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https://livingheritagejourneys.eu/cpresources/twentytwentyfive/    boiler genie  2025-02-02
  

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NoneAfter opening the week with a perfectly clean injury report, Los Angeles Rams offensive tackle Rob Havenstein is dealing with a shoulder injury that occurred in practice, putting his status up in the air in advance of Saturday's home game against the Arizona Cardinals. The Rams (9-6), who are on a four-game winning streak that moved them into the lead in the NFC West, have rebounded from a 1-4 start. That poor early stretch was due, in part, to injuries on the offensive line. Havenstein missed the season opener against the Detroit Lions with an ankle injury, then missed a three-game stretch in November with more ankle issues. Havenstein did not practice Thursday because of the shoulder injury, although he typically does not participate in the final practice of the week for rest purposes. The 32-year-old is in his 10th NFL season, all with the Rams going back to the team's 2015 season in St. Louis. Joe Noteboom would likely start if Havenstein is not available Saturday. The Rams can clinch the NFC West this weekend with a victory over the Cardinals (7-8), combined with a loss or tie by the Seattle Seahawks (8-7) against the Chicago Bears (4-11). --Field Level Mediagenie voice actor

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What Made The Gulfstream IV Series So Unique?Nordic Semiconductor: And We're Down AgainUS politicians on both sides have reacted to news that former US President Jimmy Carter, who as president brokered peace between Israel and Egypt and later received the Nobel Peace Prize for his humanitarian work, has died at age 100. or signup to continue reading Here are some of the immediate comments. PRESIDENT JOE BIDEN AND FIRST LADY JILL BIDEN "Today, America and the world lost an extraordinary leader, statesman and humanitarian. Over six decades, we had the honour of calling Jimmy Carter a dear friend. But, what's extraordinary about Jimmy Carter, though, is that millions of people throughout America and the world who never met him thought of him as a dear friend as well." US PRESIDENT-ELECT DONALD TRUMP "The challenges Jimmy faced as President came at a pivotal time for our country and he did everything in his power to improve the lives of all Americans. For that, we all owe him a debt of gratitude. Melania and I are thinking warmly of the Carter Family and their loved ones during this difficult time. We urge everyone to keep them in their hearts and prayers." FORMER US PRESIDENT BILL CLINTON AND FORMER SECRETARY OF STATE HILLARY CLINTON "From his commitment to civil rights as a state senator and governor of Georgia; to his efforts as President to protect our natural resources in the Arctic National Wildlife Refuge, make energy conservation a national priority, return the Panama Canal to Panama, and secure peace between Egypt and Israel at Camp David; to his post-Presidential efforts at the Carter Centre supporting honest elections, advancing peace, combating disease, and promoting democracy; to his and Rosalynn's devotion and hard work at Habitat for Humanity—he worked tirelessly for a better, fairer world." US SENATOR MITCH MCCONNELL "Elaine and I join the Senate and the nation in mourning the passing of our 39th president, Jimmy Carter." "President Carter served during times of tension and uncertainty, both at home and abroad. But his calm spirit and deep faith seemed unshakeable. Jimmy Carter served as our commander-in-chief for four years, but he served as the beloved, unassuming Sunday school teacher at Maranatha Baptist Church in Plains, Georgia for forty. And his humble devotion leaves us little doubt which of those two important roles he prized the most." US HOUSE SPEAKER MIKE JOHNSON "Today, the thoughts of Americans and the prayers of Congress are lifted up on behalf of the Carter family. President Carter's story was one of humble beginnings, and his life is a testament to the boundless opportunities available in this great nation. Because of his work in brokering the Camp David Accords and his advocacy with Habitat for Humanity, the world is a more peaceful place, and more Americans have a place to call home. No one can deny that President Carter led an extraordinary life of service to his country. May he rest in peace." US REPRESENTATIVE MIKE TURNER "I am deeply saddened to learn about the death of President Jimmy Carter. President Carter was a man of integrity who was guided by his faith. I join all Americans in saluting President Carter for his lifetime of service, first as a naval officer, then as a senator in the Georgia State Senate, then as Governor of Georgia, and, finally, as President of the United States. I would like to extend my heartfelt condolences to the Carter family." US SENATOR MARK WARNER "President Carter will be remembered by what he built and left behind for us – a model of service late into life, a tireless devotion to family and philanthropy, and a more peaceful world to call home." DAILY Today's top stories curated by our news team. WEEKDAYS Grab a quick bite of today's latest news from around the region and the nation. WEEKLY The latest news, results & expert analysis. WEEKDAYS Catch up on the news of the day and unwind with great reading for your evening. WEEKLY Get the editor's insights: what's happening & why it matters. WEEKLY Love footy? We've got all the action covered. WEEKLY Every Saturday and Tuesday, explore destinations deals, tips & travel writing to transport you around the globe. WEEKLY Going out or staying in? Find out what's on. WEEKDAYS Sharp. Close to the ground. Digging deep. Your weekday morning newsletter on national affairs, politics and more. TWICE WEEKLY Your essential national news digest: all the big issues on Wednesday and great reading every Saturday. WEEKLY Get news, reviews and expert insights every Thursday from CarExpert, ACM's exclusive motoring partner. TWICE WEEKLY Get real, Australia! Let the ACM network's editors and journalists bring you news and views from all over. AS IT HAPPENS Be the first to know when news breaks. DAILY Your digital replica of Today's Paper. Ready to read from 5am! DAILY Test your skills with interactive crosswords, sudoku & trivia. Fresh daily! Advertisement Advertisement

Thanks brooooo. A dream has come true!” replied my Syrian friend, just hours after the collapse of the Assad regime. A medical doctor who had helped countless refugees throughout the years under the auspices of the United Nations, he had spent years behind bars and had been subjected to unspeakable torture by the former regime. Throughout his 20s, he witnessed more horror and tragedy than most humans throughout their entire lives. But he is also a young and newlywed man brimming with hope for a better future—for his once-beautiful country can, if given the chance, become great again. The fall of the Assad regime has, predictably, generated mixed reactions. After all, the half-a-century-old Assad dynasty had generated a degree of stability and prosperity until the 2010 to 2011 Arab uprisings and, in more recent years, was the ”known devil” for regional actors. The new supremo of Syria, however, is Abu Mohammed al-Golani, a jihadist who spent time in the inner circles of al-Qaida before ”moderating” his image and ”nationalizing” his mission as the leader of the Hayat Tahrir al-Sham (HTS) forces. Born as Ahmad al-Sharaa in Saudi Arabia to Syrian parents, he formerly led the al-Nusra front, the Syrian branch of al-Qaida, and displayed his independent streak by defying calls to be merged into what would later become the “Islamic State” under the leadership of Abu Bakr al-Baghdadi. After years of frozen conflict, with both Russia and Iran effectively bailing out the Assad dynasty, the Syrian regime instantaneously crumbled in the face of al-Golani’s blitzkrieg offensive. With the Assad regime cut off from its bailiwick in Lattakia and Alawite coastal regions following the fall of Homs, the fall of Damascus became an inevitability. In just over a week, al-Golani beat even Taliban’s lightning record in toppling a foreign-backed regime. “Syria deserves a governing system that is institutional, no one where a single ruler makes arbitrary decisions,” the former al-Qaida-affiliate leader told CNN last week. During his appearance at the landmark Umayyad Mosque in Damascus hours into the downfall of the Assad regime, al-Golani declared: “Our message to all the sects of Syria is that ... Syria is for everyone.” As astute observers such as Charles Lister have argued, however, both al-Golani’s military victory and ”moderated” image invite scrutiny. To begin with, the Assad regime—notorious for its corruption, brutality, and narco-politics—was thoroughly hollowed out after a decade of brutal civil war. It had little chance of long-term survival once its chief patrons, Russia and Iran, shifted their focus to other strategic fronts amid the ongoing conflicts from Ukraine to Gaza. Meanwhile, the HTS leadership, known for its iron-fist rule throughout its former territories, has every reason to present a more ”moderate” image to both consolidate support in multi-sectarian Syria and crucially win international recognition despite its ”terrorist” designation. As if the Syrian upheaval wasn’t historic enough, last week saw another surreal development: the declaration of martial law in one of the world’s most prosperous democracies. Confronting political sterility and collapsing approval ratings, President Yoon Suk-yeol went for the nuclear option, just to see his short-lived martial law stymied by fierce resistance from both the Parliament, including his own party mates as well as South Korea’s fearless civil society, who collectively resisted military forces until the president backed down. Not long after, South Korean prosecutors arrested former defense minister Kim Yong-hyun on charges of treason; Yoon narrowly avoided impeachment while mulling potential resignation. In both Syria and South Korea, popular resistance prevailed against the forces of dictatorship. The path ahead, however, is filled with uncertainty. Lest we forget, the past year was filled with countless shocks, including the victory of Donald Trump, the tit-for-tat missile exchanges between Middle East’s two most powerful nations, and the all-out political war between the House of Duterte and the House of Marcos. The old order—along with its underlying assumptions—is perishing, while a new order is yet to crystalize. But as the great Italian thinker Antonio Gramsci counseled: one should combine the “pessimism of the intellect,” namely taking into account hard facts and troubling imponderables with the “optimism of the will,” namely the courage to fight for freedom and a better tomorrow. —————- [email protected] Subscribe to our daily newsletter By providing an email address. I agree to the Terms of Use and acknowledge that I have read the Privacy Policy .SGR-1505 is under clinical development by and currently in Phase I for Follicular Lymphoma. According to GlobalData, Phase I drugs for Follicular Lymphoma have a 78% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. SGR-1505 overview SGR-1505 is under development for the treatment of BTK-resistant, refractory or relapsed B-cell non-Hodgkin lymphoma, diffuse large B-cell lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma (MCL), Waldenstrom macroglobulinemia, MALT lymphoma, follicular lymphoma, Burkitt lymphoma, plasmablastic lymphoma, high-grade B-cell lymphoma, primary cutaneous follicle center lymphoma, primary effusion lymphoma, primary mediastinal large B cell lymphoma, T-cell/histiocyte rich lymphoma, ALK-positive large B-cell lymphoma, primary cutaneous diffuse large B-cell lymphoma splenic marginal zone lymphoma, nodal marginal zone lymphoma, HHV8-positive DLBCL and duodenal-type follicular lymphoma. It is administered through oral route in the form of tablet. The drug candidate acts by oncogenic activation of nuclear factor-kappa B which acts by targeting MALT1 activity. It is developed based on the artificial intelligence (AI) technology. Schrodinger overview is a healthcare technology company that provides software solutions for drug discovery. The company offers a computational platform designed with predictive modeling, data analytics and collaboration applicable to molecular discovery. Its pipeline products include SGR-1505 (MALT1) against non-Hodgkin’s lymphoma, SGR-2921 (CDC7) to treat hematological cancers and solid tumors and SGR-3515 (Wee1) for gynecological cancers, and LRRK2 for Neurology and SOS1 for cancers and others. ‘s other products include small molecule products, biological drug discovery and material science products. It provides training, documentation and support services. The company operates through offices in the US, Germany, Japan, Ireland, the UK, India, China and South Korea. is headquartered in New York City, New York, the US. For a complete picture of SGR-1505’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .

Israeli police set to probe Netanyahu’s wife over ‘harassment of witnesses’

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