48 jili

48 jili It’s Monday, December 23, and the Brooklyn Nets (11-17) and Miami Heat (13-13) are all set to square off from Kaseya Center in Miami. The Nets are currently 6-9 on the road with a point differential of -5, while the Heat have a 7-3 record in their last ten games at home. We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts. Listen to the Rotoworld Basketball Show for the latest fantasy player news, waiver claims, roster advice and more from our experts all season long. Click here or download it wherever you get your podcasts. Game details & how to watch Nets vs. Heat live today Date: Monday, December 23, 2024 Time: 7:30 pm EST Site: Kaseya Center City: Miami, FL Never miss a second of the action and stay up to date with all the latest team stats and player news. Check out our day-by-day NBA schedule page , along with detailed matchup pages that update live in-game. Game odds for Nets vs. Heat The latest odds as of Monday: Odds: Nets (+301), Heat (-382) Spread: Heat -8.5 Over/Under: 213.5 points That gives the Nets an implied team point total of 105.69, and the Heat 110.12. Want to know which sportsbook is offering the best lines for every game on the NBA calendar? Check out the NBC Sports’ Live Odds tool to get all the latest updated info from DraftKings, FanDuel, BetMGM & more! Expert picks & predictions for Monday’s Nets vs. Heat game NBC Sports Bet Best Bet Vaughn Dalzell (@VmoneySports) thinks Ben Simmons will struggle tonight: Ben Simmons Under 8.5 Points (-128) “Simmons scored 10, 12 and 15 points over the last three games versus the Cavs, Raptors and Jazz. Yet, his prop line is 8.5 at Miami -- a much more defensively focused and slower tempo team. Simmons scored 10 total points in three meetings versus Miami in 2023. I like this sell-high spot after three straight Overs. Give me Simmons Under 8.5 points down to 7.5 for +100 or better.” Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700. Our model calculates projections around each moneyline, spread and over/under bet for every game on the NBA calendar based on data points like recent performance, head-to-head player matchups, trends information and projected game totals. Once the model is finished running, we put its projections next to the latest betting lines for the game to arrive at a relative confidence level for each wager. Here are the best bets our model is projecting for today’s Nets & Heat game: Moneyline: NBC Sports Bet is recommending a play on the Miami Heat on the Moneyline. Spread: NBC Sports Bet is leaning towards a play ATS on the Brooklyn Nets at -8.5. Total: NBC Sports Bet is staying away from a play on the Game Total of 213.50. Want even more NBA best bets and predictions from our expert staff & tools? Check out the Expert NBA Predictions page from NBC Sports for money line, spread and over/under picks for every game on today’s calendar! Important stats, trends & insights to know ahead of Nets vs. Heat on Monday · The Heat have won 4 of their last 5 games at home against Eastern Conference teams · The Over is 7-3 in the Heat’s last 10 games · The Nets are 7-3 ATS in their last 10 games as a road underdog If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our NBA Top Trends tool on NBC Sports! Bet the Edge is your source for all things sports betting. Get all of Jay Croucher and Drew Dinsick’s insight weekdays at 6AM ET right here or wherever you get your favorite podcasts. Follow our experts on socials to keep up with all the latest content from the staff: - Jay Croucher (@croucherJD) - Drew Dinsick (@whale_capper) - Vaughn Dalzell (@VmoneySports) - Brad Thomas (@MrBradThomas)Seneca High School's new football leadership core had a little something to prove when 2024 began. The Indians had to show they could still be a dominant team after losing six all-state athletes from 2023. Two of those all-staters were quarterback Gavyn Hoover and running back Jackson Marrs. So they had to fill in the gap at two positions that touch the ball the most in a run-first offense that head coach Cody Hilburn runs. "The thing these guys kept hearing was 'We may take a step back and may have to rebuild a little bit.' That's been a chip on their shoulder. They carried that chip throughout the summer and throughout the season," Hilburn said. "They felt like the work they put in during the offseason, there wasn't going to be that down year." The replacements for Hoover and Marrs throughout the year have been Kaden Clouse and Brodie Probert at quarterback and Roman Miller at the running back position. Miller had gotten a share of the reps last year behind Marrs and had that extended varsity experience, but Clouse was a safety on defense last year and only got reps at quarterback in lopsided games. Clouse is 47 of 74 this year for a 63.5% completion rate and 868 yards, 15 touchdowns and only three interceptions. He's run the ball 110 times for 1,253 yards and 14 more scores. Probert is 10 for 11 for 247 yards and five touchdowns passing. He's toted the ball 75 times for 899 yards and 12 touchdowns. The two are used to splitting reps as they were doing that exact thing in junior varsity before coming the varsity quarterbacks. Miler leads the rushing attack with 1,267 yards on 134 rushes and 22 scores. "We knew what we had in him. He never comes off the field. He plays every rep at linebacker, then turns around and he's going to carry it 15 to 20 times a game," Hilburn said of Miller. That's the type of production Hilburn was looking for to replace his all-state kids in the backfield. Hilburn credits the work ethic immediately after the state championship loss last year to how these guys were able to be productive at this rate. "They knew we had to do some things differently to get back there, and that started in January," he said. "Immediate new leadership began to take place." Now that core of leaders has gotten Seneca into the Class 3 state quarterfinal round against Mount Vernon. The Indians and Mountaineers meet at 1 p.m. Saturday in Mount Vernon. "The group before us set a standard for us, and we're just trying to make that standard," Clouse said. "High expectations from the guys before us, but after a while we knew we could do just as good, if not better," Miller said. That extra work doesn't stop in the state quarterfinal week as Hilburn says his quarterback has been taking extra time to throw passes on Sunday — even though there is no practice — to just make sure he's improving his throwing ability. Seneca was also able to use its four returning offensive linemen as a foundation offensively. Now, the one that graduated was another all-state piece in Brian Bigbee. But having that experience returning on the line helped to pave the way for the guys trying to replace an all-state backfield. "It's easy to run the ball when you have a good line up front. Returning them helped a lot," Clouse said. Another key returner that blocks for Clouse, Probert and Miller is tight end Hagen Ginger. Ginger is a key part of the run game, especially when Seneca runs to the outside and he has to help set the edge. Ginger also leads the team with 17 catches for 362 yards and eight touchdowns. Ginger has helped to fill in for the void left by all-state receiver from last year Ethan Altic. Blaze Graham (10 receptions, 347 yards, six touchdowns) and Ty Harris (12 receptions, 157 yards, two touchdowns) — a transfer from Neosho — have helped to fill in as well. The defense is led by Kye Adams with 75 total tackles. He also has an interception and fumble forced this year. Hunter Hanes has 63 total tackles for the second most and also has one interception. Both are juniors. Adams is one of four players with three sacks on the team. Miller adds 55 tackles and five tackles for loss. Probert has 51 tackles and a pair of sacks. Joseph Renfro has tallied 48 tackles and three sacks to go along with eight tackles for loss, two forced fumbles and two recoveries. Clouse has 46 tackles and two interceptions. Blake Hurn and Morgan Vaughn are two key defensive pieces that were all-state athletes, and the Indians had to find a way to slow opponents down after seeing them graduate. The Indians haven't allowed more than 21 points to an opponent this year and only allow 11.5 on average. They've only been held below 40 by one team, and that same team is the only opponent to keep the final score within less than 28 points. That is Saturday's opposition of Mount Vernon. The two teams met back in Week 2 of the regular season, and Seneca won 35-14.

Pep Guardiola has pledged to step aside if he fails to turn around Manchester City’s poor run of form. The City boss is enduring the worst run of his glittering managerial career after a six-game winless streak featuring five successive defeats and a calamitous 3-3 draw in a match his side had led 3-0. The 53-year-old, who has won 18 trophies since taking charge at the Etihad Stadium in 2016, signed a contract extension through to the summer of 2027 just over a week ago. Yet, despite his remarkable successes, he still considers himself vulnerable to the sack and has pleaded with the club to keep faith. “I don’t want to stay in the place if I feel like I’m a problem,” said the Spaniard, who watched in obvious frustration as City conceded three times in the last 15 minutes in a dramatic capitulation against Feyenoord in midweek. “I don’t want to stay here just because the contract is there. “My chairman knows it. I said to him, ‘Give me the chance to try come back’, and especially when everybody comes back (from injury) and see what happens. “After, if I’m not able to do it, we have to change because, of course, (the past) nine years are dead. “More than ever I ask to my hierarchy, give me the chance. “Will it be easy for me now? No. I have the feeling that still I have a job to do and I want to do it.” City have been hampered by a raft of injuries this term, most pertinently to midfield talisman and Ballon d’Or winner Rodri. The Euro 2024 winner is expected to miss the remainder of the season and his absence has been keenly felt over the past two months. Playmaker Kevin De Bruyne has also not started a match since September. The pressure continues to build with champions City facing a crucial trip to title rivals and Premier League leaders Liverpool on Sunday. Defeat would leave City trailing Arne Slot’s side by 11 points. “I don’t enjoy it at all, I don’t like it,” said Guardiola of his side’s current situation. “I sleep not as good as I slept when I won every game. “The sound, the smell, the perfume is not good enough right now. “But I’m the same person who won the four Premier Leagues in a row. I was happier because I ate better, lived better, but I was not thinking differently from who I am.” Guardiola is confident his side will not stop battling as they bid to get back on track. He said: “The people say, ‘Yeah, it’s the end of that’. Maybe, but we are in November. We will see what happens until the end. “What can you do? Cry for that? You don’t stay long – many, many years without fighting. That is what you try to look for, this is the best (way). “Why should we not believe? Why should it not happen with us?”Penn St. 85, Fordham 66

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BOSTON (AP) — Boston Celtics center Kristaps Porzingis is slated make his season debut Monday night against the Los Angeles Clippers following offseason ankle surgery. The 7-foot-2 Latvian center was upgraded from probable to available about an 90 minutes before tipoff, though Celtics coach Joe Mazzulla said how much he'd play was to be determined. Veteran center Al Horford, who has started 14 of the Celtics 17 games this season, is out Monday with an illness. Fellow big man Luke Kornet is also sitting out as he continues to deal with hamstring tightness. “He has worked hard, he's in good shape. We'll put him in position to be healthy and be successful and do what's best for the team,” Mazzulla said. “He's been pretty consistent, just based on his work ethic and what he's done to get to this point.” Porzingis had surgery to fix a tear in the tissue that holds the ankle tendons in place. The issue during the Celtics' NBA championship run last season. Boston is 14-3 this season, but has missed his presence on the inside, with teams routinely outscoring the defending champions in the paint. Mazzulla acknowledged that how Porzingis plays on the offensive end, particularly how he operates sometimes out of the high and low post, will force some adjustment from how the team has played this season without him on the floor. “I think last year we had an opportunity to see how teams were guarding him,” Mazzulla said. "That'll take a little bit of time to figure out what the coverages are, just get used to that spacing. That'll take some time. ... Then we'll figure out how we go from there." The original window for Porzingis' return following surgery was five to six months. But Celtics president of basketball operations Brad Stevens said before the season that they didn't want to hold to a specific timeline because of the uniqueness of the injury. Porzingis injured his ankle in Game 2 of the NBA Finals against the Dallas Mavericks and missed the next two games. He returned for Game 5, contributing five points and one rebound in 16 minutes as the Celtics beat Dallas 106-88 to clinch their record 18th title. Porzingis averaged 20 points and seven rebounds in 57 games for last season. He signed a $60 million, two-year extension with Boston in the summer of 2023 after the Celtics acquired him in a trade with Washington. AP NBA:MEXICO CITY — It would take years, if ever, for Mexico to accomplish what incoming U.S. President Donald Trump is demanding to avoid tariffs: stemming the flow of migrants and drugs over the border. That’s why Mexican President Claudia Sheinbaum’s efforts to avoid a full-blown trade war might be more about doing enough for both sides to claim success. Even a quick phone call — two days after Trump threatened 25% tariffs against his southern neighbor — seemed to change the tone: Trump said on social media that the Mexican president agreed to “stop people from going to our Southern Border, effective immediately.” Sheinbaum, meanwhile, assured her constituents that she touted to Trump Mexico’s existing approach to migration, which she stressed respects human rights, and that a new deal to collaborate would avoid new tariffs, without providing specifics. The whole exchange was reminiscent of Trump’s first term, when he threatened to send troops to shut down the border and then-President Andres Manuel Lopez Obrador responded by sending the national guard to help apprehend migrants. The move had a limited immediate effect, but sent a strong image that proved enough to at least avert tariffs of up to 25% on all imports from Mexico. Trump’s threats have a “dual objective,” said Palmira Tapia, a political scientist currently working for the government of the State of Mexico. The U.S. president-elect, she said, is simultaneously seeking to appeal to his constituents and strengthen his hand in talks on migration, drugs and trade. Sheinbaum also faces two challenges: She now must find a way to appease Trump to avoid tariffs that could hit 11% of Mexico’s gross domestic product, while also avoiding the perception — at home, and in the White House — that she will easily bend to demands from up north. “She’s talking to Trump, but she’s also talking to the Mexican public. It has to do with giving a dignified response before her voters, but at the same time trying to stop Trump,” said Catalina Perez Correa, a researcher at the Supreme Court’s Center for Constitutional Studies. “She’s saying, ‘I’m not going to let myself be stepped on by Trump.’ She’s saving face in front of the Mexican public.” Migration reality Mexico has long been a stomping ground for the U.S. when it comes to migration policy. It’s been tasked under successive U.S. presidents with beefing up its border security, increasing highway checkpoints and removing migrants from freight trains they often board. Even though migration rose far beyond the 2019 levels in the years after Lopez Obrador’s show of militarizing the border, Mexico has remained an at-times willing partner, accepting most of the millions of migrants who were quickly turned away from the U.S. border during the pandemic. But it hasn’t always been eager to help: The Biden administration often viewed AMLO, as the former president was known, as needing frequent reminders of its expectations for him on enforcement. In 2023, Biden Cabinet officials even visited AMLO in Mexico City just days after Christmas to urge him to do more as a record number of migrants reached the border. Under pressure from the White House during the U.S. election, Mexico helped it decrease border crossings by 65% over an 11-month period starting in December 2023. To do so, Mexican authorities have been detaining migrants in the north of the country and busing them south. There, they are forced to wait until they get an official appointment to apply for asylum in the U.S. — which can take months, if it ever happens at all. It’s all resulted in more than double the number of apprehensions of undocumented migrants between January and August compared with a year earlier, although Mexico has deported few. Experts have said that’s creating a humanitarian crisis in some of the southern cities where migrants are shipped off to. It’s also ratcheting up tensions with some locals, who argue that there aren’t enough jobs or resources to accommodate the newcomers. “What they’re doing now in Mexico is militarization of the border,” said Perez Correa. To further reduce border crossings into the U.S., Mexico could either carry out mass deportations or offer more opportunities to migrants in its territory. Both scenarios seem unrealistic. Simply increasing deportations would go against Lopez Obrador’s policy — which Sheinbaum inherited — of trying to address the problems in their origin countries that pushed them to leave, and it would be an expense for Mexico. After Sheinbaum’s call with Trump, she reiterated her government offers migrants options for international protection in its territory or “voluntary or assisted return” to their countries. The second option doesn’t seem feasible either: Most people want to go to the U.S., where they expect to have higher-paying jobs, more family or community support, and greater safety than in Mexico. Chemical diversions Deaths related to fentanyl — the cheap, synthetic opioid — have reached epidemic levels in the U.S. That’s why reining in the flow of the drug was on Trump’s list of demands. Should recent history be any indication, intervention is never simple. The U.S. arrest of a Mexican alleged drug leader has led to prolonged shootouts in recent months. And in any case, some academics argue simply confiscating more drugs means traffickers learn to produce more, to meet U.S. demand. So far, Mexico has worked to improve its technical capabilities to detect illicit substances at its ports, especially precursor chemicals and fentanyl. “The Navy has provided material and personnel to all ports for the fulfillment of these tasks, the personnel have the necessary training to be able to detect these substances,” said Captain Jose Barradas in an interview at the Manzanillo port, in the state of Colima. “All merchandise that arrives is prone to review under strict security protocols.” Sheinbaum also picked former Mexico City police chief Omar Garcia Harfuch to lead a new national security strategy, a move that was read inside Mexico as a signal of her willingness to increase enforcement in areas where the previous administration had been more hands-off. There’s more that could be done — but it would be hard. Trying to seize these substances at ports is insufficient because synthetic drugs tend to be very small, making them more difficult to detect than traditional drugs, said Victoria Dittmar, researcher at Insight Crime. Those who produce them often innovate with their recipes and use new chemicals that are not illegal. “Mexico can open collaboration paths with the private sector, with the chemical industry, because they know perfectly well its supply chains and the vulnerable areas where there could be diversions,” she said. “This collaboration is essential.” Mexico can also work to identify intermediaries that connect fentanyl producers with chemical suppliers abroad and in the country, people who work in certain companies and are authorized to divert these substances, according to Dittmar. Still, “the main weakness is not putting demand reduction as a priority, to prevent overdose deaths,” Dittmar said. “It’s a shared responsibility. It’s not just the fault of Mexico, the U.S. or Canada, but it’s an issue that affects the entire North American region.” A senior Mexican official said that the country’s actions to address drug trafficking have moved the nation in the direction of the fentanyl crackdown that Trump is demanding. The official cited a new law that will allow for coordinated intelligence efforts that is due to be implemented next year. History repeats It’s plausible that in the medium-term Trump will lower the intensity of his threats because a trade war would be the worst case scenario for both countries, said Tapia, the political scientist. But until then, she said, “Sheinbaum is on trial as to how well she will do” relative to her predecessor, who had a respectful relationship with Trump and often praised him. One strategy that Sheinbaum could pursue: Finding ways to give Trump the appearance of political victory. That was part of the rationale behind AMLO’s deployment of the National Guard — a move Trump still talks about now. “We got thousands of Mexicans patrolling our border free of charge,” he boasted at a recent event about his relationship with AMLO. “He’s a socialist,” Trump said. “But these are minor details.” ——— (With assistance from Eric Martin, Carolina Millan and Ramsey Al-Rikabi.) ©2024 Bloomberg L.P. Visit bloomberg.com. Distributed by Tribune Content Agency, LLC.Big Tech is warming up to Trump — to gain what?

*Targets cocoa, sesame, ginger export in 2025 *Food crises reported in 31 states, severely affecting North-East Ndubuisi Francis in Abuja The Economic Management Team (EMT), led by the Minister of Finance and Coordinating Minister of the Economy, Wale Edun, met in Abuja yesterday to review critical economic policies and progress in key sectors. The meeting, it was disclosed, focused on strengthening Nigeria’s economic resilience, with presentations from the Central Bank of Nigeria (CBN) and the Ministry of Agriculture addressing foreign exchange (FX) market reforms and agricultural performance. According to a statement by the Director, Press and Public Relations, Ministry of Finance, Mohammed Manga, the CBN presentation centred around the apex bank’s activities, including enhancing capital market efficiency. This was with emphasis on the launch of the Electronic Foreign Exchange Matching System (EFEMS) to improve transparency and market operations, hhased-out high-interest FX swaps to stabilise financial markets, settlement of 80 per cent of FX forwards obligations, boosting liquidity and market confidence. It also included maintaining “robust external reserves and supported exchange rate appreciation.’ On the agricultural sector, the statement disclosed that the presentation was on the 2024 wet season performance. The presentation, the statement said, revealed that there was a 4.5 per cent increase in overall crop production, though millet declined by 0.2 per cent. They year 2024 also witnessed rising production costs as maize production costs surged by 69.7 per cent. Significant food price increases were reported, including cowpea prices which surged by 300 per cent. The statement added that food crises were reported in 31 states, severely affecting the North East. However, it noted that mechanisation and farmland expansion improved slightly, with 2 per cent growth in tractor use and a 2.3 per cent increase in cultivated farmland. For 2025, the EMT is targeting a boost in food security with hybrid seed production, technology adoption, and climate-smart practices. It also seeks to promote export crops like cocoa, sesame, and ginger, enhance rural infrastructure through cold chain facilities, feeder roads, and electrification. “The Minister commended the progress made in both sectors, urging all stakeholders to accelerate efforts toward economic stability, food security, and sustainable growth. “He emphasized the need for coordinated implementation of policies to support President Bola Ahmed Tinubu’s Renewed Hope Agenda and ensure affordable food and improved living conditions for Nigerians,” the statement said.

A Minnesota House committee voted along party lines Tuesday to have the public pay the legal bill of a Democratic lawmaker over an outside employment action. The decision covers about $10,400 in attorney fees for Rep. Bianca Virnig. The first-term Eagan legislator alleged that her former employer, a nonprofit school cooperative known as BrightWorks, reduced her pay and hours following her first session of service in the Legislature. A state law is meant to bar such an action by granting protection to legislators who return to their regular jobs when the session calendar wraps up for the year. Details of the settlement were not disclosed. But fellow Democrats say because the case was tied to her House service, reimbursement of legal fees is appropriate. “If this is precedent-setting, I think it’s a good precedent because I do think that for members of either party, if they are faced with a similar circumstance in the future, we would want them to be represented and want there to be the opportunity for them to have their rights advocated for,” said Minneapolis Rep. Jamie Long, DFL chair of the committee. Republicans objected, but came up on the losing end of a pair of 9-5 votes to pause the approval. “I find this very troubling,” said Rep. Jim Nash of Waconia. “The House of Representatives is a third party at best, and we are now going to take taxpayer dollars and pay for these legal fees when the representative, Rep. Virnig, did receive a settlement.” House Minority Leader Lisa Demuth, R-Cold Spring, said she supports the ability of Virnig to seek compensation for a possible rights violation. But she said BrightWorks should be held accountable if it was accused of violating the law instead. “Employers need to follow the law and employee and Minnesota taxpayers should not be on the hook for when that does not happen,” she said. BrightWorks didn’t respond to an email message about the matter. A request placed with the House DFL caucus for a copy of the employment dispute settlement wasn’t immediately fulfilled. Related Articles

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PLEASANTON, Calif. , Dec. 23, 2024 /PRNewswire/ -- 10x Genomics, Inc. (Nasdaq: TXG), a leader in single cell and spatial biology, announced today it had secured a permanent injunction in the U.S. District Court for the District of Delaware against the GeoMx products sold by Bruker Corporation (Nasdaq: BRKR), which acquired the product line from NanoString Technologies. To minimize the risk of disruption to ongoing research, 10x Genomics requested a carve-out for GeoMx users who installed an instrument prior to the trial in November 2023 . The injunction, which the Court said it will enter in January 2025 , is expected to prohibit Bruker from making, using, selling or offering to sell in the United States its GeoMx Digital Spatial Profiler and associated instruments, reagents and services for RNA and protein detection. At the request of 10x Genomics, the injunction will not block ongoing research by researchers who installed a GeoMx instrument prior to November 18, 2023 . Such customers can continue to purchase GeoMx reagents for use with existing GeoMx instruments for purposes of continuing their ongoing research. The Court found that making such an exception for ongoing research strikes a "workable balance between protecting the patentee's rights and protecting the public from the injunction's adverse effects." In addition, the Court affirmed the $31 million damages awarded by the November 2023 jury verdict, as well as supplemental damages and interest that will be added to the total damages when final judgment is entered. "Today's decision helps to safeguard our decade-long investment in innovation and ensures we can continue to develop groundbreaking technologies that help our customers revolutionize science," said Eric Whitaker , Chief Legal Officer at 10x Genomics. "10x exists to fuel scientific progress – not stifle it – and that is why we've done our utmost to ensure this injunction was structured to protect both our intellectual property and existing GeoMx customers' ongoing research." The Court recognized the harm NanoString's infringing conduct caused 10x when it wrote in its ruling, "Having been careful not to license its technology, 10x suffers when it proclaims itself as an innovator in spatial genomics but a competitor is using the same innovative, patented technology." Today's Court decision follows a November 2023 jury verdict that found that NanoString's GeoMx products willfully infringed seven patents exclusively licensed to 10x Genomics by Prognosys. During the trial, the jury heard testimony from the sole inventor of the patents, Illumina co-founder Mark Chee , and NanoString CEO Brad Gray and NanoString CSO Joe Beechem. After hearing all of the evidence, the jury determined that all seven patents had been infringed by NanoString, that each patent was valid, that NanoString willfully infringed those patents and that monetary damages were owed to 10x for the infringement of all seven patents. In affirming the jury's finding that NanoString willfully infringed, the Court relied on the evidence showing that NanoString knew or was willfully blind that its acts would cause infringement of 10x's rights. The asserted patents in Case No. 21-cv-653-MFK include (a) U.S. Patent No. 10,472,669; (b) U.S. Patent No. 10,961,566; (c) U.S. Patent No. 10,983,113; (d) U.S. Patent No. 10,996,219; (e) U.S. Patent No. 11,001,878; (f) U.S. Patent No. 11,008,607 and (g) U.S. Patent No. 11,293,917. About 10x Genomics 10x Genomics is a life science technology company building products to accelerate the mastery of biology and advance human health. Our integrated solutions include instruments, consumables and software for single cell and spatial biology, which help academic and translational researchers and biopharmaceutical companies understand biological systems at a resolution and scale that matches the complexity of biology. Our products are behind breakthroughs in oncology, immunology, neuroscience and more, fueling powerful discoveries that are transforming the world's understanding of health and disease. To learn more, visit 10xgenomics.com or connect with us on LinkedIn or X (Twitter) . Forward Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 as contained in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject to the "safe harbor" created by those sections. All statements included in this press release, other than statements of historical facts, may be forward-looking statements. Forward-looking statements generally can be identified by the use of forward-looking terminology such as "may," "might," "will," "should," "expect," "plan," "anticipate," "could," "intend," "target," "project," "contemplate," "believe," "see," "estimate," "predict," "potential," "would," "likely," "seek" or "continue" or the negatives of these terms or variations of them or similar terminology, but the absence of these words does not mean that a statement is not forward-looking. These forward-looking statements include statements regarding litigation and remedies as well as possible outcomes of litigation. These forward-looking statements do not reflect that our success will depend on our ability to obtain, maintain and protect our intellectual property rights, intellectual property litigation could be expensive, time-consuming, unsuccessful and could interfere with our ability to develop, manufacture and commercialize our products or technologies, litigation outcomes are unpredictable or there may be changes in our litigation strategy. These statements are based on management's current expectations, forecasts, beliefs, assumptions and information currently available to management. Actual outcomes and results could differ materially from these statements due to a number of factors and such statements should not be relied upon as representing 10x Genomics, Inc.'s views as of any date subsequent to the date of this press release. 10x Genomics, Inc. disclaims any obligation to update any forward-looking statements provided to reflect any change in 10x Genomics' expectations or any change in events, conditions or circumstances on which any such statement is based, except as required by law. The material risks and uncertainties that could affect 10x Genomics, Inc.'s financial and operating results and cause actual results to differ materially from those indicated by the forward-looking statements made in this press release include those discussed under the captions "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operations" in the company's most recently-filed 10-K for the fiscal year ended December 31, 2023 and elsewhere in the documents 10x Genomics, Inc. files with the Securities and Exchange Commission from time to time. Disclosure Information 10x Genomics uses filings with the Securities and Exchange Commission, our website ( www.10xgenomics.com ), press releases, public conference calls, public webcasts and our social media accounts as means of disclosing material non-public information and for complying with our disclosure obligations under Regulation FD. Contacts Investors: investors@10xgenomics.com Media: media@10xgenomics.com View original content to download multimedia: https://www.prnewswire.com/news-releases/us-district-court-awards-10x-genomics-permanent-injunction-in-patent-infringement-lawsuit-against-bruker-corporations-geomx-products-302338627.html SOURCE 10x Genomics, Inc.’Twas the night before Christmas, when all through the house Not a creature was stirring, not even a mouse; The stockings were hung by the chimney with care In hopes that St. Nicholas soon would be there; The children were nestled all snug in their beds, While visions of sugar-plums danced in their heads; And mamma in her kerchief, and I in my cap, Had just settled our brains for a long winter’s nap, When out on the lawn there arose such a clatter, I sprang from the bed to see what was the matter. Away to the window I flew like a flash, Tore open the shutters and threw up the sash. The moon on the breast of the new-fallen snow Gave the lustre of mid-day to objects below, When, what to my wondering eyes should appear, But a miniature sleigh, and eight tiny reindeer, With a little old driver, so lively and quick, I knew in a moment it must be St. Nick. More rapid than eagles his coursers they came, And he whistled, and shouted, and called them by name: “Now, Dasher! now, Dancer! now, Prancer and Vixen! On, Comet! on, Cupid! on, Donder and Blitzen! To the top of the porch! to the top of the wall! Now dash away! dash away! dash away all!” As dry leaves that before the wild hurricane fly, When they meet with an obstacle, mount to the sky; So up to the house-top the coursers they flew, With the sleigh full of Toys, and St. Nicholas too. And then, in a twinkling, I heard on the roof The prancing and pawing of each little hoof. As I drew in my head, and was turning around, Down the chimney St. Nicholas came with a bound. He was dressed all in fur, from his head to his foot, And his clothes were all tarnished with ashes and soot; A bundle of Toys he had flung on his back, And he looked like a peddler just opening his pack. His eyes—how they twinkled! his dimples how merry! His cheeks were like roses, his nose like a cherry! His droll little mouth was drawn up like a bow, And the beard of his chin was as white as the snow; The stump of a pipe he held tight in his teeth, And the smoke it encircled his head like a wreath; He had a broad face and a little round belly, That shook when he laughed, like a bowlful of jelly. He was chubby and plump, a right jolly old elf, And I laughed when I saw him, in spite of myself; A wink of his eye and a twist of his head, Soon gave me to know I had nothing to dread; He spoke not a word, but went straight to his work, And filled all the stockings; then turned with a jerk, And laying his finger aside of his nose, And giving a nod, up the chimney he rose; He sprang to his sleigh, to his team gave a whistle, And away they all flew like the down of a thistle. But I heard him exclaim, ere he drove out of sight, “Happy Christmas to all, and to all a good-night.” — “A Visit From St. Nicholas,” by Clement Clarke Moore Be the first to know Get local news delivered to your inbox!BOSTON (AP) — Boston Celtics center Kristaps Porzingis is slated make his season debut Monday night against the Los Angeles Clippers following offseason ankle surgery. The 7-foot-2 Latvian center was upgraded from probable to available about an 90 minutes before tipoff, though Celtics coach Joe Mazzulla said how much he'd play was to be determined. Veteran center Al Horford, who has started 14 of the Celtics 17 games this season, is out Monday with an illness. Fellow big man Luke Kornet is also sitting out as he continues to deal with hamstring tightness. “He has worked hard, he's in good shape. We'll put him in position to be healthy and be successful and do what's best for the team,” Mazzulla said. “He's been pretty consistent, just based on his work ethic and what he's done to get to this point.” Porzingis had surgery to fix a tear in the tissue that holds the ankle tendons in place. The issue limited him to seven playoff games during the Celtics' NBA championship run last season. Boston is 14-3 this season, but has missed his presence on the inside, with teams routinely outscoring the defending champions in the paint. Mazzulla acknowledged that how Porzingis plays on the offensive end, particularly how he operates sometimes out of the high and low post, will force some adjustment from how the team has played this season without him on the floor. “I think last year we had an opportunity to see how teams were guarding him,” Mazzulla said. "That'll take a little bit of time to figure out what the coverages are, just get used to that spacing. That'll take some time. ... Then we'll figure out how we go from there." The original window for Porzingis' return following surgery was five to six months. But Celtics president of basketball operations Brad Stevens said before the season that they didn't want to hold to a specific timeline because of the uniqueness of the injury. Porzingis injured his ankle in Game 2 of the NBA Finals against the Dallas Mavericks and missed the next two games. He returned for Game 5, contributing five points and one rebound in 16 minutes as the Celtics beat Dallas 106-88 to clinch their record 18th title. Porzingis averaged 20 points and seven rebounds in 57 games for last season. He signed a $60 million, two-year extension with Boston in the summer of 2023 after the Celtics acquired him in a trade with Washington. AP NBA: https://apnews.com/hub/nbaBy LISA MASCARO and ALANNA DURKIN RICHER WASHINGTON (AP) — The House Ethics Committee’s long-awaited report on Matt Gaetz documents a trove of salacious allegations , including sex with an underage girl, that tanked the Florida Republican’s bid to lead the Justice Department . Related Articles National Politics | An analyst looks ahead to how the US economy might fare under Trump National Politics | Trump again calls to buy Greenland after eyeing Canada and the Panama Canal National Politics | House Ethics Committee accuses Gaetz of ‘regularly’ paying for sex, including with 17-year-old girl National Politics | Trump wants mass deportations. For the agents removing immigrants, it’s a painstaking process National Politics | Many Americans have come to rely on Chinese-made drones. Now lawmakers want to ban them. Citing text messages, travel receipts, online payments and testimony, the bipartisan committee paints a picture of a lifestyle in which Gaetz and others connected with younger women for drug-fueled parties, events or trips, with the expectation the women would be paid for their participation. The former congressman, who filed a last-minute lawsuit to try to block the report’s release on Monday, slammed the committee’s findings. Gaetz has denied any wrongdoing and has insisted he never had sex with a minor. And a Justice Department investigation into the allegations ended without any criminal charges filed against him. “Giving funds to someone you are dating — that they didn’t ask for — and that isn’t ‘charged’ for sex is now prostitution?!?” Gaetz wrote in one post on Monday. “There is a reason they did this to me in a Christmas Eve-Eve report and not in a courtroom of any kind where I could present evidence and challenge witnesses.” Here’s a look at some of the committee’s key findings: The committee found that between 2017 and 2020, Gaetz paid tens of thousands of dollars to women “likely in connection with sexual activity and/or drug use.” He paid the women using through online services such as PayPal, Venmo, and CashApp and with cash or check, the committee said. The committee said it found evidence that Gaetz understood the “transactional nature” of his relationships with the women. The report points to one text exchange in which Gaetz balked at a woman’s request that he send her money, “claiming she only gave him a ‘drive by.’” Women interviewed by the committee said there was a “general expectation of sex,” the report said. One woman who received more than $5,000 from Gaetz between 2018 and 2019 said that “99 percent of the time” that when she hung out with Gaetz “there was sex involved.” However, Gaetz was in a long-term relationship with one of the women he paid, so “some of the payments may have been of a legitimate nature,” the committee said. Text messages obtained by the committee also show that Gaetz would ask the women to bring drugs to their “rendezvous,” the report said. While most of his encounters with the women were in Florida, the committee said Gaetz also traveled “on several occasions” with women whom he paid for sex. The report includes text message exchanges in which Gaetz appears to be inviting various women to events, getaways or parties, and arranging airplane travel and lodging. Gaetz associate Joel Greenberg, who pleaded guilty to sex trafficking charges in 2021, initially connected with women through an online service. In one text with a 20-year-old woman, Greenberg suggested if she has a friend, the four of them could meet up. The woman responded that she usually does “$400 per meet.” Greenberg replied: “He understands the deal,” along with a smiley face emoji. Greenberg asks if they are old enough to drink alcohol, and sent the woman a picture of Gaetz. The woman responded that her friend found him “really cute.” “Well, he’s down here for only for the day, we work hard and play hard,” Greenberg replied. The report details a party in July 2017 in which Gaetz is accused of having sex with “multiple women, including the 17-year-old, for which they were paid.” The committee pointed to “credible testimony” from the now-woman herself as well as “multiple individuals” who corroborated the allegation. The then-17-year-old — who had just completed her junior year in high school — told the committee that Gaetz paid her $400 in cash that night, “which she understood to be payment for sex,” according to the report. The woman acknowledged that she had taken ecstasy the night of the party, but told the committee that she was “certain” of her sexual encounters with the then-congressman. There’s no evidence that Gaetz knew she was a minor when he had sex with her, the committee said. The woman told the committee she didn’t tell Gaetz she was under 18 at the time and that he didn’t how old she was. Rather, the committee said Gaetz learned she was a minor more than a month after the party. But he stayed in touch with her after that and met up with her for “commercial sex” again less than six months after she turned 18, according to the committee. In sum, the committee said it authorized 29 subpoenas for documents and testimony, reviewed nearly 14,000 documents and contacted more than two dozen witnesses. But when the committee subpoenaed Gaetz for his testimony, he failed to comply. “Gaetz pointed to evidence that would ‘exonerate’ him yet failed to produce any such materials,” the committee said. Gaetz “continuously sought to deflect, deter, or mislead the Committee in order to prevent his actions from being exposed.” The report details a months-long process that dragged into a year as it sought information from Gaetz that he decried as “nosey” and a “weaponization” of government against him. In one notable exchange, investigators were seeking information about the expenses for a 2018 get-away with multiple women to the Bahamas. Gaetz ultimately offered up his plane ticket receipt “to” the destination, but declined to share his return “from” the Bahamas. The report said his return on a private plane and other expenses paid by an associate were in violation of House gift rules. In another Gaetz told the committee he would “welcome” the opportunity to respond to written questions. Yet, after it sent a list of 16 questions, Gaetz said publicly he would “no longer” voluntarily cooperate. He called the investigation “frivolous,” adding: “Every investigation into me ends the same way: my exoneration.” The report said that while Gaetz’s obstruction of the investigation does not rise to a criminal violation it is inconsistent with the requirement that all members of Congress “act in a manner that reflects creditably upon the House.” The committee began its review of Gaetz in April 2021 and deferred its work in response to a Justice Department request. It renewed its work shortly after Gaetz announced that the Justice Department had ended a sex trafficking investigation without filing any charges against him. The committee sought records from the Justice Department about the probe, but the agency refused, saying it doesn’t disclose information about investigations that don’t result in charges. The committee then subpoenaed the Justice Department, but after a back-and-forth between officials and the committee, the department handed over “publicly reported information about the testimony of a deceased individual,” according to the report. “To date, DOJ has provided no meaningful evidence or information to the Committee or cited any lawful basis for its responses,” the committee said. Many of the women who the committee spoke to had already given statements to the Justice Department and didn’t want to “relive their experience,” the committee said. “They were particularly concerned with providing additional testimony about a sitting congressman in light of DOJ’s lack of action on their prior testimony,” the report said. The Justice Department, however, never handed over the women’s statements. The agency’s lack of cooperation — along with its request that the committee pause its investigation — significantly delayed the committee’s probe, lawmakers said.

Liverpool held in Newcastle thriller, Arsenal inflict Amorim’s first defeatBOSTON (AP) — Boston Celtics center Kristaps Porzingis is slated make his season debut Monday night against the Los Angeles Clippers following offseason ankle surgery. The 7-foot-2 Latvian center was upgraded from probable to available about an 90 minutes before tipoff, though Celtics coach Joe Mazzulla said how much he'd play was to be determined. Veteran center Al Horford, who has started 14 of the Celtics 17 games this season, is out Monday with an illness. Fellow big man Luke Kornet is also sitting out as he continues to deal with hamstring tightness. “He has worked hard, he's in good shape. We'll put him in position to be healthy and be successful and do what's best for the team,” Mazzulla said. “He's been pretty consistent, just based on his work ethic and what he's done to get to this point.” Porzingis had surgery to fix a tear in the tissue that holds the ankle tendons in place. The issue limited him to seven playoff games during the Celtics' NBA championship run last season. Boston is 14-3 this season, but has missed his presence on the inside, with teams routinely outscoring the defending champions in the paint. Mazzulla acknowledged that how Porzingis plays on the offensive end, particularly how he operates sometimes out of the high and low post, will force some adjustment from how the team has played this season without him on the floor. “I think last year we had an opportunity to see how teams were guarding him,” Mazzulla said. "That'll take a little bit of time to figure out what the coverages are, just get used to that spacing. That'll take some time. ... Then we'll figure out how we go from there." The original window for Porzingis' return following surgery was five to six months. But Celtics president of basketball operations Brad Stevens said before the season that they didn't want to hold to a specific timeline because of the uniqueness of the injury. Porzingis injured his ankle in Game 2 of the NBA Finals against the Dallas Mavericks and missed the next two games. He returned for Game 5, contributing five points and one rebound in 16 minutes as the Celtics beat Dallas 106-88 to clinch their record 18th title. Porzingis averaged 20 points and seven rebounds in 57 games for last season. He signed a $60 million, two-year extension with Boston in the summer of 2023 after the Celtics acquired him in a trade with Washington. AP NBA: https://apnews.com/hub/nba