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PLEASANTON, Calif. , Dec. 23, 2024 /PRNewswire/ -- 10x Genomics, Inc. (Nasdaq: TXG), a leader in single cell and spatial biology, announced today it had secured a permanent injunction in the U.S. District Court for the District of Delaware against the GeoMx products sold by Bruker Corporation (Nasdaq: BRKR), which acquired the product line from NanoString Technologies. To minimize the risk of disruption to ongoing research, 10x Genomics requested a carve-out for GeoMx users who installed an instrument prior to the trial in November 2023 . The injunction, which the Court said it will enter in January 2025 , is expected to prohibit Bruker from making, using, selling or offering to sell in the United States its GeoMx Digital Spatial Profiler and associated instruments, reagents and services for RNA and protein detection. At the request of 10x Genomics, the injunction will not block ongoing research by researchers who installed a GeoMx instrument prior to November 18, 2023 . Such customers can continue to purchase GeoMx reagents for use with existing GeoMx instruments for purposes of continuing their ongoing research. The Court found that making such an exception for ongoing research strikes a "workable balance between protecting the patentee's rights and protecting the public from the injunction's adverse effects." In addition, the Court affirmed the $31 million damages awarded by the November 2023 jury verdict, as well as supplemental damages and interest that will be added to the total damages when final judgment is entered. "Today's decision helps to safeguard our decade-long investment in innovation and ensures we can continue to develop groundbreaking technologies that help our customers revolutionize science," said Eric Whitaker , Chief Legal Officer at 10x Genomics. "10x exists to fuel scientific progress – not stifle it – and that is why we've done our utmost to ensure this injunction was structured to protect both our intellectual property and existing GeoMx customers' ongoing research." The Court recognized the harm NanoString's infringing conduct caused 10x when it wrote in its ruling, "Having been careful not to license its technology, 10x suffers when it proclaims itself as an innovator in spatial genomics but a competitor is using the same innovative, patented technology." Today's Court decision follows a November 2023 jury verdict that found that NanoString's GeoMx products willfully infringed seven patents exclusively licensed to 10x Genomics by Prognosys. During the trial, the jury heard testimony from the sole inventor of the patents, Illumina co-founder Mark Chee , and NanoString CEO Brad Gray and NanoString CSO Joe Beechem. After hearing all of the evidence, the jury determined that all seven patents had been infringed by NanoString, that each patent was valid, that NanoString willfully infringed those patents and that monetary damages were owed to 10x for the infringement of all seven patents. In affirming the jury's finding that NanoString willfully infringed, the Court relied on the evidence showing that NanoString knew or was willfully blind that its acts would cause infringement of 10x's rights. The asserted patents in Case No. 21-cv-653-MFK include (a) U.S. Patent No. 10,472,669; (b) U.S. Patent No. 10,961,566; (c) U.S. Patent No. 10,983,113; (d) U.S. Patent No. 10,996,219; (e) U.S. Patent No. 11,001,878; (f) U.S. Patent No. 11,008,607 and (g) U.S. Patent No. 11,293,917. About 10x Genomics 10x Genomics is a life science technology company building products to accelerate the mastery of biology and advance human health. Our integrated solutions include instruments, consumables and software for single cell and spatial biology, which help academic and translational researchers and biopharmaceutical companies understand biological systems at a resolution and scale that matches the complexity of biology. Our products are behind breakthroughs in oncology, immunology, neuroscience and more, fueling powerful discoveries that are transforming the world's understanding of health and disease. To learn more, visit 10xgenomics.com or connect with us on LinkedIn or X (Twitter) . Forward Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 as contained in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject to the "safe harbor" created by those sections. All statements included in this press release, other than statements of historical facts, may be forward-looking statements. Forward-looking statements generally can be identified by the use of forward-looking terminology such as "may," "might," "will," "should," "expect," "plan," "anticipate," "could," "intend," "target," "project," "contemplate," "believe," "see," "estimate," "predict," "potential," "would," "likely," "seek" or "continue" or the negatives of these terms or variations of them or similar terminology, but the absence of these words does not mean that a statement is not forward-looking. These forward-looking statements include statements regarding litigation and remedies as well as possible outcomes of litigation. These forward-looking statements do not reflect that our success will depend on our ability to obtain, maintain and protect our intellectual property rights, intellectual property litigation could be expensive, time-consuming, unsuccessful and could interfere with our ability to develop, manufacture and commercialize our products or technologies, litigation outcomes are unpredictable or there may be changes in our litigation strategy. These statements are based on management's current expectations, forecasts, beliefs, assumptions and information currently available to management. Actual outcomes and results could differ materially from these statements due to a number of factors and such statements should not be relied upon as representing 10x Genomics, Inc.'s views as of any date subsequent to the date of this press release. 10x Genomics, Inc. disclaims any obligation to update any forward-looking statements provided to reflect any change in 10x Genomics' expectations or any change in events, conditions or circumstances on which any such statement is based, except as required by law. The material risks and uncertainties that could affect 10x Genomics, Inc.'s financial and operating results and cause actual results to differ materially from those indicated by the forward-looking statements made in this press release include those discussed under the captions "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operations" in the company's most recently-filed 10-K for the fiscal year ended December 31, 2023 and elsewhere in the documents 10x Genomics, Inc. files with the Securities and Exchange Commission from time to time. Disclosure Information 10x Genomics uses filings with the Securities and Exchange Commission, our website ( www.10xgenomics.com ), press releases, public conference calls, public webcasts and our social media accounts as means of disclosing material non-public information and for complying with our disclosure obligations under Regulation FD. Contacts Investors: investors@10xgenomics.com Media: media@10xgenomics.com View original content to download multimedia: https://www.prnewswire.com/news-releases/us-district-court-awards-10x-genomics-permanent-injunction-in-patent-infringement-lawsuit-against-bruker-corporations-geomx-products-302338627.html SOURCE 10x Genomics, Inc.Glazed gammonA step-by-step guide to renovating a neglected gardenextreme sport betting 。

MIAMI GARDENS, Fla. (AP) — Dolphins coach Mike McDaniel said he was caught off guard by reports early Tuesday that linebacker Shaq Barrett wants to unretire. The two-time Super Bowl winner signed a one-year deal with the Dolphins in March, then abruptly announced his retirement on social media in July, just days before the start of Miami's training camp. “Just to be candid, obviously there's a reason why you target and sign somebody," McDaniel said Tuesday afternoon. “I was fully caught off guard, or caught by surprise this morning as I found out.” McDaniel indicated the Dolphins have not had any conversations with Barrett recently. Miami holds the 32-year-old’s contractual rights. ESPN first reported the news. “It was kind of news as you guys got it,” McDaniel said. He also said he hasn't had a chance to think about Barrett potentially rejoining the team, and that his immediate focus is on Miami's Thursday night game at Green Bay. “The team is counting on me to think about the Packers,” he said. "I'll get with (GM) Chris (Grier), and we'll work through that. There's a ton of implications that go along with it in terms of team and roster stuff, so we'll work through that as we just got the news today.” Barrett has 400 tackles, 59 sacks, 22 forced fumbles and three interceptions in nine seasons — four with Denver and five with Tampa Bay. He was a second-team All-Pro with the Buccaneers in 2019, with a league-high 19 1/2 sacks. The Dolphins waived veteran safety Marcus Maye on Tuesday and activated rookie safety Patrick McMorris from injured reserve. Maye, who signed with the Dolphins in June, played in 11 games with three starts for Miami this season. He had 30 tackles and a tackle for loss. He could re-sign to the team's practice squad if he clears waivers. Maye previously played for New Orleans, but was cut in a money-saving move in March after two seasons with the Saints. Maye's release made room on the roster for McMorris, who was drafted in the sixth round by Miami in April. He began the season on injured reserve because of a calf injury. AP NFL: https://apnews.com/hub/nflBiden gives life in prison to 37 of 40 federal death row inmates before Trump can resume executions WASHINGTON (AP) — President Joe Biden on Monday announced that he is commuting the sentences of 37 of the 40 people on federal death row, converting their punishments to life imprisonment just weeks before President-elect Donald Trump, an outspoken proponent of expanding capital punishment, takes office. The move spares the lives of people convicted in killings, including the slayings of police and military officers, people on federal land and those involved in deadly bank robberies or drug deals, as well as the killings of guards or prisoners in federal facilities. The decision leaves three federal inmates to face execution. They are Dylann Roof, who carried out the 2015 racist slayings of nine Black members of Mother Emanuel AME Church in Charleston, South Carolina; 2013 Boston Marathon bomber Dzhokhar Tsarnaev; and Robert Bowers, who fatally shot 11 congregants at Pittsburgh’s Tree of life Synagogue in 2018, the deadliest antisemitic attack in U.S history. “I’ve dedicated my career to reducing violent crime and ensuring a fair and effective justice system,” Biden said in a statement. “Today, I am commuting the sentences of 37 of the 40 individuals on federal death row to life sentences without the possibility of parole. These commutations are consistent with the moratorium my administration has imposed on federal executions, in cases other than terrorism and hate-motivated mass murder.” Reaction was strong, both for and against. A Trump spokesperson called the decision “abhorrent.” House Ethics Committee accuses Gaetz of paying for sex, including with 17-year-old girl WASHINGTON (AP) — The House Ethics Committee on Monday accused Matt Gaetz of “regularly” paying for sex, including once with a 17-year-old girl, and purchasing and using illicit drugs as a member of Congress, as lawmakers released the conclusions of a nearly four-year investigation that helped sink his nomination for attorney general. The 37-page report by the bipartisan panel includes explicit details of sex-filled parties and vacations that Gaetz, now 42, took part in from 2017 to 2020 while the Republican represented Florida's western Panhandle. Congressional investigators concluded that Gaetz violated multiple state laws related to sexual misconduct while in office, though not federal sex trafficking laws. They also found that Gaetz “knowingly and willfully sought to impede and obstruct” the committee's work. “The Committee determined there is substantial evidence that Representative Gaetz violated House Rules and other standards of conduct prohibiting prostitution, statutory rape, illicit drug use, impermissible gifts, special favors or privileges, and obstruction of Congress,” the report said. Before the report came out, Gaetz denied any wrongdoing and criticized the committee's process. Luigi Mangione pleads not guilty to murder and weapons charges in UnitedHealthcare CEO's death NEW YORK (AP) — The man accused of fatally shooting the CEO of UnitedHealthcare pleaded not guilty on Monday to state murder and terror charges while his attorney complained that comments coming from New York’s mayor would make it tough to receive a fair trial. Luigi Mangione, 26, was shackled and seated in a Manhattan court when he leaned over to a microphone to enter his plea. The Manhattan district attorney charged him last week with multiple counts of murder, including murder as an act of terrorism. Mangione's initial appearance in New York’s state trial court was preempted by federal prosecutors bringing their own charges over the shooting. The federal charges could carry the possibility of the death penalty, while the maximum sentence for the state charges is life in prison without parole. Prosecutors have said the two cases will proceed on parallel tracks, with the state charges expected to go to trial first. One of Mangione’s attorneys told a judge that government officials, including New York Mayor Eric Adams, have turned Mangione into a political pawn, robbing him of his rights as a defendant and tainting the jury pool. Man faces murder charges in the death of a woman who was lit on fire in New York City subway A man is facing murder and arson charges in New York City for allegedly setting a woman on fire inside a subway train and then watching her die after she was engulfed in flames, police said Monday. The suspect, identified by police as Sebastian Zapeta, was taken into custody hours after the woman died on Sunday morning. Zapeta, 33, is a Guatemalan citizen who entered the U.S. illegally after he had been previously removed in 2018, said Jeff Carter, a spokesman for U.S. Immigration and Customs Enforcement. Surveillance video showed the suspect approach the woman, who was sitting motionless and may have been sleeping, on a stationary F train at the Coney Island-Stillwell Avenue subway station in Brooklyn and set her clothing on fire, police said. The woman's clothing "“became fully engulfed in a matter of seconds,” said Jessica Tisch, the New York City police commissioner, while the suspect remained at the scene, watching her burn from a bench on the subway platform as police and a transit worker extinguished the flames. Middle East latest: Defense minister acknowledges Israel killed Hamas leader JERUSALEM — Israel’s defense minister has confirmed that Israel assassinated Hamas’ top leader last summer and is threatening to take similar action against the leadership of the Houthi rebel group in Yemen. The comments by Israel Katz appeared to mark the first time that Israel has acknowledged killing Ismail Haniyeh, who died in an explosion in Iran in July. Israel was widely believed to be behind the blast and leaders have previously hinted at its involvement. In a speech Monday, Katz said the Houthis would meet a similar fate as the other members of an Iranian-led alliance in the region, including Haniyeh. He also noted that Israel has killed other leaders of Hamas and Hezbollah, helped topple Syria’s Bashar Assad and destroyed Iran’s anti-aircraft systems. “We will strike (the Houthis’) strategic infrastructure and cut off the head of the leadership,” he said. “Just like we did to Haniyeh, Sinwar and Nasrallah in Tehran, Gaza and Lebanon, we will do in Hodeida and Sanaa,” he said, referring to Hamas and Hezbollah leaders killed in previous Israeli attacks. Trump again calls to buy Greenland after eyeing Canada and the Panama Canal WEST PALM BEACH, Fla. (AP) — First it was Canada, then the Panama Canal. Now, Donald Trump again wants Greenland. The president-elect is renewing unsuccessful calls he made during his first term for the U.S. to buy Greenland from Denmark, adding to the list of allied countries with which he's picking fights even before taking office on Jan. 20. In a Sunday announcement naming his ambassador to Denmark, Trump wrote that, “For purposes of National Security and Freedom throughout the World, the United States of America feels that the ownership and control of Greenland is an absolute necessity." Trump again having designs on Greenland comes after the president-elect suggested over the weekend that the U.S. could retake control of the Panama Canal if something isn't done to ease rising shipping costs required for using the waterway linking the Atlantic and Pacific oceans. He's also been suggesting that Canada become the 51st U.S. state and referred to Canadian Prime Minister Justin Trudeau as “governor” of the “Great State of Canada.” Nissan and Honda to attempt a merger that would create the world's No. 3 automaker TOKYO (AP) — Japanese automakers Honda and Nissan have announced plans to work toward a merger that would form the world’s third-largest automaker by sales, as the industry undergoes dramatic changes in its transition away from fossil fuels. The two companies said they had signed a memorandum of understanding on Monday and that smaller Nissan alliance member Mitsubishi Motors Corp. also had agreed to join the talks on integrating their businesses. Automakers in Japan have lagged behind their big rivals in electric vehicles and are trying to cut costs and make up for lost time as newcomers like China's BYD and EV market leader Tesla devour market share. Honda's president, Toshihiro Mibe, said Honda and Nissan will attempt to unify their operations under a joint holding company. Honda will lead the new management, retaining the principles and brands of each company. They aim to have a formal merger agreement by June and to complete the deal and list the holding company on the Tokyo Stock Exchange by August 2026, he said. No dollar value was given and the formal talks are just starting, Mibe said. Magdeburg mourns Christmas market attack victims as fears swirl of deeper German social divisions MAGDEBURG, Germany (AP) — Mourners laid flowers near the scene of the deadly Christmas market attack on Monday as investigators puzzled over the motive of the suspect and his previous encounters with authorities were scrutinized, while fears swirled that the rampage could deepen divisions in German society. The Johanniskirche, a church a short walk from the scene of the attack, has become a central place of mourning since the suspect drove a car into the busy market on Friday evening, killing five people. A carpet of flowers now covers the broad sidewalk in front of the church. Prosecutors said the number of injured has risen to as many as 235 as more people have reported to hospitals and doctors, but it's possible there was some double-counting. Authorities have identified the suspect as a Saudi doctor who arrived in Germany in 2006 and had received permanent residency. They say he doesn't fit the usual profile of perpetrators of extremist attacks. The man described himself as an ex-Muslim who was highly critical of Islam, and on social media expressed support for the far-right. A picture has emerged of someone who had come to authorities’ attention for threatening behavior and been the subject of tipoffs, but wasn't known to have committed any violence. The interior minister of Saxony-Anhalt state, Tamara Zieschang, told lawmakers Monday that police had contacted him in September 2023 and again in October this year, but didn't comment publicly on why, German news agency dpa reported. How faith communities can be welcoming of believers with disabilities this holiday season and beyond The Rev. Shannon Blosser sees how his son loves church — the music, the singing, the communion. But the United Methodist pastor said his family hasn’t always felt like 11-year-old Noah, who is autistic, has been welcome. At one point, Blosser’s wife and the couple’s two sons stopped attending in-person services at a church where he served. “If we felt more supported, we probably would have pushed through.” Many people with disabilities, advocates and families want more religious congregations to know that there are ways to be accommodating and inclusive of people with intellectual and developmental disabilities this holiday season — and year round — and to fully embrace them and their families. “They just have to have the willingness to be the church that sees the image of God in every child and every adult,” said Blosser, who now serves two small West Virginia congregations that have been supportive of his family’s needs. Mount Olivet United Methodist Church, one of the congregations, is hosting a “Calm Christmas,” a sensory-friendly celebration and worship, where music will come from a guitar, rather than a piano, and candles will be swapped for glow sticks to avoid any dangers. There are fidget toys and a “visual schedule” to help those needing images and graphics to better process the sequence of events. Tennessee and Auburn remain 1-2 in AP Top 25 poll featuring 10 SEC teams Tennessee and Auburn remained Nos. 1-2 atop The Associated Press men's college basketball poll. It's a fitting spot for a pair of Southeastern Conference teams considering the league put 10 teams into Monday's AP Top 25. The Volunteers (11-0) and Tigers (11-1) spent a third straight week in the same position, and it marked a fourth consecutive week for Auburn sitting at No. 2. They were part of a top 10 that featured the same top-10 programs, though slightly reshuffled with Kentucky tumbling six spots to No. 10 after a loss to Ohio State. The poll also featured four additions that previously had been ranked this season, including No. 19 Mississippi State and No. 23 Arkansas to add to the SEC's season-long hauls. The SEC thrice had as many as nine ranked teams this season, including in the preseason poll. This is the first time since at least the start of the 2012-13 season that one league had 10 ranked teams. Iowa State was third, followed by Duke and Alabama to round out the top five. Florida, Kansas, Marquette and Oregon followed, with those teams all moving up one spot given the Wildcats' fall to 10th.

A step-by-step guide to renovating a neglected gardenMariah Carey sparks romance rumors with Anderson .Paak as they hold hands entering Aspen restaurant Have YOU got a story? Email tips@dailymail.com By CHRISTINE RENDON FOR DAILYMAIL.COM Published: 23:10, 23 December 2024 | Updated: 23:22, 23 December 2024 e-mail View comments Mariah Carey and Anderson .Paak raised eyebrows as they were seen enjoying dinner together in Aspen. In photos obtained by TMZ , the Leave The Door open singer, 38, sweetly held her hand as they entered Catch Steak restaurant on Sunday evening. He even gently had his hand wrapped her around her waist as they ducked into the eatery and, ever the gentleman, appeared to hold the door open for her. While the duo's display may have suggested they were an item, sources insisted to TMZ the two are not dating, and the musicians were even observed leaving the restaurant separately. Mariah, 55, and Anderson are currently collaborating on a new musical project, and the duo have been hitting up a recording studio in Aspen as of late, according to insiders. On Thursday, the duo were reportedly enjoying a dinner break from all their hard work at Catch. Mariah Carey raised eyebrows as she was seen entering an Aspen restaurant hand in hand with fellow musician Anderson .Paak Anderson has been giving social media followers a sneak peak of their musical collaboration, and over the summer shared video of him and Mariah at the legendary Electric Lady music studios in the Big Apple. Narrating the video, Anderson told fans: 'Oh my God Mariah Carey. Listen, you ever be star-struck, like when a star strikes you? That's what it was. But I couldn't just freeze up. We had to get into the studio and just make something.' Read More Anderson .Paak files for divorce from wife Jae Lin Anderson linked up with Mariah again this past Halloween - he shared a snap of himself dressed as a member of Daft Punk as he celebrated the holiday alongside Carey. Mariah was last in a long-term relationship with back-up dancer Bryan Tanaka however they went their separate ways last year, while in January Anderson filed for divorce from Jae Lin after more than 10 years of marriage. Anderson shares two sons with Jae, his second wife - Soul and Shine. The singer recently released his directorial debut, K-Pops!, which starred himself and his eldest son. The feature was inspired by what the singer, who is of mixed Black and Korean heritage, described as 'funnier aspects of the experience' of growing up biracial. The performer previously spoke to Hypebeast about why he chose to cast Soul in the feature. Anderson has been giving social media followers a sneak peak of their musical collaboration, and over the summer shared video of him and Mariah at the legendary Electric Lady music studios in the Big Apple Anderson linked up with Mariah again this past Halloween - he shared a snap of himself dressed as Daft Punk as he celebrated the holiday alongside Carey 'I wanted to write a movie that would explore that dynamic and those familial relationships. And also, I get to sneak in quality time with my son while shooting,' he said. Meanwhile, the 'Queen of Christmas' has been spending the last few days in snowy Aspen after wrapping her Christmas Time Tour. The tour was announced in August and it celebrated the 30th anniversary of her timeless holiday hit, All I Want For Christmas Is You. The first show was on November 6 in Highland, California, and the closing concert was December 17 in Brooklyn. Meanwhile, the 'Queen of Christmas' has been spending the last few days in snowy Aspen after wrapping her Christmas Time Tour Mariah's setlist was rounded out with 26 songs and the concert was around 90 minutes-long. Audiences enjoyed renditions of the superstar's biggest, most recognizable songs as well as holiday classics. It's become customary for Carey to promote her mid-90s Christmas album during the last two months of the year. The lead single is ubiquitous around the holiday season as fans annually push it back to the top of the music charts. Mariah Carey Share or comment on this article: Mariah Carey sparks romance rumors with Anderson .Paak as they hold hands entering Aspen restaurant e-mail Add commentKaspersky’s detection systems have discovered an average of 467,000 malicious files per day in 2024, marking a 14% increase compared to the previous year. It said certain types of threats saw significant growth with experts reporting a 33% surge in Trojan detections compared to 2023. These and other findings are described in the Kaspersky Security Bulletin (KSB) – an annual series of reports analysing major developments in the cybersecurity landscape. Windows continued to be the primary target for cyberattacks, accounting for 93% of all malware-filled data detected daily. Malicious families disseminated through various scripts and different MS Office document formats ranked among the top three threats, accounting for 6% of all malicious files detected daily. Kaspersky’s detection systems discovered a significant increase in Windows malware – 19% from 2023 to 2024. The most widespread type of malware continues to be Trojans – malicious programs that disguise themselves as legitimate software – with a surge of 33% from 2023 to 2024. There has also been a 2.5-fold (150%) increase in the use of Trojan-droppers – programs designed to deliver other malware to a victim’s computer or phone without the victim noticing. “The number of new threats grows every year as adversaries continue to develop new malware, techniques and methods to attack users and organisations. This year was no exception to this, and there were dangerous trends observed, such as attacks on trusted relationships and supply chains, including those on open-source packages (e.g., the XZ case). There were massive phishing and malicious campaigns targeting social media users and a rise in banking malware. And, of course, the use of AI tools to generate new malware or facilitate phishing attacks. In this evolving cyber threat landscape, the use of reliable security solutions is vital. Kaspersky experts are always dedicated to countering new and challenging cyberthreats, ensuring a secure online experience for users as well as robust cybersecurity and the latest threat intelligence for organisations,” comments Kaspersky Head of Anti-Malware Research Vladimir Kuskov. These discoveries are based on Kaspersky detections of malicious files from January to October and are part of Kaspersky Security Bulletin (KSB) – an annual series of predictions and analytical reports on key shifts within the cybersecurity world. To stay protected, the recommendations below should be followed. n Use the latest Threat Intelligence information to stay aware of actual TTPs used by threat actors n Back up the corporate data regularly. Backups should be isolated from the network. Make sure you can quickly access the backups in an emergency if needed

Most years, the pro wrestling rumor mill might ease off a little for the winter months before really heating back up again for WrestleMania season. But that's just an impossibility this year. Not only is one of WWE's flagship shows headed to Netflix soon, the company has also revived Saturday Night's Main Event for a big event soon, too. As such, there are massive rumblings making the rounds that involve names like The Rock. Tack on details about the how and why of Netflix programming and the usual expected buzz about surprise returns, and the mill is packed more than usual. To help fans keep pace, here is a quick look at the most notable rumors and whether fans should buy or sell on each. The Rumor Not all that long ago, The Rock made a big return at the Bad Blood PLE...and hasn't been seen since. According to Fightful Select (h/t Randall Ortman of Cageside Seats), there was no greater plan for the segment—all involved just wanted fans to see him. Reaction Ok? The whole thing was weird in the moment because Rock's music hit, he came out and did his goosebumps-slapping thing, then held up a few fingers, never walked down the ramp to the ring and the show ended. But there was, at least, some hope that it was planned and hinting at something bigger. Buy or Sell? Buy. To get cliche, this is par for the course when it comes to Rock's involvement. Last year was as sloppy as it gets before 'Mania and risked derailing the likes of Cody Rhodes. That there's no actual plan right now seems obvious. The Rumor Surely, at least, Rock will be at Raw's debut episode of Netflix, right? According to Wrestling Observer Newsletter (h/t Ortman ), the company doesn't have "official word" from Rock about his commitment. Reaction Regardless of his availability for 'Mania, it always felt like Rock would be involved in the Netflix debut. He does, after all, have more at stake in WWE than ever before after that TKO merger. Buy or Sell? Sell. This is exactly what one would leak while trying to hold back a surprise, right? Rock is going to be there because it is too important to miss and, if he's eventually committing to 'Mania, it's the perfect stage with the maximum amount of eyeballs to kick off whatever feud they do. The Rumor Whether WWE will maintain the PG rating in the new streaming era is a hot debate. According to Wrestling Observer Radio's Bryan Alvarez (h/t Ortman ), one big change is coming—they won't censor crowd chants anymore. Reaction This might just be the best way to do it. Actual on-screen characters cussing left and right doesn't add much to the story. But the organic, passionate reactions of fans in the buildings at shows? That's something special that is earned by the performers and shouldn't be edited. Buy or Sell? Buy all the stock. Censoring crowd noise and natural reactions makes the viewing experience worse and WWE has to know it. Refusing to lean into the advantages of getting off cable television would be silly. The Rumor Drew McIntyre shockingly returned and attacked Sami Zayn recently. According to PW Insider (h/t Ortman ), this only happened because Bronson Reed suffered an injury at the Survivor Series PLE. Reaction McIntyre was inevitable. He was always going to hang around the main-event scene, too, so it's not all that shocking he returned and did what he did while CM Punk moves on to other things. Buy or Sell? Big sell. It's hard to see what one has to do with the other and Reed's injury doesn't sound all too serious. McIntyre's star power around this time and into the 'Mania build was a must, and some of the Bloodline saga stuff resolving at Survivor Series opened the door. The Rumor Finn Bálor keeps spotlighting in a major way. And that's by design, it seems. According to WrestleVotes (h/t Ortman ), there is a "sustained singles push" for Bálor on the way in 2025. Reaction If it can happen for Damian Priest, it can certainly happen for Bálor. He's an awesome singles star and even gets the supernatural going sometimes with The Demon persona, so perhaps we see that again in the process. Buy or Sell? Easy buy. Bálor's faction has and will fall apart. Beyond the injury concerns, he's always been a globally renowned top singles star who seemed destined for huge singles things in WWE. He'd be a fun foil for the likes of Gunther.Hypertriglyceridemia Clinical Trials 2024: EMA, PDMA, FDA Approvals, Medication, Therapies, Mechanism of Action, Route of Administration and Companies by DelveInsight 12-26-2024 04:17 PM CET | Health & Medicine Press release from: DelveInsight Business Research Hypertriglyceridemia Clinical Trials (Albany, United States) As per DelveInsight's assessment, globally, Hypertriglyceridemia pipeline constitutes 20+ key companies continuously working towards developing 20+ Hypertriglyceridemia treatment therapies, analysis of Clinical Trials, Therapies, Mechanism of Action, Route of Administration, and Developments analyzes DelveInsight. "Hypertriglyceridemia Pipeline Insight, 2024" report by DelveInsight outlines comprehensive insights into the present clinical development scenario and growth prospects across the Hypertriglyceridemia Market. The Hypertriglyceridemia Pipeline report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. The report also covers a detailed description of the drug, including the mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, collaborations, mergers acquisition, funding, designations, and other product-related details. Request for Sample Report @ https://www.delveinsight.com/sample-request/hypertriglyceridemia-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr Some of the key takeaways from the Hypertriglyceridemia Pipeline Report: • Hypertriglyceridemia Companies across the globe are diligently working toward developing novel Hypertriglyceridemia treatment therapies with a considerable amount of success over the years. • Hypertriglyceridemia companies working in the treatment market are Eli Lilly and Company, OrsoBio, Marea Therapeutics, Arrowhead Pharmaceuticals, NorthSea Therapeutics, Ionis Pharmaceuticals, 89bio, Inc., and others, are developing therapies for the Hypertriglyceridemia treatment • Emerging Hypertriglyceridemia therapies in the different phases of clinical trials are- LY3875383, TLC-2716, MAR001, ARO-APOC3, NST-1024, Olezarsen, Pegozafermin, and others are expected to have a significant impact on the Hypertriglyceridemia market in the coming years. • On April 2024, Arrowhead Pharmaceuticals announced results of a Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Plozasiran in Adults With Hypertriglyceridemia. • On March 2024, Marea Therapeutics announced results of a Phase 1b/2a Randomized, Double-Blind, Placebo-controlled Study of the Safety and Efficacy of MAR001 in Patients With Metabolic Dysfunction. • In December 2022, Ionis Pharmaceuticals initiated an open-label extension study ofolezarsen (ISIS 678354) administered subcutaneously to patients with severe hypertriglyceridemia(SHTG). This is a multi-center, open-label study of up to 700 participants with SHTG who would berolled over from studies ISIS 678354-CS5 (NCT05079919) or ISIS 678354-CS6 (NCT05552326). Day 1of this study may be same as the Week 53 visit of either ISIS 678354-CS5 or ISIS 678354-CS6, as applicable. • In August 2022, Ionis Pharmaceuticals initiated a randomized, double-blind, placebocontrolled, Phase III study of olezarsen (ISIS 678354) administered subcutaneously to patients withsevere hypertriglyceridemia. Hypertriglyceridemia Overview Hypertriglyceridemia is a condition characterized by high levels of triglycerides in the blood, which are a type of fat found in the bloodstream. While triglycerides are essential for storing energy, elevated levels can increase the risk of cardiovascular diseases like heart attack and stroke. Several factors can contribute to hypertriglyceridemia, including genetics, diet, obesity, sedentary lifestyle, alcohol consumption, diabetes, and certain medications. Symptoms are often absent, but in severe cases, individuals may experience abdominal pain, pancreatitis (inflammation of the pancreas), and eruptive xanthomas (fatty deposits under the skin). Hypertriglyceridemia Diagnosis is typically made through a blood test measuring triglyceride levels after fasting for 8 to 12 hours. Treatment involves lifestyle modifications such as adopting a healthy diet low in sugar, refined carbohydrates, and saturated fats, regular exercise, weight management, and limiting alcohol intake. In some cases, medications like statins, fibrates, omega-3 fatty acids, or niacin may be prescribed to help lower triglyceride levels. Hypertriglyceridemia Prevention strategies include maintaining a healthy weight, exercising regularly, limiting alcohol intake, and consuming a balanced diet rich in fruits, vegetables, whole grains, and lean proteins. Managing underlying conditions like diabetes and hypothyroidism is also crucial in preventing and managing hypertriglyceridemia. Regular monitoring and follow-up with healthcare providers are essential for individuals with this condition. Get a Free Sample PDF Report to know more about Hypertriglyceridemia Pipeline Therapeutic Assessment- https://www.delveinsight.com/report-store/hypertriglyceridemia-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr Emerging Hypertriglyceridemia Drugs Under Different Phases of Clinical Development Include: • LY3875383: Eli Lilly and Company • TLC-2716: OrsoBio • MAR001: Marea Therapeutics • ARO-APOC3: Arrowhead Pharmaceuticals • NST-1024: NorthSea Therapeutics • Olezarsen: Ionis Pharmaceuticals • Pegozafermin: 89bio, Inc. Hypertriglyceridemia Route of Administration Hypertriglyceridemia pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs, such as • Intra-articular • Intraocular • Intrathecal • Intravenous • Ophthalmic • Oral • Parenteral • Subcutaneous • Topical • Transdermal Hypertriglyceridemia Molecule Type Hypertriglyceridemia Products have been categorized under various Molecule types, such as • Oligonucleotide • Peptide • Small molecule Hypertriglyceridemia Pipeline Therapeutics Assessment • Hypertriglyceridemia Assessment by Product Type • Hypertriglyceridemia By Stage and Product Type • Hypertriglyceridemia Assessment by Route of Administration • Hypertriglyceridemia By Stage and Route of Administration • Hypertriglyceridemia Assessment by Molecule Type • Hypertriglyceridemia by Stage and Molecule Type DelveInsight's Hypertriglyceridemia Pipeline Report covers around 20+ products under different phases of clinical development like • Late-stage products (Phase III) • Mid-stage products (Phase II) • Early-stage product (Phase I) • Pre-clinical and Discovery stage candidates • Discontinued & Inactive candidates • Route of Administration Further Hypertriglyceridemia product details are provided in the report. Download the Hypertriglyceridemia pipeline report to learn more about the emerging Hypertriglyceridemia therapies at: https://www.delveinsight.com/sample-request/hypertriglyceridemia-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr Some of the key companies in the Hypertriglyceridemia Therapeutics Market include: Key companies developing therapies for Hypertriglyceridemia are - Eli Lilly and Company, OrsoBio, Marea Therapeutics, Arrowhead Pharmaceuticals, NorthSea Therapeutics, Ionis Pharmaceuticals, 89bio, Inc., and others Hypertriglyceridemia Pipeline Analysis: The Hypertriglyceridemia pipeline report provides insights into • The report provides detailed insights about companies that are developing therapies for the treatment of Hypertriglyceridemia with aggregate therapies developed by each company for the same. • It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Hypertriglyceridemia Treatment. • Hypertriglyceridemia key companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects. • Hypertriglyceridemia Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type. • Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Hypertriglyceridemia market. The report is built using data and information traced from the researcher's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations, and featured press releases from company/university websites and industry-specific third-party sources, etc. Download Sample PDF Report to know more about Hypertriglyceridemia drugs and therapies- https://www.delveinsight.com/sample-request/hypertriglyceridemia-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr Hypertriglyceridemia Pipeline Market Drivers • Increased Consumption of Unhealthy Diet, increase in research and developmental activities are some of the important factors that are fueling the Hypertriglyceridemia Market. Hypertriglyceridemia Pipeline Market Barriers • However, high-cost associated with the disease, limited awareness about the disease and other factors are creating obstacles in the Hypertriglyceridemia Market growth. Scope of Hypertriglyceridemia Pipeline Drug Insight • Coverage: Global • Key Hypertriglyceridemia Companies: Eli Lilly and Company, OrsoBio, Marea Therapeutics, Arrowhead Pharmaceuticals, NorthSea Therapeutics, Ionis Pharmaceuticals, 89bio, Inc., and others • Key Hypertriglyceridemia Therapies: LY3875383, TLC-2716, MAR001, ARO-APOC3, NST-1024, Olezarsen, Pegozafermin, and others • Hypertriglyceridemia Therapeutic Assessment: Hypertriglyceridemia current marketed and Hypertriglyceridemia emerging therapies • Hypertriglyceridemia Market Dynamics: Hypertriglyceridemia market drivers and Hypertriglyceridemia market barriers Request for Sample PDF Report for Hypertriglyceridemia Pipeline Assessment and clinical trials- https://www.delveinsight.com/sample-request/hypertriglyceridemia-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr Table of Contents 1. Hypertriglyceridemia Report Introduction 2. Hypertriglyceridemia Executive Summary 3. Hypertriglyceridemia Overview 4. Hypertriglyceridemia- Analytical Perspective In-depth Commercial Assessment 5. Hypertriglyceridemia Pipeline Therapeutics 6. Hypertriglyceridemia Late Stage Products (Phase II/III) 7. Hypertriglyceridemia Mid Stage Products (Phase II) 8. Hypertriglyceridemia Early Stage Products (Phase I) 9. Hypertriglyceridemia Preclinical Stage Products 10. Hypertriglyceridemia Therapeutics Assessment 11. Hypertriglyceridemia Inactive Products 12. Company-University Collaborations (Licensing/Partnering) Analysis 13. Hypertriglyceridemia Key Companies 14. Hypertriglyceridemia Key Products 15. Hypertriglyceridemia Unmet Needs 16 . Hypertriglyceridemia Market Drivers and Barriers 17. Hypertriglyceridemia Future Perspectives and Conclusion 18. Hypertriglyceridemia Analyst Views 19. Appendix 20. 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DNR report: Improved ice conditions bring out anglersTORONTO — Canada's main stock index pushed higher to end Monday up almost 150 points on light trading action, while U.S. stock markets also gained ahead of the Christmas break. "Today is a quiet pre-Christmas Day of trading," said Kevin Burkett, a portfolio manager at Victoria, B.C.-based Burkett Asset Management. While markets in both Canada and the U.S. were mild, Burkett suggests watching the markets closely during the holiday season, a contrast to what's typically a sleepy period for markets. "We're continuing to watch markets very closely here because you've got some tectonic plate shifting in terms of the macroeconomic backdrop," he said. "It's all the political conversations both in Canada and in the U.S." Burkett added fiscal policy seems to be disconnected from monetary policy in the post-pandemic period. "The fiscal policy may shift and that shift absolutely has market implications both in the short and long term," he said. The S&P/TSX composite index was up 149.50 points at 24,748.98. Statistics Canada released its latest numbers on Canada's economic growth, up 0.3 per cent in October — driven by the mining, quarrying, and oil and gas extraction sector. The loonie continued its slide, trading for 69.47 cents US compared with 69.61 cents US on Friday. The telecom sector was the biggest loser at the closing on TSX, which Burkett attributed to "tax loss selling happening at the end of the year." Competition Bureau Canada announced on Monday it was suing Rogers Communications Inc. for allegedly making misleading claims about its infinite wireless plans. The stock price for Rogers, which is hovering near 52-week lows, fell 0.7 per cent on Monday. Meanwhile, BCE was down almost 1.4 per cent and Telus dropped 0.9 per cent. Burkett suggested the day's poor performance among telecom companies was likely tax loss selling since it's almost the end of the year. "It's been a tough year for the communication services sector," he said. South of the border, communications services was the top-performing sector, led by large-cap tech companies. Several big technology companies helped support the gains, including chip companies Nvidia and Broadcom. In New York, the Dow Jones industrial average was up 66.69 points at 42,906.95. The S&P 500 index was up 43.22 points at 5,974.07, while the Nasdaq composite was up 192.29 points at 19,764.89. The February crude oil contract was down 22 cents at US$69.24 per barrel and the February natural gas contract was down six cents at US$3.35 per mmBTU. The February gold contract was down US$16.90 at US$2,628.20 an ounce and the March copper contract was down one cent at US$4.09 a pound. This report by The Canadian Press was first published Dec. 23, 2024. Companies in this story: (TSX: GSPTSE, TSX: CADUSD, TSE: BCE, TSE: RCI. B) Ritika Dubey, The Canadian PressFive things to know about QB Brandon Allen, the 49ers’ starter against the Packers this weekend

WASHINGTON (AP) — President Joe Biden on Monday announced that he is commuting the sentences of 37 of the 40 people on federal death row, converting their punishments to life imprisonment just weeks before President-elect Donald Trump , an outspoken proponent of expanding capital punishment, takes office. The move spares the lives of people convicted in killings , including the slayings of police and military officers, people on federal land and those involved in deadly bank robberies or drug deals, as well as the killings of guards or prisoners in federal facilities. The decision leaves three federal inmates to face execution. They are Dylann Roof, who carried out the 2015 racist slayings of nine Black members of Mother Emanuel AME Church in Charleston, South Carolina; 2013 Boston Marathon bomber Dzhokhar Tsarnaev ; and Robert Bowers, who fatally shot 11 congregants at Pittsburgh’s Tree of life Synagogue in 2018 , the deadliest antisemitic attack in U.S history. “I’ve dedicated my career to reducing violent crime and ensuring a fair and effective justice system,” Biden said in a statement . “Today, I am commuting the sentences of 37 of the 40 individuals on federal death row to life sentences without the possibility of parole. These commutations are consistent with the moratorium my administration has imposed on federal executions, in cases other than terrorism and hate-motivated mass murder.” Reaction was strong, both for and against. A Trump spokesperson called the decision “abhorrent.” “These are among the worst killers in the world and this abhorrent decision by Joe Biden is a slap in the face to the victims, their families, and their loved ones." said Trump spokesman Steven Cheung. "President Trump stands for the rule of law, which will return when he is back in the White House after he was elected with a massive mandate from the American people.” Heather Turner, whose mother was killed during the 2017 robbery of a Conway, South Carolina, bank, blasted the decision in a social media post, saying Biden didn't consider the victims of these crimes. “The pain and trauma we have endured over the last 7 years has been indescribable,” Turner wrote on Facebook, describing weeks spent in court in search of justice as “now just a waste of time.” “Our judicial system is broken. Our government is a joke,” she said. "Joe Biden’s decision is a clear gross abuse of power. He, and his supporters, have blood on their hands.” Some of Roof's victims supported Biden's decision to leave him on death row. Michael Graham, whose sister Cynthia Hurd was killed by Roof, said Roof's lack of remorse and simmering white nationalism in the U.S. means Roof is the kind of dangerous and evil person the death penalty is intended for. “This was a crime against a race of people who were doing something all Americans do on a Wednesday night — go to Bible study,” Graham said. “It didn’t matter who was there, only that they were Black.” The Biden administration in 2021 announced a moratorium on federal capital punishment to study the protocols used, which suspended executions during Biden's term. But Biden actually had promised to go further on the issue in the past, pledging to end federal executions without the caveats for terrorism and hate-motivated, mass killings. While running for president in 2020, Biden's campaign website said he would “work to pass legislation to eliminate the death penalty at the federal level , and incentivize states to follow the federal government’s example.” Similar language didn't appear on Biden's reelection website before he left the presidential race in July. “Make no mistake: I condemn these murderers, grieve for the victims of their despicable acts, and ache for all the families who have suffered unimaginable and irreparable loss,” Biden's statement said. “But guided by my conscience and my experience as a public defender, chairman of the Senate Judiciary Committee, vice president, and now president, I am more convinced than ever that we must stop the use of the death penalty at the federal level.” He took a political jab at Trump, saying, “In good conscience, I cannot stand back and let a new administration resume executions that I halted.” Trump, who takes office on Jan. 20, has spoken frequently of expanding executions. In a speech announcing his 2024 campaign , Trump called for those “caught selling drugs to receive the death penalty for their heinous acts.” He later promised to execute drug and human smugglers and even praised China's harsher treatment of drug peddlers. During his first term as president, Trump also advocated for the death penalty for drug dealers . There were 13 federal executions during Trump's first term, more than under any president in modern history, and some may have happened fast enough to have contributed to the spread of the coronavirus at the federal death row facility in Indiana. Those were the first federal executions since 2003. The final three occurred after Election Day in November 2020 but before Trump left office the following January, the first time federal prisoners were put to death by a lame-duck president since Grover Cleveland in 1889. Biden faced recent pressure from advocacy groups urging him to act to make it more difficult for Trump to increase the use of capital punishment for federal inmates. The president's announcement also comes less than two weeks after he commuted the sentences of roughly 1,500 people who were released from prison and placed on home confinement during the COVID-19 pandemic, and of 39 others convicted of nonviolent crimes, the largest single-day act of clemency in modern history. The announcement also followed the post-election pardon that Biden granted his son Hunter on federal gun and tax charges after long saying he would not issue one, sparking an uproar in Washington. The pardon also raised questions about whether he would issue sweeping preemptive pardons for administration officials and other allies who the White House worries could be unjustly targeted by Trump’s second administration. Speculation that Biden could commute federal death sentences intensified last week after the White House announced he plans to visit Italy on the final foreign trip of his presidency next month. Biden, a practicing Catholic, will meet with Pope Francis, who recently called for prayers for U.S. death row inmates in hopes their sentences will be commuted. The U.S. Conference of Catholic Bishops, which has long called for an end to the death penalty, said Biden's decision is a “significant step in advancing the cause of human dignity in our nation” and moves the country “a step closer to building a culture of life.” Martin Luther King III, who publicly urged Biden to change the death sentences, said in a statement shared by the White House that the president "has done what no president before him was willing to do: take meaningful and lasting action not just to acknowledge the death penalty’s racist roots but also to remedy its persistent unfairness.” Madeline Cohen, an attorney for Norris Holder, who faced death for the 1997 fatal shooting of a guard during a bank robbery in St. Louis, said his case “exemplifies the racial bias and arbitrariness that led the President to commute federal death sentences,” Cohen said. Holder, who is Black, was sentenced by an all-white jury. Weissert reported from West Palm Beach, Florida. Associated Press writers Jeffrey Collins in Columbia, South Carolina, and Jim Salter in O'Fallon, Missouri, contributed to this report.

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