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SGR-1505 is under clinical development by and currently in Phase I for Follicular Lymphoma. According to GlobalData, Phase I drugs for Follicular Lymphoma have a 78% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. SGR-1505 overview SGR-1505 is under development for the treatment of BTK-resistant, refractory or relapsed B-cell non-Hodgkin lymphoma, diffuse large B-cell lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma (MCL), Waldenstrom macroglobulinemia, MALT lymphoma, follicular lymphoma, Burkitt lymphoma, plasmablastic lymphoma, high-grade B-cell lymphoma, primary cutaneous follicle center lymphoma, primary effusion lymphoma, primary mediastinal large B cell lymphoma, T-cell/histiocyte rich lymphoma, ALK-positive large B-cell lymphoma, primary cutaneous diffuse large B-cell lymphoma splenic marginal zone lymphoma, nodal marginal zone lymphoma, HHV8-positive DLBCL and duodenal-type follicular lymphoma. It is administered through oral route in the form of tablet. The drug candidate acts by oncogenic activation of nuclear factor-kappa B which acts by targeting MALT1 activity. It is developed based on the artificial intelligence (AI) technology. Schrodinger overview is a healthcare technology company that provides software solutions for drug discovery. The company offers a computational platform designed with predictive modeling, data analytics and collaboration applicable to molecular discovery. Its pipeline products include SGR-1505 (MALT1) against non-Hodgkin’s lymphoma, SGR-2921 (CDC7) to treat hematological cancers and solid tumors and SGR-3515 (Wee1) for gynecological cancers, and LRRK2 for Neurology and SOS1 for cancers and others. ‘s other products include small molecule products, biological drug discovery and material science products. It provides training, documentation and support services. The company operates through offices in the US, Germany, Japan, Ireland, the UK, India, China and South Korea. is headquartered in New York City, New York, the US. For a complete picture of SGR-1505’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .80jili login

Trump names Andrew Ferguson as head of Federal Trade Commission to replace Lina KhanALTOONA, Pennsylvania, Dec 10 (Reuters) - Luigi Mangione, the suspect charged with murder in the shooting of a top UnitedHealth executive, briefly struggled with officers and angrily shouted while being escorted into a Pennsylvania courthouse on Tuesday, as a clearer picture of his motives began to emerge a day after his arrest ended a massive manhunt. Mangione , 26, turned toward a group of reporters and yelled in part, "...completely out of touch and an insult to the intelligence of the American people!" before deputies pushed him away. It was not clear to what he was referring. At the court hearing, his defense lawyer told a judge that Mangione would oppose extradition to New York, where he is charged with murder and other crimes. That decision could delay the process by weeks but is unlikely to block his eventual transfer; for now, Mangione will remain in jail in Pennsylvania, where he faces gun and forgery charges. His attorney, Tom Dickey, said at a news conference that Mangione planned to plead not guilty to the charges. Brian Thompson, the CEO of UnitedHealth's (UNH.N) , opens new tab insurance arm, one of the largest health insurers in the U.S., was shot dead on the morning of Dec. 4 outside a hotel in Manhattan in what police said was a targeted attack, sparking a manhunt that led to Mangione's arrest. More clues about his possible motivation were coming to light on Tuesday. When arrested, Mangione was in possession of a handwritten manifesto that offered insight into his mindset, according to police. The New York Times reported that an internal New York City Police report analyzing the document concluded that Mangione viewed the killing as a justified response to what he believed to be corruption in the healthcare industry. "These parasites simply had it coming," the manifesto said, according to the Times. Mangione suffered from chronic back pain that limited his daily life, according to friends, his social media postings and other news reports. His profile on X shows a background image of an x-ray with what appears to be screws and plates inserted in a lower back. An employee at TrueCar told Reuters that Mangione worked at the car-buying website as a data engineer from 2022 to late 2023. In mid-2023, Mangione took about two months off for what the employee's manager described as back-related issues. The employee, who asked not to be named, described Mangione as "incredibly smart" and very friendly to his co-workers. He said that the company offered employees health insurance through UnitedHealth as well as other choices, such as Aetna. From January through June 2022, Mangione lived at the Surfbreak co-living community in Honolulu, where he led a book club and surfed, hiked and rock-climbed, the founder of the group, R.J. Martin, told the Hawaiian outlet Civil Beat. Martin said Mangione had suffered back pain caused by misaligned vertebrae pinching Mangione's spinal cord, and he left for the mainland at some point for surgery. But he went "radio silent" in June or July, Martin told Civil Beat. Mangione never showed any indication of violence, Martin later told MSNBC. "The Luigi that I knew is completely incompatible with an assassin," he said, describing him as funny, kind and thoughtful. At one point, Mangione suggested Surfbreak's book club read the manifesto of Ted Kaczynski - the U.S. domestic bomber known as the Unabomber - as a joke, according to Martin. On the book-themed social media site Goodreads, a poster with Mangione's name praised Kaczynski's book "Industrial Society and Its Future" as "prescient" about modern society, called him an "extreme political revolutionary" and suggested violence was a legitimate form of resistance in some circumstances. Mangione was spotted at a McDonald's on Monday by an employee who thought he looked like the gunman in surveillance images released by police. Mangione, an Ivy League graduate who was also the valedictorian of a private all-boys school in Maryland, had a loaded ghost gun - an untraceable firearm assembled from parts - and a silencer, officials said on Monday. Both the weapon and his clothing closely resembled those used by the gunman. He also had multiple fake identifications, including a fraudulent New Jersey ID that matched the one used by the gunman to check into a Manhattan hostel days before the shooting, according to authorities. Mangione's family released a statement saying they knew only what had been reported in the media. "Our family is shocked and devastated by Luigi's arrest," the family said in a statement posted to the X account of Maryland lawmaker Nino Mangione. "We offer our prayers to the family of Brian Thompson and we ask people to pray for all involved." The gunman managed to elude capture for days after the attack last Wednesday outside the Hilton hotel in midtown Manhattan. Thompson's murder unleashed a wave of frustration from Americans struggling to afford medical care and those who have been denied claims or care. Thompson, a father of two, had been CEO of UnitedHealthcare since April 2021, part of a 20-year career with the company. He had been in New York to attend the company's annual investor conference. Sign up here. Reporting by Julio-Cesar Chavez in Altoona and Rich McKay in Atlanta; Additional reporting by Brad Brooks, Andrew Hay and Kanishka Singh; Writing by Joseph Ax; Editing by Paul Thomasch, Bill Berkrot and Rosalba O'Brien Our Standards: The Thomson Reuters Trust Principles. , opens new tab

BRITS brace themselves for more Baltic weather as a -6C freezing fog hits the north with snow set to fall just before Christmas. Storm Darragh has barely blown over but The Met Office has already issued another slew of yellow weather warnings. Across parts of Scotland a freezing fog will arrive, covering Glasgow , starting today until 11am tomorrow. The warning stated: "Areas of freezing fog will continue to make travel conditions rather difficult overnight and Wednesday morning." Temperatures will reach down to -6C in some areas with light wind also cautioned. This means that public services might be delayed or even cancelled, with slower journey times in general. Read more News Cyclists are more at risk on the roads with the chill exacerbating any icy patches along the tarmac. Slippery roads might also affect cars, motorbikes and any other road vehicle. The yellow warning issues to Glasgow has a medium likelihood and a low impact - meaning if you're in the area you are likely to be affected by fog, but it might not be too extreme. It covers central Glasgow as well as some areas further out including Lanark, Alexandria, Cumbernauld, and parts of Stirling. Most read in The Sun These parts could get frosty and even face some snow over the long nights with "widespread frost under prolonged cloud break" according to the Met Office. Nowhere else in the UK has been issued any weather warning following Storm Darragh but flood warnings remain in place. Brits have also been warned it will "be breezy" in other areas of the UK but by Wednesday it should clear up for most. This comes as the wreckage of storm Darragh continues to shock the country, with two deaths from falling trees on Saturday. The fourth named storm of the season brought strong winds to many parts of the country over the weekend with millions warned to stay indoors. Thousands were left without power and flights, trains, and buses were cancelled for safety reasons. Entertainment fixtures, like football, were also cancelled for both travel and safety reasons. As what will happen over Christmas, the Met Office has said on Wednesday 25 December there will be unsettled conditions. The forecaster warned of frosts and fog, with strong gusts winds and drizzle moving up from the southeast. On Christmas week, the Met Office revealed some Brits can expect the white stuff to fall. Read More on The US Sun The forecaster's long range weather forecast from December 22 to January 5 reads: "Some sleet and snow is also likely at times, especially on high ground in the north." Unfortunately most are more likely to get a wet Christmas than a white one. According to the Met Office Driving safely in fog Foggy conditions can make it difficult to see the road ahead, be prepared for this by following these simple steps: Make sure you know where your fog light switch is before you set off. Keep a bigger distance between you and the car in front. Be prepared for a sudden bank of fog or drifting, patchy fog. Check your mirrors and slow down before entering fog. Use fog lights when visibility drops below 100 metres, which is roughly the length of a football pitch. Don't use full beam as fog reflects the light back. Once the fog has lifted switch off your fog lights. How does fog affect flights and ferry crossings Fog can affect schedules for flights and ferry crossings. People cope better with delays or cancellations when they follow some small and easy steps: Check the weather for your departure location regularly. Make sure you check your phone for messages from your airline or ferry company. You can also check their websites and social media platforms for additional updates. Arrive on time at the airport or ferry terminal, even if delays are expected. Pack your hand luggage with delays in mind. For example, some people may need to pack extra prescription medicine or baby food. How to avoid transport delays Give yourself the best chance of avoiding delays on your journey by following this two-step checklist: CHECK: check bus and train timetables and the road conditions AMEND: amend your travel plans

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Swiss company B’ZEOS, with pioneering seaweed -based packaging, has secured funding from Faber and ICIG Ventures. B’ZEOS’ mission statement is “the future of sustainable packaging is seaweed,” and this funding success marks a significant moment in its goal to revolutionize the packaging industry, which is largely populated with plastic. After a previously successful round of funding, B’ZEOS is now up to over €5 million (USD $5.2 million) of money raised. “We’ve developed a truly sustainable seaweed -based packaging solution,” said Guy Maurice, Founder & SeaEO of B’ZEOS, in a statement. “Our focus extends beyond eco-friendliness; we’re providing a scalable, industry-ready alternative for global packaging manufacturers.” Read more: Plastic Bags On Beaches Have Reduced By 80% Since Charge Introduced B’ZEOS hopes the collaboration with Faber and ICIG will result in accelerated product development, faster response to industry needs, and smooth commercial production for corporate partners. Faber has also shown an interest in advancing ocean-based, sustainable technology. Seaweed power The seaweed -based packaging B’ZEOS creates is home-compostable and eco-friendly, but its innovation also makes it able to integrate with existing production lines. Other advantages of seaweed include low land and freshwater usage, no microplastics released, and the fact it can grow rapidly. B’ZEOS has already collaborated with the likes of Nestlé to demonstrate its effectiveness. Read more: Notpla Secures £20 Million In Funding For Plastic-Free Seaweed Packaging “With the rising demand for sustainable packaging , we’re thrilled to partner with B’ZEOS and support their mission to transform the industry at scale,” said Rita Sousa, Partner at Faber. “This investment aligns with our commitment to backing ocean-based innovations that drive environmental change and reshape industries for a sustainable future .” Read more: The Wondrous Benefits Of SeaweedTrump names Andrew Ferguson as head of Federal Trade Commission to replace Lina Khan

UConn dropped its first game since February on Monday, losing to Memphis in the quarterfinals of the Maui Invitational. The Huskies, winners of the past two national championships, had won 17 games in a row dating back to a February 20, 2024, loss to Creighton. The Tigers shot 54.7 percent in the 99-97 win, one of their biggest in seven seasons under head coach Penny Hardaway. Senior guard Tyrese Hunter scored 26 points on 8-of-13 shooting, including 7-of-10 from beyond the arc, as Memphis pulled off the 8.5-point upset. Memphis had a chance to win in regulation, but UConn sophomore guard Solo Ball hit a three with one second left in the second half to send the game to overtime. Solo. Ball. pic.twitter.com/ujgqsZ2nCS UConn began last season 7-0 before its first loss on December 1, 2023, at Kansas, 69-65. It went 30-2 the rest of the 2023-24 season, ending with a win over Purdue in the national final. Monday's loss shouldn't be much cause for concern for the Huskies. While they certainly must improve on the defensive end, head coach Dan Hurley's track record suggests UConn will be just fine. The win might say more about Memphis, which missed last year's NCAA Tournament after being bounced from the first round of the AAC tourney by Wichita State. Per ESPN, Memphis has won five in a row against AP-ranked teams. THE TIGERS HAVE DONE IT Memphis defeats No. 2 UConn, winning its FIFTH straight game against an AP-ranked opponent dating back to the beginning of last season!!️ pic.twitter.com/OwyZnn9dIF The win over UConn was the Tigers' first regular-season win against a top-10 opponent since February 2022, when they beat then-AP No. 6 Houston, 69-59. Per KenPom , Memphis entered Monday's game ranked 33rd in the country (out of 364 college basketball teams), while UConn ranked sixth.

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