental health services and state-run hospitals. Sangvai, a Duke University medical school professor, recently served as Duke Regional Hospital president and is current president of the North Carolina Medical Board, which licenses and disciplines doctors. Esparza, a former U.S. Small Business Administration administrator and previous candidate for state treasurer from Charlotte, is in place to succeed Cashwell leading the Department of Administration. The department oversees many internal business affairs within government, including purchasing and contracting, the state’s motor fleet, and government buildings and property. Leslie Cooley Dismukes, the criminal bureau chief within Stein's state Department of Justice, is the governor-elect's choice to lead the Department of Adult Correction, which includes the state's prisons and probation and parole services. Dismukes was previously a criminal division chief for the U.S. attorney's office for eastern North Carolina. Other Stein Cabinet choices named Monday were McKinley Wooten Jr. leading the Department of Revenue and Jocelyn Mitnaul Mallette leading the Department of Military and Veterans Affairs. Wooten has had a long state government career and is currently an assistant revenue secretary. Mallette has been a private attorney who graduated from the U.S Air Force Academy and served as an Air Force intelligence officer and prosecutor. Cabinet secretaries yet to be announced include those who would lead the commerce, public safety, information technology and transportation departments. Copyright 2024 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed without permission. Get local news delivered to your inbox!

Smoggy Sasolburg illustrates conflict between economy and clean air

Title: Unveiling the Internet's Edgy Universe: The Rise of Influencers Pushing the BoundariesEx-Nine chief Hugh Marks appointed new ABC bossUnlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her health insurance covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the much-hyped medications didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It's a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It's all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person's response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are typically prescribed along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn't happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It's not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn't respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I'm hoping it's slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.

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NEW YORK , Dec. 11, 2024 /PRNewswire/ -- Scholastic Corporation (NASDAQ: SCHL) announced today that its Board of Directors declared a quarterly cash dividend of $0.20 per share on the Company's Class A and Common Stock for the third quarter of fiscal 2025. The dividend is payable on March 14, 2025 , to all shareholders of record as of the close of business on January 31, 2025 . About Scholastic For more than 100 years, Scholastic Corporation (NASDAQ: SCHL) has been meeting children where they are – at school, at home and in their communities – by creating quality content and experiences, all beginning with literacy. Scholastic delivers stories, characters, and learning moments that empower all kids to become lifelong readers and learners through bestselling children's books, literacy- and knowledge-building resources for schools including classroom magazines, and award-winning, entertaining children's media. As the world's largest publisher and distributor of children's books through school-based book clubs and book fairs, classroom libraries, school and public libraries, retail, and online, and with a global reach into more than 135 countries, Scholastic encourages the personal and intellectual growth of all children, while nurturing a lifelong relationship with reading, themselves, and the world around them. Learn more at www.scholastic.com . SCHL: Financial View original content to download multimedia: https://www.prnewswire.com/news-releases/scholastic-corporation-announces-third-quarter-dividend-302329290.html SOURCE Scholastic Corporation

As the Chinese Lunar New Year approaches, anticipation for the annual Spring Festival Gala, the most-watched television event in China, continues to mount. In recent news, it has been revealed that six language-based programs are currently undergoing review for inclusion in the Gala, with popular comedians Yue Yunpeng and Sun Yue making their presence felt during the review process.

At the recent unveiling event held at the Ministry of Industry and Information Technology, Xiaomi, a renowned Chinese tech company known for its smartphones and various smart devices, showcased its latest innovation in the automotive industry – the small SUV YU7. With a starting price of 30,000 Yuan, this new entry promises to bring a fresh perspective to the competitive SUV market in China.

With his spot in the last 32 secured, Zhang Anda now sets his sights on the next challenge that awaits him in the Snooker Scottish Open. As he prepares to face off against another top-ranked player, fans can expect more thrilling matches and breathtaking moments from this talented snooker sensation.As the sector grappled with these challenges, there was a growing realization that adaptability and innovation were crucial for private banks to survive and thrive in the competitive landscape. Those banks that were able to embrace digital transformation, leverage data analytics, and prioritize customer experience were able to carve out a niche for themselves and stay ahead in the game.

Noninvasive imaging method can penetrate deeper into living tissue December 11, 2024 Massachusetts Institute of Technology Researchers developed a non-invasive imaging technique that enables laser light to penetrate deeper into living tissue, capturing sharper images of cells. This could help clinical biologists study disease progression and develop new medicines. Facebook Twitter Pinterest LinkedIN Email Metabolic imaging is a noninvasive method that enables clinicians and scientists to study living cells using laser light, which can help them assess disease progression and treatment responses. But light scatters when it shines into biological tissue, limiting how deep it can penetrate and hampering the resolution of captured images. Now, MIT researchers have developed a new technique that more than doubles the usual depth limit of metabolic imaging. Their method also boosts imaging speeds, yielding richer and more detailed images. This new technique does not require tissue to be preprocessed, such as by cutting it or staining it with dyes. Instead, a specialized laser illuminates deep into the tissue, causing certain intrinsic molecules within the cells and tissues to emit light. This eliminates the need to alter the tissue, providing a more natural and accurate representation of its structure and function. The researchers achieved this by adaptively customizing the laser light for deep tissues. Using a recently developed fiber shaper -- a device they control by bending it -- they can tune the color and pulses of light to minimize scattering and maximize the signal as the light travels deeper into the tissue. This allows them to see much further into living tissue and capture clearer images. Greater penetration depth, faster speeds, and higher resolution make this method particularly well-suited for demanding imaging applications like cancer research, tissue engineering, drug discovery, and the study of immune responses. "This work shows a significant improvement in terms of depth penetration for label-free metabolic imaging. It opens new avenues for studying and exploring metabolic dynamics deep in living biosystems," says Sixian You, assistant professor in the Department of Electrical Engineering and Computer Science (EECS), a member of the Research Laboratory for Electronics, and senior author of a paper on this imaging technique. She is joined on the paper by lead author Kunzan Liu, an EECS graduate student; Tong Qiu, an MIT postdoc; Honghao Cao, an EECS graduate student; Fan Wang, professor of brain and cognitive sciences; Roger Kamm, the Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering; Linda Griffith, the School of Engineering Professor of Teaching Innovation in the Department of Biological Engineering; and other MIT colleagues. The research will appear in Science Advances . Laser-focused This new method falls in the category of label-free imaging, which means tissue is not stained beforehand. Staining creates contrast that helps a clinical biologist see cell nuclei and proteins better. But staining typically requires the biologist to section and slice the sample, a process that often kills the tissue and makes it impossible to study dynamic processes in living cells. In label-free imaging techniques, researchers use lasers to illuminate specific molecules within cells, causing them to emit light of different colors that reveal various molecular contents and cellular structures. However, generating the ideal laser light with certain wavelengths and high-quality pulses for deep-tissue imaging has been challenging. The researchers developed a new approach to overcome this limitation. They use a multimode fiber, a type of optical fiber which can carry a significant amount of power, could couple it with a compact device called a "fiber shaper." This shaper allows them to precisely modulate the light propagation by adaptively changing the shape of the fiber. Bending the fiber changes the color and intensity of the laser. Building on prior work, the researchers adapted the first version of the fiber shaper for deeper multimodal metabolic imaging. "We want to channel all this energy into the colors we need with the pulse properties we require. This gives us higher generation efficiency and a clearer image, even deep within tissues," says Cao. Once they had built the controllable mechanism, they developed an imaging platform to leverage the powerful laser source to generate longer wavelengths of light, which are crucial for deeper penetration into biological tissues. "We believe this technology has the potential to significantly advance biological research. By making it affordable and accessible to biology labs, we hope to empower scientists with a powerful tool for discovery," Liu says. Dynamic applications When the researchers tested their imaging device, the light was able to penetrate more than 700 micrometers into a biological sample, whereas the best prior techniques could only reach about 200 micrometers. "With this new type of deep imaging, we want to look at biological samples and see something we have never seen before," Liu adds. The deep imaging technique enabled them to see cells at multiple levels within a living system, which could help researchers study metabolic changes that happen at different depths. In addition, the faster imaging speed allows them to gather more detailed information on how a cell's metabolism affects the speed and direction of its movements. This new imaging method could offer a boost to the study of organoids, which are engineered cells that can grow to mimic the structure and function of organs. Researchers in the Kamm and Griffith labs pioneer the development of brain and endometrial organoids that can grow like organs for disease and treatment assessment. However, it has been challenging to precisely observe internal developments without cutting or staining the tissue, which kills the sample. This new imaging technique allows researchers to noninvasively monitor the metabolic states inside a living organoid while it continues to grow. With these and other biomedical applications in mind, the researchers plan to aim for even higher-resolution images. At the same time, they are working to create low-noise laser sources, which could enable deeper imaging with less light dosage. They are also developing algorithms that react to the images to reconstruct the full 3D structures of biological samples in high resolution. In the long run, they hope to apply this technique in the real world to help biologists monitor drug response in real-time to aid in the development of new medicines. "By enabling multimodal metabolic imaging that reaches deeper into tissues, we're providing scientists with an unprecedented ability to observe nontransparent biological systems in their natural state. We're excited to collaborate with clinicians, biologists, and bioengineers to push the boundaries of this technology and turn these insights into real-world medical breakthroughs," You says. This research is funded, in part, by MIT startup funds, a U.S. National Science Foundation CAREER Award, an MIT Irwin Jacobs and Joan Klein Presidential Fellowship, and an MIT Kailath Fellowship. Story Source: Materials provided by Massachusetts Institute of Technology . Original written by Adam Zewe. Note: Content may be edited for style and length. Related Multimedia : Journal Reference : Cite This Page :