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Kings fire coach Mike Brown less than halfway through his 3rd season, AP source saysAcross the Middle East and beyond, the fall of Syria’s authoritarian government at the hands of jihadi militants set off waves of jubilation, trepidation and alarm. Expatriate Syrians and many residents across the Middle East exulted at the overthrow of a leader who led his country through 14 years of civil strife that left half a million Syrians dead and displaced millions to countries around the world. Others worried about still more instability rocking a region in turmoil. Governments — whether allies or opponents of Assad — scrambled to absorb the sudden, stunning development and assess the implications for the Middle East and the world. In Lebanon, thousands of Syrians headed for the Masnaa border crossing to return to their home country, despite the uncertainty. “Anything is better than Bashar,” said Sami Abdel-Latif, a refugee from Hama who was heading back to join his wife and four children. “This is a feeling we’ve been waiting 14 years for,” said Malak Matar, who was preparing to return to the capital Damascus. Now, he said, “Syrians have to create a state that is well organized and take care of their country.” Many citizens in Syria's neighboring countries reacted with joy to news Assad was gone. In Jordan’s capital, Amman, resident Muhab al-Majali said his fall marked the end of “unjust and tyrannical rule.” “I believe that the future is beautiful and prosperous for the Syrians,” he said. Others were not so sure, in a region that saw the energy of the 2011 Arab Spring democracy movement collapse into conflict and authoritarian rule. Saeed Sawy, an engineer in the Egyptian capital, Cairo, predicted that Syria’s rebel groups would descend into infighting over the country’s future. “We saw this happen before,” he said. “We saw this in Libya, in Tunisia, in Yemen and Sudan. People rejoice over the fall of tyrants, then they disagree and fight, and a civil war starts.” Syria’s neighbors stepped up security along their borders. Lebanon said it was closing all but one of its land border crossings with Syria. Jordan also closed a border crossing. Israeli Prime Minister Benjamin Netanyahu said Israeli forces had — temporarily, he said — seized a buffer zone in the Golan Heights established by a 1974 ceasefire agreement, after Syrian troops abandoned their positions. Airstrikes were reported on a military airport near Damascus, which has previously been targeted by Israel, and on other Syrian military sites. Iran, a key ally of Assad, said the Syrian people should decide their country’s future “without destructive, coercive foreign intervention.” The Foreign Ministry in Tehran said Iran supports Syria’s unity and national sovereignty, and hopes to see “the end of military conflicts, the prevention of terrorist activities and the start of a national dialogue” with the participation of all groups. The Iraqi government, which is close to Iran, said it “supports all international and regional efforts seeking to open a dialogue” for Syria. Egypt’s foreign ministry urged a “comprehensive political process” to establish a new era of peace in the war-torn county. The head of Yemen’s internationally recognized government welcomed the fall of Assad as “a historic moment.” Yemen’s government is at war with the Houthi rebels, who are backed by Iran. Turkey has backed anti-Assad militant groups in Syria, and could play a key role in what happens next. Turkish Foreign Minister Hakan Fidan said the fall of Assad brought “hope.” He called on the world to help “unite and reconstruct” Syria. Fidan, who met in Qatar on Saturday with diplomats from Russia and Iran, the main backers of the Assad regime, said regional and global powers should try “to act with prudence and calm.” The war sent millions of Syrians fleeing to Europe and expatriates took to the streets in celebration in cities including Paris, London, Stockholm, Helsinki and Athens. Many European governments welcomed Assad’s departure while urging a rapid return to stability. “The end of Assad’s dictatorship is a positive and long-awaited development,” said Kaja Kallas, the European Union’s newly appointed foreign policy chief, in a post on X. “Our priority is to ensure security in the region. I will work with all the constructive partners, in Syria and the region.” German Chancellor Olaf Scholz said in a statement that the end of Assad’s rule was “good news,” adding that “what matters now is that law and order are quickly restored in Syria.” France’s foreign ministry welcomed the fall of Assad, saying “the Syrian people have suffered too much.” British Prime Minister Keir Starmer also welcomed the end of Assad’s "barbaric regime.” “We call on all sides to protect civilians and minorities and ensure essential aid can reach the most vulnerable in the coming hours and days,” he said. United Nations Secretary-General Antonio Guterres also called for calm and urged work to ensure an “orderly political transition to renewed institutions.” Russia, which backed Assad with troops and warplanes, said it has been following the “dramatic events” in Syria “with extreme concern.” Foreign Minister Andrii Sybiha of Ukraine, which is at war with Russia, wrote on X that the ousted Syrian leader had suffered the fate of “all dictators who bet on (Russian President Vladimir) Putin. He always betrays those who rely on him.” In Washington, President Joe Biden was meeting with his national security team Sunday for an update on the situation in Syria. President-elect Donald Trump said in a social media post Saturday, before Assad’s fall was confirmed: “Syria is a mess, but is not our friend, & THE UNITED STATES SHOULD HAVE NOTHING TO DO WITH IT. THIS IS NOT OUR FIGHT. LET IT PLAY OUT. DO NOT GET INVOLVED!” The U.S. has about 900 troops in Syria, including U.S. forces working with Kurdish allies in the opposition-held northeast to prevent any resurgence of the Islamic State group.The Sacramento Kings have fired coach Mike Brown less than halfway through his third season with the team mired in a five-game losing streak, a person familiar with the decision told The Associated Press. The person spoke on condition of anonymity Friday because the firing hadn't been announced by the team. ESPN first reported the firing. Brown won NBA Coach of the Year in his first season in 2022-23, when he helped Sacramento end the longest playoff drought in NBA history at 16 seasons. But Sacramento lost in the play-in tournament last year and was off to a 13-18 start this season, leading to the move to fire Brown about six months after he agreed to a contract extension through the 2026-27 season. The Kings have lost an NBA-worst nine games this season after leading in the fourth quarter with the worst one coming in Brown's final game as coach Thursday night against Detroit. Sacramento led by 10 points with less than three minutes to play only to collapse down the stretch. Jaden Ivey converted a four-point play with 3 seconds left when he made a 3-pointer in the right corner and was fouled by De’Aaron Fox. That gave the Pistons a 114-113 win, leaving the Kings in 12th place in the Western Conference. The Kings came into the season with hopes of finishing in the top six in the West and avoiding the play-in tournament after acquiring DeMar DeRozan in a sign-and-trade deal over the summer to add to a core that featured Fox, Domanta Sabonis and Keegan Murray. Fox, who is in the second-to-last year of his five-year, $163 million contract, declined to sign an extension in the offseason. He said on a podcast with Draymond Green earlier this month that he wanted to be on a team that could “compete at a high level.” Sacramento has been far from that this season, thanks in large part to an NBA-worst 3-11 record in games decided by five points or fewer. Brown publicly criticized Fox for his role in the game-winning play Thursday night, saying he should have been closer to Ivey instead of committing a foul on a close out. "You should be hugged up to your man at the 3-point line,” Brown said. “Everybody should, and why there was a closeout by Fox, I’m not sure. I got to go back and watch the tape. But for sure 100% we told our guys, can’t give up a 3, can’t give up a 3, can’t give up a 3, stay on the high side, stay on the high side.” Brown has a 107-88 record in two-plus seasons in Sacramento with a winning record in both of his full seasons. Rick Adelman is the only other coach to post a winning record in a full season since the Kings moved to Sacramento Brown previously had two stints as coach in Cleveland and spent one-plus season as Lakers coach. He has a 455-304 record and has made the playoffs in seven of his nine full seasons. He won Coach of the Year twice, also getting the award in Cleveland in 2008-09. AP NBA: https://apnews.com/hub/NBA7xm casino bangladesh login 。

Arteta wanted his team to prove their European credentials following some underwhelming displays away from home, and the Gunners manager got exactly what he asked for. Goals from Gabriel Martinelli, Kai Havertz, Gabriel Magalhaes, Bukayo Saka and Leandro Trossard got their continental campaign back on track in style following the 1-0 defeat at Inter Milan last time out. A memorable victory also ended Sporting’s unbeaten start to the season, a streak of 17 wins and one draw, the vast majority of which prompted Manchester United to prise away head coach Ruben Amorim. The Gunners had failed to win or score in their two away games in the competition so far this season, but they made a blistering start in the Portuguese capital and took the lead after only seven minutes. Declan Rice fed overlapping full-back Jurrien Timber, who curled a low cross in behind the home defence for Martinelli to finish at the far post. Arsenal doubled their lead in the 20th minute thanks to a glorious ball over the top from Thomas Partey. Saka escaped the clutches of his marker Maximiliano Araujo to beat the offside trap and poke the ball past advancing goalkeeper Franco Israel for Havertz to tap home. It was a scintillating first-half display which completely overshadowed the presence of Viktor Gyokeres in Sporting’s attack. The prolific Sweden striker, formerly of Coventry, has been turning the heads of Europe’s top clubs with his 24 goals in 17 games this season – including a hat-trick against Manchester City earlier this month. But the only time he got a sniff of a run at goal after an optimistic long ball, he was marshalled out of harm’s way by Gabriel. David Raya was forced into one save, tipping a fierce Geovany Quenda drive over the crossbar. But Arsenal added a third on the stroke of half-time, Gabriel charging in to head Rice’s corner into the back of the net. To rub salt in the wound, the Brazilian defender mimicked Gyokeres’ hands-over-his-face goal celebration. That may have wound Sporting up as they came out after the interval meaning business, and they pulled one back after Raya tipped Hidemasa Morita’s shot behind, with Goncalo Inacio netting at the near post from the corner. Former Tottenham winger Marcus Edwards fired over, as did Gyokeres, with Arsenal temporarily on the back foot. But when Martin Odegaard’s darting run into the area was halted by Ousmane Diomande’s foul, Saka tucked away the penalty. Substitute Trossard added the fifth with eight minutes remaining, heading in the rebound after Mikel Merino’s shot was saved, and Gyokeres’ miserable night was summed up when his late shot crashed back off the post.

Globus Medical stock soars to all-time high of $84.89

Telangana declares 7 days’ state mourning to honour ManmohanTaste Test: This 31-Year-Old Canadian Whisky Can Stand with the Best Ultra-Aged Single MaltsTang Contemporary Art in Hong Kong welcomes the new year with Oracle , a solo exhibition by Japanese artist and fashion designer Ryunosuke Okazaki . With a focus on prayer, peace and spirituality, Okazaki presents a profound meditation on humanity’s relationship with the sacred through his signature of intricate forms, winding lines and infinite spirals. Drawing from ancient texts like the Nihon Shoki and Kojiki , the exhibition reimagines oracles as living entities imbued with spiritual significance. In this space, they are less an absolute truth and more an unresolved mystery, reflecting humanity’s ongoing dialogue with the divine. This influence is echoed in Okazaki’s artistic exploration which emphasizes materiality as an active participant in creating meaning. Blending the simplicity of Jomon pottery with technological precision, his works evoke a symbiosis between humanity, nature and technology. Hailing from Hiroshima, the artist weaves historical memory and advanced technologies into an alluring exploration of spirituality in the modern age. Through recurring themes of prayer, Zen meditation and the principle of “non-action,” his works muddy the lines between material and spiritual realms, reconnecting art to the ineffable essence of existence. Oracle will open at Tang Contemporary Art Hong Kong on January 11 and will be on view through February 19, 2025. Tang Contemporary Hong Kong 20/F, Landmark South, 39 Yip Kan Street, Wong Chuk Hang, Hong KongTailwinds and stronger balance sheets: 5 large-cap stocks with the right mix of two ratios & upside potential of up to 32%

The expanded Big Ten is poised to be a major player in this season's College Football Playoff. The 18-team conference had three of the top-four teams in the AP poll this week — No. 1 Oregon, No. 2 Ohio State and No. 4 Penn State. A one-loss Indiana team is ranked 10th but is still very much a contender to make the playoff, given how many Southeastern Conference teams have three defeats or more. Indiana's rise has been perhaps the Big Ten's biggest story this season. Much of the spotlight was on newcomers Oregon, Southern California, UCLA and Washington, but aside from the top-ranked Ducks, that foursome has struggled to impress. Meanwhile, the Hoosiers won their first 10 games under new coach Curt Cignetti before losing at Ohio State last weekend. Oregon beat Ohio State 32-31 back in October, and if the Buckeyes beat rival Michigan this weekend, they'll earn a rematch with the Ducks for the Big Ten title. And it's entirely possible another matchup between those two teams awaits in the CFP. Dillon Gabriel has quarterbacked Oregon to an unbeaten record, throwing for 3,066 yards and 22 touchdowns in 11 games. But don't overlook Iowa's Kaleb Johnson and his 21 rushing TDs, and quarterback Kurtis Rourke has been a big part of Indiana's improvement. Penn State's Abdul Carter has eight sacks and two forced fumbles and could be one of the top edge rushers drafted this year. Oregon (11-0, 8-0), Ohio State (10-1, 7-1), Penn State (10-1, 7-1), Indiana (10-1, 7-1), Illinois (8-3, 5-3), Iowa (7-4, 5-3), Michigan (6-5, 4-4), Minnesota (6-5, 4-4), Washington (6-5, 4-4), Southern California (6-5, 4-5), Nebraska (6-5, 3-5) and Rutgers (6-5, 3-5) have already reached the six-win mark for bowl eligibility. Michigan State (5-6, 3-5) and Wisconsin (5-6, 3-5) can join them. There may not be many firings in general at the top level of college football. The prospect of sharing revenue with athletes in the future might lead schools to be more judicious about shedding one coach and hiring a new one. Who should be most worried in the Big Ten? Well, Lincoln Riley is struggling to stay above .500 in his third season at USC. Purdue is 1-10, but coach Ryan Walters is only in his second season. Maryland's Mike Locksley has been there six years and his Terrapins are 4-7, but this was his first real step backward after guiding the team to three straight bowl wins. Cignetti has shown it is possible for a coaching change to push a previously moribund program to some impressive heights in a short amount of time — but the improvement has been more incremental at Michigan State following Jonathan Smith's arrival. Sherrone Moore wasn't a completely unknown commodity at Michigan after he won some massive games in place of a suspended Jim Harbaugh last year. But in his first season completely at the helm, the Wolverines have declined significantly following their national title a season ago. The Big Ten is home to one of the most dynamic freshmen in the country in Ohio State receiver Jeremiah Smith. He has 52 catches for 899 yards and nine touchdowns. Highly touted quarterback Dylan Raiola has teamed up with fellow freshman Jacory Barney (49 catches) to lead Nebraska to bowl eligibility. Ohio State is on track to land the Big Ten's top class, according to 247 Sports, but the big news recently was quarterback Bryce Underwood flipping from LSU to Michigan. If the Wolverines do in fact keep Underwood in his home state, that would be a big development for Moore. Get local news delivered to your inbox!NoneAn online debate over foreign workers in tech shows tensions in Trump's political coalition

EDMONTON — Leaders of the Prairie provinces are urging Canada to act on American concerns over illegal cross-border traffic of people and drugs to stave off the looming threat of 25 per cent tariffs. Alberta Premier Danielle Smith, Saskatchewan Premier Scott Moe, and Manitoba Premier Wab Kinew said Tuesday that Canada must do better to address the concerns of its largest trading partner. Incoming U.S. president Donald Trump promised Monday to impose the tariffs on his first day in office in January. He said he would keep the tariffs in place until Canada and Mexico stop illegal border crossings and prevent drugs such as fentanyl from entering the U.S. Kinew said 25 per cent tariffs would mean a recession for his province and that Canada needs to show the new U.S. administration it's serious about security and tackling the drug crisis. He said it begins with Canada’s pledge to NATO allies to spend two per cent of its gross domestic product on defence by 2032. "First and foremost, (it’s about) hitting that target of two per cent spending on defence,” said Kinew. “That gets us in the game just to be taken seriously as a security partner with the U.S. If we don't do it, it's going to become a trade problem." In a video posted to social media, Alberta's premier said Canada needs to reach its pledged commitment on defence. "If their trade partners are looking to be free riders on American security interests, that's also going to harm the relationship," Smith said, adding, "You also have to take seriously the asylum seekers." Smith added in another post that the incoming Trump administration has "valid concerns related to illegal activities" at the border. The U.S. is Alberta’s largest trading partner, with $188 billion in bilateral trade in 2023. Last year, energy products accounted for more than 80 per cent of that trade, or about $134 billion. Smith said the vast majority of Alberta's energy exports to the U.S. are "delivered through secure and safe pipelines," which "do not in any way contribute to these illegal activities." In Saskatchewan, Moe said he understands Trump’s position on border security. “As Canadians, we can all benefit from additional border security stopping the flow of illegal drugs and migrants across our borders,” he said in a social media post. He said his province plans to use all levers at its disposal to stop the tariffs and will approach the U.S. directly. Moe added the proposed tariffs would hurt Saskatchewan’s export-based economy and drive up prices on both sides of the border. Speaking to CTV early Tuesday, Moe said his government would represent Saskatchewan interests alongside the federal government, fellow premiers "and on our own when necessary." "We have a strong relationship with a number of the administration that President Trump has appointed," Moe said. In 2023, Saskatchewan’s exports to the U.S. amounted to almost $27 billion after hitting a record high of $29 billion in 2022. Its top exports include crude oil, potash and canola. Prime Minister Justin Trudeau has convened an emergency meeting for Wednesday with the country's premiers to discuss the tariffs. This report by The Canadian Press was first published Nov. 26, 2024. — With files from Jeremy Simes in Regina and Brittany Hobson in Winnipeg Lisa Johnson, The Canadian Press

US budget airlines are struggling. Will pursuing premium passengers solve their problems? DALLAS (AP) — Delta and United Airlines have become the most profitable U.S. airlines by targeting premium customers while also winning a significant share of budget travelers. That is squeezing smaller low-fare carriers like Spirit Airlines, which filed for bankruptcy protection on Monday. Some travel industry experts think Spirit’s troubles indicate less-wealthy passengers will have fewer choices and higher prices. Other discount airlines are on better financial footing but also are lagging far behind the full-service airlines when it comes to recovering from the COVID-19 pandemic. Most industry experts think Frontier and other so-called ultra-low-cost carriers will fill the vacuum if Spirit shrinks, and that there's still plenty of competition to prevent prices from spiking. Bitcoin ticks closer to $100,000 in extended surge following US elections NEW YORK (AP) — Bitcoin is jumping again, setting another new high above $99,000 overnight. The cryptocurrency has been shattering records almost daily since the U.S. presidential election, and has rocketed more than 40% higher in just two weeks. It's now at the doorstep of $100,000. Cryptocurrencies and related investments like crypto exchange-traded funds have rallied because the incoming Trump administration is expected to be more “crypto-friendly.” Still, as with everything in the volatile cryptoverse, the future is hard to predict. And while some are bullish, other experts continue to warn of investment risks. Stock market today: Wall Street gains ground as it heads for a winning week Stocks gained ground on Wall Street, keeping the market on track for its fifth gain in a row. The S&P 500 was up 0.2% in afternoon trading Friday. The Dow Jones Industrial Average climbed 333 points and the Nasdaq composite was essentially flat. Retailers had some of the biggest gains. Gap soared after reporting quarterly results that easily beat analysts' estimates. EchoStar fell after DirecTV called of its purchase of that company's Dish Network unit. European markets closed mostly higher and Asian markets ended mixed. Treasury yields held relatively steady in the bond market. Crude oil prices gained ground. Australia rejects Elon Musk's claim that it plans to control access to the internet MELBOURNE, Australia (AP) — An Australian Cabinet minister has rejected X Corp. owner Elon Musk’s allegation that the government intends to control all Australians' access to the internet through legislation that would ban young children from social media. Treasurer Jim Chalmers said on Friday that Musk’s criticism was “unsurprising” after the government introduced legislation to Parliament that would fine platforms including X up to $133 million for allowing children under 16 to hold social media accounts. The spat continues months of open hostility between the Australian government and the tech billionaire over regulators’ efforts to reduce public harm from social media. Parliament could pass the legislation as soon as next week. Oil company Phillips 66 faces federal charges related to alleged Clean Water Act violations LOS ANGELES (AP) — Oil company Phillips 66 has been federally indicted in connection with alleged violations of the Clean Water Act in California. The Texas-based company is accused of discharging hundreds of thousands of gallons of industrial wastewater containing excessive amounts of oil and grease. The U.S. Department of Justice announced the indictment on Thursday. Phillips is charged with two counts of negligently violating the Clean Water Act and four counts of knowingly violating the Clean Water Act. An arraignment date has not been set. A spokesperson for the company said it was cooperating with prosecutors. US regulators seek to break up Google, forcing Chrome sale as part of monopoly punishment U.S. regulators want a federal judge to break up Google to prevent the company from continuing to squash competition through its dominant search engine after a court found it had maintained an abusive monopoly over the past decade. The proposed breakup floated in a 23-page document filed late Wednesday by the U.S. Justice Department calls for Google to sell its industry-leading Chrome web browser and impose restrictions designed to prevent Android from favoring its search engine. Regulators also want to ban Google from forging multibillion-dollar deals to lock in its dominant search engine as the default option on Apple’s iPhone and other devices. What you need to know about the proposed measures designed to curb Google's search monopoly U.S. regulators are proposing aggressive measures to restore competition to the online search market after a federal judge ruled that Google maintained an illegal monopoly. The sweeping set of recommendations filed late Wednesday could radically alter Google’s business. Regulators want Google to sell off its industry-leading Chrome web browser. They outlined a range of behavioral measures such as prohibiting Google from using search results to favor its own services such as YouTube, and forcing it to license search index data to its rivals. They're not going as far as to demand Google spin off Android, but are leaving that door open if the remedies don't work. Apple and Google face UK investigation into mobile browser dominance LONDON (AP) — A British watchdog says Apple and Google aren't giving consumers a genuine choice of mobile web browsers. The watchdog's report Friday recommends they face an investigation under new U.K. digital rules taking effect next year. The Competition and Markets Authority took aim at Apple, saying the iPhone maker’s tactics hold back innovation by stopping rivals from giving users new features like faster webpage loading. The CMA’s report also found that Apple and Google manipulate the choices given to mobile phone users to make their own browsers “the clearest or easiest option.” Apple said it disagreed with the findings. Atlantic City casino earnings fall nearly 14% in 3rd quarter ATLANTIC CITY, N.J. (AP) — Atlantic City’s casinos saw their operating profits decline by nearly 14% in the third quarter of this year. New Jersey gambling regulators say the nine casinos had a collective gross operating profit of $236.5 million in the third quarter. That was down 13.8% from the third quarter of 2023. Every casino was profitable, but only two — Caesars and Hard Rock — saw their profits increase in the third quarter compared with a year ago. Hard Rock had the highest average hotel occupancy at over 95%, and Ocean had the highest average hotel room price at $335. German auto supplier Bosch to cut 5,500 jobs in further sign of carmakers' woes FRANKFURT, Germany (AP) — Germany's technology and services company Bosch is cutting its automotive division workforce by as many as 5,500 jobs in the next several years, in another sign of the headwinds hitting the German and global auto industries. The company cited stagnating global auto sales, too much factory capacity in the auto industry compared to sales prospects and a slower than expected transition to electric-powered, software-controlled vehicles. Some 3,500 of the job reductions would come before the end of 2027 and would hit the part of the company that develops driver assistance and automated driving technologies. About half those job reductions would be at locations in Germany.NoneNone

Brandon Libby, 36, left, enters a Cumberland County Superior Courtroom for a hearing in February. Libby was charged with murder in the death of his girlfriend in 2021. Shawn Patrick Ouellette/Staff Photographer A Standish man accused of killing his girlfriend is headed to trial next week, and prosecutors plan to challenge his version of events with a reconstruction of the shooting. Brandon Libby, 37, has been charged with murder in connection with the death of Amanda Brown, whom police found dead in their home in 2021. Libby pleaded not guilty that fall. He rejected a plea offer from the Office of the Maine Attorney General in June, which would have capped his sentence at 42 years. Police responded to a call on June 16, 2021, and forced their way into the couple’s Standish home, where they found Brown, 29, who had been shot in the stomach and killed. Police found Libby barricaded in a home about 14 miles away in North Waterboro before convincing him to come out and talk. It wasn’t until after he was indicted by a grand jury in November 2021 that he was taken to the Cumberland County Jail, where he has spent three years waiting for trial. Libby is scheduled for trial Dec. 4. In excerpts of a police interview that prosecutors played in court during a pretrial hearing Tuesday, Libby could be heard saying that Brown pointed the gun at him first. He suggested that the gun went off after he tried pushing it out of her hand. Larry Rose, a Maine State Police sergeant who said he reconstructed the shooting, said in court that he reviewed Brown’s autopsy report, police reports and videos of the home where Brown was found. Gunshot markings on Brown’s clothing suggest that the gun was fired at extremely close range, with the muzzle against her shirt, Rose said. An employee from the Maine State Police crime lab tried replicating those markings by firing guns at varying distances, Rose said, but it only worked when the gun was in close contact. Deputy Chief Medical Examiner Dr. Liam Funte helped Rose determine the trajectory of the bullet, from its entry point in Brown’s stomach to where it stopped in her back, Rose said. Rose even demonstrated for Superior Justice Thomas McKeon how he believes the gun was fired, using a small plastic blue gun on Maine State Police detective Justin Huntley, who stood in Brown’s place. The sergeant said his theory was peer-reviewed. He also said the plastic gun was similar to the one used to shoot Brown. Rose also demonstrated for McKeon what Libby said happened. But the officer said it would have been “difficult” for the gun to go off the same way, according to Libby’s version. “It doesn’t get to the angle that it needs to be,” Rose said, theatrically pretending to knock the gun from Huntley’s hand. Libby attorney Matthew Crockett said in an email Tuesday that Libby’s legal team had no response to Rose’s testimony but “look(s) forward to presenting our defense next week.” Libby’s lawyers previously opposed the state’s plans to show Rose’s reconstruction, but they withdrew that objection Tuesday. Earlier this year, Libby tried to prevent the use of several statements he made to police while they were bringing him to a hospital, after he had been bitten by one of their K-9s in North Waterboro. Although Libby’s statements were made before police read him his Miranda rights, Superior Justice MaryGay Kennedy agreed that the statements were fair game for the state because police told him repeatedly he didn’t have to talk with them. Trial rescheduled for Standish man accused of killing girlfriend in 2021 Judge denies motions to throw out evidence, statements before Standish man’s murder trial Comments are not available on this story. Send questions/comments to the editors. « PreviousAfter institutions for people with disabilities close, graves are at risk of being forgotten

Hinton scores 15 points as Harvard takes down New Hampshire 72-62

Machine learning reveals behaviors linked with early Alzheimer's, points to new treatments November 26, 2024 Gladstone Institutes Scientists used a new video-based machine learning tool to pinpoint otherwise-undetectable signs of early disease in mice that were engineered to mimic key aspects of Alzheimer's. Their work sheds light on a new strategy for identifying neurological disease earlier than currently possible and tracking how it develops over time. Facebook Twitter Pinterest LinkedIN Email Subtle signs of Alzheimer's disease can emerge decades before a diagnosis -- often in the form of irregular behaviors that reflect very early stages of brain dysfunction. But until now, identifying and measuring these slight behavioral changes in a scientific way hasn't been feasible, not even when studying Alzheimer's in mice. In a study published in Cell Reports, a team of scientists at Gladstone Institutes used a new video-based machine learning tool to pinpoint otherwise-undetectable signs of early disease in mice that were engineered to mimic key aspects of Alzheimer's. Their work sheds light on a new strategy for identifying neurological disease earlier than currently possible and tracking how it develops over time. "We've shown the potential of machine learning to revolutionize how we analyze behaviors indicative of early abnormalities in brain function," says Gladstone investigator Jorge Palop, PhD, senior author of the study. "We leveraged a valuable tool that opens the door to a more complete understanding of devastating brain disorders and how they begin." The scientists used a machine learning platform called VAME, short for "Variational Animal Motion Embedding," to analyze video footage of mice exploring an open arena. The open-source tool identified subtle behavioral patterns captured on camera -- changes that might not be noticed by simply looking at the mice. Tracking Disorganized Behavior VAME's deep learning platform is unlike conventional behavioral tests in mice, which often center around preconceived tasks that the animals are challenged to complete. Among the limitations of those tests, they can't capture the full range of spontaneous behavioral changes caused by disease -- particularly in early stages, explains Stephanie Miller, PhD, staff scientist at Gladstone and first author of the study. They also lack scalability and often rely on labor-intensive methods. For the Gladstone study using VAME, the team evaluated two types of mice that simulated different aspects of Alzheimer's. In both models, the machine learning tool identified a significantly increased level of "disorganized behavior" as the mice aged. For example, the mice exhibited unusual patterns of behavior and transitioned more often between different activities -- factors that might be associated with memory and attention deficits. "Similar machine learning approaches could be used one day to study spontaneous behaviors in humans, potentially providing early diagnosis of neurological diseases," Miller says, noting that smartphone-quality video is sufficient for VAME analysis. "I envision this technology will be used to assess patients in the clinic and even in their homes. It gives scientists and doctors a way to solve the very hard problem of diagnosing preclinical stages of disease." Miller began experimenting with VAME several years ago when the technology was still in its infancy. She and Palop collaborated with the team of Stefan Remy, MD, in Germany, which initially developed the platform. Together, they helped demonstrate VAME's utility for neuroscience research in a study published in Communications Biology . Evaluating a Potential Treatment Adding another dimension to their new study, the Gladstone team used VAME to learn whether a potential therapeutic intervention for Alzheimer's would prevent the disorganized behavior in mice. The scientists leveraged prior research from Gladstone investigator Katerina Akassoglou, PhD, who discovered that a blood-clotting protein called fibrin creates a cascade of toxic effects when it leaks into the brain through damaged blood vessels. By blocking fibrin's toxic effects, Akassoglou's lab has been able to prevent the neurodegeneration that leads to cognitive decline and to protect against Alzheimer's in animals. To find out if this therapeutic strategy could safeguard mice from Alzheimer's-linked behaviors, the team genetically blocked fibrin from triggering toxic inflammation in the brain. This intervention reduced the development of abnormal behaviors in the Alzheimer's mice. "It was highly encouraging to see that blocking fibrin's inflammatory activity in the brain reduced virtually all of the spontaneous behavioral changes in Alzheimer's mice, reaffirming that fibrin and the ensuing neuroinflammation are key drivers of the disease," says Akassoglou, also an author of the study. "Machine learning can offer an unbiased way to evaluate potential treatments in the lab -- and I believe it may ultimately become an invaluable clinical tool, as well." Palop and Miller are now working with other Gladstone teams who study neurological disease to help them employ the VAME technology for new behavioral studies. "My goal is to make this tool and similar approaches more accessible to biologists and clinicians in order to shorten the time it takes to develop powerful new medicines," Miller says. About the Study The study, "Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models," appears in the November 26 issue of Cell Reports . Authors include Stephanie Miller, Kevin Luxem, Kelli Lauderdale, Pranav Nambiar, Patrick Honma, Katie Ly, Shreya Bangera, Mary Bullock, Jia Shin, Nick Kaliss, Yuechen Qiu, Catherine Cai, Kevin Shen, K. Dakota Mallen, Zhaoqi Yan, Andrew Mendiola, Takashi Saito, Takaomi Saido, Alexander Pico, Reuben Thomas, Erik Roberson, Katerina Akassoglou, Pavol Bauer, Stefan Remy, and Jorge Palop. Story Source: Materials provided by Gladstone Institutes . Original written by Kelly Quigley. Note: Content may be edited for style and length. Journal References : Cite This Page :Arsenal make Mikel Arteta proud after smashing Sporting LisbonArteta wanted his team to prove their European credentials following some underwhelming displays away from home, and the Gunners manager got exactly what he asked for. Goals from Gabriel Martinelli, Kai Havertz, Gabriel Magalhaes, Bukayo Saka and Leandro Trossard got their continental campaign back on track in style following the 1-0 defeat at Inter Milan last time out. A memorable victory also ended Sporting’s unbeaten start to the season, a streak of 17 wins and one draw, the vast majority of which prompted Manchester United to prise away head coach Ruben Amorim. The Gunners had failed to win or score in their two away games in the competition so far this season, but they made a blistering start in the Portuguese capital and took the lead after only seven minutes. Declan Rice fed overlapping full-back Jurrien Timber, who curled a low cross in behind the home defence for Martinelli to finish at the far post. Arsenal doubled their lead in the 20th minute thanks to a glorious ball over the top from Thomas Partey. Saka escaped the clutches of his marker Maximiliano Araujo to beat the offside trap and poke the ball past advancing goalkeeper Franco Israel for Havertz to tap home. It was a scintillating first-half display which completely overshadowed the presence of Viktor Gyokeres in Sporting’s attack. The prolific Sweden striker, formerly of Coventry, has been turning the heads of Europe’s top clubs with his 24 goals in 17 games this season – including a hat-trick against Manchester City earlier this month. But the only time he got a sniff of a run at goal after an optimistic long ball, he was marshalled out of harm’s way by Gabriel. David Raya was forced into one save, tipping a fierce Geovany Quenda drive over the crossbar. But Arsenal added a third on the stroke of half-time, Gabriel charging in to head Rice’s corner into the back of the net. To rub salt in the wound, the Brazilian defender mimicked Gyokeres’ hands-over-his-face goal celebration. That may have wound Sporting up as they came out after the interval meaning business, and they pulled one back after Raya tipped Hidemasa Morita’s shot behind, with Goncalo Inacio netting at the near post from the corner. Former Tottenham winger Marcus Edwards fired over, as did Gyokeres, with Arsenal temporarily on the back foot. But when Martin Odegaard’s darting run into the area was halted by Ousmane Diomande’s foul, Saka tucked away the penalty. Substitute Trossard added the fifth with eight minutes remaining, heading in the rebound after Mikel Merino’s shot was saved, and Gyokeres’ miserable night was summed up when his late shot crashed back off the post.