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REDWOOD SHORES, Calif. , Dec. 5, 2024 /PRNewswire/ -- Reichman Jorgensen Lehman & Feldberg LLP (RJLF) has filed a lawsuit on behalf of a coalition of manufacturers, businesses, affordable housing interests, and workers seeking to prevent enforcement of South Coast Air Quality Management District regulations that effectively ban certain gas appliances. The plaintiffs, representing thousands of California residents, businesses, and workers, include Rinnai America Corporation , Noritz America Corporation , National Association of Homebuilders , California Manufacturers & Technology Association , California Restaurant Association , California Hotel & Lodging Association , and California Apartment Association , all represented by RJLF and Sean Kneafsey of the Kneafsey Law Firm . Californians for Homeownership is represented by Matt Gelfand , Restaurant Law Center is represented by Angelo Amador , and the California State Pipe Trades Council by McCracken, Stemerman & Holsberry . The coalition's suit asserts that the District's zero-NOx emissions rule for certain appliances, which effectively bans those gas appliances, is preempted by the federal Energy Policy and Conservation Act (EPCA) and should be blocked. The District's rule not only effectively mandates the use of electric appliances in new buildings but also forces costly retrofits to electric in existing buildings when appliances are replaced. This rule threatens the reliability and affordability of energy for millions of Californians, will impose enormous costs and disruption on businesses and workers, and will reduce the availability of affordable housing. Earlier this year, the U.S. Court of Appeals for the Ninth Circuit held that Berkeley, California's ban on gas piping in new buildings was preempted by EPCA ( California Restaurant Association v. City of Berkeley , 89 F.4th 1094 (9th Cir. 2024)) . The District's rule is legally indistinguishable, and the same result applies. "This case is pivotal to reinforcing the federal and state roles in setting national energy policy," said Sarah Jorgensen , lead counsel for the plaintiffs at RJLF. "The District's mandate for electric appliances in both new construction and forced retrofits not only jeopardizes our clients' work, business, and interests but also disregards established federal law. California must comply with the law." The case is Rinnai America Corp. et al. v. South Coast Air Quality Management District , No. 2:24-cv-10482 , in the United States District Court for the Central District of California . About Reichman Jorgensen Lehman & Feldberg LLP Reichman Jorgensen Lehman & Feldberg LLP (RJLF) is a national trial firm that handles high-stakes energy, commercial, intellectual property, and white collar disputes. The firm is majority women-owned, reinventing the practice of law without the billable hour in favor of fee arrangements that align client interests. RJLF's attorneys are diverse, exceptionally credentialed, and passionate about trial advocacy. From offices in Silicon Valley, New York , Washington, D.C. , Austin , and Atlanta , the firm tries cases and argues appeals throughout the country. For more information, visit www.reichmanjorgensen.com . Contact Sarah Jorgensen [email protected] (650) 623-1403 SOURCE Reichman Jorgensen Lehman & Feldberg LLPlucky ukulele chords 。

( MENAFN - Investor Brand Network) DealFlow Events has announced further details for its highly anticipated Microcap conference , slated to take place at the iconic Borgata Hotel Casino & Spa in Atlantic City from Jan. 28-30, 2025. The event serves as a premier platform for growth companies and will bring together more than 100 presenters and over 500 institutional, accredited and retail investors for three days of company presentations, one-on-one meetings, and unparalleled networking opportunities. Presenting companies span a variety of sectors, including financial services, cybersecurity, healthcare, biotechnology and clean energy. The agenda's multi-track format is designed to provide comprehensive insights and foster connections between companies and investors. Key highlights include a company track platform for CEOs to present their businesses in group sessions and private one-on-one meetings with professional investors, as well as keynote addresses and panels where industry experts will share cutting-edge insights on market trends and strategies. To view the full press release, visit About DealFlow Events DealFlow, the host of hundreds of events over the past 21 years, is renowned for its Microcap, SPAC, PIPE, Reg A, Activist Investor, Venture Debt, and other investment-themed conferences. For more information and a list of upcoming events, please visit . About CurrencyNewsWire CurrencyNewsWire (“CNW”) is a state-of-the-art digital hub that aggregates and disseminates news and information covering the fast-moving financial markets. It is one of 70+ brands within the Dynamic Brand Portfolio @ IBN that delivers: (1) access to a vast network of wire solutions via InvestorWire to efficiently and effectively reach a myriad of target markets, demographics and diverse industries; (2) article and editorial syndication to 5,000+ outlets ; (3) enhanced press release enhancement to ensure maximum impact; (4) social media distribution via IBN to millions of social media followers; and (5) a full array of tailored corporate communications solutions . CNW covers companies, currencies and events that impact traditional fiat currencies and their market dynamics; cryptocurrencies, blockchain technologies and digital assets; the Federal Reserve's policies and their influence on financial markets; global economic and monetary trends and their far-reaching influence; regulatory changes and their implication; as well as banking, finance, financial innovations, and investment strategies. CNW is the central platform for understanding the multifaceted world of currencies and finance. For more information, please visit Please see full terms of use and disclaimers on the CurrencyNewsWire website applicable to all content provided by CNW, wherever published or re-published: /Disclaimer CurrencyNewsWire Los Angeles, CA 310.299.1717 Office [email protected] CurrencyNewsWire is powered by IBN MENAFN26122024000224011066ID1109033807 Legal Disclaimer: MENAFN provides the information “as is” without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the provider above.Copy link Copied Copy link Copied Subscribe to gift this article Gift 5 articles to anyone you choose each month when you subscribe. Already a subscriber? Login When Life360, the popular family-tracking app, revealed earlier this year that it would introduce advertising to its platform, fund manager Roland Houghton was ecstatic. After years of watching the stock, Houghton knew the strategy was the catalyst he had been waiting for so he swiftly doubled down on his investment. The shares hit a record high this week. Copy link Copied Copy link Copied Subscribe to gift this article Gift 5 articles to anyone you choose each month when you subscribe. Already a subscriber? Login Introducing your Newsfeed Follow the topics, people and companies that matter to you. Latest In Equity markets Fetching latest articles Most Viewed In Markets

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Too early to celebrate – Arne Slot keeps leaders Liverpool focusedFor the rich, working from home has morphed into working from boatAll Three Patients Treated in First Dose Cohort Administered Fludarabine-free Conditioning and Show Rapid, Deep, and Sustained B-cell Depletion with Favorable Safety Profile First Patient to Reach 6-Month Follow-up Remains in DORIS Clinical Remission and Free of All Immunosuppressive Therapies Company Plans to Initiate Dose Expansion at First Dose Level of 360M Cells SAN DIEGO, Dec. 09, 2024 (GLOBE NEWSWIRE) -- Fate Therapeutics, Inc. (NASDAQ: FATE), a clinical-stage biopharmaceutical company dedicated to bringing a first-in-class pipeline of induced pluripotent stem cell (iPSC)-derived cellular immunotherapies to patients with cancer and autoimmune disorders, today presented new clinical and translational data from the Company’s FT819 Phase 1 Autoimmunity study for moderate-to-severe systemic lupus erythematosus (SLE) at the American Society of Hematology (ASH) Annual Meeting being held in San Diego, CA. The first three study patients, each of whom presented with active lupus nephritis (LN) despite having been treated with multiple standard-of-care therapies, received fludarabine-free conditioning followed by a single dose of FT819 at 360 million cells. There were no dose-limiting toxicities (DLTs), no events of any grade of cytokine release syndrome (CRS), immune effector-cell associated neurotoxicity syndrome (ICANS), or graft-versus-host disease (GvHD), and rapid, deep, and sustained elimination of CD19+ B cells in the periphery was observed during the first month of treatment. FT819 is the Company’s off-the-shelf, CD19-targeted, 1XX CAR T-cell product candidate comprised of CD8αβ+ T cells with a memory phenotype and high CXCR4 expression to promote tissue trafficking. “We continue to be very pleased with early clinical observations of fludarabine-free conditioning and FT819 off-the-shelf, CAR T-cell therapy in patients with moderate-to-severe SLE. The remarkable experience of the first patient treated in April is ongoing, as the patient remains on-study in drug-free clinical remission. In addition, the initial clinical and translational data from the two additional patients treated at the first dose level continue to support the potential for disease transformation,” said Bob Valamehr, President of Research and Development of Fate Therapeutics. “We are now initiating dose expansion at this first dose level to accelerate development, and are also escalating dose based on the favorable safety profile observed. In addition, I am pleased to announce that the first patient has now been treated with FT819 as an add-on to maintenance therapy without conditioning chemotherapy. We believe our therapeutic approach is highly-differentiated and has the potential to transform disease outcomes without requiring patient apheresis, discontinuation of maintenance therapy, intense conditioning chemotherapy, and extended hospitalization.” FT819 Phase 1 Autoimmunity Study The ongoing multi-center, Phase 1 clinical trial for patients with moderate-to-severe SLE is designed to evaluate the safety, pharmacokinetics, and anti-B cell activity of FT819 (NCT06308978). The first three patients, all of whom presented with active LN despite having been treated with multiple standard-of-care therapies, received fludarabine-free conditioning consisting of either cyclophosphamide alone or bendamustine alone, followed by a single dose of FT819 at 360 million cells. In all three patients, FT819 was detected in the peripheral blood and rapid, deep, and sustained elimination of CD19+ B cells in the periphery was observed during the first month of treatment. All three patients remain on-study, and there have been no DLTs and no events of any grade of CRS, ICANS, or GvHD. Based on these clinical observations, the Company is initiating dose expansion in up to 10 patients at this first dose level, and is also escalating dose to 720 million cells. The Company’s FT819 Phase 1 Autoimmunity study also includes a second treatment arm to assess the safety, pharmacokinetics, and anti-B cell activity of a single dose of FT819 as an add-on to maintenance therapy without conditioning chemotherapy in patients with SLE. The first patient has now been treated in this second arm, which is being conducted in parallel with the study’s conditioning arm. FT819 Patient 1 Case Study The first patient treated in the Phase 1 Autoimmunity study presented with active LN and severe disease, which was marked by renal BILAG A (British Isles Lupus Assessment Group) disease activity score based on biopsy, SLEDAI-2K (Systemic Lupus Erythematosus Disease Activity Index) score of 20, FACIT-Fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue) score of 33 (range 0-52, where a score of 52 indicates no fatigue) and PGA (Physician Global Assessment) score of 2.5 (where a score of 3 indicates most severe activity). Following administration of fludarabine-free conditioning and treatment with a single dose of FT819 at 360 million cells, the patient was discharged from the hospital without notable adverse events (AEs) after a protocol-required three-day stay. Rapid elimination of CD19+ B cells in the periphery was observed following treatment, and B-cell recovery by Month 3 was predominantly comprised of naïve, non-class switched B cells with near-complete elimination of switched memory B cells and deep depletion of plasmablasts, indicative of an immune reset. The patient reported that her debilitating fatigue had entirely resolved without further treatment, and treatment with methylprednisolone was discontinued at Month 3. The patient achieved DORIS (definition of remission in SLE) clinical remission, including with resolution of arthritis and active urinary sediment and with a substantial reduction in proteinuria, as of Month 6 follow-up. The patient continues on-study, in DORIS clinical remission, and remains free of all immunosuppressive therapy. iPSC-derived CAR T-cell Product Platform The Company also highlighted the scientific progress of its proprietary iPSC-derived CAR T-cell product platform at the ASH Annual Meeting. In an oral presentation entitled “ Off-the-shelf Product Candidate Incorporates Novel Sword & Shield Technology Designed to Promote Functional Persistence without Conditioning Chemotherapy ”, the Company compared its novel Sword & Shield technology, which utilizes a 4-1BB-targeted CAR (ADR) alongside the complete knock-out of CD58 (CD58KO) to both target and evade host alloreactive immune cells, to other host immune evasion strategies. In preclinical studies of allogeneic models, the Company showed that its Sword and Shield Technology specifically engaged with alloreactive T cells and supported functional persistence while avoiding the killing of general host T cells and activated anti-tumor T cells. This unique observation was not seen with other approaches that are either too broad and undesirably eliminate most of the host immune system or have limited coverage and cannot adequately protect the allogeneic cell product. In a second presentation entitled “ Development of Induced Pluripotent Stem Cell-Derived T Cells Exhibiting Phenotypic and Functional Attributes of Primary CAR T Cells ”, the Company conducted a series of high-resolution analyses to show stimulated iPSC-derived T cells elicit primary T-cell like activation, proliferation, transcriptional and functional program engagement, and iPSC-derived CAR T cells uniquely emulate antigen-mediated response similar to primary-derived autologous CAR T cells. About Fate Therapeutics’ iPSC Product Platform Human induced pluripotent stem cells (iPSCs) possess the unique dual properties of unlimited self-renewal and differentiation potential into all cell types of the body. The Company’s proprietary iPSC product platform combines multiplexed-engineering of human iPSCs with single-cell selection to create clonal master iPSC lines. Analogous to master cell lines used to mass produce biopharmaceutical drug products such as monoclonal antibodies, the Company utilizes its clonal master iPSC lines as a starting cell source to manufacture engineered cell products which are well-defined and uniform in composition, can be stored in inventory for off-the-shelf availability, can be combined and administered with other therapies, and can potentially reach a broad patient population. As a result, the Company’s platform is uniquely designed to overcome numerous limitations associated with the manufacture of cell therapies using patient- or donor-sourced cells. Fate Therapeutics’ iPSC product platform is supported by an intellectual property portfolio of over 500 issued patents and 500 pending patent applications. About Fate Therapeutics, Inc. Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to bringing a first-in-class pipeline of induced pluripotent stem cell (iPSC)-derived cellular immunotherapies to patients with cancer and autoimmune diseases. Using its proprietary iPSC product platform, the Company has established a leadership position in creating multiplexed-engineered master iPSC lines and in the manufacture and clinical development of off-the-shelf, iPSC-derived cell products. The Company’s pipeline includes iPSC-derived natural killer (NK) cell and T-cell product candidates, which are selectively designed, incorporate novel synthetic controls of cell function, and are intended to deliver multiple therapeutic mechanisms to patients. Fate Therapeutics is headquartered in San Diego, CA. For more information, please visit www.fatetherapeutics.com . Forward-Looking Statements This release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995 including statements regarding the safety and therapeutic potential of the Company’s iPSC-derived CAR T-cell product candidates, including FT819, the advancement of and plans related to the Company's product candidates, clinical studies and preclinical research and development programs, the Company’s progress, plans and timelines for the clinical investigation of its product candidates, including the expected clinical development plans for FT819, the initiation and continuation of enrollment in the Company’s clinical trials, the initiation of additional clinical trials and additional dose cohorts in ongoing clinical trials of the Company’s product candidates, the timing and availability of data from the Company’s clinical trials, the therapeutic and market potential of the Company’s research and development programs and product candidates, the Company’s clinical and product development strategy, and the Company’s expectations regarding progress, plans, and timelines. These and any other forward-looking statements in this release are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to, the risk that the Company’s research and development programs and product candidates, including those product candidates in clinical investigation, may not demonstrate the requisite safety, efficacy, or other attributes to warrant further development or to achieve regulatory approval, the risk that results observed in prior studies of the Company’s product candidates, including preclinical studies and clinical trials, will not be observed in ongoing or future studies involving these product candidates, the risk of a delay or difficulties in the initiation and conduct of, or enrollment of patients in, any clinical trials, the risk that the Company may cease or delay preclinical or clinical development of any of its product candidates for a variety of reasons (including requirements that may be imposed by regulatory authorities on the initiation or conduct of clinical trials, changes in the therapeutic, regulatory, or competitive landscape for which the Company’s product candidates are being developed, the amount and type of data to be generated or otherwise to support regulatory approval, difficulties or delays in patient enrollment and continuation in the Company’s ongoing and planned clinical trials, difficulties or delays in manufacturing or supplying the Company’s product candidates for clinical testing, failure to demonstrate that a product candidate has the requisite safety, efficacy, or other attributes to warrant further development, and any adverse events or other negative results that may be observed during preclinical or clinical development), and the risk that its product candidates may not produce therapeutic benefits or may cause other unanticipated adverse effects. For a discussion of other risks and uncertainties, and other important factors, any of which could cause the Company’s actual results to differ from those contained in the forward-looking statements, see the risks and uncertainties detailed in the Company’s periodic filings with the Securities and Exchange Commission, including but not limited to the Company’s most recently filed periodic report, and from time to time in the Company’s press releases and other investor communications. Fate Therapeutics is providing the information in this release as of this date and does not undertake any obligation to update any forward-looking statements contained in this release as a result of new information, future events or otherwise. Contact: Christina Tartaglia Precision AQ 212.362.1200 christina.tartaglia@precisionaq.com

German startup FibreCoat has bagged €20mn in Series B funding as it looks to bring its super-resistant materials to the burgeoning space industry. FibreCoat spunout from RWTH Aachen University in 2020. The startup has developed a patented process for coating fibres with metals and plastics during the spinning stage. This creates fibres that are lightweight and conductive, yet strong and durable — at a fraction of conventional costs. These can then be spun together to form reinforced composites. So far, FibreCoat has focused on securing clients in the automotive, construction, and defence industries, where the materials are particularly useful for radiation shielding and weight reduction applications. Now the company is setting its sights on upward. Spacecraft require materials that can withstand extreme temperatures, radiation, and electromagnetic interference (EMI) without adding unnecessary weight. “Space is a rapidly growing sector, and launchers and satellites increasingly need coated fibres to endure harsh conditions,” said Dr. Robert Brull, CEO of FibreCoat. What day is today? It's CYBER MONDAY! TNW Conference is offering an exclusive 30% discount on their startup and scaleup programs this week only. This is the best deal you'll get before prices change in January. Luxembourg-based NewSpace Capital co-led the funding round, bringing vital expertise as the startup looks to cash in on the expanding space ecosystem, projected to reach $1.8trn by 2035. “Space and terrestrial supply chains are converging,” said Bogdan Gogulan, managing partner at NewSpace Capital, adding that FibreCoat has the potential to address critical challenges across a swathe of industries. FibreCoat will use the fresh funds to ramp up R&D and scale production as it looks to commercialise its fibre coating technology. The startup is far from the only spinout access story to emerge from RWTH Aachen in recent years. One of the fastest growing is Cylib. The startup is currently constructing what is set to be Europe’s largest EV battery recycling plant . Cylib’s founders — Dr Lilian Schwich, Paul Sabarny, and Dr Gideon Schwich — launched the company after a decade of battery recycling research at RWTH Aachen. The partners claim their method uses 30% less energy than competitors. Another big player is Black Semiconductor, which raised €254.4mn back in June . That’s a massive raise for any startup, let alone a European one. Even more impressive is that the company is only four years old. Brothers Daniel and Sebastian Schall launched Black Semiconductor in 2020. The startup is developing a new type of chip-connecting technology using the “wonder material” graphene.Venture 53 Invests in DEXA: The Autonomous Delivery Future is HereNone