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jackpot slotvip Liverpool punish rivals’ errors with dominant win over Leicester to stretch lead( MENAFN - ACN NewsWire) Hua medicine Announces Successful U.S. Phase I Results on Its 2nd Generation GKA Candidate SHANGHAI, Nov 30, 2024 - (ACN Newswire) - Hua Medicine (the“Company”, HKEx stock code: 2552) announced today that the Company has successfully completed a Phase I clinical trial on its 2nd generation GKA candidate in U.S. at the 9th China BioMed Innovation and investment conference (CBIIC). The Phase Ia clinical trial of the second-generation GKA (HM-002-1005) was conducted in the United States in 40 subjects with Type 2 diabetes (T2D). This trial was randomized, double-blind, placebo-controlled, single-dose, focusing on safety, tolerability, and pharmacokinetics. The second-generation GKA is a novel molecular entity with optimized physicochemical properties, holding new patents, and serving as the prodrug of dorzagliatin (HMS5552). This study designed for once-daily oral administration. Its aim is to extend the drug's action duration in the body through sustained-release technology, enhance patient compliance, and prolong the stimulation of GLP-1 secretion in the intestines. The Single Ascending Dose (SAD) study demonstrates that HM-002-1005 tablets can be rapidly converted to HMS5552 in the human body, with minimal exposure level of prodrug in both blood and urine. The t1/2 (biological half-life) after a single dose of HM-002-1005 tablets was prolonged compared to dorzagliatin tablets. The Cmax of HMS5552 in plasma after a 184.5mg single dose is comparable to the plasma concentration of HMS5552 after a 75mg single dose of dorzagliatin tablet; likewise, the daily AUC of HMS5552 in plasma after a single dose of HM-002-1005 tablets is comparable to the exposure level of HMS5552 after a 75mg BID dose of dorzagliatin tablets. The research indicates that HM-002-1005 tablets are near-completely converted to HMS5552 in human, and its pharmacokinetic characteristics support for once-daily oral administration. The development of HM-002-1005 tablets not only contributes to enhancing patient medication adherence and effectively control blood glucose levels within 24 hours; meanwhile, it also offers the opportunity to explore the Maximum Tolerated Dose above 150mg daily to achieve better efficacy. The 75 mg BID dose regiment was developed under the concept of Minimum Therapeutic Effective Dose in Chinese T2D patients who suffered from an impairment of insulin secretion and significant reduction of early phase insulin. The different disease characters of T2D with obesity in western patient population would benefit dorzagliatin from its effects on GLP-1 secretion and improvement of insulin sensitivity. With the confirmation that the exposure level of HM-002-1005 tablets at 184.5mg is comparable to dorzagliatin tablets at 75mg (BID), we will further optimize the dosage form followed by a Multiple Ascending Dose (MAD) clinical development of the 2nd generation GKA in China and the United States. Dr. Li CHEN, founder and CEO of Hua Medicine, stated,“Hua Medicine has always been committed to treating Type 2 diabetes at its root cause by restoring patients' ability to autonomously regulate blood glucose levels. Over the course of a decade, the Company has selected dosing and clinical research protocols that are safe and effective for the majority of Chinese diabetes patients, leading to the successful development of GKA and the clinical application of dorzagliatin. Building on this foundation, the Company will undergo a strategic upgrade by further exploring the therapeutic potential of GKA, enriching its product pipeline and seeking partners both domestically and internationally, in order to benefit a broader range of patients, expand into global markets, and effectively establish the brand identity of GKA medications while maximizing the commercial potential of our global first-in-class drugs.” About Hua Medicine Hua Medicine (The“Company”) is an innovative drug development and commercialization company based in Shanghai, China, with companies in the United States and Hong Kong. Hua Medicine focuses on developing novel therapies for patients with unmet medical needs worldwide. Based on global resources, Hua Medicine teams up with global high-calibre people to develop breakthrough technologies and products, which contribute to innovation in diabetes care. Hua Medicine's cornerstone product HuaTangNing (Dorzagliatin tablets), targets the glucose sensor glucokinase, restores glucose sensitivity in T2D patients, and stabilizes imbalances in blood glucose levels in patients. HuaTangNing was approved by the National Medical Products Administration (NMPA) of China on September 30th, 2022. It can be used alone or in combination with metformin for adult T2D patients. For patients with chronic kidney disease (CKD), no dose adjustment is required. It is an oral hypoglycemic drug that can be used for patients with Type 2 diabetes with renal function impairment. For more information Hua Medicine Website: Investors E-mail: ... Media E-mail: ... MENAFN30112024002725003249ID1108941842 Legal Disclaimer: MENAFN provides the information “as is” without warranty of any kind. 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Marianne Williamson launches bid to become next DNC chairIn the latest episode of Newshour Agenda, Madhavdas GK discusses demise of former PM Manmohan Singh. Former Prime Minister Manmohan Singh on Thursday passed away after he was admitted to the emergency department of AIIMS Delhi. Prime Minister Narendra Modi and other leaders from across political parties paid tributes to the former Prime Minister. Watch the show to know more. #sampitroda #manmohansingh #manmohansinghdemise #congress #timesnowFollow Madhavdas G:On X(Formerly Twitter): https://x.com/madhavgk On Instagram: https://www.instagram.com/madhavgk?igsh=MTg5eWdwMTZ4cndtcw==

Africa’s top billionaires have amassed their wealth through innovation, resilience, and visionary business strategies, transforming industries along the way. From manufacturing and mining to telecommunications and consumer goods, these industry leaders are not only shaping Africa’s economic landscape but also leaving a global impact. Explore the sectors they dominate, the lifestyles they lead, and the journeys that brought them success, revealing how their influence extends far beyond their financial worth to drive change across the continent. PAY ATTENTION: Got a Minute? Complete Our Quick Survey About Legit.ng Today! 1. Aliko Dangote Net Worth: $15.6 billion Sector: Manufacturing (Cement, Sugar, Flour) Aliko Dangote, the richest man in Africa for over a decade, built his wealth through Dangote Group, a conglomerate that dominates the African market in cement, sugar, and flour production. Despite his immense wealth, Dangote maintains a relatively low-profile lifestyle. His journey began with trading commodities, and today, he is spearheading projects like the Dangote Refinery, which will significantly impact Nigeria's oil industry . Read also Just in: Lagos seals Adeboye’s RCCG, 8 other top establishments, full list emerges PAY ATTENTION : Standing out in social media world? Easy! "Mastering Storytelling for Social Media" workshop by Legit.ng. Join Us Live! 2. Johann Rupert Net Worth: $10.7 billion Sector: Luxury Goods Johann Rupert, a South African billionaire, heads Compagnie Financière Richemont, known for luxury brands like Cartier and Montblanc. His understated yet luxurious lifestyle reflects his company’s high-end clientele. Rupert’s journey was rooted in his father’s tobacco business, which he diversified into the global luxury goods empire it is today. 3. Nicky Oppenheimer Net Worth: $8.4 billion Sector: Mining (Diamonds) Nicky Oppenheimer, a diamond magnate, made his fortune through the Oppenheimer family’s 40% stake in De Beers, the world’s largest diamond producer. His family sold its stake in 2012 for $5.1 billion. Though private, Oppenheimer enjoys philanthropy, particularly in environmental conservation. His journey started in the diamond mines, and he eventually steered De Beers to global prominence. 4. Abdulsamad Rabiu Net Worth: $8.1 billion Sector: Manufacturing (Cement, Sugar, Real Estate) Read also Nigeria, Brazil sign MoU to boost agribusiness across all 774 local governments Abdulsamad Rabiu is another Nigerian industrialist who made his wealth through BUA Group, a conglomerate in cement, sugar, and real estate. Known for his quiet and modest lifestyle, Rabiu expanded his family business into one of Nigeria’s largest manufacturing companies. His journey highlights his ability to navigate Nigeria’s complex business environment. 5. Nassef Sawiris Net Worth: $7.2 billion Sector: Construction, Chemicals Egypt’s Nassef Sawiris, part of the wealthiest family in Egypt, runs Orascom Construction and is heavily invested in global giants like Adidas. His journey in construction has made him one of the world’s most influential investors. Despite his vast fortune, Sawiris prefers to keep a low profile. 6. Mike Adenuga Net Worth: $6.1 billion Sector: Telecommunications, Oil Mike Adenuga, Nigeria’s second-richest man, made his fortune in telecommunications and oil, founding Globacom, Nigeria’s second-largest telecom company. He also owns Conoil, a major oil exploration firm. Known for his opulent lifestyle, Adenuga’s journey is marked by his relentless ambition, starting with small ventures and growing into a telecom and oil powerhouse. Read also Tinubu’s govt, Brazil sign MoU to boost agribusiness in Nigeria 7. Issad Rebrab Net Worth: $5.1 billion Sector: Food and Beverage Algeria’s Issad Rebrab made his fortune through Cevital, the country’s largest privately-held conglomerate. Cevital operates one of the world’s largest sugar refineries. Known for his down-to-earth lifestyle, Rebrab’s journey began in humble beginnings before establishing a food empire that spans across continents. 8. Naguib Sawiris Net Worth: $3.3 billion Sector: Telecom, Media Naguib Sawiris, Nassef’s brother, has a stronghold in the telecom industry with Orascom Telecom, which was sold to Russia’s VimpelCom in 2011. A lover of luxury, Naguib is known for his flamboyant lifestyle and sharp business acumen. He now focuses on media and political ventures in Egypt. 9. Patrice Motsepe Net Worth: $2.9 billion Sector: Mining South Africa’s Patrice Motsepe, the first Black African billionaire, founded African Rainbow Minerals, which mines gold, platinum, and other precious metals. Known for his philanthropy, Motsepe has pledged half of his wealth to charity. His journey started in the law, before transitioning to mining, where he saw massive success. Read also Mike Adenuga: Ally speaks out amid rumours of billionaire's death, calls him "the spirit of Africa" 10. Koos Bekker Net Worth: $2.5 billion Sector: Media, Technology Koos Bekker transformed Naspers from a South African newspaper publisher into a global e-commerce and media giant, investing in platforms like Tencent. Bekker’s modest lifestyle contrasts with the digital empire he’s built. His journey underscores visionary leadership, taking calculated risks in emerging markets. 11. Mohamed Mansour Net Worth: $2.5 billion Sector: Diversified (Automotive, Retail) Mohamed Mansour oversees the Mansour Group, a family-owned conglomerate with interests in automotive and retail sectors, including the distribution of General Motors vehicles. Mansour is known for his reserved yet philanthropic lifestyle, with investments spanning Africa , Europe, and beyond. 12. Strive Masiyiwa Net Worth: $1.9 billion Sector: Telecommunications Strive Masiyiwa, a Zimbabwe an billionaire, founded Econet, one of the largest telecom companies in Africa. Masiyiwa is a prominent philanthropist and advocate for African entrepreneurship. His journey is marked by resilience, overcoming regulatory challenges in Zimbabwe to create a telecom giant that serves millions across the continent. Read also Fuel crisis: Amid NNPCL shake up, Buhari’s appointee, 1 other named as alleged major problems 13. Mohammed Dewji Net Worth: $1.5 billion Sector: Manufacturing Tanzania’s Mohammed Dewji, CEO of MeTL Group, transformed a small trading business into a $1.5 billion conglomerate. Dewji, Africa’s youngest billionaire, is known for his active lifestyle and philanthropy. His journey reflects the power of family legacy and strategic investment in manufacturing. 14. Prateek Suri Net Worth: $1.4 billion Sector: Consumer Electronics, Investment, Manufacturing Prateek Suri, founder of Maser Group and MDR Investments popularly known as technology tiger of Africa, made his fortune in the consumer electronics and tech space after valuation crossing $5bn after acquired by SCG, focusing on frontier technologies and large-cap ventures in Africa mining and infrastructure, shipping and AI and the GCC region. Known for his high-energy lifestyle, Suri’s journey highlights innovation in manufacturing and technology, with an eye on transforming Africa’s tech landscape. Suri is Africa’s youngest billionaire with net worth $1.4bn Read also Which is the richest family in Nigeria? Top 10 ranked by wealth 15. Youssef Mansour Net Worth: $1.1 billion Sector: Retail, Consumer Goods Youssef Mansour, part of Egypt’s wealthy Mansour family, has built his wealth through Metro, Egypt’s largest supermarket chain, and other consumer goods ventures. He lives a low-profile lifestyle, focusing on expanding his family’s retail empire across Africa and the Middle East. 16. Othman Benjelloun Net Worth: $1.1 billion Sector: Banking, Insurance Othman Benjelloun, a Moroccan banking magnate, founded BMCE Bank, one of Africa’s leading financial institutions. Benjelloun is known for his classic and traditional lifestyle. His journey through finance has positioned him as one of the most influential bankers in North Africa. 17. Michiel Le Roux Net Worth: $1 billion Sector: Banking Michiel Le Roux founded Capitec Bank, one of South Africa’s most successful retail banks, revolutionizing affordable banking for the masses. Le Roux enjoys a relatively simple lifestyle, focusing on the banking sector and making banking accessible for all. His journey reflects his focus on innovation in financial inclusion. Read also Okele's net worth, real name, age, wife, house and car 18. Christoffel Wiese Net Worth: $1 billion Sector: Retail Christoffel Wiese, South Africa’s retail giant, made his fortune through Shoprite, the continent’s largest retailer. Known for his lavish lifestyle, Wiese’s journey has seen both remarkable successes and setbacks, but his influence on African retail remains unmatched. 19. Youssef Dewji Net Worth: $900 million Sector: Manufacturing, Real Estate Youssef Dewji, part of the influential Dewji family in Tanzania, has seen tremendous success in the manufacturing and real estate sectors, expanding his family’s business legacy. His modest lifestyle belies his impressive business acumen. 20. Aziz Akhannouch Net Worth: $900 million Sector: Oil and Gas Aziz Akhannouch, Morocco’s oil and gas magnate, is also a politician, serving as the country’s Prime Minister. His family owns Akwa Group, a conglomerate focused on petroleum products. Akhannouch maintains a relatively low public profile, balancing his political and business commitments. Read also Top 10 richest women in the world in 2024 and how they made their money Conclusion Africa’s leading billionaires are at the forefront of driving economic transformation, channeling investments into critical sectors and shaping industries that will define the continent’s future. Their inspiring journeys highlight the impact of resilience, innovation, and a shared vision for a more prosperous and dynamic Africa. PAY ATTENTION: Сheck out news that is picked exactly for YOU ➡️ find the “Recommended for you” block on the home page and enjoy! Source: Legit.ngNone

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PM Manmohan Singh will always remain in the history of Indian politics as a debatable figure, whose contributions towards the world economy has been nothing short of phenomenal. On countless occasions, he has saved India as well its allies from severe economic crisis, and his efforts towards building Indo-US relations may have been criticized back then, but the Asian country is surely reaping the benefits of the same now, with a different Prime Minister at the helm. ET Year-end Special Reads Corporate Kalesh: Top family disputes of India Inc in 2024 The world of business lost these eminent people in 2024 Fast, faster, fastest: How 2024 put more speed into your shopping Did India-US relation building help both countries during former PM Manmohan Singh's regime? There is a lot of difference in opinion around the contribution of PM Singh towards the building of India-US relations. The 2008 nuclear deal takes the cake, but the ties with the United States still did not help the country in attaining a permanent seat in the UN Security Council back then. The Khobragade spat from back then had also severed the Washington-Delhi ties, with China, then and now, remaining a major challenge for India, with the US not doing much to help in talks between the two countries. Pakistan has always remained like a thorn to India's side, and the US has been rather volatile on the Indo-Pak concept, with each President adapting different strategies. Only in recent times has the US grown explicitly critical about Pakistan's military strategies, including the fact that it is now building long-range tactical nuclear missiles through its weapons development program. US' on-off pivot policy in Asia has created much of a problem for Delhi over the years, especially in Singh's tenure, and even though he tried, his government could not achieve much in this aspect. FAQs: When did PM Manmohan Singh passed away? PM Manmohan Singh passed away on December 26, 2024, after being admitted to a hospital in New Delhi. 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PM Manmohan Singh served two terms as the Prime Minister of India, both the collision governments being known as UPA I and UPA II respectively. (You can now subscribe to our Economic Times WhatsApp channel )

Manmohan Singh's father may have believed his bookworm son would one day lead India, but the understated technocrat with the trademark blue turban, who died Thursday at the age of 92, never dreamed it would actually happen. Singh was pitchforked into leading the world's largest democracy in 2004 by the shock decision of Congress leader Sonia Gandhi to turn down the role after leading the party to an upset win over the ruling Hindu nationalists. He oversaw an economic boom in Asia's fourth-largest economy in his first term, although slowing growth in later years marred his second stint. Known as "Mr Clean", Singh nonetheless saw his image tarnished during his decade-long tenure when a series of corruption cases became public. As finance minister in the early 1990s, he was hailed at home and abroad for initiating big-bang reforms that opened India's inward-looking economy to the world. Known as a loyalist to the Gandhi political dynasty, Singh studied economics to find a way to eradicate poverty in the vast nation and never held elected office before becoming PM. But he deftly managed the rough and tumble of Indian politics -- even though many said Sonia Gandhi, the Italian-born widow of the assassinated Rajiv Gandhi, was the power behind the throne. Born in 1932 in the mud-house village of Gah in what is now Pakistan, Singh moved to the holy Sikh city of Amritsar as a teenager around the time the subcontinent was split at the end of British rule into mainly Hindu India and Muslim Pakistan. His father was a dry-fruit seller in Amritsar, and he had nine brothers and sisters. He was so determined to get an education he would study at night under streetlights because it was too noisy at home, his brother Surjit Singh told AFP in 2004. "Our father always used to say Manmohan will be the prime minister of India since he stuck out among the 10 children," said Singh. "He always had his nose in a book." Singh won scholarships to attend both Cambridge, where he obtained a first in economics, and Oxford, where he completed his PhD. He worked in a string of senior civil posts, served as a central bank governor and also held various jobs with global agencies such as the United Nations. Singh was tapped in 1991 by then Congress prime minister P.V. Narasimha Rao to reel India back from the worst financial crisis in its modern history -- currency reserves had sunk so low the country was on the brink of defaulting on foreign loans. Singh unleashed sweeping change that broke sharply with India's Soviet-style state-directed economy. In his first term he steered the economy through a period of nine-percent growth, lending the country the international clout it had long sought. He also sealed a landmark nuclear deal with the US that he said would help India meet its growing energy needs. But by 2008 there was growing disquiet among the ruling alliance's left-leaning parties about the pact, while high inflation -- notably food and fuel prices -- hit India's poor hard. Still, voters remained drawn to his calm, pragmatic persona, and in 2009 Congress steered its alliance to a second term. Singh vowed to step up financial reforms to drive economic growth, but he came under increasing fire from critics who said he had done nothing to stop a string of corruption scandals on his watch. Several months before the 2014 elections, Singh said he would retire after the polls, with Sonia Gandhi's son Rahul earmarked to take his place if Congress won. But Congress crashed to its worst-ever result at that time as the Hindu-nationalist Bharatiya Janata Party, led by Narendra Modi, won a landslide. More recently, an unflattering book by a former aide titled "The Accidental Prime Minister" portrayed him as timid and controlled by Sonia Gandhi. Singh -- who said historians would be kinder to him than contemporary detractors -- became a vocal critic of Modi's economic policies, and more recently warned about the risks that rising communal tensions posed to India's democracy. pmc-grk/abh/fox/leg/smsAP News Summary at 1:11 p.m. EST