Jared Polis passed the Hunter pardon IQ test — will the rest of his party?Georgia's Dasha Vidmanova, Columbia's Michael Zheng win NCAA singles titles

This report is from today's CNBC Daily Open, our international markets newsletter. CNBC Daily Open brings investors up to speed on everything they need to know, no matter where they are. Like what you see? You can subscribe here . 24/7 San Diego news stream: Watch NBC 7 free wherever you are New highs for S&P and Nasdaq U.S. markets were mixed on Monday . The S&P 500 and Nasdaq Composite climbed to new highs, but the Dow Jones Industrial Average dipped. Asia-Pacific stocks traded higher on Tuesday . Japan's Nikkei 225 jumped around 2.1%, buoyed by chip-related stocks such as Tokyo Electron and Lasertec , which shrugged off new rounds of U.S. export curbs . Intel CEO ousted Intel ousted CEO Pat Gelsinger over the weekend. The decision, made public Monday, was motivated by the board's lack of confidence in Gelsinger's plans, said a source. Replacing him as interim co-CEOs are CFO David Zinsner and products CEO MJ Holthaus. Gelsinger was named CEO in 2021, but couldn't turnaround the struggling company. Trump pledges to block U.S. Steel acquisition U.S. President-elect Donald Trump vowed to block the acquisition of U.S Steel by Japan's Nippon Steel , in a Monday post on his social platform Truth Social. The two companies reached a $14.9 billion deal in December. The U.S. Committee on Foreign Investment is reviewing the deal to ensure it doesn't incur national security risks. $56 billion package for Musk denied Tesla CEO Elon Musk failed to get his $56 billion 2018 pay package reinstated. A Delaware judge upheld her prior ruling that the compensation plan was improperly granted. Tesla shareholders had voted in June to "ratify" the package. The judge, however, wrote in her opinion that "Even if a shareholder vote could have a ratifying effect, it could not do so here." [PRO] Goldman's refreshed conviction list Goldman Sachs maintains a "Conviction List," which contains stocks it expects to perform better than the S&P. The Wall Street bank just refreshed its list of global stocks, including three it gave potential upside of more than 40% . Money Report European markets set for higher open but France's political upheaval is in focus Trump repeats vow to ‘block' Nippon Steel's bid for U.S. Steel Investors are still buzzing with positive sentiment, pushing stocks up to new records, but some analysts are concerned the good feelings are on frail footing. The S&P 500 added 0.24% and the Nasdaq Composite , electrified by Tesla's 3.5% rise and Super Micro Computer's 29% surge , climbed 0.97%. Both indexes closed at fresh highs. The Dow Jones Industrial Average slipped 0.29%, though it briefly breached the 45,000 level during the day. "The holiday season is in full swing and spirits seem bright, at least among investors," UBS wrote in a Monday note. Indeed, 56.4% of consumers expect stock prices to rise over the next year, according to a survey by The Conference Board. That's the highest level on record. Not to be a downer this holiday season, but analysts see signs that optimism might have some roots in wonderland. Stocks might have had an incredible rally in November , but that was probably investors "pric[ing] in the upside from the new, pro-business administration," Jay Hatfield, founder and CEO of InfraCap, told CNBC. Now, investors "need to get details — not just tweets — but details of what the policy is," Hatfield added, suggesting the upward momentum might take a pause for now. Investment bank Oppenheimer also noted that stocks are still expensive. "Benchmarks [are] showing forward PE multiples that are higher than their five-year averages," wrote chief investment strategist John Stoltzfus on Monday. UBS thinks the exuberance among investors is "raising concern about the markets getting frothy." Froth implies that things will settle down, which is not necessarily a bad thing in the long run. Oppenheimer, though, thinks the bull market is "driven by fundamentals" that will steer it higher in the next year, despite high valuations. Likewise, Savita Subramanian, head of U.S. equity and strategy at Bank of America, sees "ample reason to stick with stocks over bonds for the long-term." The layer of frothy milk adds to a cappuccino's delight, after all, and doesn't detract from the coffee below. — CNBC's Lisa Kailai Han, Alex Harring and Pia Singh contributed to this report. Also on CNBC Investors are filled with the holiday spirit The stock market had a November to remember November was a month to remember for stocksSan Francisco wins 85-64 over FordhamSan Francisco wins 85-64 over Fordham

CAMBRIDGE, Mass., Nov. 26, 2024 (GLOBE NEWSWIRE) -- Fulcrum Therapeutics, Inc.® (the “Company”) (Nasdaq: FULC), a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases, today announced that management will participate in the following conferences: Piper Sandler 36th Annual Healthcare Conference December 3, 2024 Fireside Chat at 12:00 pm ET, Participation link: HERE New York, New York Citi 2024 Global Healthcare Conference December 4, 2024 Miami, Florida Evercore ISI 7th Annual HealthCONx Conference December 5, 2024 Miami, Florida The webcast of the Piper Sandler fireside chat will be accessible by visiting the "Events and Presentations" section of Fulcrum Therapeutics’ website at https://ir.fulcrumtx.com/events-and-presentations . A replay of the webcasts will be available on Fulcrum Therapeutics’ website for at least 30 days following the presentations. About Fulcrum Therapeutics Fulcrum Therapeutics is a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases in areas of high unmet medical need. Fulcrum’s lead program in clinical development is pociredir, a small molecule designed to increase expression of fetal hemoglobin and in development for the treatment of sickle cell disease (SCD). Fulcrum uses proprietary technology to identify drug targets that can modulate gene expression to treat the known root cause of gene mis-expression. For more information, visit www.fulcrumtx.com and follow us on Twitter/X (@FulcrumTx) and LinkedIn. Contact: Chris Calabrese LifeSci Advisors, LLC ccalabrese@lifesciadvisors.com 917-680-5608None

Georgia's Dasha Vidmanova, Columbia's Michael Zheng win NCAA singles titlesNone

NoneOn Football analyzes the biggest topics in the NFL from week to week. For more On Football analysis, head here . Saquon Barkley has become the Shohei Ohtani of the NFL. There’s no better home run hitter playing football right now. Barkley had touchdown runs of 72 and 70 yards for the Philadelphia Eagles in a 37-20 victory over the Los Angeles Rams on Sunday night. He now has five runs of 50-plus yards this season and is on pace to break Eric Dickerson’s single-season record of 2,105 yards set in 1984. Barkley’s historic performance against the Rams — his 255 yards set a team record — captivated a national audience and turned him into a fan favorite for the AP NFL MVP award. He’s not the betting favorite, however. Josh Allen has the best odds at plus-150, according to Bet MGM Sportsbook. Two-time MVP Lamar Jackson is next at plus-250 followed by Barkley at plus-400. Running backs have won the award 18 times, including three-time winner Jim Brown, who was the AP’s first NFL MVP in 1957. Quarterbacks have dominated the award, winning it 45 times. Only three players who weren’t QBs or RBs have been MVP. It takes a special season for a non-QB to win it mainly because the offense goes through the signal caller. Quarterbacks handle the ball every offensive snap, run the show and get the credit when things go well and the blame when it doesn’t. Adrian Peterson was the most recent non-QB to win it when he ran for 2,097 yards and 12 touchdowns for the Minnesota Vikings in 2012. Playing for a winning team matters, too. Nine of the past 11 winners played for a No. 1 seed with the other two winners on a No. 2 seed. The Vikings earned the sixth seed when Pederson was MVP. Barkley is a major reason why the Eagles (9-2) are leading the NFC East and only trail Detroit (10-1) by one game for the top spot in the conference. Does he have a realistic chance to win the MVP award? Kicker Mark Moseley was the MVP in the strike-shortened 1982 season when he made 20 of 21 field goals and 16 of 19 extra points in nine games for Washington. If voters once selected a kicker, everyone has a chance, especially a game-changer such as Barkley. Defensive tackle Alan Page was the MVP in 1971 and linebacker Lawrence Taylor won it in 1986. Running back Christian McCaffrey finished third in voting last year and wide receiver Justin Jefferson placed fifth in 2022. The Offensive Player of the Year award and Defensive Player of the Year award recognize the best all-around players on both sides of the ball, allowing voters to recognize non-QBs if they choose. Wide receivers and running backs have won the AP OPOY award seven times over the past 11 seasons. McCaffrey was the 2023 winner. The AP’s new voting format introduced in 2022 also gives non-QBs a better opportunity to get MVP recognition. Voter submit their top five picks for each award, with a weighted point system. Previously, voters made one choice for each award. A nationwide panel of 50 media members who regularly cover the league vote for MVP and seven other awards. The awards are based on regular-season performance. The Chiefs (10-1) and Bills (9-2) already are in position to lock up postseason berths right after Thanksgiving. Kansas City clinches a playoff berth with a win over Las Vegas on Black Friday and a loss by Miami on Thursday night, or a win plus a loss by Denver on Monday night. Buffalo can wrap up a fifth straight AFC East title with a victory over San Francisco on Sunday and a loss by the Dolphins. It’s not a given that the Dallas Cowboys will be looking for a new head coach after this season. Owner Jerry Jones said Tuesday on local radio that Mike McCarthy could end up getting a contract extension. “I don’t think that’s crazy at all. This is a Super Bowl-winning coach. Mike McCarthy has been there and done that. He has great ideas. We got a lot of football left,” Jones said. McCarthy led the Cowboys (4-7) to three straight 12-win seasons, but they went 1-3 in the playoffs and haven’t reached the NFC championship game since winning the Super Bowl 29 years ago. Injuries have contributed to the team’s struggles this season, but Dallas was just 3-5 before Dak Prescott was lost for the rest of the season. The Cowboys upset Washington last week and their next four games are against teams that currently have losing records. If they somehow end up 9-8 or even 8-9, Jones could make a case for keeping McCarthy. AP NFL: https://apnews.com/hub/nflNone