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(BPT) - This article was sponsored and developed by Neurocrine Biosciences, Inc. Cerebral palsy (CP) is a neurodevelopmental disorder affecting movement and posture that begins in early childhood development. It is the most common cause of motor disability in children, affecting about one in 345 children in the United States. 1-2 It may happen as a result of lack of oxygen during or around birth, stroke, infection, a problem with metabolism or other problems that cause injury or affect the development of parts of the brain involved in movement control in the first few years of life. 3 CP is a permanent condition, affecting a person for their entire life. People living with CP typically have motor problems, which may include spasticity (abnormal muscle tightness), dyskinesia (uncontrolled movements) or ataxia (poor muscle control), and many people have a mix of these motor disorders. 4 Dyskinesia due to CP (DCP) is one of the most disabling forms of CP and impacts approximately 10% to 20% of people living with CP. 5-6 According to the Cerebral Palsy Foundation (CPF), the combination of irregular and unpredictable movements (chorea) and twisting and repeating movements (dystonia) often disrupt activities and cause significant functional impairment, including the ability to maintain balance, walk or fine motor control. 7 Heather Riordan, M.D., Neurologist and Movement Disorders Specialist, Director of the Phelps Center for Cerebral Palsy at the Kennedy Krieger Institute, discusses the symptoms of chorea and impact on patients in a video shared on the CPF website here . About 30% of people with DCP are affected mostly by these involuntary and irregular movements (chorea), while dystonia is the predominant motor finding in the remaining 70%. 8 However, it is common for both chorea and dystonia movements to be present together. 6 For people living with DCP, these movements can occur in any region of the body, including the arms and legs, torso and face and may vary in severity. They are often triggered or made worse by stimulation or stress. Because dyskinesia can occur at rest and/or when actively using the body, the problems with movement are very burdensome in day-to-day living, with discomfort and pain affecting the quality of life for people and their caregivers. 9 Jen Lyman, mom to a son with DCP, highlights how dyskinesia makes communicating more difficult. "The most difficult thing about dyskinesia is watching my son struggle to do things that he wants to do, but the extra movements get in the way...special things, such as using a touch screen to video chat with his grandmother, are nearly impossible despite his best efforts to use his hands and fingers. Something so simple, yet so special for him should be effortless." DCP has a wide-ranging impact on the individual, including lifelong challenges with movement, a higher risk of other medical issues, a higher rate of mental health challenges and difficulties with communication. 10-12 "Those of us who have the privilege to serve patients with dyskinetic, hyperkinetic or mixed cerebral palsy see the functional impact of this very challenging type of tone every day," said Susan Biffl, M.D., Rehabilitation Medicine Specialist at Rady Children's Hospital-San Diego and Assistant Professor at UC San Diego School of Medicine. "Patients face challenges with self-care, independence, mobility, communication, fine motor skills that affect occupational and recreational activities, swallowing, social interactions and even sleep. As this tone is variable, it is much more challenging to treat than more consistent tone issues, such as spasticity." Treatment Options There are currently no Food and Drug Administration-approved treatments for DCP. Dystonia and chorea are often managed separately as they respond differently to various treatments, which can make treatment challenging. 3 Most drugs being investigated for DCP have focused on dystonia, and more research is needed to determine potential treatments for chorea. New treatment options are needed to help manage these movement disorders and improve daily function and quality of life for those affected. "After 20 years of caring for individuals with cerebral palsy, I continue to find those with dyskinetic cerebral palsy among the most challenging to treat, largely due to the limited effectiveness of available pharmacologic options," said Joyce Oleszek, M.D., Professor, Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine. "There is an urgent need for more robust evidence to support pharmacologic treatments for this condition, given its profound impact on function, comfort and quality of life." Ongoing Research Clinical studies are important in the development of treatment options, allowing researchers to evaluate the safety and effectiveness of new medicines. The data from clinical studies are used to determine if an investigational treatment can be approved for use to treat certain disorders. There are ongoing clinical studies evaluating potential treatments for DCP, including one for chorea. Neurocrine Biosciences is conducting the KINECT ® -DCP clinical study, a Phase 3, randomized, double-blind placebo-controlled study investigating the study drug, valbenazine, for the treatment of DCP. The clinical study is currently enrolling children, adolescents and adults six to 70 years of age who have been diagnosed with DCP. "The Cerebral Palsy Foundation is excited to partner with Neurocrine Biosciences on this study," said Rachel Byrne, Executive Director of the Cerebral Palsy Foundation. "We are proud to support strong research that can potentially bring meaningful change to the lives of those living with cerebral palsy." If you or someone you know may be eligible for this research study, please visit the study website for additional information here: FindADCPStudy.com . REFERENCES © 2024 Neurocrine Biosciences, Inc. All Rights Reserved. CAP-NBI-US-0115 12/2024 NBI-98854-DCP3018_11DecMatRelease_v1.0_25November2024The Dangers of Isolated Gameplay: A Faith-Based Approach to VR Headsets
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The Aam Aadmi Party (AAP) on Thursday announced its first list of 11 candidates for the Delhi Assembly election scheduled for February next year. Both the Bharatiya Janata Party (BJP) and the Congress are yet to announce their candidates. Out of the 11 candidates, six had switched to the ruling party in the last two months, three each from the BJP and the Congress. The party has dropped three of its sitting MLAs. The names were announced after a meeting of AAP’s political affairs committee, the highest decision-making body of the party, which is headed by party national convener Arvind Kejriwal. AAP has been in power in Delhi since 2015 and had won 67 of the 70 seats in the 2015 Assembly poll and 62 seats in the 2020 poll. ‘Set to launch campaign’ Addressing mediapersons, AAP Delhi convener Gopal Rai said, “With the announcement of candidates, AAP has now geared up to accelerate its campaign for the Assembly election. Starting today, AAP is preparing to launch a massive campaign across the city. The details will be shared soon.” Mr. Rai said AAP remains confident that under the leadership of Mr. Kejriwal, the people will re-elect the party in the election to continue the momentum of progress and development in the Capital. The AAP leader said the candidates were announced early as eight of these 11 constituencies currently do not have AAP MLAs. “To strengthen its campaign in these areas, the party has prioritised them in the first list.” The BJP and the Congress targeted AAP over giving tickets to leaders from other parties who had joined it as recently as Sunday. The BJP said six candidates being entrants from other parties showed that AAP is scared of “anti-incumbency”. The Congress alleged that Mr. Kejriwal was desperate to save his party as three of the 11 candidates in the first list were “Congress discards”. Published - November 22, 2024 01:39 am IST Copy link Email Facebook Twitter Telegram LinkedIn WhatsApp Reddit Aam Aadmi Party / Delhi / election / Bharatiya Janata Party / Indian National Congress
JOHN Swinney has said he didn’t believe a man can get pregnant - as his government’s lawyers argue the opposite in the supreme court. Scottish Government briefs have spent the past two days claiming a person can be a woman even if they were born male. 3 First Minister John Swinney has said he doesn't believe a man can get pregnant Credit: Andrew Barr 3 Ruth Crawford KC is claiming that those who have a gender recognition certificate should have the same legal protections as biological women Ruth Crawford KC - acting for SNP ministers - told the Supreme Court that people who obtain a gender recognition certificate (GRC) are entitled to the same protections under law as biological women. In a 40-page statement to the court, Nats ministers also insist references to a woman who is pregnant in the Equality Act would also apply to a ‘pregnant man’ who was born female. Ms Crawford was responding to a legal challenge brought by a Scottish women’s rights group over whether trans women can be regarded as female under the terms of the 2010 Equality Act. She was pressed by the judges on how she squared her position with issues affecting the bodies of females, such as pregnancy - the so-called “pregnant man” issue - or cervical screenings. Read more Politics stories PARTY'S OVER Nigel Farage's Reform Party could wreck SNP's hold over Holyrood FREEBIES ROW Under-fire SNP minister under MORE pressure over trip to glitzy film premiere She responded that the “pregnant man” issue was “very clearly a matter of deep political water” that should either be left for Parliament to resolve, or treated, along with things such as cervical screenings, as a “matter of fact” regardless of a GRC. But First Minister Mr Swinney today also appeared to contradict his government’s lawyers on the issue - saying he did not believe a man could get pregnant. Asked whether he did believe that, the SNP leader said: “No, I don’t.” And pressed on why his lawyers were arguing exactly that, Mr Swinney said: “I think there are many complex arguments being put forward in the Supreme Court judgement and I don’t think they come down to the simplicity of the question you’ve put to me.” Most read in The Scottish Sun BUS BEAST Kilmarnock fan famous for foul-mouthed post-match rants exposed as paedophile THREAT CONCERN Glasgow councillor APOLOGISES for Gers fans comment in shock pub row SICKO CAGED ScotRail worker caught in vigilante paedo sting at train station jailed CASH VOW Nurse cancels £30k Scots fairytale wedding after 'rose-tinted glasses come off' Speaking today, feminist KC Joanna Cherry - a former SNP MP - said: “I am pleased that John recognises this biological reality but I’m presently sitting in the UK Supreme Court watching his Government’s lawyers argue the opposite.” It is the latest evidence heard in a long-running legal challenge by feminist rights groups including For Women Scotland. Moment Scottish Tory leader Russell Finlay pours pint before necking it in Glasgow Lawyers acting on behalf of For Women Scotland set out their arguments in the two-day hearing on Tuesday, urging judges to recognise the “facts of biological reality”. They added: “Our position is your sex, whether you are a man or a woman or a girl or a boy, is determined from conception in utero, even before one’s birth, by one’s body. It is an expression of one’s bodily reality. It is an immutable biological state.” But Scots Gov lawyer Ms Crawford told the Court today: “We submit there are only two sexes or genders, and a person whose sex becomes that of a man or woman in consequence of a GRC belongs to that sex, and will have the protection afforded under the Equality Act.” She countered claims that a gender certificate was a “legal fiction” or of merely symbolic value. She described it as a “fundamental right” similar to adoption, telling the court a gender recognition certificate affected an individual’s relationship with the state, and with private organisations such as employers. A GRC is an official document available to those over 18 who can prove they have been living in their chosen gender for at least two years. A verdict in the hearing before Lord Reed, Lord Hodge, Lord Lloyd-Jones, Lady Rose and Lady Simler is not expected until a later date. 3 SNP ministers insist references to a woman who is pregnant in the Equality Act would also apply to a ‘pregnant man’ who was born female Credit: Andrew BarrThis photo shows Hana Bank's dealing room in Seoul, Dec. 3. Yonhap Stock markets will open as usual Wednesday, the finance ministry said, following President Yoon Suk Yeol's unexpected declaration of emergency martial law overnight, which was subsequently lifted. The decision was made during an emergency meeting held earlier in the day between Finance Minister Choi Sang-mok and top economic and financial officials, according to the ministry. The benchmark KOSPI and the tech-heavy KOSDAQ markets are scheduled to open at 9 a.m. and close at 3:30 p.m. The decision came as the foreign exchange market and overseas Korean stock-related markets, which had displayed instability following Yoon's surprise declaration, began to stabilize after the measure was lifted only hours later, the ministry said. Korea lifts martial law, relieving some market uncertainty 2024-12-04 07:05 | Markets The South Korean won slid to as low as 1,441 per dollar during offshore trading hours following the declaration late Tuesday. The won recovered slightly to close at 1,415.8 won. The KOSPI 200 overnight futures index also faced significant losses, sinking more than 5 percent during the session before closing with a 1.8 percent drop. Finance Minister Choi Sang-mok reassured investors, pledging that the government would take every possible measure to stabilize the financial and foreign exchange markets, including providing unlimited liquidity if necessary. The ministry also emphasized its commitment to market stability, stating that a governmentwide monitoring system is in place to closely observe financial market conditions. (Yonhap)
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Fans of George R. R. Martin's A Song of Ice and Fire fantasy novels have long, long, long, awaited the planned sixth entry in the series, The Winds of Winter. But after more than a decade of delays, even Martin is acknowledging the possibility that it may never come to be. “Unfortunately, I am 13 years late,” he told the outlet. “Every time I say that, I’m [like], ‘How could I be 13 years late?’ I don’t know, it happens a day at a time.” “But that’s still a priority," he continued. "A lot of people are already writing obituaries for me. [They’re saying] ‘Oh, he’ll never be finished.’ Maybe they’re right. I don’t know. I’m alive right now! I seem pretty vital!” It's only the latest in what's been an increasingly bleak wait for The Winds of Winter, with the most recent entry in the series, A Dance With Dragons, publishing in 2011. That's the same year that HBO premiered the insanely popular TV series Game of Thrones, which is based on the A Song of Ice and Fire series and drew a lot more eyes to the world of Westeros. Martin made the reveal in November 2023 that he's written 1,100 pages of The Winds of Winter, which wouldn't be so disappointing if it weren't the same number of pages he had written a year prior. Before that, in 2022 , he said he was "about three-quarters of the way done," and that the book would likely be more than 1,500 pages. Most recently, this past September, Martin admitted that he hadn't made as much progress as he would've liked to, as his various TV shows "ate up" much of his time. It's also worth mentioning that The Winds of Winter isn't even set to be the final book in A Song of Ice and Fire. A seventh novel, A Dream of Spring, was set to close out the series, although many fans have all but given up hope for that . ( Note : The THR article calls The Winds of Winter the "sixth and final book" in the A Song of Ice and Fire series, but we're assuming that's just a mistake; Martin's never formally canceled A Dream of Spring publicly). Still, in a glimmer of hope, Martin did note in the interview that he could never retire, as he's "not a golfer." So hey, there's that! Even if we never get The Winds of Winter, there's plenty happening in Westeros on the TV side. House of the Dragon is still on track for four seasons , with the third expected to start production early next year. Another spinoff, A Knight of the Seven Kingdoms, is set to arrive sometime in late 2025 , and there's even been early talk of a Game of Thrones movie . Alex Stedman is a Senior News Editor with IGN, overseeing entertainment reporting. When she's not writing or editing, you can find her reading fantasy novels or playing Dungeons & Dragons.
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The Raspberry Pi series of inexpensive single-board computers (or SBCs) built around an ARM system on a chip have greatly changed the landscape of do it yourself computing projects in the past 15 years. The germ of the idea came in 2006, when a group of employees at the University of Cambridge's Computer Laboratory who were concerned by a year-over-year decline in the number of computer science students and the skill level of those students who did enroll. Learning how to code had been part and parcel of the 1980s computer-owning experience, but in the 1990s and beyond, it became a less necessary skill. Introducing incredibly inexpensive computers designed for DIY projects that would encourage younger computer enthusiasts to learn programming languages was thus the catalyst for launching the Raspberry Pi organization and product line. The Raspberry Pi line is divided into four series of boards. Those are the flagship Pi with the most horsepower and connectivity options, the Zero series with a smaller form factor and fewer ports with lower specs, the Compute Module series for embedded applications, and the Pico series, which are very small microcontroller boards that don't run Linux or have removable storage, instead being programmed by flashing a binary onto the built-in flash storage. They're best for single-purpose uses, like controlling other devices. The Pico series has a new update, the $7 Raspberry Pi Pico 2 W . Let's take a look at what this board brings to the table with its feature set. What sets the Raspberry Pi Pico series apart from its cousins like the Raspberry Pi Zero series is that instead of being a cut-down version of the flagship Raspberry Pi, it's supposed to be a low-cost alternative to older Arduino boards. If you're new to Arduino boards , they're much more straightforward than Raspberry Pi boards, without the need to load an operating system onto it or worry about a user interface. Instead, you write your code in the Arduino software on your primary computer and flash it to the board. The Pico series works the same way. If you're looking at comparing the Raspberry Pi Pico to Arduino boards , though they're broadly similar, they use different programming languages and have different pinouts. Spec-wise, the Pico 2 W boasts dual Arm Cortex-M33 or dual Hazard3 RISC-V processor running at 150MHz, 520KB of on-chip SRAM, newly included 2.4GHz 802.11n Wi-Fi with support for Bluetooth 5.2, plus various security features with full documentation. As of this writing, there's just one professional review of the Pico 2 W available online, from Les Pounder at Tom's Hardware . That review is very positive, giving the board 4.5 stars out of five and noting that the addition of Wi-Fi was the big game changer. The review also praises the new model for coming with an increase in power while keeping the price low. If you don't need Wi-Fi, the regular Pico 2 is fine, but this is the one for your " internet of things " projects.
