panaloko online game login
panaloko online game login
On a rare two-game skid, No. 24 Arizona faces DavidsonGlobal Business Travel Insurance Market Set to Reach $20.19 Billion by 2030, Driven by Multi-Trip Coverage and AI Innovation Across Europe, North America, and Asia-Pacific: Know about the latest updates
City of Greeley announces John Herge as the new Director of Strategy(All times Eastern) Schedule subject to change and/or blackouts Friday, Dec. 20 COLLEGE BASKETBALL (MEN’S) 4 p.m. ESPNU — Chris Paul HBCU Challenge: Norfolk St. vs. Grambling St., Uncasville, Conn. 6:30 p.m. ESPNU — Chris Paul HBCU Challenge: Delaware St. vs. Alabama St., Uncasville, Conn. 8 p.m. FOX — St. John’s at Providence 8:30 p.m. ESPNU — Cincinnati vs. Dayton, Cincinnati COLLEGE BASKETBALL (WOMEN’S) 8:30 p.m. FS1 — Ohio St. vs. Stanford, San Francisco 11 p.m. FS1 — Creighton vs. UCLA, San Francisco COLLEGE FOOTBALL Noon ESPN — The StaffDNA Cure Bowl: Ohio vs. Jacksonville St., Orlando, Fla. 3:30 p.m. ESPN2 — The Union Home Mortgage Gasparilla Bowl: Tulane vs. Florida, Tampa, Fla. 8:10 p.m. ABC — CFP First Round: Indiana at Notre Dame ESPN — CFP First Round: Indiana at Notre Dame ESPN2 — CFP First Round: Indiana at Notre Dame (Command Center) GOLF 3:30 a.m. GOLF — DP World Tour: The AfrAsia Bank Mauritius Open, Second Round, Mont Choisy Le Golf, Grand-Baie, Mauritius Noon GOLF — PGA Tour: The PNC Championship Pro-Am, Ritz-Carlton Golf Club, Orlando, Fla. 4 a.m. (Saturday) GOLF — DP World Tour: The AfrAsia Bank Mauritius Open, Third Round, Mont Choisy Le Golf, Grand-Baie, Mauritius HORSE RACING 3 p.m. FS2 — NYRA: America’s Day at the Races NBA BASKETBALL 7:30 p.m. NBATV — Milwaukee at Cleveland NBA G-LEAGUE BASKETBALL 11 a.m. ESPNU — Winter Showcase: Texas vs. Motor City, Orlando, Fla. 1 p.m. NBATV — Winter Showcase: San Diego vs. Long Island, Orlando, Fla. 1:30 p.m. ESPNU — Winter Showcase: Mexico City vs. Rip City, Orlando, Fla. 3:30 p.m. NBATV — Winter Showcase: Cleveland vs. Salt Lake, Orlando, Fla. 4 p.m. ESPNEWS — Winter Showcase: Delaware vs. Santa Cruz, Orlando, Fla. TENNIS 6 a.m. TENNIS — Next Gen ATP Finals: Round Robin 11 a.m. TENNIS — Next Gen ATP Finals: Round Robin The Associated Press created this story using technology provided by Data Skrive TV listings provided by LiveSportsOnTV .Edo: FRSC confirms death of two persons in road accident
Stock market today: Wall Street stabilizes after Wednesday's sell-offA user manual for yeast's genetic switches December 19, 2024 Kobe University When introducing genes into yeast to make it produce drugs and other useful substances, it is also necessary to reliably switch the production on or off. Researchers have found three gene regulation design principles that provide a flexible guideline for the effective control of microbiological production. Facebook Twitter Pinterest LinkedIN Email When introducing genes into yeast to make it produce drugs and other useful substances, it is also necessary to reliably switch the production on or off. A Kobe University team found three gene regulation design principles that provide a flexible guideline for the effective control of microbiological production. It's said that DNA is the blueprint of life, telling our cells what to produce. But DNA also contains the switches telling those cells when to produce something and how much of it. Therefore, when introducing new genes into cells to produce useful chemicals such as drugs or raw materials for chemical production, it is also necessary to include a genetic switch, a piece of DNA called a "promoter," that tells the cells to start production as needed. Kobe University bioengineer TOMINAGA Masahiro says: "The problem is that these promoters cannot be used in a plug-and-play manner unless researchers deeply understand how they interact with other genetic elements. Indeed, there are not so many cases in which researchers use artificial promoters to precisely control the cellular production and achieve their research purpose." Sometimes the production is too low, sometimes it is "leaky," meaning that it cannot be turned off at will. This is especially true for bioengineering yeast, which is more complex in its genetic regulation compared to bacteria. But this increased complexity also enables its use to produce many useful chemicals. As experts in modifying yeast cells, Tominaga and colleagues from the team led by ISHII Jun took a systematic approach to working out how to design effective promoters. "We came up with the idea that by carefully describing our process of improving a prototype promoter, we could prepare a 'user manual' for how to achieve high-performance and precise control so that these genetic systems could be more widely used," Tominaga explains. In a paper now published in the journal Nature Communications , they describe three design principles for yeast promoters. First, if researchers not only need large amounts of the product but also the ability to switch the production on or off at will, they should introduce multiple copies of the regulatory elements enabling this within the promoter. This reduces leakiness and increases the productivity. Second, the distance between promoter elements should be as small as possible to enhance the productivity even more. And third, the promoter should be insulated from surrounding DNA by including extra DNA before it to further reduce leakiness. Tominaga says: "We showed that a promoter's performance can be improved more than 100-fold by simply modifying its surrounding sequence. This is the first study to clearly propose a solution to the problem why potent yeast promoters work in some environments and not in others." The Kobe University bioengineers demonstrated the usefulness of their system by showcasing the production of two pharmaceutically useful proteins, so-called "biologics." Not only could they produce these two biologics in separate yeast strains but also in the same strain and with the ability to independently control which biologic is produced at any time. The latter is important because it has potential applications in hospitals, as the team explains in the study: "In addition to the conventional fermentation of single biologics, the rapid and single-dose production of multiple biologics with a single yeast strain at the point of care is crucial for emergencies that require production speed and flexibility rather than purity and productivity." They also achieved the notoriously difficult production of a coronavirus protein that can be used for the production of treatments, further showcasing both the usefulness and the flexibility of their design principles. Tominaga explains his wider outlook on the implications of this study: "Synthetic biology advocates creating new biological functions by rewriting genome sequences. The reality is however that we are often confused by unexpected changes resulting from our edits. We hope that our study is the first step towards the ability to design every single base in the genome with clear intentions." This research was funded by the Japan Agency for Medical Research and Development (grants JP21ae0121002, JP21ae0121005, JP21ae0121006, JP21ae0121007, JP20ae0101055 and JP20ae0101060), the Japan Science and Technology Agency (grants JPMJCR21N2 and JPMJGX23B4) and the Japan Society for the Promotion of Science (grants JP23K26469, JP23H01776 and JP18K14374). It was conducted in collaboration with researchers from the Pharma Foods International Co. Ltd and National Institute of Health Sciences. Story Source: Materials provided by Kobe University . Note: Content may be edited for style and length. Journal Reference : Cite This Page :
Traders working on the floor of the New York Stock Exchange, during morning trading on Nov 26, 2024 in New York City. NEW YORK - Wall Street stocks powered to fresh records Nov 26, shrugging off a threat from President-elect Donald Trump to enact new tariffs on Mexico, Canada and China. The Dow Jones Industrial Average finished up 0.3 per cent at 44,860.31, its third straight closing record. The broad-based S&P 500 rose 0.6 per cent to 6,021.63, also a record, while the tech-rich Nasdaq Composite Index gained 0.6 per cent to 19,174.30. Trump, who doesn’t take office until Jan 20, made his threat in social media posts Nov 25 night, announcing huge import tariffs against neighbours Canada and Mexico and also rival China if they do not stop illegal immigration and drug smuggling into the United States. Investors view Trump’s inclination towards trade protectionism as a headwind to economic growth and higher equity prices. But Tuesday’s response suggests the market views the warning as a bargaining chip. “In theory, higher tariffs should not be good news for stocks. But, you know, I think the market’s chosen to think of (it) as a negotiating tactic,” said Mr Steve Sosnick, of Interactive Brokers. “You have bullish sentiment,” said LBBW’s Karl Haeling. “People are tending to look at things as positively as possible.” In other economic news, the Conference Board’s consumer confidence index rose to 111.7 this month, up from 109.6 in October, boosted by greater optimism surrounding the labour market. Among individual companies, Best Buy tumbled 4.9 per cent as it cut its full-year sales outlook after a big slowdown in sales leading into the presidential election. The electronics retailer said sales have rebounded since the election. Other retailers also fell, including Burlington Stores, down 1.6 per cent; Dick’s Sporting Goods, down 1.4 per cent; and Kohl’s, down 17 per cent. Amgen dropped 4.8 per cent after reporting that trials of its MariTide drug led to weight loss of up to 20 percent after 52 weeks. The drop in shares appeared to show disappointment that the impact was not even greater. REUTERS Join ST's Telegram channel and get the latest breaking news delivered to you. Read 3 articles and stand to win rewards Spin the wheel now
Vietnam's ambitions to modernize its military and diversify international partnerships were on full display at the 2024 Vietnam International Defense Expo, an exhibition that concluded with defense enterprises signing 16 contracts worth over $286 million, along with 17 strategic cooperation agreements with international defense firms. The exhibition, which took place from Dec. 19-22 in Hanoi, featured more than 240 defense industry companies and represented 49 countries. Vietnamese Prime Minister Pham Minh Chinh said the expo was “an affirmation of Vietnam's role and contribution in international defense cooperation” and a “symbol of trust, respect and goodwill in cooperation between nations for a world of peace, stability and prosperity.” Experts noted that the vast number of international companies at the exhibition reflected Vietnam’s long-term approach to diversifying its foreign partners. "If you look at the list of invited firms and defense firms and companies at the expo, you can see there’s a wide range of companies from many different countries,” said Hanh Nguyen, a research fellow at the Yokosuka Council on Asia-Pacific Studies based in Japan. “This decision reflects Vietnam's long-standing foreign policy approach, which is to strive to build partnerships with every country regardless of their political system or ideology," he added. Bich Tran, a postdoctoral fellow at the Lee Kuan Yew School of Public Policy in Singapore, shared a similar sentiment, explaining to VOA that the presence of Chinese, Russian and Western countries at the expo showed that Vietnam is committed to the principle of diversifying its foreign relations. “Vietnam has talked about diversifying its arms supplies for many years, but I think Russia’s invasion of Ukraine forced Vietnam to facilitate the process. So with this expo, [Vietnam] has the opportunity to talk with many different partners, to look around to see what will work,” Tran said. American firms Boeing and Lockheed Martin, French company Airbus, and Chinese state-owned China North Industries Corporation (NORINCO) attended the expo. NORINCO's participation marked the first time for a Chinese company. Concurrently, Vietnam’s general-secretary of the Communist Party, To Lam, met with visiting Chinese Defense Minister Dong Jun. Despite the active participation and discussion between Beijing and Hanoi officials, Nguyen said the expo is unlikely to become a breakthrough point for arms sales between the two countries, noting that Vietnam has concerns over the transparency performance of Chinese military equipment. Nguyen The Phuong, a doctoral candidate in maritime security at the University of New South Wales, told VOA that “Vietnam will never, ever buy any lethal weapons from China,” adding that Vietnam’s reluctance to buy weapons from China is a “long-standing principle dating back to the ‘70s and '80s.” Phuong said Vietnam is preparing to advance and upgrade its outdated systems, “focusing on the modernization of the Vietnamese army and maritime defense needs.” “Vietnam is trying to modernize its navy and air force and trying to turn them into modernized and capable services after 2030. So, there are a lot of things that the Vietnamese military wants to improve from buying more aircraft for its air force, building more warships for its navy, and especially the capability to monitor.” Contributing to Hanoi’s need to modernize is the potential for conflict in the South China Sea, a geopolitically disputed territory that is both a critical maritime route for global trade and a region rich in resources, including oil, natural gas and fish stock. On Dec. 10, the South China Morning Post reported that Vietnam is actively building military facilities on several islands and reefs in the Spratly Islands — key territories in the South China Sea. "Vietnam's military strategy in the South China Sea can be summed up in one word: deterrence. Or more precisely, deterrence by denial," said Phuong, explaining that Vietnam’s decisions at the expo reflect an ambition to increase its coastal military capabilities. Another takeaway from the expo is Hanoi’s cooperation with the United States. Speaking at the expo, U.S. Ambassador to Vietnam Marc Napper said the United States' goal is to ensure that Vietnam "has everything it needs to defend its interests at sea, in the air, on the ground and in cyberspace.” Tran said this goal demonstrates that the U.S.-Vietnam defense cooperation is shifting from a single arms assistance model to a broader multilateral cooperation framework.NEW YORK , Nov. 26, 2024 /PRNewswire/ -- Rhuna, an advanced event management platform developed by the creators of UNTOLD—ranked #3 globally by DJ Mag and one of the world's largest music festivals—announces its partnership with Plume, the first fully-integrated layer-1 modular blockchain focused on Real World Asset Finance (RWAfi). Reaching over 2 million attendees across 165 events, including partnerships with iconic organizers like UNTOLD Festival, this collaboration is set to revolutionize the $700B+ live events industry with cutting-edge innovation. Building the Future of Onchain Events Rhuna's platform integrates into Plume Network, leveraging its ecosystem of 180+ projects, over 200M transactions, and support from 3.5M testnet users. This partnership enables innovative blockchain solutions that modernize event management, offering capabilities such as: Rhuna's Proven Track Record Rhuna's platform has already revolutionized event management in the Web2 space, with: This collaboration amplifies Rhuna's ability to scale globally while delivering cost-effective, engaging, and personalized event experiences. Why This Matters The partnership addresses key challenges in the events industry, combining Rhuna's expertise with Plume's blockchain infrastructure to deliver tangible results, while creating transparent and scalable tools for secure, decentralized event management. " This partnership is a major milestone for the integration of blockchain into real-world industries, " said Chris Yin , CEO of Plume. " With Rhuna's proven success in live events and Plume's infrastructure, we're unlocking the full potential of Web3 to transform how events are managed and experienced. " " We're excited to partner with Plume Network, whose focus on RWAfi and modular blockchain infrastructure perfectly aligns with Rhuna's mission. Plume's technology enhances our platform's scalability, security, and efficiency, helping us deliver seamless, blockchain-powered solutions for event organizers and attendees in real-world asset integration. This partnership is a key step in transforming the events industry, " said Sveatoslav Vizitiu, CEO of Rhuna. About Rhuna Rhuna is a white-label event management platform integrating modular solutions for payments, marketing, ticketing, and analytics into a seamless, blockchain-powered infrastructure. Founded by the creators of UNTOLD, Rhuna's mission is to scale events of all sizes while delivering cost-effective, engaging, and personalized attendee experiences. Learn more at rhuna.io or contact sveat@rhuna.io . Twitter | Website | Discord | Telegram About Plume Plume is the first fully integrated L1 modular blockchain focused on RWAfi, offering a composable, EVM-compatible environment for onboarding and managing diverse real-world assets. With 180+ projects on its private devnet, Plume provides an end-to-end tokenization engine and a network of financial infrastructure partners, simplifying asset onboarding and enabling seamless DeFi integration for RWAs. Learn more at plumenetwork.xyz or contact press@plumenetwork.xyz . View original content to download multimedia: https://www.prnewswire.com/news-releases/700b-industry-shake-up-rhuna-x-plume-transforming-events-for-2m-attendees--200m-blockchain-transactions-302316970.html SOURCE Plume Network
Cambridge spinout Molyon bets on lithium-sulfur in race for better batteries
Dell Technologies Q3 revenue falls short of estimates as weak PC demand weighsOn a rare two-game skid, No. 24 Arizona faces DavidsonJoin our newsletter to get the latest military space news every Tuesday by veteran defense journalist Sandra Erwin. WASHINGTON — Gen. Chance Saltzman, the Space Force’s top officer, announced Dec. 17 that the service will establish a new Futures Command in early 2025, a move aimed at giving the military’s newest branch more analytical firepower to justify its programs and spending. Speaking at the Center for Strategic and International Studies (CSIS), Saltzman said the new command will help provide “the data set that we can then use in the budget fights” — a crucial capability as the Space Force faces growing congressional scrutiny over its acquisition speed and strategic focus. CSIS on Tuesday hosted an event marking the Space Force’s fifth anniversary. Saltzman and other officials at the event highlighted growing concerns about China’s rapidly advancing space capabilities, which include everything from satellite-killing weapons to new communications systems that could give Beijing an edge in future conflicts. The Futures Command will expand on work currently done by the Space Warfighting Analysis Center (SWAC), adding new organizations focused on threat analysis and capability planning to determine what forces and systems the Space Force needs to counter emerging challenges. The new command also will have a dedicated wargaming team to test potential technologies through tabletop exercises and learning campaigns, and will do requirements validation to ensure new programs have rigorous analytical backing. Speaking last week at the Spacepower Conference in Orlando, Florida, Kelly Hammett, who leads the Space Force’s Rapid Capabilities Office, suggested the Futures Command could help streamline how the service handles requests from regional military commands, creating “a prioritized set of requirements” rather than trying to juggle competing demands. Lt. Gen. Shawn Bratton, deputy chief of space operations for strategy, plans and programs, told reporters at the Spacepower Conference that the plan is to name a two-star commander and begin a basing process to select a headquarters location. The SWAC is currently based in Colorado Springs. Although Saltzman first unveiled plans for the Futures Command in February 2024, the decision to push its establishment to early 2025 appears designed to give the incoming administration a voice in shaping the new organization’s structure and priorities. Even as the Space Force moves to strengthen its planning capabilities, it’s facing heat from Capitol Hill over the pace of its technology development. “We can no longer afford to wait eight or more years to develop requirements, and conduct long drawn-out competition processes,” Rep. Mike Rogers (R-Ala.), chairman of the House Armed Services Committee, said at the CSIS event. “Nor can we afford these endless cost-plus development contracts.” Rogers, a key oversight figure for military space programs, pushed for the Space Force to develop more acquisition and technology experts rather than focusing primarily on operators. “After all, what are those operators going to operate if acquirers aren’t acquiring?” he noted.
Join our newsletter to get the latest military space news every Tuesday by veteran defense journalist Sandra Erwin. WASHINGTON — Gen. Chance Saltzman, the Space Force’s top officer, announced Dec. 17 that the service will establish a new Futures Command in early 2025, a move aimed at giving the military’s newest branch more analytical firepower to justify its programs and spending. Speaking at the Center for Strategic and International Studies (CSIS), Saltzman said the new command will help provide “the data set that we can then use in the budget fights” — a crucial capability as the Space Force faces growing congressional scrutiny over its acquisition speed and strategic focus. CSIS on Tuesday hosted an event marking the Space Force’s fifth anniversary. Saltzman and other officials at the event highlighted growing concerns about China’s rapidly advancing space capabilities, which include everything from satellite-killing weapons to new communications systems that could give Beijing an edge in future conflicts. The Futures Command will expand on work currently done by the Space Warfighting Analysis Center (SWAC), adding new organizations focused on threat analysis and capability planning to determine what forces and systems the Space Force needs to counter emerging challenges. The new command also will have a dedicated wargaming team to test potential technologies through tabletop exercises and learning campaigns, and will do requirements validation to ensure new programs have rigorous analytical backing. Speaking last week at the Spacepower Conference in Orlando, Florida, Kelly Hammett, who leads the Space Force’s Rapid Capabilities Office, suggested the Futures Command could help streamline how the service handles requests from regional military commands, creating “a prioritized set of requirements” rather than trying to juggle competing demands. Lt. Gen. Shawn Bratton, deputy chief of space operations for strategy, plans and programs, told reporters at the Spacepower Conference that the plan is to name a two-star commander and begin a basing process to select a headquarters location. The SWAC is currently based in Colorado Springs. Although Saltzman first unveiled plans for the Futures Command in February 2024, the decision to push its establishment to early 2025 appears designed to give the incoming administration a voice in shaping the new organization’s structure and priorities. Even as the Space Force moves to strengthen its planning capabilities, it’s facing heat from Capitol Hill over the pace of its technology development. “We can no longer afford to wait eight or more years to develop requirements, and conduct long drawn-out competition processes,” Rep. Mike Rogers (R-Ala.), chairman of the House Armed Services Committee, said at the CSIS event. “Nor can we afford these endless cost-plus development contracts.” Rogers, a key oversight figure for military space programs, pushed for the Space Force to develop more acquisition and technology experts rather than focusing primarily on operators. “After all, what are those operators going to operate if acquirers aren’t acquiring?” he noted.
MANCHESTER, NH – Elliot Health System is launching a Cardiothoracic Surgery Program with plans to offer open heart surgery to patients starting in January 2026. This critical step forward expands upon the existing expertise of The Elliot cardiovascular team, which provides patients with the latest technology and care including advanced cardiac imaging, advanced heart failure treatment, interventional cardiology, cardiac rehabilitation, electrophysiology, nuclear cardiology, and cardio-oncology. “As Manchester’s most comprehensive nonprofit health system, we are laser-focused on delivering on our mission to best care for our community. To fulfill this promise, we continue to evolve with the hard work and dedication of our staff and providers—expanding our services to ensure every individual receives the comprehensive care they deserve,” said Elliot Health System President and CEO Dr. Greg Baxter. “With the transformative step of adding heart surgery to our existing expertise in cardiovascular care, The Elliot can offer patients a fully comprehensive range of cardiac care services with outstanding surgeons and providers who are proven and have served the greater Manchester community for decades.” The Elliot’s cardiovascular team has grown throughout 2024 with additional Board-certified cardiologists. In Fall 2025, a newly dedicated location will open on the Elliot Hospital campus for cardiovascular services to best serve patients. Learn more about The Elliot’s cardiovascular services at ElliotHospital.org/Cardiovascular . We don’t spam! You're on the list! Check your inbox or spam folder to confirm your subscription.Dejounte Murray is rejoining the Pelicans against Raptors and drawing inspiration from his mother
Rakovina Announces Debentureholder Election To Receive Shares In Partial Satisfaction Of Debenture Interest Payment Obligations
