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Syrian opposition fighters have reached the suburbs of the capital, Damascus, and government forces are withdrawing from the strategic city of Homs as the rebels' surprising offensive picks up speed and President Bashar Assad's whereabouts are unknown. Homs is an important intersection between Damascus and Syria’s coastal provinces that are the Syrian leader’s base of support. In Damascus, residents described a city on edge, with security forces on the streets and many shops running out of staple foods. The rapidly developing events have shaken the region. Lebanon said it was closing all its land border crossings with Syria except for one that links Beirut with Damascus. Jordan closed a border crossing with Syria, too. Eight key countries gathered with the U.N. special envoy on Syria on the sidelines of the Doha Summit for two hours of discussions Saturday night, and more will follow. The U.N. envoy seeks urgent talks in Geneva to ensure an “orderly political transition.” Here's the Latest: Two officials with Iran-backed Iraqi militias in Syria say the militias are monitoring the situation and have not made a decision to enter in support of Iran’s ally, Syrian President Bashar Assad. One of the officials said Iranian militias had withdrawn to Iraq from their positions in Syria. “All the militias are waiting to see what Bashar Assad will do in Damascus. If he resists and does not allow Damascus to fall, it is possible that the Iraqi factions will intervene for the purpose of support,” he said. The officials spoke on condition of anonymity because they were not authorized to speak publicly about the matter. -- Qassim Abdul-Zahra in Baghdad Multi-country discussions on Syria have ended on the sidelines of the Doha Summit. Iraqi Foreign Minister Fuad Hussein says the countries will issue a statement, and there will be follow-up talks “taking into consideration the practical and real situation on the ground.” He said the talks, which lasted over two hours Saturday evening, focused on how to stop the fighting. Eight key countries including Saudi Arabia, Russia, Egypt, Turkey and Iran gathered with the U.N. special envoy for Syria, Geir Pedersen. When asked where Syrian President Bashar Assad is, Iraq's foreign minister replied, “I don’t know.” He declined to speculate on whether Assad would be overthrown. Opposition fighters have reached the Damascus suburbs. BEIRUT — Lebanon’s Health Ministry says two Israeli airstrikes in southern Lebanon on Saturday killed six people and wounded five others. The ministry said an airstrike on the village of Beit Leif killed five people and wounded five, while a drone strike on the village of Deir Serian killed one person. Israel’s military said it was looking into the report. Despite a ceasefire that went into effect on Nov. 27 to end the 14-month fighting between Israel and Lebanon-based Hezbollah militants that had escalated into all-out war, violations of the truce have continued. The director of Kamal Adwan Hospital in northern Gaza says the facility came under heavy Israeli bombardment again on Saturday and three medical staff were killed. Dr. Hussam Abu Safia in a statement posted by Gaza’s Health Ministry said the hospital was hit by over 100 projectiles and bombs, and electricity was cut off. He said the surgery department and neonatal unit were hit, and he pleaded for “immediate coordination for repair operations.” Kamal Adwan is one of the last remaining hospitals in northern Gaza. Israeli forces are pressing an offensive that has almost completely sealed off the area from humanitarian aid for two months. Israel’s military said it wasn’t aware of any attack Saturday. The hospital director on Friday said Israeli strikes had killed at least 29 people including four medical staff. Israeli Lt. Gen. Herzi Halevi says the military is monitoring the Syrian border to make sure that “local factions do not direct actions towards us,” adding that Israel is not intervening in the events in Syria. Israel’s military has said it is reinforcing its deployment along the border with Syria. Halevi said if “confusion” arises and actions are directed toward Israel by “local factions” taking control of parts of Syria, Israel has a strong “offensive response.” The United Nations humanitarian coordinator in Syria says the U.N. is relocating non-critical staff outside the country. Adam Abdelmoula in a statement Saturday called it a precautionary measure to protect U.N. teams. “Let me emphasize—this is not an evacuation and our dedication to supporting the people of Syria remains unwavering,” Abdelmoula said. The statement did not say how many U.N. staffers were leaving Syria as opposition fighters reached the suburbs of Syria’s capital, Damascus. The statement said the fighting in Syria has displaced over 370,000 people as the humanitarian situation deteriorates, “with many seeking refuge in the northeast and others trapped in frontline areas, unable to escape.” Foreign ministers and senior diplomats from eight key countries including Saudi Arabia, Russia, Egypt, Turkey and Iran have gathered on the sidelines of the Doha Summit along with the U.N. special envoy for Syria, Geir Pedersen, to discuss the situation in Syria. The talks continued late Saturday and no details were immediately available. Qatar, Jordan and Iraq also were part of the discussions as opposition fighters closed in on the Syrian capital, Damascus. BAGHDAD — An Iraqi government spokesperson says about 2,000 Syrian army soldiers have crossed into Iraq seeking refuge as opposition forces advance in Syria. Bassem al-Awadi said the soldiers’ equipment and weapons were registered and taken into custody by the Iraqi army. “We dealt with them according to the principle of good neighborliness and humanity,” he said Saturday. Al-Awadi also said Iraqi officials are concerned about the security of the al-Hol camp and other facilities in northeast Syria where suspected Islamic State group members and their families are detained. The facilities are guarded by U.S.-backed Kurdish forces. Al-Awadi said there is “high security coordination” between Iraqi officials and those forces to “prevent the prisoners from escaping.” Syria's army says it is fortifying its positions in the suburbs of Damascus and in the country’s south, as opposition fighters close in on the capital. The army statement on Saturday also asserted that Syria is being subjected to a “terrorist” and propaganda campaign aiming to destabilize and spread chaos. The statement also said the military is continuing with operations in areas including the central provinces of Hama and Homs, and that it has killed and wounded hundreds of opposition fighters. At least two people were wounded in a car-ramming attack in the West Bank on Saturday, according to the Israeli army and rescue services. The army said the attack took place in the area of the Fawwar refugee camp, near the city of Hebron. It said a soldier was severely wounded, and security forces were looking for the attacker. Israel’s Magen David Adom rescue service said another man in his 40s suffered light injuries from shrapnel. The West Bank has seen a surge in violence since Hamas’ Oct. 7, 2023 attack out of Gaza sparked the war there. Israel has intensified its military raids in the West Bank, targeting what it says are militants planning attacks, and there has also been a rise in Palestinian attacks on Israelis. The Israeli military says it is helping United Nations forces to head off an attack on a U.N. position in Syria close to the Israeli border. The army said in a statement Saturday that an attack was carried out by “armed individuals” on a U.N. post near the Syrian town of Hader and it was “assisting U.N. forces in repelling the attack.” On Friday, Israel’s military said it would reinforce its forces in the Golan Heights and near the border with Syria, where civil war has reignited between the government and opposition fighters. Hamas has released a video showing Israeli hostage Matan Zangauker making an emotional plea for his release and describing the conditions he and other hostages face in Gaza after being seized in the Oct. 7, 2023 attack on Israel. His mother, Einav, has become a symbol of the fight to bring back the hostages and is an outspoken critic of Prime Minister Benjamin Netanyahu’s government. Matan Zangauker, speaking under duress, appealed to the public to protest in front of Netanyahu’s home and “not let him sleep even for a minute.” Zangauker also referred to 420 days of being held by Hamas militants. “We want to return before we go crazy. Isolation is killing us, and the darkness here is frightening,” he said, describing having little food and medicine and “undrinkable” water. President-elect Donald Trump has made his first extensive comments on dramatic advances by opposition fighters in Syria, saying the besieged President Bashar Assad didn’t deserve U.S. support to stay in power. “THIS IS NOT OUR FIGHT,” Trump posted on the Truth Social platform on Saturday. Syrian opposition activists and regional officials have been watching closely for any indication from both the Biden administration and the incoming Trump administration of how the U.S. would handle the sudden advances against Syria’s Russian- and Iranian-allied leader. Trump condemned the overall U.S. handling of the 13-year civil war in Syria, but spoke favorably of the routing of Assad and Russian forces. ISTANBUL — Turkish President Recep Tayyip Erdogan said Saturday that there was “now a new reality in Syria” following the rapid advance of rebel forces. Speaking in Gaziantep, a city less than 30 miles (48 kilometers) from the Syrian border, Erdogan said that “increasing attacks on civilians” in Syria’s northwest Idlib province “triggered the latest events like the straw that broke the camel’s back.” It was not possible for Turkey to ignore developments in a country with which it shares a lengthy border and it would not allow any threats to its national security, he added in a televised speech. “Our wish is for our neighbor Syria to attain the peace and tranquility it has been longing for for 13 years,” he told a rally of supporters. “We want to see a Syria where different identities live side by side in peace. We hope to see such a Syria in the very near future.” Erdogan claimed President Bashar Assad had erred in rebuffing Turkey’s previous efforts to establish relations, saying Damascus “could not appreciate the value of the hand Turkey extended.” Ankara has supported anti-Assad rebel groups since the early months of the conflict and hosts 3 million refugees dislodged by the fighting. While Turkey lists HTS, the group leading the latest offensive, as a terrorist organization, the Turkey-backed Syrian National Army has worked alongside it. BEIRUT — A resident of the Syrian capital of Damascus says the city is very tense as troops and members of security agencies are deployed on main streets and intersections. The resident told The Associated Press that many shops are closed and those that are open have run out of main commodities such as sugar. He added that if food products are available, some shops are selling them for a price three times higher than usual. “The situation is very strange. We are not used to that,” the resident said on condition of anonymity, fearing retributions. “People are worried whether there will be a battle (in Damascus) or not.” — Bassem Mroue in Beirut DOHA, Qatar — Russia’s foreign minister says he has met his Turkish and Iranian counterparts in Doha and that all three countries were calling for an “immediate end to hostile activities” in Syria. Russia and Iran are the chief supporters of Syria’s government, while Turkey backs opposition fighters trying to remove President Bashar Assad from power. Speaking at the annual Doha Forum, Sergey Lavrov said Russia continues to help the Syrian army confront insurgents, military via airstrikes. Asked whether Assad’s rule is threatened by the fast-moving rebel offensive, he said, “We are not in the business of guessing what’s gong to happen.” He blamed the United States and the West for the events in Syria and said, “We are very sorry for the Syrian people who became a subject of another geopolitical experiment. “We are doing everything we can not to make terrorists prevail, even if they say they are not terrorists,” Lavrov said, referring to the de facto leader of the Syrian insurgents, Abu Mohammed al-Golani, who says he has cut links with al-Qaida. His group, Hayat Tahrir al-Sham, is listed as a terrorist organization by the U.S. and United Nations. He said Russia, Iran and Turkey want the full implementation of a U.N. resolution, which endorsed a road map to peace in Syria. Resolution 2254 was adopted unanimously in December 2015. The measure called for a Syrian-led political process, starting with the establishment of a transitional governing body, followed by the drafting of a new constitution and ending with U.N.-supervised elections. Lavrov also downplayed reports that Moscow had withdrawn ships from Russia’s base in Syrian city of Tartus, saying that the vessels had left to take part in naval exercises in the Mediterranean. DOHA, Qatar — The U.S. envoy who brokered the ceasefire between Israel and Hezbollah says the deal has created a new opportunity for Lebanon to reshape itself. Amos Hochstein told the Doha Forum that the weakness of Hezbollah after nearly 14 months of fighting along, along with blows to its Syrian and Iranian allies, give the Lebanese military and government a chance to reassert itself. “Now is the moment with this ceasefire to rebuild Lebanon again for a much more prosperous future and stronger state institutions,” Hochstein told The Associated Press on the sidelines of the conference. He said Lebanon needs “to do its part” by rebuilding its economy, choosing a president after years of delays and strengthening its central government to attract investors. “And the international community has a requirement and a responsibility to support Lebanon after this devastating conflict and after years of Hezbollah control,” he said. Hochstein told the conference that the turning point in ceasefire efforts was Hezbollah dropping its pledge to keep fighting as long as the war in Gaza continues. He said the change in position was the result of the heavy losses inflicted on Hezbollah, and Lebanese public opinion in favor of delinking the two conflicts. He said key tests for the ceasefire will be whether Israel carries out its promised phased withdrawal from southern Lebanon over the coming two months and whether the Lebanese army is able to move into those areas. BEIRUT — Insurgents and a war monitor say opposition fighters are taking over military posts evacuated by Syrian government forces in the country’s south, bringing them closer to the capital, Damascus. An insurgent official known as Maj. Hassan Abdul-Ghani posted on the Telegram messaging app that opposition fighters are now in the town of Sanamein, about 20 kilometers (12 miles) from the southern outskirts of Damascus, President Bashar Assad’s seat of power. Rami Abdurrahman, who heads the Britain-based opposition Syrian Observatory for Human Rights, said insurgents have entered the town of Artouz, which is about 10 kilometers (6 miles) southwest of Damascus. Opposition fighters have captured wide parts of Syria, including several provincial capitals, since they began their offensive on Nov. 27. BEIRUT — Lebanon’s government has approved a plan to deploy more troops along the border with Israel, part of the ceasefire deal that ended the Israel-Hezbollah war. In a rare Cabinet meeting outside of Beirut, held Saturday at a military base in the southern port city of Tyre, the government also approved a draft law to reconstruct buildings destroyed during the Israel-Hezbollah war that broke out in October 2023 and ended with a U.S.-brokered ceasefire last week. Information Minister Ziad Makary told reporters after the meeting that the committee whose job is to monitor the ceasefire that went into effect on Nov. 27 will hold its first meeting on Monday. The committee is made up of military officials from the U.S., France, Israel and Lebanon as well as the U.N. peacekeeping force deployed along the border. As part of the ceasefire deal, during the first 60 days Israeli troops will have to withdraw from Lebanon, while Hezbollah will have to pull its heavy weapons away from the border area to north of the Litani river. The Lebanese army said this week it will begin recruiting more soldiers, apparently to deploy them along the border with Israel. BEIRUT — The Syrian army withdrew from much of southern Syria on Saturday, leaving more areas of the country, including two provincial capitals, under the control of opposition fighters, the military and an opposition war monitor said. The redeployment away from the provinces of Daraa and Sweida came as Syria’s military sent large numbers of reinforcements to defend the key central city of Homs, Syria’s third largest, as insurgents approached its outskirts. The rapid advances by insurgents are a stunning reversal of fortunes for Syria’s President Bashar Assad , who appears to be largely on his own, with erstwhile allies preoccupied with other conflicts. His chief international backer, Russia, is busy with its war in Ukraine, and Lebanon’s powerful Hezbollah, which at one point sent thousands of fighters to shore up his forces, has been weakened by a yearlong conflict with Israel. Iran, meanwhile, has seen its proxies across the region degraded by Israeli regular airstrikes. JERUSALEM — Israeli security forces killed a Palestinian man after he attacked them at a border crossing in the Israeli-occupied West Bank on Saturday morning, police said. The man shot firecrackers at security forces at the checkpoint and threatened them with a knife, the police statement said. The man wore a t-shirt emblazoned with a symbol of the Islamic State militant group, according to an Associated Press reporter Israeli fire has killed at least 700 Palestinians in the West Bank since the Israel-Hamas war began last year, Palestinian health officials said. In that time, Palestinian militants have launched a number of attacks on soldiers at checkpoints and within Israel. DOHA, Qatar — The prime minister of Qatar says he has seen new momentum in Gaza ceasefire efforts since the U.S. presidential election, with the incoming Trump administration seeking an end to the conflict before it takes office. Sheikh Mohammed bin Abdulrahman Al Thani, a key mediator in the ceasefire efforts, declined to give specifics of the negotiations but told an international conference in Doha that the gaps between the sides are not large. Qatar, which has served as a mediator throughout the 14-month war, suspended its efforts last month in frustration over the lack of progress. But Sheikh Mohammed said his government has re-engaged in recent days after determining a new willingness by both parties to reach a deal. ’We have sensed after the election that the momentum is coming back,” he told the Doha Forum on Saturday. He said has been in touch with both the outgoing Biden administration and the incoming Trump administration and found that while there are some differences in approach, both are committed to the same goal of ending the war. ’We have seen a lot of encouragement from the incoming administration in order to achieve a deal, even before the president comes to the office,” Sheikh Mohammed said. He declined to discuss details, saying he wanted to “protect the process,” but expressed hope for a deal “as soon as possible.” ’If you look at the gaps and the disagreements, they are not something substantial that really affects the agreement,” he said. CAIRO — At least 29 people were killed, including four medical staff, when Israeli strikes pummeled the area around one of the last remaining hospitals in northern Gaza, Palestinian officials said. The situation in and around the Kamal Adwan hospital is “catastrophic,” according to Dr. Hussam Abu Safia, the director of the hospital. The dead included five children and five women, according to the hospital casualty list, which was obtained by The Associated Press. Friday’s strikes also wounded 55 people including six children and the five women, according to the hospital. Kamal Adwan Hospital in Beit Lahiya is one of the few hospitals still partially operating in the Gaza’s northernmost province , where Israeli forces are pressing an offensive that has almost completely sealed off the area from humanitarian aid for two months. Israel’s military denied that its forces had struck the hospital or operated inside it. The army said that in the past few weeks, “coordinated efforts with international organizations have been underway in order to transfer patients, companions, and medical staff to other hospitals.” An Indonesian medical team which had been assisting in Kamal Adwan for the past week was forced to evacuate on foot after the area was surrounded by Israeli soldiers, according to a statement from the team. The Israeli military did not immediately comment on the medical team’s expulsion. Dr. Rik Peeperkorn, the World Health Organization representative in the Palestinian territories, said an Israeli tank approached the hospital at around 4 a.m. Friday. Although no official Israeli evacuation order was issued, “people started to climb the wall to escape, and this panic attracted IDF (Israeli) fire,” he said. He spoke by video from Gaza to journalists in Geneva. Kamal Adwan Hospital has been struck multiple times over the past two months since Israel launched a fierce military operation in northern Gaza against Hamas militants. In October, Israeli forces raided the hospital, saying that militants were sheltering inside and arrested a number of people, including some staff. Hospital officials denied the claim. MANAMA, Bahrain — Saudi Arabia’s foreign minister has reiterated the kingdom’s call for an end to the war in the Gaza Strip. Prince Faisal bin Farhan described Israel as acting with “impunity and is getting away without punishment” in its war on Hamas there. The prince said that any permanent solution requires a two-state solution, with the Palestinians having east Jerusalem as their capital. After the speech, Prince Turki al-Faisal, a prominent royal in the kingdom who led Saudi intelligence for more than two decades and served as ambassador to the U.S. and Britain, took the stage. He harshly criticized Israel’s conduct in the wars. “Israel has become an apartheid, colonial and genocidal state,” Prince Turki said. “It is about time for the world to address that issue and take the necessary steps to bring those who are thus charged by the International Criminal Court to justice.” Israeli officials could not be immediately reached for comment on Prince Turki’s remarks. The Saudis spoke at the International Institute for Security Studies’ Manama Dialogue in Bahrain.By JOSH DUBOW | Associated Press Athletics president Dave Kaval will resign from the organization after being the public face of the organization’s departure from Oakland after 57 seasons . Related Articles Oakland Athletics | Rickey being Rickey: Memorable moments from Henderson’s larger-than-life career Oakland Athletics | Oakland A’s teammates, sports luminaries mourn Rickey Henderson Oakland Athletics | From the archives: How Oakland A’s legend Rickey Henderson was molded by ‘Billy Ball’ Oakland Athletics | Rickey Henderson: Oakland remembers the ballplayer who grew up in Bushrod Oakland Athletics | Photos: A look back at Rickey Henderson, the Man of Steal Kaval has been president of the A’s for the past eight years and will step down from the role on Dec. 31 to pursue new business opportunities in California. Sandy Dean, a longtime business partner with the Fisher family that owns the team, will serve as interim president and a search to fill the full-time role will begin in 2025, when the A’s begin what they hope will be a three-year stint in Sacramento before the franchise ultimately settles in Las Vegas. Kaval and team president John Fisher were at the center of Oakland fans’ growing discontent as multiple potential East Bay stadium plans failed, the franchise’s biggest stars were traded away and ticket prices increased at the same time the franchise annually fielded a team with one of the lowest payrolls in baseball. Kaval will forever remembered for saying the team was on a “parallel path” that included the ballpark plans in Oakland and Las Vegas, a path that ultimately ended with the team playing its final game in Oakland in September . Kaval made the decision to step down after the team had cleared its final major hurdles to get a stadium built in Las Vegas. The Las Vegas Stadium Authority approved lease, non-relocation and development documents earlier this month for the Athletics to construct a $1.75 billion stadium on the Strip. Other details remain to be worked out, such as a development agreement with Clark County, but groundbreaking likely will take place in the spring and the team expects to be in the new stadium in Las Vegas for the start of the 2028 season. “We are grateful for Dave’s contributions and leadership over the past eight years,” A’s owner John Fisher said in a statement. “He guided our organization through a period of significant transition, and we sincerely thank him for his unwavering commitment to the team. As we look ahead to the next chapter of our franchise, the team will continue to grow under new leadership, driving the organization toward success during our interim years in West Sacramento and at our new home in Las Vegas.” Kaval failed in his efforts to get a new stadium built for the team in downtown Oakland and eventually helped the organization reach the deal to move to Las Vegas, ending a run of of 57 seasons in Oakland. The A’s will play at least the next three seasons at a minor league ballpark in West Sacramento, California. Kaval had previously served as president of the MLS’ San Jose Earthquakes, who are also owned by the Fisher family. When he first came to the A’s, he drew praise for his open-door policy to hear from fans and for changes he made at the Oakland Coliseum. He brought in food trucks for games and opened the “Treehouse” a 10,000-square-foot area that included a bar, lounge and patio for fans to watch games from left field. Kaval took a less public role in the Bay Area after the team announced plans in 2023 to move to Las Vegas, but by then his perceived role as the villain (along with Fisher) in the A’s saga had already been well established. In May 2021, while Kaval and other A’s officials were in Las Vegas exploring possibilities to move the team to the area, he rankled two Bay Area fan bases with a single tweet. While attending the Vegas Golden Knights’ home playoff game he posted a video on the social media platform now known as X of the boisterous crowd on its feet at T-Mobile Arena just before the drop of the puck. “Wow! #StanleyCup playoffs! @GoldenKnights,” Kaval tweeted in regards to the atmosphere inside the arena. Sharks fans were angered because he was complimenting a hated rival, and A’s fans were enraged because it was at the same time his team was losing to the Seattle Mariners at the Coliseum. Kaval was outwardly optimistic about a new ballpark getting done in Oakland early in his tenure. In 2017, he announced the team had decided on a piece of land in the Peralta Community College District in Laney College. But the plan was met with quick opposition from city leaders and residents who were concerned the stadium would displace low-income families and businesses in the Chinatown and East Lake neighborhoods. A year later, Kaval and the A’s publicly announced their intentions to build their new ballpark at Howard Terminal near Jack London Square. The Oakland City Council in 2021 voted to approve a non-binding term sheet to continue negotiations with the team over the $12 billion proposal that included the ballpark and a mixed-use development project. But Kaval said the team would not accept that term sheet while the two sides disagreed over infrastructure costs. It was around that time Kaval publicly spoke about a “parallel path” that included the ballpark plans in Oakland and Las Vegas . In June 2023, Nevada Gov. Joe Lombardo signed a bill that would give the A’s $380 million in public money toward their Las Vegas stadium. The A’s began the application process for relocation a week later, and MLB owners unanimously approved the team’s eventual move that November.And with its lease at the Oakland Coliseum up in 2024, the team announced last April it would move temporarily to Sutter Health Park, home of the Sacramento River Cats, rather than extend their lease at their home venue they initially moved to in 1968. In September, the A’s played their final game at the Coliseum, where the team won four World Series and six American League pennants in 57 seasons. Staff writer Laurence Miedema and The Sacramento Bee contributed to this report. ___ AP MLB: https://apnews.com/hub/MLB
B.C. Premier Eby says Canada will negotiate from 'position of strength' on US tariffImphal, November 24: Hours after announcing the resumption of regular classes in all educational institutions, including schools and universities from Monday, the education departments of the Manipur government on Sunday night ordered the closure of all the educational institutions in the five valley districts on Monday and Tuesday, officials said. Director of Education (Schools) L. Nandakumar Singh and Joint Secretary (Higher and Technical Education Department), Daryal Juli Anal in separate orders asked all the district and zonal level officers to take appropriate steps to close all government, private, and government-aided educational institutions including colleges and universities on Monday and Tuesday. Manipur Unrest: Additional Central Force Arrive in Trouble-Torn State After Home Minister Amit Shah’s Decision To Deploy 50 CAPF Units Following Emergency Meet in Delhi. Earlier on Sunday, Singh and Anal in separate orders asked all the district and zonal level officers to take appropriate steps to resume the classes of all government, private, government-aided educational institutions including colleges and universities from Monday. For more than a week, regular classes in all educational institutions, including schools and universities in five valley districts remained closed from November 16 due to escalating violence and mob attacks. The Education Department, in consultation with the Home Department, has decided to close the normal classes in all the educational institutions on November 25 and 26, an official said. Manipur Violence: All Educational Institutions in Imphal Valley To Remain Closed Till November 23 for Safety of Students, Teachers and Staff. He said that considering the safety of the students, teachers and non-teaching staff, all the government and government-aided educational institutions, including state universities were closed till November 23 in five valley districts -- Imphal West, Imphal East, Thoubal, Bishnupur and Kakching. Officials said that with no major incident reported from any of the five districts, curfew was relaxed during the past few days for several hours in the daytime to facilitate the people to purchase essential items and carry out other essential work. Meanwhile, the Manipur Home Department extended the suspension of mobile Internet and data services in seven districts till Monday evening as a precautionary measure. Officials of the Home Department said that though no incident was reported from any of the seven districts, as a precautionary measure, the suspension of mobile Internet and data services has been extended till November 25. The seven districts, comprising both the valley and hills, are Imphal West, Imphal East, Bishnupur, Thoubal, Kakching, Kangpokpi, and Churachandpur. (The above story first appeared on LatestLY on Nov 24, 2024 11:48 PM IST. For more news and updates on politics, world, sports, entertainment and lifestyle, log on to our website latestly.com ).
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The rising price of paying the national debt is a risk for Trump's promises on growth and inflation WASHINGTON (AP) — Donald Trump has big plans for the economy. He also has big debt problem that'll be a hurdle to delivering on those plan. Trump has bold ambitions on tax cuts, tariffs and other programs. But high interest rates and the price of repaying the federal government’s existing debt could limit what he’s able to do. The federal debt stands at roughly $36 trillion, and the spike in inflation after the pandemic has pushed up the government’s borrowing costs such that debt service next year will easily exceed spending on national security. 'Wicked' and 'Gladiator' make gravity-defying theater debuts NEW YORK (AP) — “Wicked” and “Gladiator II” have debuted in theaters with a combined $270 million in ticket sales. Their worldwide performance breathed fresh life into global box office results that have struggled lately. Together the films turned the moviegoing weekend into one of the busiest of the year. Jon M. Chu’s lavish big-budget musical “Wicked,” starring Ariana Grande and Cynthia Erivo, debuted with $114 million domestically and $164.2 million globally. Ridley Scott’s “Gladiator II” is a sequel to his 2000 best picture-winning original and launched with $55.5 million in ticket sales. “Moana 2” is being released Wednesday, so it looks like Hollywood might be looking at historic sales over the Thanksgiving holiday. Trump's Republican Party is increasingly winning union voters. It's a shift seen in his labor pick WASHINGTON (AP) — Working-class voters helped Republicans make steady election gains this year and expanded a coalition that increasingly includes rank-and-file union members. It's a political shift spotlighting one of President-elect Donald Trump’s latest Cabinet picks: a GOP congresswoman, who has drawn labor support, to be his labor secretary. Oregon Rep. Lori Chavez-DeRemer narrowly lost her bid for a second term this month, despite strong backing from union members. They're a key part of the Democratic base but are gravitating in the Trump era toward a Republican Party traditionally allied with business interests. Trump raced to pick many Cabinet posts. He took more time to settle on a treasury secretary WASHINGTON (AP) — President-elect Donald Trump launched a blitz of picks for his Cabinet, but he took his time settling on billionaire investor Scott Bessent as his choice for treasury secretary. The Republican not only wanted someone who jibes with him, but an official who can execute his economic vision and look straight out of central casting while doing so. With his Yale University education and pedigree trading for Soros Fund Management before establishing his own funds, Bessent will be tasked with a delicate balancing act. Trump expects him to help reset the global trade order, enable trillions of dollars in tax cuts, ensure inflation stays in check, manage a ballooning national debt and still keep the financial markets confident. Trump chooses Bessent to be treasury secretary, Vought as budget chief, Chavez-DeRemer for Labor WASHINGTON (AP) — President-elect Donald Trump has chosen hedge fund manager Scott Bessent, an advocate for deficit reduction, to serve as his next treasury secretary. Bessent, 62, is founder of hedge fund Key Square Capital Management. He previously had worked on and off for Soros Fund Management since 1991. Trump also said he would nominate Russell Vought, 48, to lead the Office of Management and Budget, a position he held during Trump's first term. And Trump chose Rep. Lori Chavez-DeRemer, an Oregon Republican, as his labor secretary, and Scott Turner, a former football player who worked in Trump’s first administration, as his housing secretary. Afraid of losing the US-Canada trade pact, Mexico alters its laws and removes Chinese parts MEXICO CITY (AP) — Mexico has been taking a bashing for allegedly serving as a conduit for Chinese parts and products into North America. Officials here are terrified that a re-elected Donald Trump or politically struggling Justin Trudeau could simply expel their country from the U.S.-Mexico-Canada free trade agreement. Mexico's ruling Morena party is so afraid its has gone on a campaign to get companies to replace Chinese parts with locally made ones. And its legislators are consciously tweaking the wording of major laws to try to make them compatible with the trade pact's language. Mexico hopes the rules of the trade pact would prevent the U.S. or Canada from simply walking away. Australia withdraws a misinformation bill after critics compare it to censorship CANBERRA, Australia (AP) — Australia’s government has withdrawn a bill that would give a media watchdog power to monitor digital platforms and require them to keep records about misinformation and disinformation on their networks. Communications Minister Michelle Rowland said Sunday that the government was unable to drum up the support needed to pass the legislation. The opposition spokesman, David Coleman, said the bill “betrayed our democracy” and amounted to “censorship laws in Australia.” The bill would have granted the Australian Communications and Media Authority power over digital platforms by approving an enforceable code of conduct or standards for social media companies if self-regulation fell short. He'll be the last meatpacker in the Meatpacking District. Here's how NYC's gritty 'hood got chic NEW YORK (AP) — The last meatpackers in New York's Meatpacking District have agreed to end their leases early and make way for development on their city-owned lot. A third-generation meatpacker says he is ready to retire and he'll be proud to be there when the building closes. The closure date has not been set, but will mark the end of over a century of industrial life in the Meatpacking District. Starting in the 1970s, a new nightlife scene emerged as bars and nightclubs moved in. Today it's a hub for shopping, tourism, and recreation and only echoes of that grit remain. US budget airlines are struggling. Will pursuing premium passengers solve their problems? DALLAS (AP) — Delta and United Airlines have become the most profitable U.S. airlines by targeting premium customers while also winning a significant share of budget travelers. That is squeezing smaller low-fare carriers like Spirit Airlines, which filed for bankruptcy protection on Monday. Some travel industry experts think Spirit’s troubles indicate less-wealthy passengers will have fewer choices and higher prices. Other discount airlines are on better financial footing but also are lagging far behind the full-service airlines when it comes to recovering from the COVID-19 pandemic. Most industry experts think Frontier and other so-called ultra-low-cost carriers will fill the vacuum if Spirit shrinks, and that there's still plenty of competition to prevent prices from spiking. What to know about Scott Bessent, Trump's pick for treasury secretary WASHINGTON (AP) — President-elect Donald Trump has chosen money manager Scott Bessent, an advocate for deficit reduction and deregulation, to serve as his next treasury secretary. Bessent is a past supporter of Democrats who has become an enthusiastic supporter of Trump. He’s an advocate of cutting spending while extending the tax cuts approved by Congress in Trump’s first term. He has said tariffs imposed during a second Trump administration would be directed primarily at China.
Tesla Just Unveiled a New Mezcal—and We Got a TasteNEW YORK, Dec. 07, 2024 (GLOBE NEWSWIRE) -- Y-mAbs Therapeutics, Inc. (the "Company" or "Y-mAbs") YMAB , a commercial-stage biopharmaceutical company focused on the development and commercialization of novel radioimmunotherapy and antibody-based therapeutic products for the treatment of cancer, today announced the presentation of CD38-SADA in Non-Hodgkin Lymphoma (NHL) preclinical data and trial in progress posters at the 66 th American Society of Hematology (ASH) Annual Meeting & Exposition being held on December 7 –10, 2024, in San Diego, California. A poster titled " CD38-SADA, a S elf- A ssembling and D is- A ssembling Bispecific Fusion Protein for Two-Step Pretargeted Radioimmunotherapy of Non-Hodgkin Lymphoma " characterizes the selective binding of CD38-SADA to DOTA-chelated lanthanide metals and high-avidity binding to CD38, a tumor specific antigen overexpressed across a range of lymphoma cells. Data from this poster demonstrate anti-tumor efficacy of CD38-SADA when used with Lutetium 177 (Lu 177 )-DOTA in a two-step approach to pre-targeted radioimmunotherapy ("PRIT"). Tumor responses in a xenograft mouse model were rapid and dose-dependent, further supporting the clinical development of CD38-SADA PRIT in patients with CD38-positive lymphoid malignancies. "This preclinical analysis provides important insights into the unique pharmacology of CD38-SADA and its therapeutic potential for NHL," said Brian H. Santich, Ph.D., the lead author and co-inventor of the SADA PRIT technology platform. "The anti-tumor efficacy positively correlated with increasing doses of Lu 177 -DOTA and CD38-SADA, which informed the study design and initial dosing regimen of our Trial 1201 in patients with NHL." In addition, Y-mAbs presents a trial-in-progress poster from its ongoing Phase 1 (Trial 1201) clinical study evaluating the safety and tolerability of CD38-SADA PRIT with Lu 177 -DOTA in adults with relapsed or refractory NHL. Trial 1201 is a first-in-human, dose-escalation, open-label, multicenter study composed of two parts. Part A includes dose escalation of the CD38-SADA bispecific fusion protein to define the optimal safe dose of the CD38-SADA protein, the administration interval between CD38-SADA and Lu 177 -DOTA, and the Lu 177 -DOTA dose for tumor imaging. In Part B, dose escalation of Lu 177 -DOTA will establish the optimal therapeutic dose of the radioactive payload. For each part, the escalation is based on a 3+3 trial design of 4 planned dose levels. "We are pleased to share the details of this Phase 1 clinical trial, which is investigating a potentially transformative approach to pre-targeted radioimmunotherapy for patients with relapsed and refractory NHL," said Vignesh Rajah, MBBS, DCH, MRCP (UK), Chief Medical Officer. "This is our second clinical program evaluating the SADA PRIT technology platform and our first in hematological malignancies." The abstract details are below: Abstract Title: " CD38-SADA, a Self-Assembling and Dis-Assembling Bispecific Fusion Protein for Two-Step Pretargeted Radioimmunotherapy of Non-Hodgkin Lymphoma" Format : Poster Presentation, ID: 1599 Date and Time: Saturday, December 7, 2024, 5:30 PM-7:30 PM Abstract Title: " CD38-SADA Pretargeted Radioimmunotherapy (PRIT) with Lutetium 177 (Lu177)-DOTA in Adult Patients with Relapsed or Refractory Non-Hodgkin Lymphoma: A First-in-Human Phase 1 Trial" Format : Poster Presentation, ID: 4434.1 Date and Time: Monday, December 9, 2024, 6:00 PM-8:00 PM Researchers at Memorial Sloan Kettering Cancer Center (MSK), including Dr. Nai-Kong Cheung, developed the SADA technology for radioimmunotherapy, which is exclusively licensed by MSK to Y-mAbs. Dr. Cheung has intellectual property rights and interests in the technology, and as a result of this licensing arrangement, MSK has institutional financial interests in the technology. About Y-mAbs Y-mAbs is a commercial-stage biopharmaceutical company focused on the development and commercialization of novel, radioimmunotherapy and antibody-based therapeutic cancer products. The Company's technologies include its investigational Self-Assembly DisAssembly ("SADA") Pretargeted Radioimmunotherapy Platform ("PRIT") and bispecific antibodies generated using the Y-BiClone platform. The Company's broad and advanced product pipeline includes the anti-GD2 therapy DANYELZA® (naxitamab-gqgk), the first FDA-approved treatment for patients with relapsed or refractory high-risk neuroblastoma in the bone or bone marrow after a partial response, minor response, or stable disease to prior therapy. About CD38-SADA PRIT CD38-SADA is a bispecific fusion protein that tightly binds to the CD38 antigen and to select radionuclides chelated to tetraxetan (or "DOTA"). CD38-SADA contains a p53-derived domain that drives the self-assembly of CD38-SADA tetramers, which possess four distinct binding sites for CD38. In the first step of pre-targeted radiotherapy, non-radiolabeled-CD38-SADA tetramers are infused and bind with high avidity to CD38-positive tumors, while unbound CD38-SADA disassembles into low molecular weight monomers that are removed by the kidney. The second infusion delivers the "radioactive payload," which binds to the CD38-SADA on tumor cells for localized irradiation. CD38-SADA PRIT with Lutetium 177 (Lu 177)-DOTA is now under clinical investigation in Trial 1201 (NCT05994157). Forward-Looking Statements Statements in this press release about future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Such statements include, but are not limited to, statements about our business model, including financial outlook for 2024 and beyond, including estimated operating expenses, use of cash and cash equivalents and DANYELZA product revenue and sufficiency of cash resources and related assumptions; expectations with respect to the Company's future financial performance; implied and express statements regarding the future of the Company's business, including with respect to expansion and its goals; expectations with respect to the Company's plans and strategies, development, regulatory, commercialization and product distribution plans, including the timing thereof; expectations with respect to the Company's products and product candidates, including potential territory and label expansion of DANYELZA and the potential market opportunity related thereto and potential benefits thereof, and the potential of the SADA PRIT technology and potential benefits and applications thereof; expectations relating to key anticipated development milestones, including potential expansion and advancement of commercialization and development efforts, including potential indications, applications and geographies, and the timing thereof; expectations with respect to current and future clinical and pre-clinical studies and the Company's research and development programs, including with respect to timing and results; expectations regarding collaborations or strategic partnerships and the potential benefits thereof; and other statements that are not historical facts. Words such as ‘‘anticipate,'' ‘‘believe,'' "contemplate," ‘‘continue,'' ‘‘could,'' ‘‘estimate,'' ‘‘expect,'' "hope," ‘‘intend,'' ‘‘may,'' ‘‘might,'' ‘‘plan,'' ‘‘potential,'' ‘‘predict,'' ‘‘project,'' ‘‘should,'' ‘‘target,'' "will," ‘‘would',' "guidance," "goal," "objective," and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Our product candidates and related technologies are novel approaches to cancer treatment that present significant challenges. Actual results may differ materially from those indicated by such forward-looking statements as a result of various factors, including but not limited to: risks associated with the Company's financial condition and need for additional capital; the risks that actual results of the Company's restructuring plan and revised business plan will not be as expected; risks associated with the Company's development work; cost and success of the Company's product development activities and clinical trials; the risks of delay in the timing of the Company's or its partners' regulatory submissions or failure to receive approval of its drug candidates; the risks related to commercializing any approved pharmaceutical product including the rate and degree of market acceptance of product candidates; development of sales and marketing capabilities and risks associated with failure to obtain sufficient reimbursement for products; risks related to the Company's dependence on third parties including for conduct of clinical testing and product manufacture as well as regulatory submissions; the Company's ability to enter into new partnerships or to recognize the anticipated benefits from its existing partnerships; risks related to government regulation; risks related to market approval, risks associated with protection of the Company's intellectual property rights; risks related to employee matters and managing growth; risks related to the Company's common stock, risks associated with macroeconomic conditions, including the conflict between Russia and Ukraine and sanctions related thereto, the state of war between Israel and Hamas and the related risk of a larger regional conflict, inflation, increased interest rates, uncertain global credit and capital markets and disruptions in banking systems; and other risks and uncertainties affecting the Company including those described in the "Risk Factors" section included in the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2023, and the Company's Quarterly Report on Form 10-Q for the quarterly periods ended March 31, 2024, and September 30, 2024, and future filings and reports by the Company. Any forward-looking statements contained in this press release speak only as of the date hereof, and the Company undertakes no obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise. SADA®, SADA PRIT®, DANYELZA® and Y-mAbs® are registered trademarks of Y-mAbs Therapeutics, Inc. Investor Contact: Courtney Dugan VP, Head of Investor Relations cdu@ymabs.com © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.Dior Conners hits game-winning 3 with a second left as Appalachian State tops William & Mary, 79-76
Kyle Moody Elected as Board Member of TRIAD Real Estate Investors AssociationUSU football: Eleven former Aggies headed to other FBS programs; transfer portal trackerNone
